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Drug Abuse Warning Network, 2005: National
Drug Abuse Warning Network, 2005: National

... 2005, based on data from the Drug Abuse Warning Network (DAWN). DAWN is a public health surveillance system that monitors drug-related ED visits for the Nation and for selected metropolitan areas. DAWN estimates pertain to the entire United States, including Alaska, Hawaii, and the District of Colum ...
Multicentric Lymphoma in the Dog
Multicentric Lymphoma in the Dog

... multi-agent chemotherapy protocol called CHOP. Treatment with CHOP has a greater than 90% remission rate in dogs with B-cell lymphoma. Dogs with advanced disease at the time of diagnosis (e.g., bone marrow involvement or involvement of non-lymphoid organs), T-cell ...
LSEHWP40
LSEHWP40

... (through PubMed resource) and Scopus from January 2000 to June 2013. The studies were selected and included based on the PICOS approach. Studies were included if they contained primary data on the influence of RA medications on the disease activity of pregnant women with RA, as well as any foetal co ...
Syndrome of Inappropriate Antidiuretic Hormone and Cerebral Salt
Syndrome of Inappropriate Antidiuretic Hormone and Cerebral Salt

... Lithium has been used historically for SIADH. It works in the same manner as demeclocycline by causing nephrogenic DI, but it is even less predictable than demeclocycline, working in only about 30% of patients.13 Lithium is given orally, at a dose of 900 mg daily. Lithium was compared with demeclocy ...
ACCUTANE® (isotretinoin) CAPSULES Avoid Pregnancy
ACCUTANE® (isotretinoin) CAPSULES Avoid Pregnancy

... increased risk of spontaneous abortion. In addition, premature births have been reported. It is strongly recommended that a prescription for Accutane should not be issued by the prescriber until a female patient has had negative results from two urine or serum pregnancy tests, one of which is perfor ...
LIPOSOMES FOR THE DELIVERY OF NUCLEIC ACID DRUGS A
LIPOSOMES FOR THE DELIVERY OF NUCLEIC ACID DRUGS A

... Cationic lipids possess inherent fusogenic properties of their own, cationic lipids were originally believed to require fusogenic “helper” lipids for efficient NA delivery. Fusogenic liposomes facilitate the intracellular delivery of complexed plasmid DNA by fusing with the membranes of the target c ...
low-dose diuretics for first-line and combined treatment of
low-dose diuretics for first-line and combined treatment of

... Since the first VA Cooperative trial published in 1967, thiazide-type diuretics have been the basis of antihypertensive therapy in the majority of placebo-controlled outcome trials in which CVD events, including strokes, CHD, and HF have been reduced by BP lowering. (2) A comprehensive meta-analysis ...
A Pilot Open Study of Long Term High Dose Creatine Augmentation
A Pilot Open Study of Long Term High Dose Creatine Augmentation

... this compound raise the possibility of developing a new augmentation therapeutic strategy in schizophrenia especially in patients demonstrating negative and cognitive symptomatology. Methods: Seven inpatients with chronic schizophrenia presenting with treatment resistant negative symptoms were enrol ...
Hereditary Hemochromatosis Since Discovery of the HFE Gene
Hereditary Hemochromatosis Since Discovery of the HFE Gene

... Although none of the random controls in the initial studies were homozygous for C282Y, larger studies have indicated that the frequency of C282Y homozygotes in the general population is ⬍0.5% (16, 17 ). A third base alteration that replaces serine with cysteine (S65C) is present in ⬃1.5% of the Euro ...
B. Pharmacy 2009-10
B. Pharmacy 2009-10

... 3 hrs/ week 1. Quantitative Analysis and Data Handling: Introduction to concept of Quality Control and Assurance in Pharmaceutical Industry and role of Statistics in pharmaceutical analysis. Significance of quantitative analysis in quality control, different techniques of analysis, preliminaries and ...
Tamsulosin and erectile dysfunction
Tamsulosin and erectile dysfunction

