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Adverse Side Effects in Horses Following the Administration of
Adverse Side Effects in Horses Following the Administration of

... dystonia (i.e., abrupt onset, sometimes bizarre muscular spasms affecting mainly the musculature of the head and neck), and akathisia (inner restlessness, compulsion to move).12,16,18 Typical antipsychotics, such as fluphenazine, have a higher affinity for dopamine D2 receptors than dopamine and as ...
β-Blocker Ingestion: An Evidence-Based Consensus
β-Blocker Ingestion: An Evidence-Based Consensus

... Scope of the Problem and Importance of this Guideline Drugs that antagonize the b-adrenergic receptor (b-blockers, b-adrenergic antagonists) are potentially lethal when taken in overdose. According to the Toxic Exposure Surveillance System (TESS) of the American Association of Poison Control Centers ...
ce lesson - Canadian Healthcare Network
ce lesson - Canadian Healthcare Network

... for the Study of Pain as “pain without apparent biological value that has persisted beyond the normal tissue healing time (usually taken to be 3 months).” 9 Worldwide, its prevalence and severity are underappreciated by both society and healthcare providers. As an example, a random sample of more th ...
Pass Assured`s Pharmacy Technician Training Program
Pass Assured`s Pharmacy Technician Training Program

... 2 doses/day x 10 days = 20 doses If the child can take capsules, this would be twenty 250 mg capsules. If the child requires a liquid product, Cefaclor is available in a reconstitutable suspension which has a concentration of 250 mg/5 ml. The volume to dispense would be: 5 ml/dose x 20 doses = 100 m ...
Nanobodies
Nanobodies

... !  9 clinical studies in 5 different programmes !  Low observed immunogenicity in non-clinical development •  incidence between 0% and 37% in safety pharmacology/toxicology studies •  generally not impeding the interpretation of PK/PD and safety studies •  low incidence of clearing ADA ...
etoposide injection usp
etoposide injection usp

... survival in these studies, comparisons between treatment groups were performed for the elderly subset. In the one study (etoposide in combination with cyclophosphamide and vincristine compared with cyclophosphamide and vincristine or cyclophosphamide, vincristine, and doxorubicin) where age was a si ...
datasheet
datasheet

... The most frequent adverse reactions to metoclopramide are restlessness, drowsiness, fatigue and lassitude, which occur in approximately 10% of patients. Less frequently, insomnia, headache, dizziness may occur. Rare (less than 1 in 1,000 cases) of acute depression have been reported. Symptoms of met ...
ZOCOR - Merck.com
ZOCOR - Merck.com

... 1.3 Adolescent Patients with Heterozygous Familial Hypercholesterolemia (HeFH) ZOCOR is indicated as an adjunct to diet to reduce total-C, LDL-C, and Apo B levels in adolescent boys and girls who are at least one year post-menarche, 10-17 years of age, with HeFH, if after an adequate trial of diet t ...
RECENT NANOTECHNOLOGICAL ASPECTS IN COSMETICS AND DERMATOLOGICAL PREPARATIONS  Review Article
RECENT NANOTECHNOLOGICAL ASPECTS IN COSMETICS AND DERMATOLOGICAL PREPARATIONS Review Article

... of active medicaments as well cosmetic ingredients. Use of carrier system in nanotechnology has added advantage of improved skin penetration, depot effect with sustained release drug action. This review article discusses advantages, disadvantages, method of preparation and pharmaceutical application ...
When should the sequential parallel comparison design be used in
When should the sequential parallel comparison design be used in

... as more ill than they actually are, so that if later evaluations are more accurate, patients appear to have improved even if they were receiving only placebo). There are far-ranging public health consequences associated with the false-negative statistical results associated with high placebo respons ...
Thiomersal - SmartPractice Denmark
Thiomersal - SmartPractice Denmark

... medications that do not list thiomersal or any of its synonyms. Live-virus vaccines, including influenza, tick borne encephalitis, hepatitis vaccine and many heat-killed or recombinant vaccines may contain thiomersal. In general, patients with thiomersal allergy will not react to thiomersal when the ...
Prescribing Information
Prescribing Information

