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Predictors of neonatal abstinence syndrome in
Predictors of neonatal abstinence syndrome in

... the time of delivery or the calculated cumulative dose throughout pregnancy with length of stay or duration of treatment required. Increasing birth weight and gestational age found to be strongly associated with development of NAS which can be explained by more conversion of buprenorphine to norbupr ...
Novel familial cases of ICCA (infantile convulsions with paroxysmal
Novel familial cases of ICCA (infantile convulsions with paroxysmal

... years old, she was referred to the specialized clinic for attacks triggered by sudden movement that lasted for a maximum of 30 seconds and could be as frequent as ten per day. The attacks started with transient irregular twitching of the upper extremities. Typically, the paroxysms consisted of dysto ...
DNMT3A mutations occur early or late in patients with
DNMT3A mutations occur early or late in patients with

... E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have been accepted for publication. E-publishing of this PDF file has bee ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.

... infection is one of the major threats to human health due to the lack of relevant vaccine and drugs to cure AIDS. Highly active anti-retroviral therapy (HAART) strategy involves the use of combination anti-retroviral agents for synergistic therapeutic outcomes. With the adoption of HAART, the averag ...
Update of the Topical Treatment of Psoriasis
Update of the Topical Treatment of Psoriasis

... context, what is needed is a critical evaluation of the efficiency, efficacy, and safety of the available active ingredients. ...
new york state medicaid program laboratory procedure
new york state medicaid program laboratory procedure

... Ferritin (82728) is performed in combination with Vitamin B12 or Folate, or any of the Organ or Disease Oriented Panels (80048-80076), or any of the individual chemistry analyte codes listed in the fee schedule (see Rule 6A), the maximum reimbursable fee for 82728 is $5.70. 6C. When two or more Hepa ...
PHI-Canto video tutorial text - PHI-base
PHI-Canto video tutorial text - PHI-base

... And we move onto Step5c adding an annotation term. # In this case to the curation type ‘PHI phenotype’. # I am looking for ‘unaffected pathogenicity’ in the search box # which is one of 9 upper level PHI phenotype outcome terms used in the preliminary annotation. Subsequent additional PHI phenotype ...
Enlis Genome Research - Release Notes
Enlis Genome Research - Release Notes

... - Variation Filter tool: Added filter for DANN predicted deleterious variations, with the option to select different score levels - Variation Filter tool: Added "Ignore No-call positions" to "Not in single genome" and "Not in genome set" filters. This allows for improved comparisons between genomes ...
View Prescribing Details
View Prescribing Details

... should not exceed 20 mg daily in these patients. Contraindication  Known hypersensitivity to any component of Ranoxen™ Plus (Naproxen and Esomeprazole) or substituted benzimidazoles.  History of asthma, urticaria or allergic-type reactions after taking aspirin or other NSAIDs.  Use during the per ...
Effects of risperidone, amisulpride and nicotine on eye
Effects of risperidone, amisulpride and nicotine on eye

... 1998), drug effects in schizotypal populations are less well explored (Wonodi et al. 2006). Such an approach may help to enhance the understanding of schizotypy as a potential model system for future drug development (Koychev et al. 2011). Accordingly, the goal of this study was to investigate pharm ...
Atarax™
Atarax™

... The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient. Hydroxyzine may potentiate meperidine and ba ...
Homocysteine: a promising biomarker of folate antagonist
Homocysteine: a promising biomarker of folate antagonist

... such as: i) individual needs of an ii) individual patient at a iii) given time during the course of disease. Therefore, a search for biomarkers has been continuing and speeded up in recent years with the recent advent in pharmacogenomics [42] and predictive oncology [102]. Under optimal conditions, ...
EMERGENCY DEPARTMENT VISITS INVOLVING NARCOTIC PAIN RELIEVERS AUTHORS INTRODUCTION
EMERGENCY DEPARTMENT VISITS INVOLVING NARCOTIC PAIN RELIEVERS AUTHORS INTRODUCTION

... INTRODUCTION Narcotic pain relievers are prescription pain medications that act on the brain to provide relief from pain. Chemically similar to heroin, they also have the potential to produce a feeling of euphoria. Although narcotic pain relievers offer important medical benefits when used appropria ...
Omega-Conotoxins as Experimental Tools and Therapeutics in Pain
Omega-Conotoxins as Experimental Tools and Therapeutics in Pain

