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Practicalities in the Use of Obesity Pharmacologic Agents
Practicalities in the Use of Obesity Pharmacologic Agents

... • If <3% weight loss after 12 wks, either discontinue or advance to full dose phentermine 15/ topiramate ER 92 (transition dose phentermine 11.25/ topiramate ER 69 for 2 wks) • If <5% weight loss after 12 wks on full dose, discontinue (take every other day for 1 wk) Phentermine and topiramate extend ...
GATE 2009 Pharmaceutical Sciences Question Paper
GATE 2009 Pharmaceutical Sciences Question Paper

... As per the Drugs and Cosmetics Act, the HEPA filters are required to filter the air in the pharmaceutical manufacturing unit. Grade A filter is used for (A) (B) (C) (D) ...
DOSAGE FORMS AND STRENGTHS
DOSAGE FORMS AND STRENGTHS

... FORADIL capsule every 12 hours using the AEROLIZER Inhaler. The patient must not exhale into the device. The total daily dose of FORADIL should not exceed one capsule twice daily (24 mcg total daily dose). More frequent administration or administration of a larger number of inhalations is not recomm ...
Woody - CTN Dissemination Library
Woody - CTN Dissemination Library

... • Randomized trial of OROS-MPH for adolescents seeking treatment for substance use problems • All patients received weekly CB therapy • Surprising finding: Substance use and ADHD improved equally in both groups ...
MARKED VARIABILITY IN PERI-PARTUM ANESTHETIC MANAGEMENT OF PATIENTS ON
MARKED VARIABILITY IN PERI-PARTUM ANESTHETIC MANAGEMENT OF PATIENTS ON

... opioids in patients on buprenorphine maintenance therapy (BMT). Methods: After institutional review board approval for the study protocol, retrospective peripartum anesthesia/analgesia data of BMT patients for five-year period were accessed and analyzed. Results: Out of reviewed 51 patient charts, n ...
Review of PREP Guidelines
Review of PREP Guidelines

... NYS DOH Guidance Pre-prescription education  The pill Truvada ®has two drugs in it that are commonly used to treat HIV in persons who are HIV-positive.  When taken daily by people who are HIV-negative, they can block HIV from infecting the body. The pill needs to be taken every day in order for t ...
Sufentanil Citrate Injection USP
Sufentanil Citrate Injection USP

... Pregnant Women: Sufentanil has been shown to have an embryocidal effect in rats and rabbits when given at doses 2.5 times the upper human dose for a period of 10 days to over 30 days. These effects were probably due to maternal toxicity (decreased food consumption with increased mortality) following ...
Downloaded
Downloaded

... panic and stress disorders, major depressive disorders, obsessive compulsive disorders, phobias, anxiety disorders, and borderline personality disorders. Selective serotonin reuptake inhibitors (SSRIs) are the antidepressant drugs most commonly prescribed during pregnancy. However, concerns have rec ...
FORMULATION AND IN-VITRO EVALUATION OF THERMOREVERSIBLE RIZATRIPTAN BENZOATE NASAL GEL  Research Article
FORMULATION AND IN-VITRO EVALUATION OF THERMOREVERSIBLE RIZATRIPTAN BENZOATE NASAL GEL Research Article

... parenteral route is undesirable or impractical if a drug is intended for the treatment of chronic diseases. Therefore an alternative route of administration would be preferred. For the past few decades, the transdermal route has been explored for a number of drugs, but its use is limited due to low ...
Design and Characterization of Fast Dissolving Films of Valsartan
Design and Characterization of Fast Dissolving Films of Valsartan

... effective antihypertensive without many side effects of angiotensin II receptor antagonists and offers the possibility of frequent dosing to deal with hypertension. In order to enhance the solubility of valsartan and subsequently dissolution and absorption, this research work is undertaken. Solid di ...
SEMINAR ON - Pharmawiki.in
SEMINAR ON - Pharmawiki.in

... low-mol.wt drugs as well as therapeutic peptides and proteins . Nose to brain delivery has been reported either in humans or animal models of Alzheimer’s disease, brain tumours, epilepsy, pain and sleep disorders . Nose to the CNS may occur via olfactory neuroepithelium. ...
The present study is to compare the efficacy of
The present study is to compare the efficacy of

