• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Open letter
Open letter

... the pharmaceutical company’s answers to the EMA’s questions at the end of each of these stages. This lack of transparency means that available scientific information that would be useful to prescribers and patients is lost. Releasing it would increase European citizens’ confidence in the EMA’s decis ...
a study to assess the knowledge and practices of self medication
a study to assess the knowledge and practices of self medication

... in 42% of the young women and severe in 58%. Seventy-three patients (93%) reported taking at least one medication for menstrual pain. The majority (91%) used OTC medications, but 21% reported obtaining additional prescription medications, including acetaminophen and codeine, ibuprofen and hydrocodon ...
Ensembl Variations
Ensembl Variations

... Find the TranscriptSNPView page for human PTPN22. ...
LSD Music final accepted - Spiral
LSD Music final accepted - Spiral

Antiretroviral Therapy in HIV Infection
Antiretroviral Therapy in HIV Infection

... Copyright 2013, Turner White Communications, Inc., Strafford Avenue, Suite 220, Wayne, PA 19087-3391, www.turner-white.com. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, electronic, photocopyi ...
Title of the Topic
Title of the Topic

... Peptic ulcer diseases (PUD) are the disorder of the gastrointestinal system and millions of people suffer from this disease globally. The main causes of peptic ulcers are hyperacidity, excessive intake of alcohol, overeating, high intake of spicy foods, food poisoning, high intake of coffee, smoking ...
Moxy® drug-coated balloon: a novel device for the treatment of
Moxy® drug-coated balloon: a novel device for the treatment of

... novo femoropopliteal stenosis. Treatment with another DCB (paclitaxelcoated at 3 µg/mm2, hydrophilic carrier) resulted in significantly lower late loss at six months33 and lower TLR rates at two years follow-up34. Further evidence of DCB efficacy is being investigated in the LEVANT I multicentre, si ...
Clinical Relevance of Drug Releases Testing
Clinical Relevance of Drug Releases Testing

... In vivo dissolution (profile) In vivo absorption (profile) In vivo pharmacokinetic profile Sensitive to efficacy or safety ...
Verso linee guida europee su NAFLD/NASH
Verso linee guida europee su NAFLD/NASH

... Long-term maintenance approach, combining physical activity according to the principles of cognitivebehavioural treatment Low-to-moderate fat and moderateto-high carbohydrate intake Low-carbohydrate ketogenic diets or high-protein ...
The Australian Multicenter Trial of Growth Hormone
The Australian Multicenter Trial of Growth Hormone

... regarding their perceived major areas of disability, i.e. energy, mood, and sleep. The GHDQ consists of 30 questions relating to these three subscales or domains, each answered on a 10-cm visual analog scale, completed on an IBM portable computer, on which mean and range of responses was recorded. M ...
SOP Criteria for Variant Classification
SOP Criteria for Variant Classification

... Reputable source recently reports variant as pathogenic but the evidence is not available to the laboratory to perform an independent evaluation Note [BMGL]: only invoke when there is new evidence from the source that was not considered for other criteria during the variant evaluation. ...
Chapter 1 Introduction to Evolutionary Computation and Genetic
Chapter 1 Introduction to Evolutionary Computation and Genetic

... variety of classical optimization techniques, discovered that altering physical variables in a random manner (ensuring small modifications were more frequent than larger ones) proved to be a very effective technique. This gave rise to a form of evolutionary algorithm that they termed an evolutionary ...
Issue 4 - Society of Forensic Toxicologists
Issue 4 - Society of Forensic Toxicologists

... The above distinguished group will spend countless hours making sure that this organization makes progressive, sound decisions to protect the integrity and reputation of SOFT, as well as to ensure a stable, continued successful organization well into the future. Six years is the average length of co ...
Antidepressant medication table for Adults
Antidepressant medication table for Adults

... disorder or CHF ...
product monograph - Ask Novartis Pharma
product monograph - Ask Novartis Pharma

... should also enquire whether the patient has been treated with ACTH preparations in the past, and, if so, make sure that the treatment gave rise to no hypersensitivity reactions (see CONTRAINDICATIONS). Allergic reactions may occur in response to SYNACTHEN* DEPOT, which tend to be more severe in pati ...
Definitions and Concepts
Definitions and Concepts

... • Bioavailability is defined as the rate and extent (amount) of drug absorption. • The relative amount of an administration dose of a particular drug that reaches the systemic circulation intact and the rate at which this occurs is known as the bioavailability. ...
MS Contin - Purdue Pharma
MS Contin - Purdue Pharma

... depressants (sleep aids, tranquilizers) because dangerous additive effects may occur resulting in serious injury or death. ...
Hepatotoxicity of Antituberculosis Therapy
Hepatotoxicity of Antituberculosis Therapy

... ALT, is the strongest confirmation of the diagnosis (3). Rechallenge may, in some instances, endanger the patient and is usually confined to essential drugs or used when multiple potentially hepatotoxic drugs have been administered concomitantly (4). Dimensions of the Problem ...
1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights

... marker of destabilization of asthma and requires re-evaluation of the patient and treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, eg, corticosteroids. 5.3 Use of Anti-Inflammatory Agents The use of beta-adrenergic-agonist bronchodilators alone ...
Dangers of Statin Drugs
Dangers of Statin Drugs

... According to the research of Dr. Golomb, nerve problems are a common side effect from statin use; patients who use statins for two or more years are at a four to 14fold increased risk of developing idiopathic polyneuropathy compared to controls.11 She reports that in many cases, patients told her th ...
Making sense of itraconazole pharmacokinetics
Making sense of itraconazole pharmacokinetics

... triazoles) are all structurally similar with a five-membered azole ring and a complex side chain. They have a broad range of mostly fungistatic activity which varies significantly between the members of the group and two in vitro studies have shown that itraconazole may be fungicidal against certain ...
Non-IOP-Lowering and Unconventional IOP
Non-IOP-Lowering and Unconventional IOP

... such methods. The first includes unconventional methods to lower the intraocular pressure, e.g. alternative drugs such as marijuana. The second category includes treatments that do not affect IOP at all, but nonetheless aim to decrease the rate of progression of vision loss. The use of complementary ...
UNIVERSITY OF KENTUCKY
UNIVERSITY OF KENTUCKY

... Just because a product is labeled ‘natural’ it is not guaranteed to be safe Natural products must be approved by the FDA Natural products may be used to diagnose, treat, cure, or prevent disease The exact mechanism of action of the supplement can be found in the product insert ...
THE PREVALENCE AND CONTROL OF HYPERTENSION AMONG
THE PREVALENCE AND CONTROL OF HYPERTENSION AMONG

... Hypertension is a major cardiovascular disease risk factor and when present in diabetic patients increases the cardiovascular disease burden substantially. It has been documented that hypertension in diabetic patients markedly increases the risks of coronary heart disease, stroke, nephropathy and re ...
Detection of Five Rare Cystic Fibrosis Mutations Peculiar to
Detection of Five Rare Cystic Fibrosis Mutations Peculiar to

... (21 ), and two alleles have been described in France (22 ). Our data confirm some genetic differences in the CF mutations between Southern and Northern Italy (5 ). Several mutations highly frequent in Northern Italy (R1162X and 71115G3 A) have not been detected in Southern Italy, neither has T338I, ...
< 1 ... 239 240 241 242 243 244 245 246 247 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report