• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Herbal Medication Pitfalls Question “Natural Product” or Drug
Herbal Medication Pitfalls Question “Natural Product” or Drug

... medicines available. However, one must be aware of the power of herbs to heal and, if misused, to cause imbalance. Herbs produce no side effects when used in the amounts required to effect a cure. Negative effects occur only when one fails to observe the cautions that herbalists have recognized afte ...
Enhancing Prescription Medicine Adherence: A National Action Plan August 2007
Enhancing Prescription Medicine Adherence: A National Action Plan August 2007

... of more than 100 organizations that are working to stimulate and improve communication on the appropriate use of medicines -- convened a group of advisors from leading professional societies, voluntary health organizations, and patient advocacy groups to assess the extent and nature of poor medicine ...
Clinical Guidelines and Procedures for the Use of Naltrexone in the
Clinical Guidelines and Procedures for the Use of Naltrexone in the

... Selective Serotonin Reuptake Inhibitors (SSRI) may be prescribed if patient has features of clinical depression. Many heroin users will complain of dysphoria during withdrawal and in the first few days of naltrexone treatment but this usually resolves spontaneously. There is no evidence to support t ...
Scientist finds the gene that determines major sensitivity to bitter taste
Scientist finds the gene that determines major sensitivity to bitter taste

... Dr. Fox's chemical, called phenylthiocarbamide (PTC), has been used widely since its discovery to detect genetic variation in tasting abilities. Studies soon after the incident in Fox's lab showed that there is a genetic component that influences how PTC tastes. Scientists found that people were muc ...
G U I D E L I N E S ... ADVISORY  COMMITTEE Scope
G U I D E L I N E S ... ADVISORY COMMITTEE Scope

... effect one cure and a greater percentage of children who receive antibiotics experience side effects such as vomiting, diarrhea and rash than those who receive placebo.5,7,9,27-30 Twenty to 30 per cent of episodes of AOM are caused by viruses.1,4,13,15,28 Determining which cases of AOM are caused by ...
Bayer Aspirin Complex 500mg/30mg Granules for Oral Suspension
Bayer Aspirin Complex 500mg/30mg Granules for Oral Suspension

... - renal dysfunction, which may progress to renal failure with oligo-hydroamniosis; the mother and the neonate, at the end of pregnancy, to: - possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses. - inhibition of uterine contractions resulting in d ...
Understanding Physicochemical Properties for
Understanding Physicochemical Properties for

... significant influences on almost all other physicochemical properties. Salt formation is well built upon the dissociation concept, which has been extensively exploited during active pharmaceutical ingredient (API) manufacture for purpose of purification, processibility, and other aspects of pharmace ...
PRODUCT MONOGRAPH CLARUS Isotretinoin 10 mg and 40 mg
PRODUCT MONOGRAPH CLARUS Isotretinoin 10 mg and 40 mg

... Clinical studies of isotretinoin did not include sufficient numbers of subjects aged 65 years and over to determine whether they respond differently from younger subjects. Although reported clinical experience has not identified differences in responses between elderly and younger patients, effects ...
Patients with chronic pain deserve a better quality of life. Through
Patients with chronic pain deserve a better quality of life. Through

... Patients with chronic pain deserve a better quality of life. Through education, we can take great steps toward achieving this goal. Over 75 million Americans experience chronic pain—more than those with diabetes, heart disease, and cancer combined. Pain is also the most common reason for individuals ...
View/Open
View/Open

... DRUGS AFFECTING RENIN-ANGIOTENSIN SYSTEM AND PLASMA KININS involved in cognitive function and memory in animals. Thus Ang IV improves memory. Some vascular, renal and other peripheral effects of Ang IV have also been described. Angiotensin (1-7) This heptapeptide can be produced from Ang I or Ang II ...
More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin
More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin

... but routine coagulation assays did not predict this effect. Thrombin generation reversal was dependent on the concentration of dabigatran and each reversal drug normalization occurred at the lower concentration of dabigatran with most agents, but not at higher concentrations [21]. In humans the resu ...
influence of oxcarbazepine on the antinociceptive action of
influence of oxcarbazepine on the antinociceptive action of

