RNA-Seq Alignment v1.0 App Guide
... (or read pairs) and the genome, using a Suffix Array index. Different parts of a read can be mapped to different genomic positions, corresponding to splicing or RNA-fusions. The genome index includes known splice-junctions from annotated gene models, allowing for sensitive detection of spliced reads ...
... (or read pairs) and the genome, using a Suffix Array index. Different parts of a read can be mapped to different genomic positions, corresponding to splicing or RNA-fusions. The genome index includes known splice-junctions from annotated gene models, allowing for sensitive detection of spliced reads ...
Tandem duplications and the limits of natural
... et al. 2014, Zhou et al. 2008, Katju and Lynch 2006). Surveys within single genomes have suggested that whole gene duplications may form at low rates in comparison with SNPs, with even lower mutation rates for complex variants such as chimeric genes (Rogers, Bedford and Hartl 2009, Rogers et al. 201 ...
... et al. 2014, Zhou et al. 2008, Katju and Lynch 2006). Surveys within single genomes have suggested that whole gene duplications may form at low rates in comparison with SNPs, with even lower mutation rates for complex variants such as chimeric genes (Rogers, Bedford and Hartl 2009, Rogers et al. 201 ...
Analyzing Loss of Heterozygosity in in Partek Genomics Suite™ v6.6
... vendors) to detect regions heterozygous in ‘normal’ samples (e.g. 1×A, 1×B allele) that are homozygous (e.g. AA or BB) in cancer (or study) samples. The workflow can be successfully applied for the three main applications: detection of copy-neutral LOH; confirmation of allele deletions detected ...
... vendors) to detect regions heterozygous in ‘normal’ samples (e.g. 1×A, 1×B allele) that are homozygous (e.g. AA or BB) in cancer (or study) samples. The workflow can be successfully applied for the three main applications: detection of copy-neutral LOH; confirmation of allele deletions detected ...
Phenotype Variations of TAS2R38 Gene and Its Bioecological
... The part of them thinks differently; they consider that according to the phenotypic expressions of this gene, varied ration is observed in different populations of different age groups. For instance, according to the current data of the molecular – genetic research on TAS2R16 gene, which was conduct ...
... The part of them thinks differently; they consider that according to the phenotypic expressions of this gene, varied ration is observed in different populations of different age groups. For instance, according to the current data of the molecular – genetic research on TAS2R16 gene, which was conduct ...
Genome-wide search for signatures of selection in three
... Brazilian sheep are descendants of animals imported during the colonization period and, since then, have been subject to systematic and non-systematic evolutionary processes. This has led to the development of local breeds adapted to the diverse Brazilian environmental conditions (Mariante et al., 2 ...
... Brazilian sheep are descendants of animals imported during the colonization period and, since then, have been subject to systematic and non-systematic evolutionary processes. This has led to the development of local breeds adapted to the diverse Brazilian environmental conditions (Mariante et al., 2 ...
The Underlying Similarity of Diversity Measures Used in
... The simplest definition of diversity comes from the answer to the question “how different is everybody from everybody else?” If every chromosome is identical, there is no difference between any two chromosomes and hence there is no diversity in the population. If each chromosome is completely differ ...
... The simplest definition of diversity comes from the answer to the question “how different is everybody from everybody else?” If every chromosome is identical, there is no difference between any two chromosomes and hence there is no diversity in the population. If each chromosome is completely differ ...
24 Recombination Hotspots in Nonallelic Homologous Recombination
... parents. A collection of de novo NAHR events can then be fine-mapped to identify and ultimately sequence the rearrangement breakpoints. Not all recurrent rearrangements result from NAHR (11) and so the preliminary identification of similar sized rearrangements must be followed by the mapping of brea ...
... parents. A collection of de novo NAHR events can then be fine-mapped to identify and ultimately sequence the rearrangement breakpoints. Not all recurrent rearrangements result from NAHR (11) and so the preliminary identification of similar sized rearrangements must be followed by the mapping of brea ...
this PDF file - E-Journal Faculty of Medicine Universitas
... In the homozygous state there is a decrease in enzyme functions up to 60%. Meanwhile, in heterozygotes, the decrease is only about 30%. MTHFR C677T polymorphism gene may alter folate metabolism and low folate intake may result in increased levels of homocysteine. This may lead to a decrease in DNA m ...
