Charles University in Prague Faculty of Pharmacy in Hradec Králové
... the blood-brain barrier (BBB), which separates the blood from the cerebral parenchyma thus limiting the brain uptake of the majority of drugs. Among the several carriers, which have been developed to overcome this problem, liposomes have attracted significant attention as promising agents for brain- ...
... the blood-brain barrier (BBB), which separates the blood from the cerebral parenchyma thus limiting the brain uptake of the majority of drugs. Among the several carriers, which have been developed to overcome this problem, liposomes have attracted significant attention as promising agents for brain- ...
Full book.large
... suggested, this has nothing to do with any moral stance on my part. Overall, I consider myself a libertarian when it comes to the use of drugs. As long as the choice is made based on knowledge, and no one but the individual making that choice is affected, what people do to themselves is their own bu ...
... suggested, this has nothing to do with any moral stance on my part. Overall, I consider myself a libertarian when it comes to the use of drugs. As long as the choice is made based on knowledge, and no one but the individual making that choice is affected, what people do to themselves is their own bu ...
Pharmacology and the Nursing Process, 4th ed
... Italian broad beans (fava beans) Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Italian broad beans (fava beans) Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
Lamictal XR (lamotrigine) Extended-Release Tablets
... (1) Taking Estrogen-Containing Oral Contraceptives: In women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Cli ...
... (1) Taking Estrogen-Containing Oral Contraceptives: In women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Cli ...
B N ULLETI I N F O R M A T I O...
... after consuming mixed drinks her husband prepared, the wife fell into a deep sleep and vaguely recalled her husband’s having sexually abused her. One evening, when both the husband and wife had separate plans to be out of the house, the wife returned home and found the husband at home with the babys ...
... after consuming mixed drinks her husband prepared, the wife fell into a deep sleep and vaguely recalled her husband’s having sexually abused her. One evening, when both the husband and wife had separate plans to be out of the house, the wife returned home and found the husband at home with the babys ...
Cobicistat / Tenofovir disoproxil fumarate / Emtricitabine / Elvitegravir
... Primary pharmacodynamics. The integrase inhibitor EVG is a new chemical entity which showed potent anti-HIV-1 activity in vitro. Studies were included in the clinical part of the submission along with clinical anti-viral studies, but there were sufficient details in the virology summary to demonstra ...
... Primary pharmacodynamics. The integrase inhibitor EVG is a new chemical entity which showed potent anti-HIV-1 activity in vitro. Studies were included in the clinical part of the submission along with clinical anti-viral studies, but there were sufficient details in the virology summary to demonstra ...
the PDF
... psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of piracetam were observed in clinical trials. In the meantime, hundreds of drugs have been evaluated in clinical trials or in preclinical experiments. To classify the compounds, a concept is proposed assi ...
... psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of piracetam were observed in clinical trials. In the meantime, hundreds of drugs have been evaluated in clinical trials or in preclinical experiments. To classify the compounds, a concept is proposed assi ...
Warnings and Precautions
... Quetiapine fumarate dose should be increased up to 5 fold of the original dose when used in combination with a chronic treatment (e.g., greater than 7 to 14 days) of a potent CYP3A4 inducer (e.g. phenytoin, carbamazepine, rifampin, avasimibe, St. John’s wort, etc.). The dose should be titrated based ...
... Quetiapine fumarate dose should be increased up to 5 fold of the original dose when used in combination with a chronic treatment (e.g., greater than 7 to 14 days) of a potent CYP3A4 inducer (e.g. phenytoin, carbamazepine, rifampin, avasimibe, St. John’s wort, etc.). The dose should be titrated based ...
Paediatric formulations of L-arginine for the use in urea cycle disorders
... The fact that children are at risk as they are administered inappropriate medicines has been internationally recognised [146]. Often unlicensed and off-label medicines are the only ones available yet which have not been clinically tested for safety, efficacy and quality in this age group. Most medic ...
