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ODESSA STATE MEDICAL UNIVERSITY
ODESSA STATE MEDICAL UNIVERSITY

... hypokaliemia, as well as provoke the development of heart failure. Systemic application of local anesthetics. In patients with neuropathic pain, local anesthetic is sometimes injected to induce sedation and central analgesia. The analgesic effect often exceeds the time pharmacokinetic profile of a l ...
Improving survival in pulmonary arterial hypertension EDITORIAL M. Humbert
Improving survival in pulmonary arterial hypertension EDITORIAL M. Humbert

... treatments are still unknown [13, 14]. There is a substantial need for long-term observational studies that evaluate the different treatments, in terms of survival, side-effects, quality of life and costs. As head-to-head comparisons of currently approved therapies are not available, the choice of o ...
Chronic  Myeloid  Leukemia  Clinical  Practice ... (Malaysia) Chairman
Chronic Myeloid Leukemia Clinical Practice ... (Malaysia) Chairman

... availability of tyrosine kinase inhibitors (TKI) have transformed the landscape of treating CML. Today, there is a potential for long term disease control or even cure. Despite the excellent clinical practice guidelines (CPG) available e.g. NCCN guidelines, there are needs to develop customized guid ...
ASSIST - World Health Organization
ASSIST - World Health Organization

... Thank you for agreeing to take part in this brief interview about alcohol, tobacco products and other drugs. I am going to ask you some questions about your experience of using these substances across your lifetime and in the past three months. These substances can be smoked, swallowed, snorted, inh ...
LSD, mushrooms and other hallucinogenic drugs
LSD, mushrooms and other hallucinogenic drugs

... The persons taken into care for hallucinogenic drug use are, on average, older than cannabis or ecstasy users (28 years as against 25 and 24 years respectively). In relation to age, they show characteristics somewhere between those for cannabis or ecstasy users and opiate users. They differ from the ...
formulation and evalution of medicated chewing gum of
formulation and evalution of medicated chewing gum of

... Chewing Gum has been used for centuries to clean the mouth and freshen breath. Medicated Chewing Gums are solid, single dose preparations with a base consisting mainly of gum that is intended to be chewed but not swallowed. They contain one or more active substance which released by chewing and are ...
1 SUMMARY OF PRODUCT CHARACTERISTICS 1 - CBG-MEB
1 SUMMARY OF PRODUCT CHARACTERISTICS 1 - CBG-MEB

... Suicide-related behaviours (suicide attempt and suicidal thoughts), and hostility (predominantly aggression, oppositional behaviour and anger) were more frequently observed in clinical trials among children and adolescents treated with antidepressants compared to those treated with placebo. Fluoxeti ...
What do I need to do when I get home... the hospital?
What do I need to do when I get home... the hospital?

... dyspnea, pruritus, and rash) have been reported. In the event of a severe reaction, discontinue DIFICID Only use DIFICID for infection proven or strongly suspected to be caused by C. difficile. Prescribing DIFICID in the absence of a proven or strongly suspected C. difficile infection is unlikely t ...
Pharmacological Characterization of Noroxymorphone as a New
Pharmacological Characterization of Noroxymorphone as a New

... little is known about the antinociceptive effects of noroxymorphone. We present an in vivo pharmacological characterization of noroxymorphone in rats. METHODS: The antinociceptive properties of noroxymorphone were studied with thermal and mechanical models of nociception in rats. RESULTS: Intratheca ...
OLMESARTAN MEDOXOMIL/HYDROCHLOROTHIAZIDE 20/12
OLMESARTAN MEDOXOMIL/HYDROCHLOROTHIAZIDE 20/12

... Thiazides cross the placental barrier and appear in cord blood. They may cause fetal electrolyte disturbances and possible other reactions that have occurred in adults. Cases of neonatal thrombocytopenia, or fetal or neonatal jaundice have been reported with maternal thiazide therapy. If pregnancy o ...
BAOJ Pharmaceutical Sciences
BAOJ Pharmaceutical Sciences

... most widely studied enhancers of this group. Pyrrolidones have been used as permeation promoters for numerous molecules including hydrophilic (e.g. mannitol, 5-fluorouracil and sulphaguanidine) and lipophilic (betamethasone-17-benzoate, hydrocortisone and progesterone) permeants. As with many studie ...
Subscribe to Hints & Tips
Subscribe to Hints & Tips

... been around for over ten years, so to keep it as functional and userfriendly as possible we’re refreshing the production software we use. The new version will be available in the next few months, and you may notice some very slight cosmetic differences along with some minor changes to the functional ...
4427 Naltrexone/Carers.NSW
4427 Naltrexone/Carers.NSW

