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Genetics
Genetics

... severe phenotype (clinical manifestation) will arise in the patient. For example, patients with a 20/25 genotype are unlikely to present 24 hours a day ...
Projected Spending on Prescription Drugs Used to Treat Mental
Projected Spending on Prescription Drugs Used to Treat Mental

... United States. The primary purpose of this presentation: – Aim 1) Present new estimates on MHSA prescription drug spending from 1986 – 2003; – Aim 2) Explore qualitatively factors with potential to influence future use and spending of prescription drugs used to treat mental health disorders ...
Is It Making a Difference? [PDF, 8.72MB]
Is It Making a Difference? [PDF, 8.72MB]

... doses of parecoxib were given in six cases, with patients receiving up to five doses. The other seven patients received only one dose, but two had risk factors: one was also taking a diuretic and an angiotensin II receptor antagonist; and the other had pre-existing mild diabetic nephropathy. The pat ...
Discrimination Is Good Doug Kalish
Discrimination Is Good Doug Kalish

... On the positive side, knowing the genetic profile of a patient should allow doctors to select the most clinically effective and the most cost effective course of treatment. When these therapies reduce the costs to the insurers, they will include these therapies as part of the health benefit package. ...
Asparaginase
Asparaginase

... L-Asparaginase is a contact irritant in both powder and solution forms. The drug must be handled and administered with caution. Induction treatment of acute lymphoblastic leukemia with L-asparaginase may induce rapid lysis of blast cells. Prophylaxis against tumor lysis syndrome with vigorous IV hyd ...
Drug İnteractions
Drug İnteractions

... the stomach, assisting in the formation of a GI bleed. Additionally, NSAIDs decrease the cohesive properties of platelets necessary in clot formation. PREVENTION: Avoid concomitant use of an NSAID with warfarin. If anti-pyretic effects are desired, then consider acetaminophen. Acetaminophen in doses ...
What is in a name
What is in a name

... mouth, constipation, urinary retention, blurred vision, tachycardia, sedation) ...
What`s a Designer baby? What is PGD? The term `designer baby
What`s a Designer baby? What is PGD? The term `designer baby

... In vitro fertilization (IVF) technique involves the fertilization of the egg by the sperm in test tubes, outside the mother's body. This allows doctors to screen the embryos. Genetic screening has made it possible to eliminate genes associated with several genetic defects and terminal illnesses. A r ...
Lynparza, Opdivo, Rapivab, and Savavsa
Lynparza, Opdivo, Rapivab, and Savavsa

... •Embryofetal toxicity: Opdivo can cause fetal harm. Advise patient of potential risk to a fetus and use of effective contraception during treatment and for at least five months after the last dose. Contraindications. There are no contraindications listed. Drug Interactions. No formal pharmacokinetic ...
The Future of Healthcare Five Basic Rights of Medication Delivery
The Future of Healthcare Five Basic Rights of Medication Delivery

... therapies required intravenous (IV) medication and fluids, machines with alarms were initiated which controlled the proper fluid and lessened complications. • LTC did not have the staff to observe the flow of IV fluids, nor the machines to regulate this flow. Patients stayed in the hospital longer. ...
BIO 10 Lecture 2
BIO 10 Lecture 2

... same allele for a gene is homozygous. An individual that carries two different alleles for a gene is heterozygous. – In a heteroygote, only one allele is physically expressed; this allele is dominant (A) over the unexpressed, recessive (a) allele. ...
Melinta Therapeutics Announces FDA Acceptance of Investigational
Melinta Therapeutics Announces FDA Acceptance of Investigational

... topical radezolid for the treatment of mild-to-moderate acne. Melinta and a partner are collaborating on the development of radezolid for the treatment of dermatological conditions including acne under a December 2014 agreement. Since that time, the companies have successfully developed a formulatio ...
Situation Analysis of Drug Abuse in Pakistan
Situation Analysis of Drug Abuse in Pakistan

... 70.3% injected by “professional injectors/street doctors” during the past month • Only 38.6% always injected with a new needle • 31.2% used someone else’s needle/syringe at last injection & 23% of IDUs passed on needle/syringe to another IDU • 56% had never heard of preventive programs Ref: HASP Nat ...
PHARMACOLOGY SKILLS 2
PHARMACOLOGY SKILLS 2

... ___________________ injections skip this phase of pharmacokinetics as the drug is placed directly into the circulation. 8) All blood that circulates to the small intestines must travel through the _________________ on its way to the systemic circulation. This is also the main organ of ______________ ...
Slide 1
Slide 1

... round a letter that represents an egg • Fill in the chart • There is a ____% chance the baby will be a girl. • Which parent determines the baby’s sex? ...
Pharmacy Myths
Pharmacy Myths

... Taking more than the recommended dose may cause adverse effects such as stomach bleeding, as well as liver or kidney problems Effects of certain prescription medications can be increased or decreased by non-prescription medications Patients should tell their physician and pharmacist about ALL med ...
Is a Drug Polar or Non-polar (and why does this matter?)
Is a Drug Polar or Non-polar (and why does this matter?)

... 3) Explain what is meant by ‘targeted therapy’, using two examples of transtuzumab (Herceptin) and imatinib (Gleevec). 4) Why has the concept of ‘personalized medicine’ been so difficult to ...
drug-Sedatatives
drug-Sedatatives

...  Pyrazolopyrimidines - Sonata (zaleplon) ½ life is 1 hour, so is handy for people who awaken during the night, since can take another pill.  Cyclopyrrolones - Lunesta (eszopiclone) a good choice for people who waking up too early.  Melatonin Receptor Stimulator - Rozerem (ramelteon) Is the only n ...
Presentation Part II
Presentation Part II

... Many “OD DEATHS” caused by what it is cut with (Fentanyl-Quinine-etc) Cheaper that Rx Opioids…”Balloon Effect” will Increase Demand ...
View Presentation Document
View Presentation Document

... METHAMPHETAMINE The Drug of the new millenium ...
Drugs - Green Local Schools
Drugs - Green Local Schools

... Street drugs – drugs that have limited, if any medical benefit; commonly abused and traded on the streets ...
Pharmacokinetics - The Cambridge MRCPsych Course
Pharmacokinetics - The Cambridge MRCPsych Course

... NB Plasma assays usually report ‘total’ rather than ‘free’ drug levels ...
Initiating Clinical Research - Leicestershire Partnership NHS Trust
Initiating Clinical Research - Leicestershire Partnership NHS Trust

Cutaneous or Discoid Lupus Erythematosus
Cutaneous or Discoid Lupus Erythematosus

... Avoiding exposure to the sun and using sunscreens are important measures to protect the skin from ultraviolet light. Topical therapy (applied directly to the skin) with steroids or immune-modulating drugs may be successful in mild cases. Systemic therapy with oral vitamin E, steroids, and other immu ...
2008 April - GeriatRx Pharmacy
2008 April - GeriatRx Pharmacy

... study of 749 seniors showed that those with the highest level of physical activity were 27% less likely to develop vascular dementia compared to those with the lowest level. Unfortunately, there was no correlation between exercise and the development of Alzheimer’s Disease. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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