... A double blind design was used and the drugs were administered 5 minutes before induction of anaesthesia..All patients were assessed for fitness of anaesthesia pre operatively and were given nil per oral 6 hours prior to surgery. The age and weight of the patients were noted. The basal heart rate, b ...
The use of clozapine plasma levels in optimising therapy
The use of clozapine plasma levels in optimising therapy

... Centorrino et al (1995) found that there was no association between the degree of leucopenia caused by clozapine and clozapine or norclo zapine plasma levels. Clozapine serum levels are difficult to predict from the dose given and there are many factors which influence the serum level obtained. Shor ...
QTL-mapping  of  individual  resistance  against  American Apis mellifera
QTL-mapping of individual resistance against American Apis mellifera

... segregant analysis with subsequent finemapping of haploid drone offspring from a single honeybee queen we identified one significant and three suggestive quantitative trait loci (QTL) as well as one significant epistatic interaction influencing prepupal survival after AFB infection. While we were no ...
Hepatotoxicity by Acetaminophen and Amiodarone in
Hepatotoxicity by Acetaminophen and Amiodarone in

... the same as in mammals.1,2 Thus, zebrafish may be promising non-rodent alternative model in toxicology which has an advantage over the traditionally used models.3,4 Acetaminophen has been widely used for > 50 years in the treatment of pain and fever and provides for the safe and effective relief of ...
Coma after levetiracetam overdose
Coma after levetiracetam overdose

Appendix 5 - Cancer Care Ontario
Appendix 5 - Cancer Care Ontario

... Many drugs used in the treatment of cancer patients are excreted by the kidney (carboplatin, methotrexate etc). For some drugs the kidney may be the only or major route of excretion. Abnormalities in renal function may therefore reduce the excretion of a drug, leading to higher drug levels for longe ...
Review of Opioids and Treatment of Opioid Dependence Medical Director, PCSS-O
Review of Opioids and Treatment of Opioid Dependence Medical Director, PCSS-O

... Pharmacology of Opioids  First pass after oral ingestion varies: morphine only 15% orally available but methadone 80-90%  Duration of analgesia 3-6 hours but constipation or respiratory depression may last longer in drugs such as methadone  Metabolized by liver (glucuronidation or P450 CYP 2D6, ...
Menopause drugs compared - Consumer Reports Health
Menopause drugs compared - Consumer Reports Health

... risk of heart disease if they take hormones, but they still face an elevated risk of breast cancer, blood clots, and stroke. Some of the initial confusion occurred because the original findings of the WHI and other studies of women taking hormones didn’t fully separate out results for younger (unde ...
Chemicals/drugs-hepatotoxicants: An overview
Chemicals/drugs-hepatotoxicants: An overview

... MTX for neoplastic diseases has been associated with abnormalities of liver biochemical tests. It is noted that dose of MTX 0.250 mg/kg body weight i.p. given for 4 weeks to animal responsible to induced necrosis in liver cell [32]. Azathioprine induced hepatotoxicity Azathioprine (AZA) is an import ...
Inherited Representations are Read in
Inherited Representations are Read in

... Genetic representation is not a matter of tight causal connection, like that seen ...
Product Monograph Template - Standard
Product Monograph Template - Standard

... Osteonecrosis of the jaw: Osteonecrosis of the jaw (ONJ) has been reported in patients with cancer receiving treatment regimens including bisphosphonates. Many of these patients were also receiving chemotherapy and corticosteroids. The majority of reported cases have been associated with dental proc ...
drug dosage and therapy
drug dosage and therapy

... performed in caring for sick and injured patients. The appropriate drug given in the correct dosage will very often hasten a patient's recovery. On the other hand, an inappropriate drug or dosage may worsen a patient's condition or even result in his death. The enlisted person charged with the admin ...
Medication Administration Guidelines
Medication Administration Guidelines

... 1. All prescription and non-prescription medication should be sent or brought to school by the parent with instructions on giving the medication at school. *All prescription medication must be contained in the prescription bottle, properly labeled by the pharmacist. ( The pharmacist will provide the ...
Tetracycline group in children
Tetracycline group in children

... bioavailability[1]. Absorption is greater in the fasting state and the percentage of an oral dose absorbed on an empty stomach is low for chlortetracyclines (30%); intermediate for oxytetracycline, demeclocycline, tetracycline (60% to 80%); and high for doxycycline (95%) and minocycline (100%). High ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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