... In the homozygous state there is a decrease in enzyme functions up to 60%. Meanwhile, in heterozygotes, the decrease is only about 30%. MTHFR C677T polymorphism gene may alter folate metabolism and low folate intake may result in increased levels of homocysteine. This may lead to a decrease in DNA m ...
Tutorial - QIAGEN Bioinformatics
... Figure 1: Toolbox folder structure after installation of the Bisulfite Sequencing plugin. Bisulfite sequencing is the use of bisulphite treatment of DNA to determine its pattern of methylation. DNA methylation was the first discovered epigenetic mark, and remains the most studied. Changes in cytosin ...
... Figure 1: Toolbox folder structure after installation of the Bisulfite Sequencing plugin. Bisulfite sequencing is the use of bisulphite treatment of DNA to determine its pattern of methylation. DNA methylation was the first discovered epigenetic mark, and remains the most studied. Changes in cytosin ...
PDF
... However, the honeybee, Apis mellifera, has extremely high recombination rates, averaging 19– 37 cM/Mb [2–4], which corresponds to more than 5 crossovers per chromosome pair per meiosis. Such high rates are observed in other social insects but not their solitary cousins [5,6]. This suggests that high ...
... However, the honeybee, Apis mellifera, has extremely high recombination rates, averaging 19– 37 cM/Mb [2–4], which corresponds to more than 5 crossovers per chromosome pair per meiosis. Such high rates are observed in other social insects but not their solitary cousins [5,6]. This suggests that high ...
CHROMOSOMES AND DISEASE
... Extra copy of a numbered chromosome (an autosome): The most common example of a disorder seen in newborn babies that is due to an extra copy of an autosome is called Down syndrome. In 1866, a physician named John Langdon Down who worked with people with intellectual disabilities, observed that a num ...
... Extra copy of a numbered chromosome (an autosome): The most common example of a disorder seen in newborn babies that is due to an extra copy of an autosome is called Down syndrome. In 1866, a physician named John Langdon Down who worked with people with intellectual disabilities, observed that a num ...
PDF File - Friends Science Publishers
... located on chromosome arm 5BL (Stock et al., 1996). The disomic was not sensitive to radiation, but some monosomic lines which showed increased resistance after irradiation were judged to be radiosensitive. Yield-related traits such as tiller number, heading date, plant height, flag leaf length and ...
... located on chromosome arm 5BL (Stock et al., 1996). The disomic was not sensitive to radiation, but some monosomic lines which showed increased resistance after irradiation were judged to be radiosensitive. Yield-related traits such as tiller number, heading date, plant height, flag leaf length and ...
Large-scale Analysis of Pseudogenes in the Human Genome
... pseudogenes cannot produce transcripts due to the lack of functional promoters. Very rarely, some pseudogenes have retained or acquired a functional promoter so they can be transcribed, but these transcripts are not translated due to lack of translational or splicing signal sequences. As the result ...
... pseudogenes cannot produce transcripts due to the lack of functional promoters. Very rarely, some pseudogenes have retained or acquired a functional promoter so they can be transcribed, but these transcripts are not translated due to lack of translational or splicing signal sequences. As the result ...
SNP discovery
... • Not easy to run in a high-throughput system due to “limitations in multiplex levels” ...
... • Not easy to run in a high-throughput system due to “limitations in multiplex levels” ...
AT3 (Acyltransferase) Gene Isolated from Capsicum frutescens cv
... Several enzymes are involved in Capsaicin biosynthesis. Capsaicin synthase (CS) is the last enzyme which has an important role in capsaicin biosynthesis by condensing vanillylamin with acyl moieties to produce capsaicin. CS also serves as a regulator for the formation of capsaicin [9]. Acyltransfera ...
