QTL Mapping and Analysis for the Traits Related to Pod Dehiscence
... Abstract Pod dehiscence (Pod shattering) (PD) is an important reproductive trait in soybean, while this trait also causes major yield losses in the mechanically harvested soybeans. In this research, QTL mapping and correlation analysis of three related traits (PD trait(PDH), ratio of thickness to wi ...
... Abstract Pod dehiscence (Pod shattering) (PD) is an important reproductive trait in soybean, while this trait also causes major yield losses in the mechanically harvested soybeans. In this research, QTL mapping and correlation analysis of three related traits (PD trait(PDH), ratio of thickness to wi ...
AUTISM AS A PARADIGMATIC COMPLEX GENETIC DISORDER
... with autism (28, 29). More research to characterize the serotonin system, particularly in the periphery, could yield important information about the abnormalities found in ASD. One example of this approach is an association mapping study of whole blood serotonin independent of psychiatric disorder, ...
... with autism (28, 29). More research to characterize the serotonin system, particularly in the periphery, could yield important information about the abnormalities found in ASD. One example of this approach is an association mapping study of whole blood serotonin independent of psychiatric disorder, ...
methadone hydrochloride oral concentrate USP
... QD for 3 to 4 days) resulted in an approximately 50% reduction in methadone exposure and withdrawal symptoms occurred concurrently. Upon discontinuation of phenytoin, the incidence of withdrawal symptoms decreased and methadone exposure increased to a level comparable to that prior to phenytoin admi ...
... QD for 3 to 4 days) resulted in an approximately 50% reduction in methadone exposure and withdrawal symptoms occurred concurrently. Upon discontinuation of phenytoin, the incidence of withdrawal symptoms decreased and methadone exposure increased to a level comparable to that prior to phenytoin admi ...
GLUCOSE TRANSPORTER TYPE 1 DEFICIENCY SYNDROME (G1D)
... experience all of the characteristic symptoms and the severity of each symptom can vary tremendously between individuals. d. How common is G1D? G1D is a rare disorder. Fewer than 300 cases have been reported since the disease was identified in 1991. However, the number of affected individuals may ac ...
... experience all of the characteristic symptoms and the severity of each symptom can vary tremendously between individuals. d. How common is G1D? G1D is a rare disorder. Fewer than 300 cases have been reported since the disease was identified in 1991. However, the number of affected individuals may ac ...
ASAM: Safe Methadone Induction and Stabilization
... Objectives: Methadone is a well-studied, safe, and effective medication when dispensed and consumed properly. However, a number of studies have identified elevated rates of overdose and death in patients being treated with methadone for either addiction or chronic pain. Among patients being treated ...
... Objectives: Methadone is a well-studied, safe, and effective medication when dispensed and consumed properly. However, a number of studies have identified elevated rates of overdose and death in patients being treated with methadone for either addiction or chronic pain. Among patients being treated ...
Five components of the ethylene-response pathway
... and hypocotyls. The genes corresponding to wei1, wei4, and wei5 were isolated using a positional cloning approach. The wei1 mutant harbored a recessive mutation in TIR1, which encodes a component of the SCF protein ubiquitin ligase involved in the auxin response. wei4, a dominant mutant, resulted fr ...
... and hypocotyls. The genes corresponding to wei1, wei4, and wei5 were isolated using a positional cloning approach. The wei1 mutant harbored a recessive mutation in TIR1, which encodes a component of the SCF protein ubiquitin ligase involved in the auxin response. wei4, a dominant mutant, resulted fr ...
Multilocus genetic models of handedness closely resemble
... are well described by single-locus Mendelian models. Here we summarize a large genome-wide association study (GWAS) that finds no significant associations with handedness and is consistent with a meta-analysis of GWASs. The GWAS had 99% power to detect a single locus using the conventional criterion ...
... are well described by single-locus Mendelian models. Here we summarize a large genome-wide association study (GWAS) that finds no significant associations with handedness and is consistent with a meta-analysis of GWASs. The GWAS had 99% power to detect a single locus using the conventional criterion ...
Genome-Wide Copy Number Variation in Epilepsy: Novel
... cause is unknown in the vast majority of cases. Copy number variants (CNVs) are known to play an important role in the genetic etiology of many neurodevelopmental disorders, including intellectual disability (ID), autism, and schizophrenia. Genome-wide studies of copy number variation in epilepsy ha ...
... cause is unknown in the vast majority of cases. Copy number variants (CNVs) are known to play an important role in the genetic etiology of many neurodevelopmental disorders, including intellectual disability (ID), autism, and schizophrenia. Genome-wide studies of copy number variation in epilepsy ha ...
