Gene clusters for β-lactam antibiotics and control of their expression
... The cefG gene contains two introns and is linked to cefEF, but in the opposite orientation. Bioinformatic analysis of cefG revealed 55% identical residues with the met2 genes of Aspergillus fumigatus and Ascobolus immersus. The met2 genes encode O-acetyl homoserine acetyl transferase activity involv ...
... The cefG gene contains two introns and is linked to cefEF, but in the opposite orientation. Bioinformatic analysis of cefG revealed 55% identical residues with the met2 genes of Aspergillus fumigatus and Ascobolus immersus. The met2 genes encode O-acetyl homoserine acetyl transferase activity involv ...
use of genomic tools to discover the cause of
... Three sire families were identified as segregating for this trait. Genome wide linkage analysis using 104 microsatellite DNA markers was used to map the gene to ECA14 (LOD > 11.0). Four genes, namely SPARC, SLC36A1, SLC36A2 and SLC36A3, were selected from the region implicated by linkage and their e ...
... Three sire families were identified as segregating for this trait. Genome wide linkage analysis using 104 microsatellite DNA markers was used to map the gene to ECA14 (LOD > 11.0). Four genes, namely SPARC, SLC36A1, SLC36A2 and SLC36A3, were selected from the region implicated by linkage and their e ...
Genomic imprinting and the units of adaptation
... Every gene is assigned an allelic type aAA, according to its nucleic acid sequence. Thus, the allele associated with the class-k gene in individual i is denoted aik. Every allele is associated with a genic value, given by g ¼ G(a), where G is the genotype function. Thus, the genic value associated w ...
... Every gene is assigned an allelic type aAA, according to its nucleic acid sequence. Thus, the allele associated with the class-k gene in individual i is denoted aik. Every allele is associated with a genic value, given by g ¼ G(a), where G is the genotype function. Thus, the genic value associated w ...
Feb 27 lecture presentation
... • Distinguish between positive and negative transcriptional regulation • Make predictions based on hypotheses • Infer protein function from mutant phenotype Pages 519-525 of textbook ...
... • Distinguish between positive and negative transcriptional regulation • Make predictions based on hypotheses • Infer protein function from mutant phenotype Pages 519-525 of textbook ...
Evolutionary consequences of polyploidy in prokaryotes and the
... Background: The origin of eukaryote-specific traits such as mitosis and sexual reproduction remains disputable. There is growing evidence that both mitosis and eukaryotic sex (i.e., the alternation of syngamy and meiosis) may have already existed in the basal eukaryotes. The mating system of the hal ...
... Background: The origin of eukaryote-specific traits such as mitosis and sexual reproduction remains disputable. There is growing evidence that both mitosis and eukaryotic sex (i.e., the alternation of syngamy and meiosis) may have already existed in the basal eukaryotes. The mating system of the hal ...
How Biologists Conceptualize Genes: An empirical study
... conception of a gene as a segment of chromosome, different allelic forms of which can be tracked via their differing effects on the phenotype. It is less easy to treat actual coding sequences in this way. The one-to-one correspondence between stretches of coding DNA and genes is challenged by the ex ...
... conception of a gene as a segment of chromosome, different allelic forms of which can be tracked via their differing effects on the phenotype. It is less easy to treat actual coding sequences in this way. The one-to-one correspondence between stretches of coding DNA and genes is challenged by the ex ...
The Fly Genome
... 180 million base pairs 120 Mbp has been sequenced The sequenced portion is euchromatin thought to be richer in gene sequences than the remaining heterochromatin Drosophila has a haploid number of 4: 3 autosomes plus 1 sex chromosome Polytene chromosomes can be easily observed in the salivary glands ...
... 180 million base pairs 120 Mbp has been sequenced The sequenced portion is euchromatin thought to be richer in gene sequences than the remaining heterochromatin Drosophila has a haploid number of 4: 3 autosomes plus 1 sex chromosome Polytene chromosomes can be easily observed in the salivary glands ...
Determination of obesity associated gene variants related
... aim of identifying body mass associated genetic variants. Sequencing was performed on the SOLiD platform, on long-range PCR fragments generated through targeted amplification of the regions of interest. Candidate single nucleotide polymorphisms (SNPs) were validated by TaqMan genotyping. We were able ...
... aim of identifying body mass associated genetic variants. Sequencing was performed on the SOLiD platform, on long-range PCR fragments generated through targeted amplification of the regions of interest. Candidate single nucleotide polymorphisms (SNPs) were validated by TaqMan genotyping. We were able ...
Information Encoding in Biological Molecules: DNA and
... Automatically finds genes and other features of the sequence Associates sequence and features with data from other sources Provides a publicly accessible web based interface to the database ...
... Automatically finds genes and other features of the sequence Associates sequence and features with data from other sources Provides a publicly accessible web based interface to the database ...
ppt_II
... Automatically finds genes and other features of the sequence Associates sequence and features with data from other sources Provides a publicly accessible web based interface to the database ...
... Automatically finds genes and other features of the sequence Associates sequence and features with data from other sources Provides a publicly accessible web based interface to the database ...
