• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
The causal meaning of Fisher`s average effect
The causal meaning of Fisher`s average effect

... Price’s (1972) remark that Fisher’s ideas can be translated into well-understood concepts such as covariance and regression without dealing with his ‘ special’ notions of average excess and average effect. In the following, we show that the two definitions of the average effect can be reconciled, in th ...
prescribing information xylocaine® ointment 5%
prescribing information xylocaine® ointment 5%

... Lidocaine should be used with caution in patients with sepsis and/or traumatized mucosa at the area of application, since under such conditions there is the potential for rapid systemic absorption. XYLOCAINE Ointment 5% (lidocaine) should be used with caution in children under the age of 2 as there ...
ע עבקנ הז ןולע טמרופ " רשואו קדבנ ונכותו תואירבה דרשמ י
ע עבקנ הז ןולע טמרופ " רשואו קדבנ ונכותו תואירבה דרשמ י

... synthesized by activation of COX-1 thereby not interfering with normal COX-1 related physiological processes in tissues, particularly the stomach, intestine and platelets. Pharmacodynamics Platelets In clinical trials using normal volunteers, CELEBRA at single doses up to 800 mg and multiple doses o ...
POTASSIUM SUPPLEMENTS (parenteral) - DavisPlus
POTASSIUM SUPPLEMENTS (parenteral) - DavisPlus

... ● Treatment includes discontinuation of potassium, administration of sodium bicarbonate to correct acidosis, dextrose and insulin to facilitate passage of potassium into cells, calcium salts to reverse ECG effects (in patients who are not receiving digoxin), sodium polystyrene used as an exchange re ...
CELEXA PM MKT Control 149419 10Jan2012 En
CELEXA PM MKT Control 149419 10Jan2012 En

... paraesthesia), sleep disturbances (including insomnia and intense dreams), agitation or anxiety, nausea and/or vomiting, tremor and headache are the most commonly reported reactions. Generally, these symptoms are mild to moderate; however, in some patients they may be severe in intensity. They usual ...


Pom-Pom_Genetics
Pom-Pom_Genetics

... Sometimes traits are determined by multiple genes. Sometimes traits are determined by multiple alleles. Sometimes, both are in effect. While you can be identified by your hair color, eye color, blue skin, sex etc. no trait identifies you more clearly and uniquely than your Human Leukocyte Antigens ( ...
PDF/153KB - Sumitomo Dainippon Pharma
PDF/153KB - Sumitomo Dainippon Pharma

... anti-apoptotic gene, may be responsible for the potential clinical anti-cancer activity observed with alvocidib. Alvocidib is an investigational intravenous small-molecule agent and it received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EM ...
COPD: FIXING the FIXABLES in 2003
COPD: FIXING the FIXABLES in 2003

... Sputum, Spasm and Swelling all have some degree of reversibility and that becomes the basis for treating COPD. New treatments are being studied and have been reported in Europe, Canada and the US. ...
A Scoping Review of Codeine Use, Misuse and
A Scoping Review of Codeine Use, Misuse and

... study. Extracts may be included in professional journals provided that suitable acknowledgement is made and that the reproduction is not associated with any form of advertising. Application for commercial reproduction should be made to the CODEMISUSED Project, European Commission, 7th Framework, EU. ...
Drug Prior Authorization Attachment AIS
Drug Prior Authorization Attachment AIS

... ISO+: EXTENDED ISO UNITS CODES ..........................................................................................................68 ...
Evaluating Statin Drugs To Treat
Evaluating Statin Drugs To Treat

... Under certain circumstances, your doctor may prescribe a statin drug even if you do not have high cholesterol. In February 2010, the FDA approved rosuvastatin (Crestor) for use by men 50 or older and women 60 or older with healthy cholesterol levels but an elevated CRP level and at least one other r ...
Can a 2 gram dose of flucloxacillin be given as a slow intravenous
Can a 2 gram dose of flucloxacillin be given as a slow intravenous

... intravenously, recommended doses are usually between 250 mg and 1 gram four times daily. These doses may be doubled in severe infections (1, 3). Other sources advise 250 mg to 2 gram every 6 hours (2). Higher doses of up to 8 gram daily in 3 or 4 divided doses may be given for osteomyelitis; in endo ...
The Human Genome Project: Genetic Screening and the
The Human Genome Project: Genetic Screening and the

