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“Up To Date”
“Up To Date”

... psychoactive substances (illegal or not). Despite a diversified outpatient care offer, general practitioners (GPs) are seen as major players in detecting and managing problems related to substance abuse. Similarly, occupational physicians (OPs) are also expected to play a role in the field of substa ...
Third Canadian Therapeutics Congress
Third Canadian Therapeutics Congress

... corticosteroids (ICS) and long-acting ƒÒ2-agonists (LABA) in the same inhaler) have been found to be more persistent and adherent than users of concurrent therapy. We wanted to investigate whether this observed difference in treatment adherence could result in an improved effectiveness for combinati ...
sued
sued

... certification … with respect to each patent which claims the listed drug … or … a use for such listed drug.” Id. § 355(j)(2)(A)(vii); see also Apotex, Inc. v. Thompson, 347 F.3d 1335, 1350-51 (Fed. Cir. 2003).1 Four certifications are available: (I) that patent information has not been filed with re ...
P.Point Lecture Template - Green River Community College
P.Point Lecture Template - Green River Community College

... chance that the couple will produce a girl that is a non-roller? Use the following steps as a general guide to solve this and other problems: 1. Select a letter to represent the gene involved • Use upper case for the dominant allele, lower case for the recessive allele. 2. Write the genotypes of the ...
Renagel (sevelamer hydrochloride)
Renagel (sevelamer hydrochloride)

... The possibility of an interaction cannot be excluded and close monitoring of blood concentrations of cyclosporin, mycophenolate mofetil and tacrolimus or dosing these medicines apart from RENAGEL to prevent GI binding (at least one hour before or three hours after RENAGEL) should be considered durin ...
Conditional likelihood score functions for mixed models in linkage
Conditional likelihood score functions for mixed models in linkage

... disease allele frequencies and penetrance parameters, and then to compute S. McPeek (1999) showed, for binary traits, arbitrary pedigree structures and affected-only phenotypes, that several allele sharing score functions S could be derived in this way. McPeek’s work was generalized in Hössjer (2003 ...
TBK1 Gene Duplication and Normal
TBK1 Gene Duplication and Normal

... The discovery that TBK1 is a glaucoma gene suggests biological pathways that may be important in the pathogenesis of NTG. Both known NTG genes, TBK1 and OPTN, function in nuclear factor–κB (NF-κB) signaling pathways,22,23 which have been previously connected with apoptosis and cell death. TBK1 and O ...
PHYSICOCHEMICAL CHARACTERIZATION OF SPRAY DRIED FORMULATION CONTAINING AMORPHOUS DRUG Research Article
PHYSICOCHEMICAL CHARACTERIZATION OF SPRAY DRIED FORMULATION CONTAINING AMORPHOUS DRUG Research Article

... Received: 10 July 2012, Revised and Accepted: 21 Aug 2012 ...
Molecular Genetics and Metabolism - Society for Inherited Metabolic
Molecular Genetics and Metabolism - Society for Inherited Metabolic

... Mitochondrial diseases are a collectively common but notoriously heterogeneous group of inherited metabolic disorders at the genetic, biochemical, and clinical levels. The central problem in respiratory chain disorders is impaired energy production, with secondary adaptations occurring throughout th ...
The purpose of this summary is exclusively educational, to provide
The purpose of this summary is exclusively educational, to provide

... Drug provocation test (DPT): (i) also referred to as drug challenge, graded challenge or test dosing; (ii) gold standard test to confirm or rule out drug hypersensitivity (in some clinical situations, it might be more useful to look for safe drug alternatives instead of performing a DPT); (iii) espe ...
World Health Organization Department of Communicable Disease Surveillance and Response WHO/CDS/CSR/DRS/2001.4
World Health Organization Department of Communicable Disease Surveillance and Response WHO/CDS/CSR/DRS/2001.4

... * Approximate or projected cost given in US dollars per test performed and reflects only cost of expendable materials unless otherwise noted. ** Cost includes salaries of microscopists and expendable supplies; does not include cost of training, supervision, or equipment. ...
efficacy and tolerability of continuous terbinafine (Lamisil®)
efficacy and tolerability of continuous terbinafine (Lamisil®)

... period. A smaller study11 has also shown a trend towards greater ef®cacy for continuous terbina®ne compared to intermittent itraconazole, but others12 have claimed that intermittent itraconazole is equally effective. The present study is the ®rst to compare continuous terbina®ne with intermittent it ...
A closer look at… - American Academy of Dermatology
A closer look at… - American Academy of Dermatology

