• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
PDF full-Text
PDF full-Text

... The hapten hypothesis is based on observations that small molecules did not induce an immune response unless they were covalently bound to a protein [19]. This concept has been widely established in allergic contact dermatitis caused by chemical agents [20-21] and in allergic reactions to BLs [22]. ...
Behavioural and neurochemical changes induced by stress
Behavioural and neurochemical changes induced by stress

... sonicated for around 30 s at medium power at 4 xC and lysates were centrifuged for 30 min at 10 000 g. The supernatant was used for SDS-polyacrylamide gel electrophoresis (PAGE) and the pellet discarded. Protein concentration was determined with the Bradford assay (Bradford, 1976). Equal amounts of ...
1.3.1.1 Summary of Product Characteristics
1.3.1.1 Summary of Product Characteristics

... placebo after three years were 8.8 %, 5.9 % and 7.8 % at the spine, femoral neck and trochanter respectively. Total body BMD also increased significantly. In the patients treated with alendronate, the proportion of patients who suffered one or more vertebral fractures was reduced by 48 % (alendronat ...
PowerPoint Presentation - LECTURE 10
PowerPoint Presentation - LECTURE 10

... • Venous Formation - Usually from slow bld flow - Can occur rapidly Stagnation of the blood flow initiate the coagulation cascade production of fibrinenmeshes RBC’s & platelets to form the thrombus. Venous thrombus has a long tail that can break off to produce an embolus. These travel to faraway s ...
Commentary: Theoretical Predictions of Flow Effects on Intestinal
Commentary: Theoretical Predictions of Flow Effects on Intestinal

... intestine to first-pass removal. However, the ranking for the predicted contribution of hepatic metabolism, when present, to firstpass removal was the opposite: SFM > QGut model > TM. The findings suggest that the fQ value strongly influences the rate of intestinal metabolism (FI and Fsys) and indir ...
Inheritance (heredity): The transmission of genes from parents to
Inheritance (heredity): The transmission of genes from parents to

... - Unit of information about heritable trait passed from parents to offspring. - Each gene has a specific location (locus) on a chromosome. * Alleles: - Alternate forms of genes. - Designated by letters. * Dominant = Capital E, A, S, T, …. The expression of dominant alleles masks the effect of recess ...
Anticonvulsants - LSU School of Medicine
Anticonvulsants - LSU School of Medicine

... • People don’t feel pain during a seizure; muscles may be sore afterward. • Person may be “different” for a while after the seizure. ...
Risk assessment report relating to paddos (psilocin and
Risk assessment report relating to paddos (psilocin and

... The Coordination Centre for the Assessment and Monitoring of new drugs (CAM) has carried out a risk assessment on psychotropic mushrooms containing the active substances psilocin and psilocybin. This drug is not associated with physical or psychological dependency, acute toxicity is largely limited ...
The dopamine reuptake inhibitor MRZ
The dopamine reuptake inhibitor MRZ

... chow (Altromin, Germany) was restricted to 15 g per animal and day to maintain them at ∼85% of their freefeeding weight. Temperature (22 ± 2 °C) and humidity (50 ± 10%) were kept constant in the animal house. ...
Newer Delivery Systems for Local Anesthesia in Dentistry
Newer Delivery Systems for Local Anesthesia in Dentistry

... user with greater tactile sensation and control compared to the traditional syringe. The available flow rates of LA delivery are controlled by a computer and thus remain consistent from one injection to the next and are delivered with a foot-activated control. The greater control over the syringe an ...
pediatric dose/route
pediatric dose/route

...  Systemic reactions to Cetacaine have not been reported. ADULT DOSE/ROUTE:  Cetacaine should be sprayed directly into each nostril for one second or less, for normal anesthesia and suppression of the gag reflex prior to attempting nasal intubation. PEDIATRIC DOSE/ROUTE:  Not indicated. NOTES:  A ...
Research Associate, Dept
Research Associate, Dept

... Several unique, Cryptosporidium specific genes and novel metabolic pathways were investigated during the work on this thesis. This effort has led to a better understanding of the biology of C. parvum. In addition, several enzymes that significantly differ from the mammalian host and may serve as pot ...
anatomy (phl 281)(2 + 1) - KSU Faculty Member websites
anatomy (phl 281)(2 + 1) - KSU Faculty Member websites