... The symptoms associated with benign prostatic hyperplasia (BPH) are related to bladder outlet obstruction, which is comprised of two underlying components: static and dynamic. The static component is related to an increase in prostate size caused, in part, by a proliferation of smooth muscle cells i ...
Chapter 16 Cholinesterase Inhibitors
Chapter 16 Cholinesterase Inhibitors

... • Controlled-release (OxyContin) ...
Wilderness Medical Kit
Wilderness Medical Kit

... unwarranted. If each WEMT is responsible for replacing OTC medications as they become outdated, it may also make sense to make each WEMT responsible for replacing prescription medications, too. If so, require WEMTs to inspect their kits on a regular basis, perhaps once every two months, and replace ...
Randomized, double-blind, placebo-controlled trial of
Randomized, double-blind, placebo-controlled trial of

... To minimize the risk of adverse effects of the trial medication on their well-being, patients were withdrawn if, at any time, they or their physician believed that they had deteriorated substantially. These patients were then given topical or oral conventional therapy. Patients who were withdrawn we ...
Lipofen (fenofibrate capsules USP) 50 mg and 150 mg
Lipofen (fenofibrate capsules USP) 50 mg and 150 mg

... The effect of LIPOFEN on coronary heart disease morbidity and mortality and non-cardiovascular mortality has not been established. The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study was a 5-year randomized, placebo-controlled study of 9795 patients with type 2 diabetes mellitu ...
DANGERS OF PHARMACEUTICAL SUBSTITUTES FOR NICOTINE
DANGERS OF PHARMACEUTICAL SUBSTITUTES FOR NICOTINE

... harmful effects of nicotine in the body, you wonder how pure doses of the stuff can possibly be deemed safe. It is unclear how this can be called therapy when one is removing nicotine with one hand and giving it back in more pure and potent form with the other. Bottom line is that you remain addicte ...
Product Information: Nanoparticle albumin
Product Information: Nanoparticle albumin

Abdominal Aortic Aneurysms(AAA)
Abdominal Aortic Aneurysms(AAA)

... - Inhibitors of MMPs (doxycycline and BB-94) or other proteases such as cathepsins and plasminogen-activator inhibitor (PAI-1) offers a tremendous therapeutic strategy to prevent AAA enlargement . - Inflammation plays an integral role in the development of AAA and expression of the inflammatory mole ...
Propoxyphene Napsylate and Acetaminophen Tablets
Propoxyphene Napsylate and Acetaminophen Tablets

... In all cases of suspected overdosage, call your regional Poison Control Center to obtain the most upto-date information about the treatment of overdose. This recommendation is made because, in general, information regarding the treatment of overdosage may change more rapidly than do package inserts. ...
formulation and evaluation of ibuprofen suppositories
formulation and evaluation of ibuprofen suppositories

... infants and children who have difficulty in swallowing, during nausea and vomiting conditions and when the patient is unconscious1. In addition this route of administration through the use of suppository can also be suitable for local and systemic therapeutic effects2-4. However, in spite being a no ...


... to that of placebo. In controlled pediatric clinical trials, the incidence of treatment-related headache, sedation and nervousness, which were rarely reported events, was similar to that of placebo. CONTRAINDICATIONS: LORATADINE (CLARITIN*) products are contraindicated in patients who have shown hyp ...
Chapter 12
Chapter 12

... Cephalosporin History  The first generation cephalosporins are mostly active against gram positive bacteria and ...
Association of KCNQ1, KCNE1, KCNH2 and SCN5A Polymorphisms
Association of KCNQ1, KCNE1, KCNH2 and SCN5A Polymorphisms

... frequent in the group of subjects with the longest QTc, which confirm the initial association described in a German population18. We found that allele SCN5A IVS24+116 A was more frequent in the group of subjects with the shortest QTc. In the initial study, Aydin et al (2005) reported an association ...
Vancomycin Assay - Beckman Coulter
Vancomycin Assay - Beckman Coulter

... Note: To convert from µg/mL to µmol/L vancomycin, multiply by 0.67. ...
Reactions to ASA/NSAIDS/and Additives
Reactions to ASA/NSAIDS/and Additives

... • Butylated hydroxyanisole (BHA) ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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