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Analysis of multiple phenotypes in genome-wide genetic mapping studies Open Access
Analysis of multiple phenotypes in genome-wide genetic mapping studies Open Access

... of variance (ANOVA) is usually performed. It tests whether the mean of a phenotype is the same in the three genotypes, AA, AB, and BB. As an alternative to ANOVA, we can perform a simple linear regression for each phenotype as a response variable and the genotypes as predictors (this analysis has 1 ...
dominant allele
dominant allele

... recessive trait. Ex. tt (Purebred) • If one is the dominant version and one is the recessive version, you show the dominant trait. ...
Analysis of multiple phenotypes in genome
Analysis of multiple phenotypes in genome

... of variance (ANOVA) is usually performed. It tests whether the mean of a phenotype is the same in the three genotypes, AA, AB, and BB. As an alternative to ANOVA, we can perform a simple linear regression for each phenotype as a response variable and the genotypes as predictors (this analysis has 1 ...
The effects of chlorpromazine and pimozide in reinforcement
The effects of chlorpromazine and pimozide in reinforcement

... six reinforcers according to the contingency that every fifth response or a 10-s interval without a response operated the dipper. The warm-up period was signalled by the houselight and was followed by a 120-s time-out period. During this time-out and the 500-s time-out periods between reinforcement ...
PDF - Bentham Open
PDF - Bentham Open

... other phase I trials, participants in cancer phase I clinical trials are patients at advanced cancer stages who consent to enroll in the trial as a last resort in seeking cure given the inherent toxicity of oncology drugs [2]. Thus, cancer phase I trials should be carefully designed to not only achi ...
PDF - Society for Healthcare Epidemiology of America
PDF - Society for Healthcare Epidemiology of America

... Vancomycin and carbapenem duration >3 days o Vancomycin and carbapenems are antibiotics where there is particular concern regarding overuse. Empiric therapy with these agents in severely ill patients is often reasonable initially but can be subsequently discontinued when more microbiological data is ...
anoro ellipta
anoro ellipta

... increase the risk of asthma-related death. Data are not available to determine whether the rate of death in patients with COPD is increased by LABA. A 28-week, placebo-controlled, US trial comparing the safety of another LABA (salmeterol) with placebo, each added to usual asthma therapy, showed an i ...
The Safe and Secure Handling of Medicines Policy
The Safe and Secure Handling of Medicines Policy

... Proper procedures have been followed such that all medicines have been stored and transported to ensure that their integrity has been maintained and to minimize risks to staff, patients and the public. ...
ralbert
ralbert

... Scientists are not certain how the IUD prevents pregnancy. Previously, researchers had reported that the IUD worked by making the uterus inhospitable to implantation. However, more recent evidence indicates that IUDs (particularly those containing copper) alter uterine and tubal fluids inhibiting th ...
Suppression of Noxious Stimulus-Evoked Activity in the Ventral
Suppression of Noxious Stimulus-Evoked Activity in the Ventral

... non-noxious stimuli after WIN 55,212-2. Non-nociceptive mechanosensitive neurons (n 5 5) were recorded in the VPL using methods based on those described by others (Angel and Clark 1975; Dong et al., 1978; Peschanski et al., 1981; Miletic and Coffield, 1989; Montagne-Clavel and Oliveras, 1995). These ...
Ch. 2 OLC questions
Ch. 2 OLC questions

... 1. In Trinidadian guppies a combination of elegant laboratory and field experiments builds a very compelling case for predator-induced evolutionary changes in color and life history traits. It is still possible, though not likely, that there are other differences between the sites above and below th ...
GENETICS Review
GENETICS Review

... What is the recombination frequency between these genes? 3.A.3.b..3 The pattern of inheritance (monohybrid, dihybrid, sex-linked, and genes linked on the same homologous chromosome) can often be predicted from data that gives the parent genotype/phenotype and/or the offspring phenotypes/genotypes. L ...
1. Assortative mating— a. affects genotype frequencies expected
1. Assortative mating— a. affects genotype frequencies expected

... 1. In Trinidadian guppies a combination of elegant laboratory and field experiments builds a very compelling case for predator-induced evolutionary changes in color and life history traits. It is still possible, though not likely, that there are other differences between the sites above and below th ...
original article efficacy of pregabalin in immediate post
original article efficacy of pregabalin in immediate post

... PG group has more sedation throughout the postoperative period than control group. Mean Ramsay sedation score were 1 in control gr (Table 5) throughout the postoperative period while mean sedation scores at 2, 6, 8, 12, 16 hrs in PG were (3.46, 3, 3, 2.5, 2.0) which were statistically significant (p ...
A review of available cholesterol- lowering medicines in South Africa
A review of available cholesterol- lowering medicines in South Africa

... • Clinical efficacy: In 2005, the Cholesterol Treatment Trialists’ Collaboration conducted a meta-analysis of 14 randomised controlled trials with 90 056 participants who had used statins for five years. The study reported that statin therapy could safely reduce the five-year incidence of cardiovas ...
Treatment in Acute MI
Treatment in Acute MI

...  The active metabolite irreversibly binds to the P2Y12 receptor  The ...
Dynacin Prescribing Information
Dynacin Prescribing Information

... growth rate has been observed in premature human infants given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and ca ...
Effect of Central Nervous System Medication Use on Decline in
Effect of Central Nervous System Medication Use on Decline in

... benzodiazepine-receptor agonists, antidepressants, and antipsychotics.16,18 The study group decided a priori to test the relationship between time-varying exposure to CNS medications and change in cognitive function.7 Appendix A shows the individual CNS medications reported by particpants and the co ...
Intravitreal Implant Options for Patients With Diabetic Eye Disease
Intravitreal Implant Options for Patients With Diabetic Eye Disease

... 70-80 mm Hg).13-15 On the other hand, 89% of patients who developed ocular hypertension at any point during the MEAD trial did so within the first three injections, and 99% of patients who developed ocular hypertension did so within the first four injections.16 This means that if a patient has not d ...
product monograph
product monograph

... benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys’ capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity. Benzyl alcohol may cause toxic reactions and anaphylactoid reactions in infants and children up to ...
abstracts
abstracts

... The fruit from modern sweet cherry (Prunus avium L.) cultivars is dramatically larger and has better quality than the fruit from its undomesticated relative, the wild forest cherry (syn. mazzard cherry). Improvements in fruit size and quality can be attributed to both trait improvements associated w ...
Infection, Genetics and Evolution
Infection, Genetics and Evolution

... HIV-1 drug resistance resulting from antiretroviral therapy far exceeds that from pre-exposure prophylaxis ...
Biology I - Genetic Problems
Biology I - Genetic Problems

... Part C: What is the genotype of Tad and Sarah’s child? _____________ What is the genotype of Tad Jones? ___________ of Sarah Smith Jones? ____________ On a Punnett square, prove that Tad and Sarah could produce a child with the attached ear lobes trait. Circle Baby Jones on the Punnett square. Is it ...
Standard operating procedures of the electrochemotherapy
Standard operating procedures of the electrochemotherapy

... most convenient drug is bleomycin, a currently used anticancer drug, but cytotoxicity of cisplatin is also increased in vivo by means of this original drug delivery approach. It is important to note that the physico-chemical basis of this treatment allow to predict that it works on all the tumours t ...
QA253_3_AntidepressMisc_final
QA253_3_AntidepressMisc_final

... Reboxetine, venlafaxine, duloxetine, mirtazapine, agomelatine and moclobemide are not considered first line antidepressants for use in breastfeeding mothers.  Because of the absence of data on use in lactation and their potential to cause serious interactions with some foods and drugs, first genera ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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