... PRACTICAL PART: ...
Infant Feeding Guidelines for Drug Using Mothers
Infant Feeding Guidelines for Drug Using Mothers

... actual amount of drugs passed to the baby through breast milk is usually minimal and will have little effect on the newborn baby. The sometimes small effect on the baby may even help withdrawal symptoms, if they are present.3 Babies born to substance-using mothers are particularly vulnerable and hav ...
PDF Format - Indian Pediatrics
PDF Format - Indian Pediatrics

... sodium potassium adenosine triphosphatase (Na-KATPase), increasing the intracellular calcium levels, thereby increasing the contractile state of the myocardium. Inhibition of Na-K-ATPase also reduces sympathetic flow from the central nervous system and reduces the renal absorption of sodium in ...
Supplementary Information (doc 408K)
Supplementary Information (doc 408K)

... pipeline. To increase confidence that homozygous calls are correctly distinguished from heterozygous calls, individuals homozygous for the reference and non-reference allele had to pass an allele balance (number of alternative reads/total number of reads) filter of less than 0.1 and greater than 0.9 ...
HIGHLIGHTS OF PRESCRIBING INFORMATION -----------------DOSAGE FORMS AND STRENGTHS------
HIGHLIGHTS OF PRESCRIBING INFORMATION -----------------DOSAGE FORMS AND STRENGTHS------

... 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and can have toxic effects on the developing fetus (often related to retardation of skeletal develo ...
Role of Corticosteroids in Oral Lesions
Role of Corticosteroids in Oral Lesions

... treatment of LP for many years. The therapeutic properties of corticosteroids were first demonstrated by Edward Kendall and Philip Hench in 1948 (Hench 1949). Corticosteroids may be applied topically as ointments, pastes, lozenges or mouthwashes or through an inhaler with a special adapter. The best ...
Cp min = 8mg /l
Cp min = 8mg /l

... plasma conc of phenytoin is within the therapeutic range , to prevent any undesirable side effects associated with increased level of phenytoin in plasma).  The time to sample phenytoin varies from patient to patient , depending mainly on the disease state the patient is treated from and his clinic ...
Name Date ______ Mrs. Geithner-Marron (Biology200) Period
Name Date ______ Mrs. Geithner-Marron (Biology200) Period

... Changes in allele frequency (and, therefore, evolution), will in turn, affect how often you see a particular phenotype (trait) in a population. o Ex. Breeders of rabbits have long been familiar with a variety of genetic traits that affect the survivability of rabbits in the wild, as well as in breed ...
Pharmaceutical Marketing: A Comparison of Different
Pharmaceutical Marketing: A Comparison of Different

... Patient Information Leaflet is a document provided along with a prescription medication to provide additional information about that drug. The first information that‟s listed is usually the brand name, the quantities of the drug available and generic name of the product. The other sections are as fo ...
Familial Aortopathy — Gene Panels
Familial Aortopathy — Gene Panels

... features of several clinical conditions that are sometimes difficult to distinguish from one another. The tests in question would allow a definitive diagnosis, stratification of the associated risks, and adaptation of the medical approach in an effort to limit or avoid life-threatening events. If a ...
Body System Adverse Effects
Body System Adverse Effects

... Copyright © 2014 by Mosby, an imprint of Elsevier Inc. ...
FORMULATION AND EVALUATION OF THERMOREVERSIBLE IN
FORMULATION AND EVALUATION OF THERMOREVERSIBLE IN

... temperature, drug content, bioadhesive strength, viscosity and in-vitro release. A 22 factorial design employed for optimization of Clonidine Hydrochloride gels with Poloxamer 407 amount (% X1) and polymer (% HPMC K15M, X2) as the prime selected independent variable, which were varied at 2 different ...
The Effects of Prolactin-Raising and Prolactin
The Effects of Prolactin-Raising and Prolactin

... to lead to osteoporosis, who exhibited findings of any endocrinological disease on physical examination or who had abnormal menstruation because of any endocrinological disease, who had menopause, mental retardation, Axis I diagnosis, malnutrition, and who used an additional psychotropic drug other ...
< 1 ... 207 208 209 210 211 212 213 214 215 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report