... with caution in diabetics as blood glucose levels may be elevated, usually after extended use. • In the overall management of portal-systemic encephalopathy, it should be recognized that there is serious underlying liver disease with complications such as electrolyte disturbance (e.g., hypokalemia) ...
Australian public assessment for radium (223Ra) dichloride
Australian public assessment for radium (223Ra) dichloride

... are symptomatic, rapidly progressive or who have developed visceral metastases. It has been found that treatment with docetaxel is commonly delayed or not administered at all in clinical practice. This is generally due to the known toxicities of docetaxel as well the clinical status of patients, suc ...
Slide 1 - The University of Sydney
Slide 1 - The University of Sydney

... Public health model for prevention of problem cannabis use • Development of credible health education – Young are sceptical about ‘scare tactics’ – Parallels with the effects of alcohol & tobacco: • respiratory risks, MVA, dependence, ...
mechanisms of la toxicity
mechanisms of la toxicity

... Weinberg and Bern, in their review, have postulated that lipid works similarly in pregnant women as in non-pregnant patients, but they also brought up some important unanswered questions regarding lipid use in parturients. It is possible that the lipid sink effect could demonstrate different charact ...
enhancement of dissolution rate of fenofibrate by
enhancement of dissolution rate of fenofibrate by

... The aim of the present study was the improvement of the dissolution rate of a poorly water-soluble drug fenofibrate (F) by using spray drying technique. Dispersions were prepared using Eudragit E-100 (E), Solutol® HS15 (S) and hydroxypropyl cellulose (HPC) at different ratios (1:1 and 1:5) by the sp ...
Current treatment of oral candidiasis: A literature review
Current treatment of oral candidiasis: A literature review

Genetic Location of Heritable Traits Through Association Studies: A
Genetic Location of Heritable Traits Through Association Studies: A

... important role in the search for the location of genes underlying certain traits, since linkage analyses provide less accurate estimations of the positions of the genes as the complexity and rareness of the traits increase, partly due to the difficulty of getting large and informative enough samples ...
Session 9: Central Nervous System Depressants
Session 9: Central Nervous System Depressants

... There are six major subcategories of CNS Depressants other than alcohol. Barbiturates More than 250 different barbiturates have been produced; of these, about 50 have been accepted for medical use. • Derivatives of Barbituric Acid • First produced in 1864 • Very common in use and abuse today Non-Bar ...
Castric et al. (MBE 2010) - GEPV
Castric et al. (MBE 2010) - GEPV

... shared between the two species (Ramos-Onsins et al. 2004), leaving open the possibility that introgression is still ongoing. We have recently documented that the gene controlling SI specificity (SRK) was undergoing introgression at a ;5-fold higher rate than the genomic background (Castric et al. 20 ...
Nasalox Insert
Nasalox Insert

... Patients sensitive to other nasal decongestants may be sensitive to this medication also. Drug Interactions Oxymetazoline causes hypertensive crisis if used simultaneously with MAO inhibitor or Tricyclic antidepressant. Use in Pregnancy and Lactation Pregnancy: Pregnancy Category C. Avoid during pre ...
the long-term evolution of multilocus traits under frequency
the long-term evolution of multilocus traits under frequency

... Abstract. Frequency-dependent disruptive selection is widely recognized as an important source of genetic variation. Its evolutionary consequences have been extensively studied using phenotypic evolutionary models, based on quantitative genetics, game theory, or adaptive dynamics. However, the genet ...
technical report 2003/ge1
technical report 2003/ge1

... As a way of avoiding the problems of confounding and reverse causation, several authors have suggested using studies based on a gene that is known to influence the level of the intermediate phenotype. It is highly unlikely that the relationship between the gene and the disease is subject to reverse ...
MOLECULAR STUDY OF IDIOPATHIC NEPHROTIC SYNDROME
MOLECULAR STUDY OF IDIOPATHIC NEPHROTIC SYNDROME

... WARNING. The access to the contents of this doctoral thesis it is limited to the acceptance of the use conditions set by the following Creative Commons license: https://creativecommons.org/licenses/?lang=en ...
Standard of Practice - Use of Sedation and General Anesthesia in
Standard of Practice - Use of Sedation and General Anesthesia in

... history, including present and past illnesses, hospital ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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