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S0730-5403_Jerry_H._Gurwitz
S0730-5403_Jerry_H._Gurwitz

... drugs rarely involved. • Budnitz study: Medication use leading to ER visits in older adults ...
Human Genetic Disorders
Human Genetic Disorders

... Genetic Disorders • Particular mutations have become more common in human populations. • The harmful effects that some mutations produce are called genetic disorders. • A person with a genetic disorder has inherited a defective gene from both parents. ...
September 2015 - Emergent BioSolutions
September 2015 - Emergent BioSolutions

... (FXIa) in lots of ANTHRASIL. Safe levels of procoagulant activity have not been established; however, procoagulant activity levels in the lots identified below approach levels that were reported when thrombotic reactions occurred with similar products. To mitigate the potential for development of th ...
July - NABP
July - NABP

... in medication appearance. So much so that patients may not question a change or, when they do, practitioners may simply reassure them that it was due to a change in manufacturer without actively investigating the reason. It is not uncommon for ISMP to receive reports from both practitioners and cons ...
SUBSTANCE ABUSE: How Drugs Affect the Body
SUBSTANCE ABUSE: How Drugs Affect the Body

... Steps of Drug Abuse 1. Experimentation – users like the unusual feelings, and want to try it again 2. Tolerance – start increasing the amounts of the drug to reduce sensitivity ...
SUBSTANCE ABUSE PHARMACOLOGY
SUBSTANCE ABUSE PHARMACOLOGY

... The Debut of a “new” phenomena called FREE BASING- The smoking of Cocaine, made infamous by the likes of Richard Pryor. It’s used spread like “wild fire” further and faster than any drug before, and went on to change the face of not only the USA but the world. How and why did this happen – CHEAP, A ...
II. Probability and Punnett Squares
II. Probability and Punnett Squares

... -Mendel used the principles of probability to explain the results of his genetic crosses. ...
Lecture 9 (Anticoags) 1. What is hemostasis? 2. What is thrombosis
Lecture 9 (Anticoags) 1. What is hemostasis? 2. What is thrombosis

... 17. What is the major indication for use of thrombolytics? What is the timeframe? 18. What is the major adverse effect of streptokinase use as a thrombolytic? 19. What drugs are not recommended for use in treatment during acute ischemic stroke? ...
Pharmacologic Implications for Special Patient Populations:
Pharmacologic Implications for Special Patient Populations:

... Drug remains in stomach longer leading to increase in absorption through stomach and delayed in absorption of drugs ...
Liposomes
Liposomes

Drug Information Sheets
Drug Information Sheets

... Cocaine is used to produce crack-crack is a derivative of cocaine ...
A Radical Prescription - V-BID
A Radical Prescription - V-BID

... Within a year, Mr. Hom says, he realized he probably would lose the bet. By late 2002, he and Dr. Mahoney already began to notice in the claims data a higher rate of prescription refills for drugs and a shift to more expensive, but often more convenient, combination drugs. A noticeable example was A ...
PV Gaps and FDAAA
PV Gaps and FDAAA

... trials to assess a known serious risk, assess signals of a serious risk, or to identify an unexpected serious risk when available data indicates the potential for a serious risk. Determination must be based on new information. Note that “new information can come from a variety of sources, including ...
Absorption, distribution, metabolism and excretion
Absorption, distribution, metabolism and excretion

... excretion. It acts as a reservoir for drug. Binding to plasma proteins is reversible Drugs highly bound to plasma proteins are in general expected to persist in body longer than those less bound and are expected to have lower therapeutic activity, less efficient distribution and less available for ...
PDF
PDF

... Cappuzzo K. Consultant Pharmacist 2006;11:911-915 ...
Is there an alternative to MRT?
Is there an alternative to MRT?

... “Changing genes which are passed on to future generations” or “changing genes in gametes and very early embryos” [meaning not temporarily as in altered gene expression – but changing the code]. ...
Counselling Patients Taking Oral Anticoagulation
Counselling Patients Taking Oral Anticoagulation

... • Patients need to be told they will need to attend the anticoagulation clinic after discharge to have their INR monitored and their warfarin dosed • Frequency of visits may vary but initially patients may need to attend weekly but over time they will become less frequent • Patients must be told to ...
Genetics Objectives/keywords
Genetics Objectives/keywords

... Genes allow for the storage and transmission of genetic information. They are a set of instructions encoded in the nucleotide sequence of each organism. Genes code for the specific sequences of amino acids that comprise the proteins that are characteristic of that organism. MA Standard 3.4 Distingui ...
Boxed Warnings Adverse Drug Reactions Poster
Boxed Warnings Adverse Drug Reactions Poster

... AGREEMENT. Ensure that the patient knows whom to call and what to do, including going to an Emergency Room if none of the provided contacts are reachable, if ...
past, present and future - National Cancer Registry Ireland
past, present and future - National Cancer Registry Ireland

... Non-persistence with tamoxifen in clinical practice is higher than previously reported. 35.2% of women discontinue tamoxifen by 3.5 years. 22.1% discontinue tamoxifen by 1 year. ...
PHM226 Sample Final Exam Questions
PHM226 Sample Final Exam Questions

... b) Outline how ketone bodies supply energy and what causes ketoacidosis. c) Supplementing rat or dog diet with carnitine and lipoic acid enables the animals to perform learning tasks until an older age. Explain the biochemistry involved. 4) a) The diagnosis of a particular porphyria usually leads to ...
Autonomic neuropathy
Autonomic neuropathy

Document
Document

... decline or deterioration has been evaluated by the interdisciplinary team to determine whether a particular drug, a particular dose, or duration of therapy may be the cause; • Documentation showing why the resident's age, weight, or other factors would require a unique drug dose or drug duration, in ...
Pharmacology
Pharmacology

... responses to drugs caused by genetic differences between individuals. Responses that are not found in the general population, such as general toxic effects, allergies, or side effects, but due to an inherited trait that produces a diminished or enhanced response to a drug. • Differences in Enzyme Ac ...
classification of antipsychotic drugs
classification of antipsychotic drugs

... The antipsychotic drugs probably owe their therapeutic effects mainly to blockade of D2 receptors. The main groups, phenothiazines, thioxanthines and butyrophenones, show preference for D2 over D1 receptors; some newer agents (e.g. remoxipride) are highly selective for D2 receptors, whereas clozapin ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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