... long sequences of base pairs.' 6 For example, it is estimated that a typical small gene contains at least 3,000 base pairs and that each human cell contains roughly three to six billion base pairs. DNA is important because it is the building block upon which the production and maintenance of many of ...
Effects on upper gastrointestinal motility
Effects on upper gastrointestinal motility

... dose is excreted in the urine unchanged or conjugated to sulfate or glucuronide. Parenteral administration of metoclopramide 10-20 mg can be employed to treat upper digestive motility disorders. Higher doses are required for other indications (e.g. prevention and treatment of vomiting associatad wit ...
INVITED REVIEW
INVITED REVIEW

... there are many other potential etiologies for painful polyneuropathies and mononeuropathies.101 For simplicity, the current review at times uses the terms “neuropathy” and “peripheral neuropathy” (which have no specific implications) in place of “polyneuropathy,” which implies a generalized, symmetri ...
Annex I: Revised CSP
Annex I: Revised CSP

... severe dehydration have been reported. The profile for adverse reactions with >1% incidence was similar for subacute (four to twelve weeks duration) and long- term (up to one year) clinical trials. The safety of long-term (greater than 12 weeks) administration of misoprostol has been demonstrated in ...
Management  of   n arcolepsy  in  ... C H A P T E R   3...
Management of n arcolepsy in ... C H A P T E R 3...

... of the published pieces of clinical evidence supporting them varies widely, and studies comparing the efficacy of different substances are lacking. Several treatments are used on an empirical basis, especially antidepressants for cataplexy, as these medications are already used widely in depressed p ...
Selective Serotonin Reuptake Inhibitor Toxicity And Serotonin
Selective Serotonin Reuptake Inhibitor Toxicity And Serotonin

... widespread use of SSRIs and the large number of overdoses, this handful of case reports from more than 10 years of experience with the drugs suggest that the SSRIs are less harmful when taken in an overdose. Is one SSRI more dangerous than the others? There seem to have been more serious effects att ...
Opioid Prescription Drug Monitoring Surveillance Report 2015
Opioid Prescription Drug Monitoring Surveillance Report 2015

... or more prescribers or pharmacies. Evidence for the threshold for defining a high dose of morphine  milligram equivalents (MME) is still being gathered.  New recommendations from the CDC state  clinicians should avoid increasing dosage to 90 MME or more,3 while Brandeis indicators suggest harmful  d ...
Inheritance QP - Aleveltopicpapers
Inheritance QP - Aleveltopicpapers

... genetically controlled. A single gene has alleles TA, TB and TC each of which codes for a different sort of trypsin inhibitor. These alleles are codominant so plant with the genotype TATB will produce two sorts of trypsin inhibitor, inhibitor A and inhibitor B. A fourth, recessive allele, To does no ...
Acute effects of LSD on amygdala activity during processing
Acute effects of LSD on amygdala activity during processing

... practice.2,3,5,6,7 Psilocybin has been studied as a treatment option for addiction, depression and for anxiety in patients with advanced stage cancer.8–11 LSD has been shown to reduce anxiety in patients with life-threatening diseases.12 With the investigation of its basic pharmacological and psycho ...
Levofloxacin 0.5% Eye Drops
Levofloxacin 0.5% Eye Drops

... Safety and effectiveness in infants below the age of one year have not bee established. Oral administration of quinolones has been shown to cause arthropathy in immature animals. There is no evidence that the ophthalmic administration of levofloxacin has any effect on weight bearing joints. Geriatri ...
Drugs The Straight Facts, Antidepressants
Drugs The Straight Facts, Antidepressants

... popularized the belief that depression (as well as all other illnesses) was caused by an imbalance of the four “humors,” substances produced by the body that were believed to regulate all bodily functions. The main four humors were phlegm, blood, yellow bile, and black bile. For instance, depression ...
Brief of the American Public Health Association, et al: MARCUS
Brief of the American Public Health Association, et al: MARCUS

< 1 ... 134 135 136 137 138 139 140 141 142 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report