... The membrane-spanning α1 subunit is arguably the most important subunit of VGCCs, as its expression is required for proper function of the protein. The α1 subunit is composed of 4 homologous domains, each with 6 transmembrane segments, which form the pore of the ion channel. Genes encoding ten disti ...
Perspectives in Medicinal Chemistry Fentanyl Buccal Tablet for the
Perspectives in Medicinal Chemistry Fentanyl Buccal Tablet for the

... Breakthrough pain (BTP) is a transitory ­exacerbation of pain that occurs on a background of chronic, ­persistent pain that is otherwise controlled by aroundthe-clock (ATC) opioids.1–3 Much of the medical literature surrounding BTP comes from studies of patients with cancer-related pain in which the ...
PRODUCT MONOGRAPH PrVOLTAREN RAPIDE®
PRODUCT MONOGRAPH PrVOLTAREN RAPIDE®

... COX-2 inhibitors. Meta-analyses of randomized clinical trials comparing several different NSAIDs suggest that diclofenac, particularly at higher doses, is associated with an increased risk of cardiovascular adverse events that is comparable to COX-2 inhibitors. Large population-based observational s ...
Feasibility, Safety, and Efficacy of a Novel Polymeric Pimecrolimus
Feasibility, Safety, and Efficacy of a Novel Polymeric Pimecrolimus

... Methods We evaluated a novel polymeric pimecrolimus-eluting stent covered with a thin parylene C diffusion barrier in a porcine coronary model and in a phase I human clinical trial. The clinical study was a prospective, nonrandomized, first-in-human hypothesis-generating study that enrolled 15 patien ...
Polymer Science -1
Polymer Science -1

... KLECOP, Nipani ...
ZOCOR® Product Monograph - Morley Evans Insight
ZOCOR® Product Monograph - Morley Evans Insight

... ADVERSE REACTIONS, Laboratory Tests). When the drug was interrupted or discontinued in these patients, the transaminase levels usually fell slowly to pretreatment levels. The increases were not associated with jaundice or other clinical signs or symptoms. There was no evidence of hypersensitivity. S ...
Media Kit - Perosphere
Media Kit - Perosphere

... 37% over the baseline value (Fig. 1). In patients receiving a single intravenous dose of PER977 (100 to 300 mg) 3 hours after the administration of edoxaban, the whole-blood clotting time decreased to within 10% above the baseline value in 10 minutes or less, whereas in patients receiving placebo, t ...
PACLitaxel - Cancer Care Ontario
PACLitaxel - Cancer Care Ontario

Ravimid laste jaoks
Ravimid laste jaoks

...  To include third countries trials linked to a PIP  To include results of all trials and of other trials ‘submitted to competent authorities’  Paediatric information to be made public Proposal made by EMEA to EC on the data fields to be included in EudraCT and those to be published on paediatric ...
Strengthen Opioid Misuse Prevention (STOP)Act.
Strengthen Opioid Misuse Prevention (STOP)Act.

... SECTION 4. G.S. 90-18.1(b) is amended by adding a new subdivision to read: "(5) If the prescription is for a targeted controlled substance as defined in Article 5 of Chapter 90 of the General Statutes and therapeutic use of the targeted controlled substance will or is expected to exceed a period of ...
A  comparison  of  the  cardiovascular ... formoterol,  salbutamol  and  fenoterol
A comparison of the cardiovascular ... formoterol, salbutamol and fenoterol

... maximum inotropic effect of formoterol was considerably less than that due to fenoterol. This difference occurred despite the cumulative dose response design employed, which effectively "biased" the results against formoterol, due to its longer duration of action. The chronotropic effect of fenotero ...
Porphyrin Metabolism & Porphyrias
Porphyrin Metabolism & Porphyrias

... Cytochrome P450 Monooxygenase System: • Cytochrome P450s (CYPs) are actually a superfamily of related, hemecontaining monooxygenase enzymes that participate in abroad variety of reactions. This system performs different functions in two separate locations in cells. • The over-all reaction catalyzed ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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