... The fact that children are at risk as they are administered inappropriate medicines has been internationally recognised [146]. Often unlicensed and off-label medicines are the only ones available yet which have not been clinically tested for safety, efficacy and quality in this age group. Most medic ...
Alaris® PK Syringe Pump
... plasma-targeted. For many drugs the relationship between plasma concentration and clinical effect was described, usually in terms of the Cp50 or Cp95 (the concentrations required to elicit a specified clinical effect in 50 or 95% of patients respectively). For an example see Ausems et al.5 During th ...
... plasma-targeted. For many drugs the relationship between plasma concentration and clinical effect was described, usually in terms of the Cp50 or Cp95 (the concentrations required to elicit a specified clinical effect in 50 or 95% of patients respectively). For an example see Ausems et al.5 During th ...
Filed - Eastern District of California Blog
... that it protects similarly situated individuals from criminal sanctions for actions ...
... that it protects similarly situated individuals from criminal sanctions for actions ...
EMMANUEL ORMAN - Kwame Nkrumah University of Science
... “I will bless the LORD at all times: His praise will continually be in my mouth” – Psalm 34:1 My sincere gratitude goes to my main supervisor, Professor Reimmel Kwame Adosraku and co-supervisors, Dr. Phyllis Addo and Dr. Michael F. Ofori, of the Noguchi Memorial Institute for Medical Research (NMIMR ...
... “I will bless the LORD at all times: His praise will continually be in my mouth” – Psalm 34:1 My sincere gratitude goes to my main supervisor, Professor Reimmel Kwame Adosraku and co-supervisors, Dr. Phyllis Addo and Dr. Michael F. Ofori, of the Noguchi Memorial Institute for Medical Research (NMIMR ...
PrDALACIN* C FLAVOURED GRANULES
... Clinical studies of clindamycin did not include sufficient numbers of patients age 65 and over to determine whether they respond differently from younger patients. Pediatrics (over one month of age): It is not known if use of clindamycin in the pediatric population is associated with differences in ...
... Clinical studies of clindamycin did not include sufficient numbers of patients age 65 and over to determine whether they respond differently from younger patients. Pediatrics (over one month of age): It is not known if use of clindamycin in the pediatric population is associated with differences in ...
5.02 atazanavir + cobicistat
... The market size estimates presented in the submission might not have been reasonable because: - The market for atazanavir/cobicistat FDC was projected based on two data points representing atazanavir use and an assumption regarding the change in market size that was not well justified. - The assumed ...
... The market size estimates presented in the submission might not have been reasonable because: - The market for atazanavir/cobicistat FDC was projected based on two data points representing atazanavir use and an assumption regarding the change in market size that was not well justified. - The assumed ...
ACE Inhibitors and Angiotensin II
... of 8mg/day) is the least expensive AIIA. A higher dose of 16mg/day may be required19, making the cost/year £165.23. Although this then brings it on par with the cost of other AIIAs at their WHO DDD, what should be taken into account is that higher doses of the other AIIAs may be required to control ...
... of 8mg/day) is the least expensive AIIA. A higher dose of 16mg/day may be required19, making the cost/year £165.23. Although this then brings it on par with the cost of other AIIAs at their WHO DDD, what should be taken into account is that higher doses of the other AIIAs may be required to control ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... Respiratory depression, including fatal cases, may occur with use of KADIAN, even when the drug has been used as recommended and not misused or abused [see Warnings and Precautions (5.2)]. Proper dosing and titration are essential and KADIAN should only be prescribed by healthcare professionals who ...
... Respiratory depression, including fatal cases, may occur with use of KADIAN, even when the drug has been used as recommended and not misused or abused [see Warnings and Precautions (5.2)]. Proper dosing and titration are essential and KADIAN should only be prescribed by healthcare professionals who ...