Leukaemia Section 3q27 rearrangements in non Hodgkin lymphoma,
... in the REAL classification; very rare cases were also reported with mantle cell lymphoma and chronic lymphocytic leukemia. 3q27 breaks are usually, but not invariably, associated with rearrangements of the BCL6 gene located at the 3q27 chromosome band; likewise rearrangements of this gene may occur ...
... in the REAL classification; very rare cases were also reported with mantle cell lymphoma and chronic lymphocytic leukemia. 3q27 breaks are usually, but not invariably, associated with rearrangements of the BCL6 gene located at the 3q27 chromosome band; likewise rearrangements of this gene may occur ...
Nucleotide Sequence of the SAC2 Gene of Saccharomyces cerevisiae .
... A temperature-sensitive mutation (actl-I) in the essential actin gene of Saccharomyces cerevisiae can be suppressed by mutations in the SAC2 gene. A cloned genomic DNA fragment that complements the cold-sensitive growth phenotype associated with such a suppressor mutation (sac2-1) was sequenced. The ...
... A temperature-sensitive mutation (actl-I) in the essential actin gene of Saccharomyces cerevisiae can be suppressed by mutations in the SAC2 gene. A cloned genomic DNA fragment that complements the cold-sensitive growth phenotype associated with such a suppressor mutation (sac2-1) was sequenced. The ...
A statistical framework for genome
... proportion of significant SNPs to all SNPs within genes that are part of the pathway to a null ratio distribution generated by phenotype randomization of the dataset. GSEA_SNP is an extension of GSEA algorithms. It converts the gene set to a corresponding SNP set and then employs a same procedure as ...
... proportion of significant SNPs to all SNPs within genes that are part of the pathway to a null ratio distribution generated by phenotype randomization of the dataset. GSEA_SNP is an extension of GSEA algorithms. It converts the gene set to a corresponding SNP set and then employs a same procedure as ...
Department of Biomedical Informatics
... (SNP) The single nucleotide polymorphism (SNP) [pronounced "snip"] is the most common form of genetic variation. As the name suggests, each SNP is a difference in a single nucleotide (A,T,C,or G) of an individual's DNA sequence, such as having AAGG instead of ATGG. There may be from 1 to 10 million ...
... (SNP) The single nucleotide polymorphism (SNP) [pronounced "snip"] is the most common form of genetic variation. As the name suggests, each SNP is a difference in a single nucleotide (A,T,C,or G) of an individual's DNA sequence, such as having AAGG instead of ATGG. There may be from 1 to 10 million ...
Foundations of Biology
... Drosophila X Chromosome 2b In division 2b of the X chromosome, a strange bulge appears in images of polytene chromosomes In situ hybridization using cosmid clones mapped to that region show hybridization on the outside of this structure, but not in the middle Figure from http://www.helsinki.fi/~sau ...
... Drosophila X Chromosome 2b In division 2b of the X chromosome, a strange bulge appears in images of polytene chromosomes In situ hybridization using cosmid clones mapped to that region show hybridization on the outside of this structure, but not in the middle Figure from http://www.helsinki.fi/~sau ...
Document
... Step 3A: Align Reads Using TopHat We will now align RNA-Seq reads to chr22 using mostly default parameters. Note: We are not providing gene information. TopHat will find splice junctions de novo. $ tophat –p 4 –o ctrl chr22 thrombin_control.txt # Run TopHAT using chr22 as reference and sequences in ...
... Step 3A: Align Reads Using TopHat We will now align RNA-Seq reads to chr22 using mostly default parameters. Note: We are not providing gene information. TopHat will find splice junctions de novo. $ tophat –p 4 –o ctrl chr22 thrombin_control.txt # Run TopHAT using chr22 as reference and sequences in ...
Rapid divergence and diversification of mammalian duplicate gene
... expression divergence of duplicate genes occurs much faster than that of single-copy genes in mammals. Thus, though natural selection may not be as efficient as in Drosophila, it still appears to play an important role in the functional divergence of duplicate genes in mammals. ...
... expression divergence of duplicate genes occurs much faster than that of single-copy genes in mammals. Thus, though natural selection may not be as efficient as in Drosophila, it still appears to play an important role in the functional divergence of duplicate genes in mammals. ...
SpliceCenter_DataBuild
... variants are mapped to the same general genomic location. The GeneBuild process uses the transcript alignments to construct an internal object-oriented representation of a gene. Each gene object contains a collection of variant objects which in turn contain collections of exon objects. BLAT alignmen ...
... variants are mapped to the same general genomic location. The GeneBuild process uses the transcript alignments to construct an internal object-oriented representation of a gene. Each gene object contains a collection of variant objects which in turn contain collections of exon objects. BLAT alignmen ...
The Gene Gateway Workbook
... official gene symbol, which is HFE for hemochromatosis, serves as a unique identifier for a gene. To be "official," a gene symbol must have been approved by the HUGO Gene Nomenclature Committee (http://www.gene.ucl.ac.uk/nomenclature/). The gene symbol is especially useful when searching other datab ...
... official gene symbol, which is HFE for hemochromatosis, serves as a unique identifier for a gene. To be "official," a gene symbol must have been approved by the HUGO Gene Nomenclature Committee (http://www.gene.ucl.ac.uk/nomenclature/). The gene symbol is especially useful when searching other datab ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.