... or abolition of antinociception (26), and their opening ñ to induction or enhancement of antinociceptive effect (27-29). The enhancement of morphineinduced effect by oxcarbazepine may have a character of a pharmacodynamic interaction taking place at the level of calcium and potassium channels. In ou ...
NORTRIPTYLINE 10MG TABLETS NORTRIPTYLINE 25MG TABLETS UKPAR
NORTRIPTYLINE 10MG TABLETS NORTRIPTYLINE 25MG TABLETS UKPAR

... of depression and to help stop children bed-wetting. Nortriptyline 10 and 25mg Tablets contain the active ingredient nortriptyline hydrochloride, a tricyclic antidepressant. No new or unexpected safety concerns arose from these applications and it was, therefore, judged that the benefits of taking N ...
The genetic basis of panic and phobic anxiety disorders
The genetic basis of panic and phobic anxiety disorders

Over-the-Counter Medications
Over-the-Counter Medications

... explaining that the products have children” to the label for anti- “humble us on a regular basis.” not been shown to be safe and histamines subject to the mono monoThe FDA presented an algoeffective for children under six, graph. rithm (see flow chart) that, in to take action against misleadAt the m ...
Hands-on session: Cox proportional hazard analysis
Hands-on session: Cox proportional hazard analysis

... If you are comparing all possible pairs of means in a large ANOVA lay-out, there are many possible tests, and a Type 1 error becomes very likely. ...
(223Ra) dichloride
(223Ra) dichloride

... are symptomatic, rapidly progressive or who have developed visceral metastases. It has been found that treatment with docetaxel is commonly delayed or not administered at all in clinical practice. This is generally due to the known toxicities of docetaxel as well the clinical status of patients, suc ...
EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM  SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT 
EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM  SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT 

... In the present work the effect of two different diluents namely dicalcium phosphate (DCP) and maize starch (MS) on the release of aceclofenac from  sustained release matrix tablets has been studied. Gum damar (GD), a hydrophobic polymer with significant binding property was used as a release  retard ...
Abuse Liability & Drug Scheduling: Role of FDA
Abuse Liability & Drug Scheduling: Role of FDA

... Prejudice, stigma and discrimination, in part, determine what drugs will be regulated, what drugs will not be regulated and what medications will be or not be made available to treat chemical dependence ...
PICO Question and Rationale
PICO Question and Rationale

... reduce the number of medication errors in pediatrics compared to the common paper system being used today?” This question is important because the pediatric population is a high-risk group for medication errors because the potential adverse drug event is three times greater than an adult hospitalize ...
Module 2: Pharmacotherapy - UCLA Integrated Substance Abuse
Module 2: Pharmacotherapy - UCLA Integrated Substance Abuse

...  Most people who use illicit drugs use a variety of different drugs  Heroin users also are heavy users of alcohol and benzodiazepines  As central nervous system (CNS) depressants, these combinations are especially dangerous and known to be significant contributors to overdose  Clinicians should ...
A Patient`s Guide to Aerosol Drug Delivery - COPD
A Patient`s Guide to Aerosol Drug Delivery - COPD

... your mouth. And some come in a dry-powder inhaler (DPI) from which you inhale a powder. We will talk later about how to use these devices correctly. But let’s get back to the different names and different forms. The term drug formulation is used to describe all medications in greater detail. Table 1 ...
Regulatory Considerations and Evolving Issues
Regulatory Considerations and Evolving Issues

... • 2004 – Increased congressional attention on postmarket drug safety due to adverse events (Vioxx, Bextra, Meridia and Crestor) • 2005 – FDA releases two guidance documents – Describe additional safety monitoring and interventions that may be appropriate for certain products – Outline FDA’s concept ...
Metastatic Melanoma Recent Advances and Emerging Therapies In the Systemic Treatment of
Metastatic Melanoma Recent Advances and Emerging Therapies In the Systemic Treatment of

... However, the median OS of patients who received ipilimumab with the gp100 vaccine did not differ significantly from that of patients who received ipilimumab alone. The risk for disease progression in patients who received ipilimumab alone was 36% lower than that for patients who received the gp100 v ...
Cymbalta - GuildLink
Cymbalta - GuildLink

... Children and Adolescents <18 years old - Duloxetine is not indicated for use in patients under 18 years of age. Race - No specific pharmacokinetic study was conducted to investigate the effects of race. Due to large interpatient variability, clinically significant differences in drug level exposure ...
< 1 ... 153 154 155 156 157 158 159 160 161 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report