The Genetics of Alcohol Metabolism
... moreover, there are variants (i.e., alleles) of some of these genes that encode enzymes with different characteristics and which have different ethnic distributions. Which ADH or ALDH alleles a person carries influence his or her level of alcohol consumption and risk of alcoholism. Researchers to da ...
... moreover, there are variants (i.e., alleles) of some of these genes that encode enzymes with different characteristics and which have different ethnic distributions. Which ADH or ALDH alleles a person carries influence his or her level of alcohol consumption and risk of alcoholism. Researchers to da ...
reported several instances of so-called " complex genes ", whose
... example mentioned previously in Saccharomyces, two new alleles arose, M1R1 and m1n1. By tetrad analysis it is possible, as already mentioned, ...
... example mentioned previously in Saccharomyces, two new alleles arose, M1R1 and m1n1. By tetrad analysis it is possible, as already mentioned, ...
Relationship of Gene Expression and Chromosomal Abnormalities in Colorectal Cancer
... by amplification (e.g., the oncogene MYC; ref. 3). However, the functional consequence of recurrent abnormalities is not always apparent, because a change in DNA copy number does not necessarily induce actual alterations in expression (4). The issue is further complicated by the observation that man ...
... by amplification (e.g., the oncogene MYC; ref. 3). However, the functional consequence of recurrent abnormalities is not always apparent, because a change in DNA copy number does not necessarily induce actual alterations in expression (4). The issue is further complicated by the observation that man ...
NRT2 - Clark University
... H.velutipes clade has, in fact, been demonstrated (Aanen, 2001). ∆ Problems with these hypotheses include the likelihood of these events being of some debate, and also the lack of additional corroborative molecular evidence such as additional ITS sequences in H. helodes. These are not necessarily fa ...
... H.velutipes clade has, in fact, been demonstrated (Aanen, 2001). ∆ Problems with these hypotheses include the likelihood of these events being of some debate, and also the lack of additional corroborative molecular evidence such as additional ITS sequences in H. helodes. These are not necessarily fa ...
12864_2008_1659_MOESM3_ESM
... The intron-containing parent gene CDC14B yielded a retrocopy in primates prior to the branching of New World monkeys, which was followed by the integration of a MER9 LTR element into the C-terminus encoding part of what corresponds to the ORF of the parent gene. A segmental duplication prior to the ...
... The intron-containing parent gene CDC14B yielded a retrocopy in primates prior to the branching of New World monkeys, which was followed by the integration of a MER9 LTR element into the C-terminus encoding part of what corresponds to the ORF of the parent gene. A segmental duplication prior to the ...
LOSS OF HETEROZYGOSITY DUE TO SHORT-TRACT AND LONG-TRACT SACCHAROMYCES CEREVISIAE Thomas Coates
... The development of medical sciences and our understanding of the biochemical nature of many disorders and diseases over the last fifty years has led to giant leaps in our ability to combat and prevent mortality and fatality from genetic and pathogenic causes. Vaccinations and the development of anti ...
... The development of medical sciences and our understanding of the biochemical nature of many disorders and diseases over the last fifty years has led to giant leaps in our ability to combat and prevent mortality and fatality from genetic and pathogenic causes. Vaccinations and the development of anti ...
CHAPTER 8
... genetic material: duplications involve a repeat of some genetic material; deficiencies, a shortage of some genetic material. Inversions do not cause a change in the total amount of genetic material. Inversions involve a change in the direction of the genetic material along a single chromosome. Trans ...
... genetic material: duplications involve a repeat of some genetic material; deficiencies, a shortage of some genetic material. Inversions do not cause a change in the total amount of genetic material. Inversions involve a change in the direction of the genetic material along a single chromosome. Trans ...
Interplay between copy number, dosage compensation and
... In contrast to work with single cell organisms, the impact of gene dosage on expression variability in metazoans is less well studied. However, a full understanding of the effect of gene copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. ...
... In contrast to work with single cell organisms, the impact of gene dosage on expression variability in metazoans is less well studied. However, a full understanding of the effect of gene copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. ...
Information Encoding in Biological Molecules: DNA and
... • The microRNA bantam regulates the Drosophila (fruitfly) gene hid by binding the 3’ UTR. Hid is involved in apoptosis, and it is possible that binding sites for bantam could be found in the 3’ UTR of other apoptosis genes as well. Obtain the 3’ UTR sequence of all Drosophila genes known to be invol ...
... • The microRNA bantam regulates the Drosophila (fruitfly) gene hid by binding the 3’ UTR. Hid is involved in apoptosis, and it is possible that binding sites for bantam could be found in the 3’ UTR of other apoptosis genes as well. Obtain the 3’ UTR sequence of all Drosophila genes known to be invol ...
the human y chromosome, in the light of evolution
... genes do not tend to jointly occupy particular chromo- ...
... genes do not tend to jointly occupy particular chromo- ...
Biotechnology: Principles and Products
... a biological organism Detailed Definition The application of the technology to modify the biological function of an organism by adding genes from another organism NDSU ...