... to ensure they are opioid free. If they do have opioids in their body Narcan will immediately bring on withdrawal symptoms which can last approximately one hour. • Certain liver conditions may exclude them from naltrexone treatment. These include acute hepatitis and alcoholic liver disease. The doct ...
Pharmacy Tech Exam Review
Pharmacy Tech Exam Review

... B) 40 ml of Amoxicillin 250/5 cc. C) 60 ml of Amoxicillin 250/5 cc. D) 100 ml of Amoxicillin 250/5 cc. QUESTION #64 ATS solution should be stored in the: A) Refrigerator. B) Injectable section. C) Liquid section. D) Topical section. QUESTION #65 Which dosage form is formulated to dissolve under the ...
Opioids for persistent pain: Good practice The British Pain Society's
Opioids for persistent pain: Good practice The British Pain Society's

... persistent pain, to help their understanding of the role of opioids in pain management. The document outlines good practice regarding decision making in relation to opioid therapy, ongoing monitoring of treatment and identification and management of problems related to opioid use. The document may b ...
Efficacy and safety of the biosimilar ABP 501 compared with
Efficacy and safety of the biosimilar ABP 501 compared with

... 1/0.738=1.355 for the RR of ACR20 responses was chosen based on a published relevant adequate and well-controlled trial8 and was expected to preserve 50% of the estimated 80% upper confidence bound of the treatment effect of the reference product compared with placebo. The 90% CI for RR was estimate ...
Intravenous Infusions
Intravenous Infusions

... The primary side effect of a heparin infusion is hemorrhage. Hemorrhage can occur at virtually any site in patients receiving heparin. An unexplained fall in hematocrit, fall in blood pressure or any other unexplained symptom should lead to serious consideration of a hemorrhagic event. An overly pro ...
Self-Study - NurseCe4Less.com
Self-Study - NurseCe4Less.com

... The primary side effect of a heparin infusion is hemorrhage. Hemorrhage can occur at virtually any site in patients receiving heparin. An unexplained fall in hematocrit, fall in blood pressure or any other unexplained symptom should lead to serious consideration of a hemorrhagic event. An overly pro ...
Genetic mapping of Theobroma cacao (Malvaceae - Funpec-RP
Genetic mapping of Theobroma cacao (Malvaceae - Funpec-RP

... Amazon and Guiana (Almeida and Valle, 2007). Cacao grows in tropical areas of the Central and South Americas, Asia and Africa (Marita et al., 2001). The fruits of T. cacao are commercially explored for the production of seeds destined to the preparation of cocoa derivatives and sub-products, mainly ...
B-8 - New Psychiatric Medications
B-8 - New Psychiatric Medications

... • Starting dose 1 mg twice daily • Target dosage range 6-12 mg twice daily • Increase by no more than 2 mg twice daily every day until target range – Slow titration due to increased risk of low blood pressure, dizziness, and falls ...
Rapid determination of Ziprasidone and Buclizine Hydrochloride in
Rapid determination of Ziprasidone and Buclizine Hydrochloride in

... ARS is a dye and a common reagent for the determination of metal ions1-3 and for some pharmaceutical formulations in spectrophotometric method4,5. ZPD is chemically known as 5- [2 - [4- (1, 2 - benzisothiazol-3yl)-1-piperazin-1yl] ethyl]-6-chloro-1, 3-dihydroindol-2-one hydrochloride. It is a novel ...
This  Guidance  updates  a  Faculty ... Professional  Development  Topic  (FACT)  on ...
This Guidance updates a Faculty ... Professional Development Topic (FACT) on ...

... efficacy are clinically relevant. Factors that influence the clinical significance of interactions include: narrow therapeutic ranges of drugs or hormones, wide individual variation in serum concentrations of drugs or hormones, and poor compliance. There is a lack of good quality, robust evidence on ...
L23-24-25 Alkaloids Medicinal Plants
L23-24-25 Alkaloids Medicinal Plants

... We talked previously about alkaloids, we have mentioned the Isoquinoline and Tetrahydroisoquinoline, these are common in plant Papaver somniferum, Quinolone and its structural isomer, Iso quinolone, in addition to tetrahydroisoquiniloine, these alkaloids are wildly spread in different plants, also w ...
‘-4 L
‘-4 L

... those products are inaccurate and based on inadequate data. You raise concerns that the monographs will inappropriately validate any synthetic conjugated estrogens drug product and mistakenly foster the inference that any such product is the same as Premarin. To support your argument, you cite state ...
Student Handout
Student Handout

... The tiny rock pocket mouse weighs just 15 grams, about as much as a handful of paper clips. A typical rock pocket mouse is 172 millimeters long from its nose to the end of its tail, which is shorter than an average pencil. Its impact on science, however, has been enormous. What’s so special about th ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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