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formulation and evaluation of ibuprofen suppositories
formulation and evaluation of ibuprofen suppositories

... infants and children who have difficulty in swallowing, during nausea and vomiting conditions and when the patient is unconscious1. In addition this route of administration through the use of suppository can also be suitable for local and systemic therapeutic effects2-4. However, in spite being a no ...
Eco-directed sustainable prescribing
Eco-directed sustainable prescribing

... jeopardizing the quality of delivered health care if prescribing guidelines are altered. Long-deemed infeasible has been the optimization of the therapeutic use of medications for preventing pollution at its source. This stance, however, has been shown to be unfounded in at least one instance, where ...
8. Anti-diabetics
8. Anti-diabetics

... Endogenous: 60% in liver & 40% in kidney (because it goes directly to the liver by the portal circulation). Exogenous: 60% kidney & 40% liver  Half-Life 5-7min (endogenous insulin) ...
HIGHLIGHTS OF PRESCRIBING INFORMATION ----------------------- WARNINGS AND PRECAUTIONS -----------------------
HIGHLIGHTS OF PRESCRIBING INFORMATION ----------------------- WARNINGS AND PRECAUTIONS -----------------------

... SELZENTRY have not been specifically studied in patients with significant underlying liver disorders. In trials of treatment-experienced HIV-1-infected subjects, approximately 6% of subjects were co-infected with hepatitis B and approximately 6% were co-infected with hepatitis C. Due to the small nu ...
hydralazine hydrochloride USP
hydralazine hydrochloride USP

... 6 - 55%), this first-pass effect being dependent on the individual's acetylator status. In response to the same oral dose, slow-acetylators show higher "apparent" plasma hydralazine levels than rapid acetylators and ranges require lower doses to maintain control of blood pressure. After intravenous ...
Drug-Induced Lupus Erythematosus
Drug-Induced Lupus Erythematosus

9-Methyl-7-Bromoeudistomin D, a Caffeine Like
9-Methyl-7-Bromoeudistomin D, a Caffeine Like

... H-MBED binding to liver microsomes from rats treated with PB, a typical inducer of CYP2B subfamily enzymes, but α-NF, a typical inhibitor of CYP1A subfamily enzymes, had no effect on this binding (fig.5). These results suggest that in rat liver microsomes, 3H-MBED probably binds to CYP1A1 and CYP2B. ...
Drugs acting on RAAS by Dr Vignesh S
Drugs acting on RAAS by Dr Vignesh S

... bradykinin and other ACE substrates ◦ No rise in level or potentiation of bradykinin, substance P occurs. ACEI related cough is rare ...
CH3 N N CF3 S NH O O
CH3 N N CF3 S NH O O

Preventing the Discovery of Plaintiff Genetic Profiles by Defendants
Preventing the Discovery of Plaintiff Genetic Profiles by Defendants

... admissibility, and because of a desire to keep this complicated subject within manageable proportions, this Article is limited to the issue of discovery of genetic information. Part I discusses the Human Genome Project and the growing ability of medical science to predict the risk of an individual's ...
Indicator
Indicator

... identified by specific ICD-9-CM and reason-for-visit (RFV) codes. An attempt was made to list other conditions that are potentially contraindicative of the application of the quality indication but are measured in N(H)AMCS (refer to unmeasured exceptions). These unmeasured exceptions should not affe ...
Breastfeeding guidelines for substance using mothers
Breastfeeding guidelines for substance using mothers

... Much confusion surrounds the issue of whether a woman should breast feed her baby whilst continuing to take drugs. Many women and their partners are concerned about breastfeeding whilst taking drugs or drinking alcohol and will ask for advice. Parents should be informed that for most drugs the benef ...
Conscious sedation - British Association of Oral Surgeons
Conscious sedation - British Association of Oral Surgeons

... on sedation for dentistry and is endorsed by the GDC’s Standards for dental professionals. It underlines: 1. The importance of the referring dentist and the sedationist considering alternative methods of pain and anxiety control and discussing these with the patient before deciding that conscious se ...
Educational Outcomes, Goals, and Objectives for
Educational Outcomes, Goals, and Objectives for

... capability to deal with a wide range of diseases and disorders that occurs in patients in the emergency environment. Graduates of the program are empowered to treat and appropriately triage the most complex chronic and acute illnesses presented by emergency department patients, including those with ...
prefilled syringes
prefilled syringes

... some time before it is used and it is essential that the plunger moves freely when required to do so, and does not become stuck to the barrel during storage. Proper processes must be in place to minimise the chances of these problems hindering a product’s approval. However, these risks are minimal a ...
Drug-Induced Diseases: Depression
Drug-Induced Diseases: Depression

... patients’ risk of depression, but these agents are no longer commonly used.10-14 The association between clonidine and depression is supported by case-report data. However, larger evaluative studies suggest that the incidence of depression in patients taking clonidine is similar to that in the gene ...
Managing Two Challenging Presentations of Acne
Managing Two Challenging Presentations of Acne

... women. Benzoyl peroxide is rated Category C but is nonetheless prescribed by some dermatologists for pregnant women. Other women may obtain the agent over-the-counter without seeking physician guidance. The apparent safety of topical erythromycin and clindamycin, both rated category B, make them att ...
Click - LDN Research Trust
Click - LDN Research Trust

... 6MP, azathioprine, ASA, biologics but have inherent risks and can be costly; LDN may be just as effective but $40/ mo, no serious side effects; May be considered primary or after initial failure. Dr. Phil Boyle from Dublin presented on LDN use in Fertility. He states that a fertility care physician ...
Extended Twin-Kinship Designs - Virginia Institute for Psychiatric
Extended Twin-Kinship Designs - Virginia Institute for Psychiatric

... • Model sex differences in transmission and effects of genes and environment • Resolve direct causal effect (DCE) of neglect from secondary genetic association with juvenile CD ...
A comparative bioequivalence study of two prolonged
A comparative bioequivalence study of two prolonged

... O-desmethylmetoprolol and alpha-hydroxymetoprolol, are β1-blocking agents, but they are substantially less potent than the parent drug and not considered ...
Emergency Medicine
Emergency Medicine

... capability to deal with a wide range of diseases and disorders that occurs in patients in the emergency environment. Graduates of the program are empowered to treat and appropriately triage the most complex chronic and acute illnesses presented by emergency department patients, including those with ...
Online resources for genetic variation study-Part One
Online resources for genetic variation study-Part One

... Genotype: Each person has two copies of all chromosomes except the sex chromosomes. The set of alleles at a given locus forms the genotype. Genotyping: the process of identifying what genotype a person has for any given locus (loci). Whole-genome genotyping of all SNPs in a human genome? (11.8 mi ...
Oral midazolam – grapefruit juice drug interaction
Oral midazolam – grapefruit juice drug interaction

Memorin - Beximco Pharmaceuticals Ltd.
Memorin - Beximco Pharmaceuticals Ltd.

... Use in Pregnancy and Lactation Pregnancy Category C: Teratology studies conducted in pregnant rats at doses up to 16 mg/kg/day (approximately 13 times the maximum recommended human dose on a mg/m2 basis) and in pregnant rabbits at doses up to 10 mg/kg/day (approximately 16 times the maximum recommen ...
Pharmacology
Pharmacology

... C. Its mechanism of action is completely different from that included low self-esteem, with frequent ruminations of chlorpromazine on her worthlessness, and hypersomnia. She was D. It is more potent as an antipsychotic drug than is chlorhyperphagic and complained that her limbs felt heavy. promazine ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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