... a biological organism Detailed Definition The application of the technology to modify the biological function of an organism by adding genes from another organism NDSU ...
Functional gene groups are concentrated within chromosomes
... C The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and re ...
... C The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and re ...
Tandem and segmental gene duplication and
... gene sequences to different regions, similar to how continental drift affects species. In this view, genome segments can be treated as geographic populations and analysed using phylogeographic approaches. Synteny: the occurrence of genomic co-linearity between homologous genes in different organisms ...
... gene sequences to different regions, similar to how continental drift affects species. In this view, genome segments can be treated as geographic populations and analysed using phylogeographic approaches. Synteny: the occurrence of genomic co-linearity between homologous genes in different organisms ...
The human genome. Implications for medicine and society
... the relative location of genetic markers on a chromosome. Genetic markers are DNA segments, that are either expressed (i.e., are genes) or not, and their inheritance can be confirmed in the laboratory (for instance, using molecular hybridization techniques such as Southern and FISH, PCR techniques, ...
... the relative location of genetic markers on a chromosome. Genetic markers are DNA segments, that are either expressed (i.e., are genes) or not, and their inheritance can be confirmed in the laboratory (for instance, using molecular hybridization techniques such as Southern and FISH, PCR techniques, ...
Y chromosome: Structure and Biological Functions
... 2) Professor, Department of Anatomy, MGM Medical College, Aurangabad, Maharashtra 3) Associate Professor and Head, Department of Genetics, Immunology, Biochemistry and Nutrition, Maharashtra University of Health Sciences, Pune 4) Assistant Professor, Department of Genetics, Immunology, Biochemistry ...
... 2) Professor, Department of Anatomy, MGM Medical College, Aurangabad, Maharashtra 3) Associate Professor and Head, Department of Genetics, Immunology, Biochemistry and Nutrition, Maharashtra University of Health Sciences, Pune 4) Assistant Professor, Department of Genetics, Immunology, Biochemistry ...
Generation of the chromosome sequences
... the gap and were not included in the gene set. For gi9507164, although the gap still exists in the May, 2004, release, we have extended sequence into that gap and can now account for all exonic sequence. Based on placements of mRNAs against chromosome 2 and 4, only one possible deletion was detected ...
... the gap and were not included in the gene set. For gi9507164, although the gap still exists in the May, 2004, release, we have extended sequence into that gap and can now account for all exonic sequence. Based on placements of mRNAs against chromosome 2 and 4, only one possible deletion was detected ...
Simple Sequence Repeats as Advantageous Mutators
... Runx-2, and yeast RAS2. Ideally, an incremental effect of repeat number should be demonstrated over a range of quantitative phenotypic differences. Although a few studies have provided data from multiple alleles [e.g., 4, 17, 32], and the triplet repeat diseases also show dependence on repeat number ...
... Runx-2, and yeast RAS2. Ideally, an incremental effect of repeat number should be demonstrated over a range of quantitative phenotypic differences. Although a few studies have provided data from multiple alleles [e.g., 4, 17, 32], and the triplet repeat diseases also show dependence on repeat number ...
TregouetD_EGEE3-presentation
... and calculate the corresponding statistical test yielding a pvalue • SNP definition Genetic variation in a DNA sequence that occurs when a single nucleotide (~ base: A,C,G,T ) in a genome is altered. Often considered as a binary 0/1 variable EGEE-III INFSO-RI-222667 ...
... and calculate the corresponding statistical test yielding a pvalue • SNP definition Genetic variation in a DNA sequence that occurs when a single nucleotide (~ base: A,C,G,T ) in a genome is altered. Often considered as a binary 0/1 variable EGEE-III INFSO-RI-222667 ...
Enthusiasm mixed with scepticism about single
... Single nucleotide polymorphisms (SNP) are frequent in our genomes, occurring on average once every thousand nucleotides. They are useful as genetic markers because SNPs evolve slowly and because they can be scored by technically simple methods. Moreover, a great deal of the functional variation that ...
... Single nucleotide polymorphisms (SNP) are frequent in our genomes, occurring on average once every thousand nucleotides. They are useful as genetic markers because SNPs evolve slowly and because they can be scored by technically simple methods. Moreover, a great deal of the functional variation that ...
Searching for fossil genes
... Most mammals, such as mice, can produce their own vitamin C and therefore do not need a source of vitamin C in their diet. The GULO gene codes for an enzyme, Lgulonolactone oxidase, involved in vitamin C synthesis. The GULO gene is present in mice and most other mammals, but is either missing, or is ...
... Most mammals, such as mice, can produce their own vitamin C and therefore do not need a source of vitamin C in their diet. The GULO gene codes for an enzyme, Lgulonolactone oxidase, involved in vitamin C synthesis. The GULO gene is present in mice and most other mammals, but is either missing, or is ...
Module 1: Introduction
... when using Excel in bioinformatics 47 BMC Bioinformatics. 2004 Jun 23;5:80 ...
... when using Excel in bioinformatics 47 BMC Bioinformatics. 2004 Jun 23;5:80 ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.