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Drug Diversion Chaitali Chheda, PharmD candidate 2008 January 10, 2008
Drug Diversion Chaitali Chheda, PharmD candidate 2008 January 10, 2008

... • Ronald McIver, 63 years old, and a doctor. He is now in jail following a conviction for drug trafficking. • One patient with a severe pain condition was given high doses of OxyContin 40 mg from the start of therapy and was allowed to control her own dosing. • She didn’t bring any medical records e ...
Basic Drug Awareness - My Surgery Website
Basic Drug Awareness - My Surgery Website

... – Other names for the drug – What type of drug is it? – How is it used? – What are its effects? – What are the problems associated with the drug? – Withdrawal phenomena? – How would you treat the addiction to this drug? ...
Drugs used in emergency cases
Drugs used in emergency cases

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Review for Heredity Unit
Review for Heredity Unit

... 3. An allele that seems to disappear (or is covered up ) when a dominant allele is present is called __________________________ 4. The passing of traits from parent to offspring. ______________________ 5. An organism’s physical appearance, or what it looks like is called its ______________________ 6 ...
General Pharmacokinetics
General Pharmacokinetics

New therapeutic alternatives to treat Acute Bacterial Skin and Skin
New therapeutic alternatives to treat Acute Bacterial Skin and Skin

... protein synthesis. Although the mechanism of action is similar to the other member of its class (Linezolid), it has better ADME (absorption, distribution, metabolism, and excretion) and side effects profile as compared to Linezolid. Other side effect such as anemia, tachycardia, blurred vision, hype ...
EVEROLIMUS - Cancer Care Nova Scotia
EVEROLIMUS - Cancer Care Nova Scotia

... Oral Systemic Therapy- Adverse Drug Reaction Management Guide ...
6.4 Traits, Genes, and Alleles TEKS 6A, 6F
6.4 Traits, Genes, and Alleles TEKS 6A, 6F

... • An allele is any alternative form of a gene occurring at a specific locus on a chromosome. – Each parent donates one allele for every gene. – Homozygous describes two alleles that are the same at a specific locus. – Heterozygous describes two alleles that are different at a specific locus. ...
Evolution of A new Species
Evolution of A new Species

... population? Shouldn’t natural selection remove these? • Alleles that are lethal in a homozygous individual may be carried in a heterozygous individual. ...
drug interactions
drug interactions

... High risk clinical setting • 3. Critically ill patients; • These patients have lost their physiological reserve in one or more systems and often require multiple drugs. • Examples include patients with renal, hepatic,respiratory,cardiac or autonomic failure;alzheimers dementia,myasthenia gravis. • ...
Hardy -- Weinberg
Hardy -- Weinberg

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Genetic Risk Scores

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Treatment of ACS Objectives “Early Invasive

... • In general, primary PCI is preferred over lytics when primary PCI is possible – Must be 90 minutes from presentation – Meta-analysis indicate mortality lower with primary PCI – Opens 90% of occluded arteries compared to 60% with lytics – Lower bleeding risk – Also indicated if contraindications to ...
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furosemide (fur-oh-se-mide) - DavisPlus

... falls risk and implement fall prevention strategies. Assess patients receiving digoxin for anorexia, nausea, vomiting, muscle cramps, paresthesia, and confusion. Patients taking digoxin are at increased risk of digoxin toxicity because of the potassium-depleting effect of the diuretic. Potassium sup ...
Lopinavir/Ritonavir solution (Kaletra)
Lopinavir/Ritonavir solution (Kaletra)

... analgesics, methadone, heart/blood-pressure medications, psychiatric medications, anti-convulsants, transplant/immunosuppressant medications, warfarin, cholesterol lowering agents, sildenafil (Viagra®), oral contraceptives (birth control pill), ergot containing migraine medications. Avoid the follow ...
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... person with definite HHT, relatives can be screened for that particular diseasecausing mutation to determine definitively whether or not they are affected • Genetic testing was unusually marketed to patients (consumers) rather than providers • Costly imaging studies and surveillance would then be re ...
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... There is some evidence that when a father is 45 years of age or older at the time of conception, there is an increased risk for dominant genetic disorders that are new to the family. The risk for these disorders does not increase dramatically at age 45, but rather the risk increases gradually each y ...
Bromazepam
Bromazepam

... Overdose of bromazepam is seldom life-threatening if the drug is taken alone, but may lead to slurred speech, areflexia, apnea, hypotension, cardiorespiratory depression and coma. Coma, if it occurs, usually lasts a few hours but it may be more protracted and cyclical, particularly in elderly patien ...
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... planned for 2Q 2013. Multiple ascending dose trial. Multicenter. Enrollment 1.5 years. ...
Evaluation and Treatment of Hypertension
Evaluation and Treatment of Hypertension

... Patients with refractory migraine studied (8-14 headache days per month or failure of 2 previous preventive treatments in patients with transformed migraine) received 10-20 mg of memantine daily for 3 months 28 patients in this open labeled study. HA frequency reduced from 21.8 days to 16.1 days (p< ...
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Unit 6 antibiotics - Faculty Sites

... Action/Use ◦ Bacteriocidal by attaching to penicillin binding proteins to inhibit cell wall synthesis ◦ Gram negative infections and when less expensive penicillins are not tolerated; 5-10% of people allergic to penicillin are also allergic to ...
Singapore scientists lead in the discovery of gene responsible for
Singapore scientists lead in the discovery of gene responsible for

... Sichuan Provincial Institute of Dermatology, Chengdu (Y.N.); Hunan Provincial Center for Disease Control and Prevention, Changsha (Z.-H.W.); Fujian Center for Disease Control and Prevention, Fuzhou (W.-B.W.); Honghe Institute of Dermatology, Honghe, Yunnan (Z.-Y.Z.); Wenshan Institute of Dermatology ...
Session 14 - Teaching Slides
Session 14 - Teaching Slides

... Fluconazole 900 mg/day for another 8 weeks Secondary prophylaxis with fluconazole 150 ...
genetic variation
genetic variation

... Forest genetic variation is a evolutionary result of adaption of environmental heterogeneity (Jelinski, 1997), and can be maintained through arboreal reproduction if the diversity was acquired through recombination, introgression, or somatic mutation (Rasmussen and Kollmann, 2007). The variation is ...
Enclosure-II
Enclosure-II

... in the treatment of hypertension and congestive heart faiure, perindopril is converted in the body into active metabolite perindroprilate, ACE inhibition is reported to occur within 1 hour of dose, to be maintained for 24 hours. Perindropril is given by mouth as the erbumine salt and should be taken ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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