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TB or Not TB??? - lookmatters.net
TB or Not TB??? - lookmatters.net

... RMP from the first line drugs plus resistance to any fluoroquinolone and at least one of three injectable second line drugs (capreomycin, kanamycin and amikacin) WHO ...
Letrozole - Wolverhampton Formulary
Letrozole - Wolverhampton Formulary

... musculoskeletal pain. Refer to the SPC for a full list of adverse effects. Letrozole was launched in November 1996 and no longer has black triangle (▲) status. Serious suspected reactions (even if well recognised or causal link uncertain) should be reported to the CSM. Monitoring Parameter ...
Rickett Benkiser - American Osteopathic Association
Rickett Benkiser - American Osteopathic Association

... Psychosis (persistent) Paranoia Seizure Elevated troponin Elevated CPK ...
Guidance for healthcare professionals on drug driving  July 2014
Guidance for healthcare professionals on drug driving July 2014

... The statutory "medical defence" This new offence does not alter in any way the clinical advice that should be given to patients in future, which, as now, is based on a proper professional judgement for each patient of what is the appropriate discussion concerning the risks of their medicines. A pati ...
SEDA - Elsevier
SEDA - Elsevier

... A case history may be summarized (including the age and sex of the patient) if it provides a clear illustration of the type of case that the physician is likely to meet, or if it has unusual features. The description should be as brief as possible, including only those elements that appear to be rel ...
Volume 14, No. 5 May 2016 - Institute for Safe Medication Practices
Volume 14, No. 5 May 2016 - Institute for Safe Medication Practices

... Analysis of aggregate data regarding mix-ups between Depo-Medrol and DepoProvera between 1999 and 2015 identified 5 additional cases reported to FAERS and 4 more reported to the ISMP MERP database, for a total of 11 reports. One of the events occurred as recently as December 2015, although the patie ...
Better Humans
Better Humans

... no regulatory framework in place to enable the licensing of drugs for use in healthy individuals. Drugs are either licensed for medicinal use in patients via the Medicines and Healthcare products Regulatory Agency or controlled under the Misuse of Drugs Act. Smart drugs are most likely to be obtaine ...
Understanding Inheritance A. 1.
Understanding Inheritance A. 1.

... B. Modeling Inheritance 1. In a situation based on chance, such as flipping a coin, the chance of getting a certain outcome can be represented by a(n) as 50:50, or 1:1. ...
to open the MS Word version of the Quarterly Action Agenda
to open the MS Word version of the Quarterly Action Agenda

... Last year, ISMP and FDA received more When prescribing either drug, the purpose than 200 reports of mix-ups between of the drug should be included with the risperiDONE and rOPINIRole, and these order, and pharmacists and nurses should events have continued. In one of the verify that the therapy matc ...
Pedigree analysis
Pedigree analysis

... Many traits in humans are controlled by genes. Some of these traits are common features like eye color, straight or curly hair, baldness, attached vs. free ear lobes, the ability to taste certain substances, and even whether you have dry or sticky earwax! Other genes may actually cause disease. Sick ...
Frequently Asked Questions
Frequently Asked Questions

... benefits of generic use are not as black and white as commonly perceived and portrayed in the media, especially for Medicaid programs. State Medicaid programs participate in a federally negotiated rebate program with drug manufacturers. This means they receive a varying percentage of the cost of eve ...
Placebos Work -- Even Without Deception
Placebos Work -- Even Without Deception

... many patients treated with the placebo reported adequate symptom relief as compared to the control group (59 percent vs. 35 percent). Also, on other outcome measures, patients taking the placebo doubled their rates of improvement to a degree roughly equivalent to the effects of the most powerful IBS ...
drug effect on orthodontic tooth movement
drug effect on orthodontic tooth movement

... (i) Corticosteroid therapy Corticosteroids are used for its anti inflammatory and immunosuppressive effects. Side effect of long-term steroid therapy includes disturbances in mineralized tissue metabolism, wound healing discrepancies in chondrogenesis & osteogenesis, bone loss and osteoporosis. Shor ...
Introduction to Genetics
Introduction to Genetics

... recessive forms of the genes. An example is the Vienna white gene which causes the blue-eyedwhite (BEW) rabbit. A rabbit carrying this gene may show some BEW characteristics, such as white patches of fur or blue eyes. ...
denta1-LECTURE- board(FOUR LECTURES)
denta1-LECTURE- board(FOUR LECTURES)

... • Drugs extensively metabolize by the liver ...
Lecture 5 pdf
Lecture 5 pdf

... Phenotype is result of complex, integrated pattern of reactions under control of more than one gene and the environment. 1. Epistasis (true non-allelic interaction) - expression of a single trait depends on interaction between 2 or more genes examples: comb shape in chickens ...
The Story of Genetics
The Story of Genetics

... It takes 2 genes to control a trait. One from the male and one from the female. The combination of the 2 genes control characteristics. ...
FOM 2313 PHARMACOLOGY AND THERAPEUTICS
FOM 2313 PHARMACOLOGY AND THERAPEUTICS

... student to study by themselves the detailed content of some lectures. Laboratory: Experimentation is the most important mode of learning in science. Therefore, there are 6 laboratory sessions in this course, including video presentation, lab demonstration and experiments on animals. Study Guide: A s ...
final examination july 2011 examination 1/2011/2012 session
final examination july 2011 examination 1/2011/2012 session

... Tamoxifen - reduce the risk of breast cancer in high-risk women. Raloxifen - more selective than tamoxifen against breast cancer. Celexocib - selective against lung cancer. Finasteride - effective against prostate cancer. ...
chapter_22
chapter_22

Small Changes are Big Steps: Making Nanotechnologies Ethically
Small Changes are Big Steps: Making Nanotechnologies Ethically

... epidemiological investigations, adherence levels below 95% dramatically reduce the chances of therapeutic success to about 50%. However, high adherence to HAART does not lead to the complete elimination of the virus from the host. Paediatric HIV has been almost eliminated in developed countries by l ...
BioRexis Appoints Vanaja V. Ragavan, MD, Vice President, Clinical
BioRexis Appoints Vanaja V. Ragavan, MD, Vice President, Clinical

... Pharmaceuticals, where she was the global head of women’s health/urology, clinical research and development. At Novartis, she was responsible for clinical development and marketing support of several product lines, such as hormone therapies, urology products and calcitonin, and for managing the stra ...
Mendel`s Genetics Webquest
Mendel`s Genetics Webquest

... 1. What is Mendel’s Law of Segregation? 2. What is used to keep track of the gametes and possible offspring combinations? 3. What is the ratio of genotypes produced in the example of crossing a heterozygous yellow pea with another heterozygous pea? Ratio of phenotypes? Vocabulary Review – ____ 1. Fa ...
Ch 8 Review - Priory Haiku
Ch 8 Review - Priory Haiku

... ______ 2. Which of the following is NOT one of Mendel’s major hypotheses? a. An individual receives two copies of a gene for each trait. b. Genes have alternative versions, which we now call alleles. c. Gametes carry several alleles for each inherited trait. d. When two alleles appear together, one ...
Genetics of Cystic Fibrosis - Cystic Fibrosis New Zealand
Genetics of Cystic Fibrosis - Cystic Fibrosis New Zealand

... As there are a number of variations in the gene, there are also variations in how CF affects the person with the condition, some have more serious complications than others, some keep very healthy most of the time. Eggs and Sperm Each will carry one copy of the gene normal gene CF gene ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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