... Several enzymes are involved in Capsaicin biosynthesis. Capsaicin synthase (CS) is the last enzyme which has an important role in capsaicin biosynthesis by condensing vanillylamin with acyl moieties to produce capsaicin. CS also serves as a regulator for the formation of capsaicin [9]. Acyltransfera ...
A set reduction and pattern matching problem motivated by Allele
... region by a DNA polymerase which extends the primer sequence and creates two copies of the flanked region. This process is repeated many times causing exponential amplification of the sequence and ensuring it is present in detectable levels (Fig. 1). Allelic variants—different sets of alleles in an ...
... region by a DNA polymerase which extends the primer sequence and creates two copies of the flanked region. This process is repeated many times causing exponential amplification of the sequence and ensuring it is present in detectable levels (Fig. 1). Allelic variants—different sets of alleles in an ...
Dynamic Changes in Aromatic Hydrocarbon Associated Catabolic
... Results from this work also indicate that more bcr copies were detected overall within the benzoate microcosms compared to the toluene microcosms. This could reflect the differences in the types of microorganisms present in the two inocula. For example microorganisms present in the river sediment us ...
... Results from this work also indicate that more bcr copies were detected overall within the benzoate microcosms compared to the toluene microcosms. This could reflect the differences in the types of microorganisms present in the two inocula. For example microorganisms present in the river sediment us ...
Unbalanced translocation, a major chromosome alteration
... number changes at breakpoints, and were detected in seven cases (70%; Figure 3b). The LOHs were further classified into (b) mitotic recombination and (c) mitotic gene conversion based on the region of LOHs (Figures 1B and 2). These alterations were detected in 14 and 17 LOHs without copy number chang ...
... number changes at breakpoints, and were detected in seven cases (70%; Figure 3b). The LOHs were further classified into (b) mitotic recombination and (c) mitotic gene conversion based on the region of LOHs (Figures 1B and 2). These alterations were detected in 14 and 17 LOHs without copy number chang ...
Genomic Databases for Tomato
... fragments from the fingerprinted BACs were hybridized to 1536 overlapping oligonucleotide (called “overgo”) probes (Cai et al. 1998) generated from markers mapped on the current high density linkage map. The overgo probes that matched to one or more BACs are referred to as “anchor points”. Currently ...
... fragments from the fingerprinted BACs were hybridized to 1536 overlapping oligonucleotide (called “overgo”) probes (Cai et al. 1998) generated from markers mapped on the current high density linkage map. The overgo probes that matched to one or more BACs are referred to as “anchor points”. Currently ...
- University of Bath Opus
... similarity in sex-biased gene expression among neighbouring genes. Whether this clustering of genes with similar expression profiles is functional or instead the result of transcriptional interference with adjacent genes displaying non-functional but significant similarity in patterns of gene expres ...
... similarity in sex-biased gene expression among neighbouring genes. Whether this clustering of genes with similar expression profiles is functional or instead the result of transcriptional interference with adjacent genes displaying non-functional but significant similarity in patterns of gene expres ...
Exome sequencing as a tool for Mendelian disease gene discovery
... nonsense single-base substitutions or small insertion– deletions (that is, indels), are predicted to have functional consequences and/or to be deleterious14. As such, the exome represents a highly enriched subset of the genome in which to search for variants with large effect sizes. Defining the exo ...
... nonsense single-base substitutions or small insertion– deletions (that is, indels), are predicted to have functional consequences and/or to be deleterious14. As such, the exome represents a highly enriched subset of the genome in which to search for variants with large effect sizes. Defining the exo ...
Hemoglobin A2: origin, evolution, and aftermath
... gene are depicted in Table 1. Although these likely arose from a nonhomologous crossing over event in variants may be unstable or have elevated oxygen affinity, which the P-globin gene from one chromosome mispaired they are not associated with a clinically significant phenowith the &globin gene of t ...
... gene are depicted in Table 1. Although these likely arose from a nonhomologous crossing over event in variants may be unstable or have elevated oxygen affinity, which the P-globin gene from one chromosome mispaired they are not associated with a clinically significant phenowith the &globin gene of t ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.