Cocaine - Computer Science
... mg dosage levels. The authors develop a model to classify ECG cycles into drug and baseline classes. Although this method achieves high accuracy (average AUC > 0.9) on clean lab data, there are several challenges in using such a model for detecting cocaine use events in the field setting. For exampl ...
... mg dosage levels. The authors develop a model to classify ECG cycles into drug and baseline classes. Although this method achieves high accuracy (average AUC > 0.9) on clean lab data, there are several challenges in using such a model for detecting cocaine use events in the field setting. For exampl ...
Intranasal (IN) Medication Administration MBED Clinical Practice
... INDICATIONS: Dexmedetomidine is indicated for short-term (< 24 hrs) sedation of intubated and mechanically ventilated patients in the intensive care setting. *Currently looking into its off-label use for procedural sedation in pediatrics when used intranasally. CLINICAL PHARMACOLOGY: Dexmedetomidine ...
... INDICATIONS: Dexmedetomidine is indicated for short-term (< 24 hrs) sedation of intubated and mechanically ventilated patients in the intensive care setting. *Currently looking into its off-label use for procedural sedation in pediatrics when used intranasally. CLINICAL PHARMACOLOGY: Dexmedetomidine ...
Haplotypes at LBX1 Have Distinct Inheritance Patterns with
... 10 degrees, without a known cause, diagnosed between age 10 and skeletal maturity. It affects 2–4% of the teenage population. Although scoliosis can be a primary or secondary feature in several dozen syndromes and can arise secondary to a variety of neuromuscular conditions, idiopathic scoliosis ari ...
... 10 degrees, without a known cause, diagnosed between age 10 and skeletal maturity. It affects 2–4% of the teenage population. Although scoliosis can be a primary or secondary feature in several dozen syndromes and can arise secondary to a variety of neuromuscular conditions, idiopathic scoliosis ari ...
Local Anesthetic Systemic Toxicity
... effects: respiratory failure, seizures, palpitations, and irregular cardiac function.2 Despite the advent of safer synthetic local anesthetics, cases of toxicity persisted, culminating in a 1979 report of the catastrophic consequences of LAST that noted a relationship between drug lipophilicity and ...
... effects: respiratory failure, seizures, palpitations, and irregular cardiac function.2 Despite the advent of safer synthetic local anesthetics, cases of toxicity persisted, culminating in a 1979 report of the catastrophic consequences of LAST that noted a relationship between drug lipophilicity and ...
Microbial Contamination Risk Assessment
... FDA Good Manufacturing Practices • In 1978 21 CFR Parts 210 Current Good Manufacturing Practice in Manufacturing, Processing, Packaging or Holding Drugs: General and 211 Current Good Manufacturing Practice for Finished Pharmaceuticals were finalized. • In 1987 FDA Guideline on General Principles of ...
... FDA Good Manufacturing Practices • In 1978 21 CFR Parts 210 Current Good Manufacturing Practice in Manufacturing, Processing, Packaging or Holding Drugs: General and 211 Current Good Manufacturing Practice for Finished Pharmaceuticals were finalized. • In 1987 FDA Guideline on General Principles of ...
neuro 2007 - addiction education home
... The aim of this study was to assess the effects of prenatal exposures to cannabinoids or carbon monoxide (CO) in an animal experimental model reproducing the environmental conditions in which a fetus develops whose mother, during pregnancy, ingests by smoking low doses of cannabinoids or CO. Particu ...
... The aim of this study was to assess the effects of prenatal exposures to cannabinoids or carbon monoxide (CO) in an animal experimental model reproducing the environmental conditions in which a fetus develops whose mother, during pregnancy, ingests by smoking low doses of cannabinoids or CO. Particu ...
Panax Ginseng - Pure Encapsulations
... Stress Support: Panax ginseng has long been utilized to assist the body in adapting to physical and emotional stress. During prolonged exercise, panax ginseng promotes endurance and stamina by sparing carbohydrates and allowing skeletal muscle to oxidize free fatty acids for energy production. Panax ...
... Stress Support: Panax ginseng has long been utilized to assist the body in adapting to physical and emotional stress. During prolonged exercise, panax ginseng promotes endurance and stamina by sparing carbohydrates and allowing skeletal muscle to oxidize free fatty acids for energy production. Panax ...
Cozaar
... can cause fetal and neonatal morbidity and death when administered to pregnant women. When pregnancy is detected, COZAAR® should be discontinued as soon as possible. The use of ARB is not recommended during pregnancy. Epidemiological evidence regarding the risk of teratogenicity following exposure t ...