... Dr. Shalita points out, the consensus of the Global Alliance for Improving Outcomes in Acne is that a topical retinoid should be used to treat all but the most severe forms of acne. As the patient responds to treatment, Dr. Berson may stop the oral antibiotics or topical antimicrobials while continu ...
Review of Interventional Pain Management
Review of Interventional Pain Management

... pain not controlled with medications by other routes, either due to high dosages or intolerable side effects. The equianalgesic dose between an oral vs intrathecal medication is approximately 300X greater. For example, 300 mg oral morphine is equal to approximately 1 mg intrathecal morphine. Some po ...
Single Nucleotide Polymorphism of Interleukin-27 Gene
Single Nucleotide Polymorphism of Interleukin-27 Gene

... the allogeneic fetus from infiltrating cytotoxic T cells [6]. These immune cells/leukocytes secrete different types/levels of interleukins that play a role in placental immunoregulation [5]. Thus, interleukins and the corresponding immune cells/leukocytes work together to maintain the immune balance ...
Predinical Experiences with Magnetic Drug Targeting: Tolerance
Predinical Experiences with Magnetic Drug Targeting: Tolerance

... concentrate epirubicin locally in tumors. As a result, the ferrofluld did not ...
abstract
abstract

... growth factors may influence the relationship between the drugs and gingival tissues. The exact mechanism of CCB’s and the increased risk of gingival overgrowth is not completely understood. GO is a calcium dependent process. CCB’s inhibit the intercellular uptake of calcium & this inhibitory action ...
SPIRIVA® 18 microgram, inhalation powder, hard capsule
SPIRIVA® 18 microgram, inhalation powder, hard capsule

... bromide inhalation powder has been used concomitantly with other drugs without clinical evidence of drug interactions. These include sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids, commonly used in the treatment of COPD. The co-administration of tiotropium bromide with o ...
ODESSA NATIONAL MEDICAL UNIVERSITY FAMILY MEDICINE
ODESSA NATIONAL MEDICAL UNIVERSITY FAMILY MEDICINE

... hypokaliemia, as well as provoke the development of heart failure. Systemic application of local anesthetics. In patients with neuropathic pain, local anesthetic is sometimes injected to induce sedation and central analgesia. The analgesic effect often exceeds the time pharmacokinetic profile of a l ...
EVALUATION OF HEPATO PROTECTIVE ACTIVITY OF ETHANOLIC ROOT EXTRACT OF
EVALUATION OF HEPATO PROTECTIVE ACTIVITY OF ETHANOLIC ROOT EXTRACT OF

... Group III (test 1): PGERE (150mg/Kg, P.O for 8days) + CCl4 Group IV (test 2): PGERE (300mg/Kg, P.O for 8days) + CCl4 ...
Complementary and Alternative Medicine Approaches to Migraine
Complementary and Alternative Medicine Approaches to Migraine

... Children Enjoy It • To teach self hypnosis for a specific purpose (such as reduction of pain or elimination of a habit) involves helping young children focus on their natural thinking styles. • Kids move in and out of altered states and imaginary activities all the time. Think IMAGINARY PLAY! • The ...
Chronic  Myeloid  Leukemia  Clinical  Practice ... (Malaysia) Chairman
Chronic Myeloid Leukemia Clinical Practice ... (Malaysia) Chairman

... availability of tyrosine kinase inhibitors (TKI) have transformed the landscape of treating CML. Today, there is a potential for long term disease control or even cure. Despite the excellent clinical practice guidelines (CPG) available e.g. NCCN guidelines, there are needs to develop customized guid ...
TREATNET Quality Standards for Drug Dependence Treatment and
TREATNET Quality Standards for Drug Dependence Treatment and

... and to implement adequate services that correspond to the various and complex needs of drug users in the course of their clinical history. * http://www.who.int/substance_abuse/facts/global_burden/en/index.html iii ...
ASSIST - World Health Organization
ASSIST - World Health Organization

... Thank you for agreeing to take part in this brief interview about alcohol, tobacco products and other drugs. I am going to ask you some questions about your experience of using these substances across your lifetime and in the past three months. These substances can be smoked, swallowed, snorted, inh ...
LSD, mushrooms and other hallucinogenic drugs
LSD, mushrooms and other hallucinogenic drugs

... The persons taken into care for hallucinogenic drug use are, on average, older than cannabis or ecstasy users (28 years as against 25 and 24 years respectively). In relation to age, they show characteristics somewhere between those for cannabis or ecstasy users and opiate users. They differ from the ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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