Blood Coagulation Pathway
... Has many features of an ideal anticoagulant Hepatotoxicity is of concern Newer oral DTIs are being developed (Dabigatran ...
... Has many features of an ideal anticoagulant Hepatotoxicity is of concern Newer oral DTIs are being developed (Dabigatran ...
Comparison of Inhaled Corticosteroids: An Update
... HFA, a new MDI was developed that could produce particles with a much smaller mass median aerodynamic diameter of 1.1 µm, compared with 3.5– 4.0 µm of the beclomethasone dipropionate suspensions in CFC-MDIs; this change significantly enhanced lung delivery of the drug.34 The other inhaled corticoste ...
... HFA, a new MDI was developed that could produce particles with a much smaller mass median aerodynamic diameter of 1.1 µm, compared with 3.5– 4.0 µm of the beclomethasone dipropionate suspensions in CFC-MDIs; this change significantly enhanced lung delivery of the drug.34 The other inhaled corticoste ...
Phenylpropanolamine There are four optical isomers of
... Anecdotal reports have suggested that ephedrine helps studying, thinking, or concentrating to a greater extent than caffeine. Some students and some white-collar workers have used ephedrine (or Ephedracontaining herbal supplements) for this purpose, as well as some professional athletes and weightli ...
... Anecdotal reports have suggested that ephedrine helps studying, thinking, or concentrating to a greater extent than caffeine. Some students and some white-collar workers have used ephedrine (or Ephedracontaining herbal supplements) for this purpose, as well as some professional athletes and weightli ...
Opium Abuse and Its Management: Global Scenario
... Myanmar and Laos In Myanmar, cumulatively from 1974 to 2000 in the treatment centres, there were about 36,000 opium users and they comprised 59% of all registered addict and opium was still the preferred drug of abuse followed by heroin (32%) (Central Registry, Department of Health Planning, Ministr ...
... Myanmar and Laos In Myanmar, cumulatively from 1974 to 2000 in the treatment centres, there were about 36,000 opium users and they comprised 59% of all registered addict and opium was still the preferred drug of abuse followed by heroin (32%) (Central Registry, Department of Health Planning, Ministr ...
Methamphetamine - Department of Electrical Engineering
... methamphetamine production. This was followed a month later by a bill passed in Canada enacting similar laws. In 1986, the U.S. government passed the Federal Controlled Substance Analogue Enforcement Act in an attempt to curb the growing use of designer drugs. Despite this, use of methamphetamine ex ...
... methamphetamine production. This was followed a month later by a bill passed in Canada enacting similar laws. In 1986, the U.S. government passed the Federal Controlled Substance Analogue Enforcement Act in an attempt to curb the growing use of designer drugs. Despite this, use of methamphetamine ex ...
Evaluation of the use of static and dynamic models to predict drug
... models (Guest et al, 2011). All evaluations showed a comparable performance of the two models. Our objective is to employ a diverse proprietary dataset of 19 DDIs to compare the mechanistic static equations with Simcyp ® V11, ensuring consistent pre-clinical input parameters in the models to underst ...
... models (Guest et al, 2011). All evaluations showed a comparable performance of the two models. Our objective is to employ a diverse proprietary dataset of 19 DDIs to compare the mechanistic static equations with Simcyp ® V11, ensuring consistent pre-clinical input parameters in the models to underst ...
6. Kelly CP. A 76-year-old man with recurrent
... will occur or which patients are at risk. Clinicians want to know what adverse effects are of a practical concern and what to do about them, but the drug information references do not often provide this type of guidance. For example, package inserts for antibiotics warn that these drugs can cause ki ...
... will occur or which patients are at risk. Clinicians want to know what adverse effects are of a practical concern and what to do about them, but the drug information references do not often provide this type of guidance. For example, package inserts for antibiotics warn that these drugs can cause ki ...
Hydrocodone Bitartrate and Acetaminophen Tablets, USP
... history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as Hydrocodon ...
... history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as Hydrocodon ...