... can cause fetal and neonatal morbidity and death when administered to pregnant women. When pregnancy is detected, COZAAR® should be discontinued as soon as possible. The use of ARB is not recommended during pregnancy. Epidemiological evidence regarding the risk of teratogenicity following exposure t ...
... country. The aim of this endeavour is to guide the medical professionals on the current methods of diagnosis and treatment based on the national drug policy. This manual deals with the treatment of uncomplicated malaria and specific antimalarials for severe disease. The general management should be ...
Product Monograph - Paladin Labs Inc.
... In addition to specific antidote treatment with Antizol, patients intoxicated with ethylene glycol or methanol should be managed as appropriate for metabolic acidosis, acute renal failure (ethylene glycol), adult respiratory distress syndrome, visual disturbances (methanol) and hypocalcemia. At freq ...
... In addition to specific antidote treatment with Antizol, patients intoxicated with ethylene glycol or methanol should be managed as appropriate for metabolic acidosis, acute renal failure (ethylene glycol), adult respiratory distress syndrome, visual disturbances (methanol) and hypocalcemia. At freq ...
Knocking down disease: a progress report on siRNA therapeutics
... asialoglycoprotein receptor (ASGPR) causes wholeliver, durable gene knockdown without limiting toxic‑ ity 40. These GalNAc–siRNA conjugates are currently being evaluated in a Phase III study for the treatment of a rare genetic neurodegenerative disease. It is likely that they will eventually replace ...
... asialoglycoprotein receptor (ASGPR) causes wholeliver, durable gene knockdown without limiting toxic‑ ity 40. These GalNAc–siRNA conjugates are currently being evaluated in a Phase III study for the treatment of a rare genetic neurodegenerative disease. It is likely that they will eventually replace ...
Gene therapy clinical trials: what about the environment?
... institutional committees in the USA and Canada. Both FDA and Health Canada have exemption rules in place to ‘avoid’ a full ERA for research and development of gene therapy products. In consequence, the regulatory level at which environmental issues are discussed differs. Marketing approvals are cen ...
... institutional committees in the USA and Canada. Both FDA and Health Canada have exemption rules in place to ‘avoid’ a full ERA for research and development of gene therapy products. In consequence, the regulatory level at which environmental issues are discussed differs. Marketing approvals are cen ...
In vitro available for inhalation from different formulations P.W. Barry, C. O'Callaghan
... the Nebuhaler® in the present study. We have also published data on recovery from Volumatic® spacers that had been washed to reduce their static charge [8], obtaining similar recoveries of salbutamol to the present study from the low static Nebuhaler® (54.3 vs 68.5 µg in particles smaller than 5 µm) ...
... the Nebuhaler® in the present study. We have also published data on recovery from Volumatic® spacers that had been washed to reduce their static charge [8], obtaining similar recoveries of salbutamol to the present study from the low static Nebuhaler® (54.3 vs 68.5 µg in particles smaller than 5 µm) ...
Chapter Pharmaceutical Compounding – Nonsterile
... COMPOUNDING FACILITIES Compounding facilities shall have an adequate space that is specifically designated for compounding of prescriptions. This space shall provide for the orderly placement of equipment and materials to prevent mixups among ingredients, containers, labels, in-process materials, an ...
... COMPOUNDING FACILITIES Compounding facilities shall have an adequate space that is specifically designated for compounding of prescriptions. This space shall provide for the orderly placement of equipment and materials to prevent mixups among ingredients, containers, labels, in-process materials, an ...
Therapy for sarcoidosis
... oftenv6 months. In a series of patients with refractory disease treated with methotrexate for prolonged periods, it was demonstrated that methotrexate could take up to 6 months to show objective evidence of effectiveness [50]. This delay in effect of methotrexate is also seen with other cytotoxic dr ...
... oftenv6 months. In a series of patients with refractory disease treated with methotrexate for prolonged periods, it was demonstrated that methotrexate could take up to 6 months to show objective evidence of effectiveness [50]. This delay in effect of methotrexate is also seen with other cytotoxic dr ...
St John`s wort versus placebo in obsessive
... Formulation: (LI 160) was different than the formulation used in some open-label studies (Alterra). The compound used in the current study is among the best characterized, and has been used in several efficacy studies, including the large NIMH study in depression. ...
... Formulation: (LI 160) was different than the formulation used in some open-label studies (Alterra). The compound used in the current study is among the best characterized, and has been used in several efficacy studies, including the large NIMH study in depression. ...