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EU Clinical Trials Register Glossary | Search for Clinical Trials
EU Clinical Trials Register Glossary | Search for Clinical Trials

... If previous trials have indicated a treatment is safe and that it also shows promise in being able to treat a condition, phase III clinical trials begin. These involve large numbers of participants usually from several hundred to several thousand subjects, and are often spread between different hosp ...
for meta-analysis
for meta-analysis

... Current guidelines: 12 months DAPT (derived primarily from clinical experience… and the use of stent in ACS) ...
General - EmergencyPedia
General - EmergencyPedia

... 28. A 70 kg male patient has the following pharmokinetic parameters; VD: 5liter/kg, clearance 8.4 litre per hour What is the half life of digoxin if the bioavailability is 0.70?. – 0.7 x Vd / clearance = 29hours = 1750minutes a) ...
LSD is a powerful hallucinogen. It has short and long term
LSD is a powerful hallucinogen. It has short and long term

... LSD is a powerful hallucinogen. It has short and long term effects. It’s possible to have a “bad trip” where the experience is negative and traumatic. There are things you can do if you or someone else has a bad trip. There are other issues with LSD as well. What’s LSD? LSD is a chemical that comes ...
heroin - UNM Biology
heroin - UNM Biology

... Heroin is a narcotic analgesic derived from morphine. It is believed to be one of the most addictive drugs in the world today. For our group this topic was selected due to interest sparked by friends and family who have used and died from heroin as well as coming from a city and state that leads the ...
Consulta: subjectFacets:"Mediterranean country" Registros
Consulta: subjectFacets:"Mediterranean country" Registros

... This study reports on the analysis of 21 local melon cultivars (Cucumis melo L.) collected in the South of Tunisia which were compared to three modern melon cultivars widely-grown in this area. The analysis was based on the morphological characterization of fruits. Modern cultivars were significantl ...
What is known about interactions between genes and the
What is known about interactions between genes and the

... Combination designs: Twin and adoption designs are each based on their own core assumptions (discussed in Section 3) and therefore each have their associated limitations. Designs that combine both approaches are the most powerful for separating the relative influence of genes and environment on huma ...
November 2014 PBAC Meeting
November 2014 PBAC Meeting

... provided in the November 2013 re-submission for the finding that OS improved in the sorafenib arm however PFS was unaltered. In these circumstances it is likely that factors other than exposure to the study drugs have influenced the survival outcome. These factors include cancer management delivered ...
Smoking Cessation chapter from CPhA`s Therapeutic Choices
Smoking Cessation chapter from CPhA`s Therapeutic Choices

March 2015 - Positive Recommendations
March 2015 - Positive Recommendations

... The PBAC advised the Minister: • that there is the high clinical need for all oral interferon-free treatments of CHC to be made available on the PBS, • that these treatments would be cost-effective at $15,000/QALY range and that there was no basis on which to recommend that any one treatment be more ...
Identifying Unexpected Impurities in Drug Products
Identifying Unexpected Impurities in Drug Products

... impurities profiling study can be completed in less than a week, if necessary. However, it should be noted that, although the TOX-RAY database is a very useful instrument in identifying impurities very rapidly, there is no absolute guarantee that the unexpected compound of interest will be fully ide ...
NSAIDS compared - Consumer Reports Health
NSAIDS compared - Consumer Reports Health

... take them for long periods of time without consulting a doctor. Taking effectiveness, safety, and cost into account, we have chosen two NSAIDs as Consumer Reports Best Buy Drugs: ■■ Naproxen—generic prescription and over-the-counter ■■ Ibuprofen—generic prescription and over-the-counter These are in ...
March - Behavioral Health Care Services
March - Behavioral Health Care Services

... After a single intramuscular (IM) injection of long-acting risperdone, there is a small initial release of the drug followed by a lag time of three weeks. The main release of the drug starts from three weeks onward, is maintained for four to six weeks, and subsides by seven weeks following the IM in ...
Guidance for the use of substitute prescribing in the
Guidance for the use of substitute prescribing in the

... use is stopped. Maintenance and detoxification are parts of the same spectrum and the evidence supports maintenance as a route to abstinence for many patients. 13 Methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT) greatly reduce mortality, illicit drug use and crimin ...
Update on Alcohol and Health
Update on Alcohol and Health

... RMC subjects were significantly more likely than controls to return to treatment (60% versus 51% in study 1, and 55% versus 37% in study 2), and to return sooner (200 days earlier in study 1 and 384 days earlier in study 2). RMC subjects had a significantly greater proportion of days abstinent than ...
lecture_8_antihistamines_decongestants_antitussives
lecture_8_antihistamines_decongestants_antitussives

... Treatment is SYMPTOMATIC only, not curative. ...
Chemotherapy Regimens Clinical Coding Standards and Guidance
Chemotherapy Regimens Clinical Coding Standards and Guidance

Relationship between Serum Acetaminophen Concentration and N
Relationship between Serum Acetaminophen Concentration and N

... Five or more ADR, n = 7 ...
How should ankle oedema caused by calcium channel blockers be
How should ankle oedema caused by calcium channel blockers be

... ankle oedema (Ankle-foot volume and pretibial subcutaneous tissue pressure) in the group treated with valsartan in addition to amlodipine therapy vs. amlodipine alone, along with significantly reduced blood pressure, suggesting that in patients who are not able to tolerate ACEIs, and ARB may be an e ...
Efficacy and Safety of As-Needed, Post Bedtime Dosing with
Efficacy and Safety of As-Needed, Post Bedtime Dosing with

... A PREVALENCE OF 10-15%.1 RELATIVELY FEW epidemiologic studies are available which provide data on the proportion of patients with specific clinical subtypes of insomnia such as difficulty with sleep onset, difficulty maintaining sleep, or more than one insomnia complaint. Ohayon and Roth, in a large (N ...
Programme and book of abstracts
Programme and book of abstracts

... Chair: Irene Breum Müller, Section of Forensic Chemistry, Department of Forensic Medicins, Faculty of Health Sciences, University of Copenhagen, Denmark O18 – Overview of DWG QA subcommittee activities - N. Meerta, Ulla-Maija Laakkonenb, Tamás Csesztregiac, Julia Nagyc and Peter Melld, aNational Ins ...
NHS Fife Guidelines for Benzodiazepine Prescribing in Benzodiazepine Dependence
NHS Fife Guidelines for Benzodiazepine Prescribing in Benzodiazepine Dependence

... This group of patients will have increased their use of benzodiazepines to above a therapeutic dose, e.g. a dose equal to or greater than 30mg diazepam or equivalent. This dose may be entirely prescribed or their prescription topped up with illicitly obtained benzodiazepines or Z-drugs. 1. Assessmen ...
Evolution 1/e
Evolution 1/e

... to determine what allele and genotype frequencies we would expect to in a population if all that is happening is alleles are being randomly assigned to gametes and those gametes meet up at random. ...
Genetics and Genomics
Genetics and Genomics

... Created by XMLmind XSL-FO Converter. ...
NIMODIPINE USE IN M.E. / CFS Page 1 N I M O D I P I N E use in
NIMODIPINE USE IN M.E. / CFS Page 1 N I M O D I P I N E use in

... study is now being done in children with M.E. (Ref. 23.) "Many patients...with symptoms of fatigue, dizziness or lightheadedness on standing, or palpitations have low blood levels of aldosterone,...a hormone produced by the adrenal gland.... The low aldosterone causes the kidney to lose salt which l ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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