Biliary Excretion of Antimicrobial Drugs
... Antimicrobial agents are among the most commonly prescribed drugs. The aim of antimicrobial chemotherapy is to eliminate an infection as rapidly as possible. To achieve this, a sufficient concentration of the drug or ...
... Antimicrobial agents are among the most commonly prescribed drugs. The aim of antimicrobial chemotherapy is to eliminate an infection as rapidly as possible. To achieve this, a sufficient concentration of the drug or ...
... preparations. In addition, tramadol and paracetamol were found to reduce the severity of pain and photophobia associated with moderate-to-severe migraine headache [97]. Intra-operative studies showed tramadol did not antagonise the hypnotic effects of volatile inhalational agents (such as isoflurane ...
Actions of bufalin and cinobufotalin, two bufadienolides respectively
... As a result of this brief study it was decided to carry out all experimental studies on ouabain binding with incubation for 2 h. The results of the ouabain-sensitive binding assays with the addition of non-labelled ouabain, bufalin and cinobufotalin are shown in Fig. 1.All nine blood samples were te ...
... As a result of this brief study it was decided to carry out all experimental studies on ouabain binding with incubation for 2 h. The results of the ouabain-sensitive binding assays with the addition of non-labelled ouabain, bufalin and cinobufotalin are shown in Fig. 1.All nine blood samples were te ...
PRODUCT MONOGRAPH PrMONUROL® Fosfomycin powder, 3g
... MONUROL (fosfomycin tromethamine) is contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container. ...
... MONUROL (fosfomycin tromethamine) is contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container. ...
Aminophylline
... considered necessary, the serum-theophylline concentration should first be assessed and the initial loading dose should be calculated on the basis that each 600 micrograms/kg of aminophylline (equivalent to about 500 micrograms/kg theophylline) will increase serum-theophylline concentration by 1 mic ...
... considered necessary, the serum-theophylline concentration should first be assessed and the initial loading dose should be calculated on the basis that each 600 micrograms/kg of aminophylline (equivalent to about 500 micrograms/kg theophylline) will increase serum-theophylline concentration by 1 mic ...
PHARMACEUTICAL SUPPOSITORIES & PESSARIES Ms.WAJIHA
... -Hand molding is useful when we are preparing a small number of suppositories: 1. The drug is made into a fine powder. 2. It is incorporated into the suppository base by kneading with it or by trituration in a mortar. 3. The kneaded mass is rolled between fingers into rod shaped ...
... -Hand molding is useful when we are preparing a small number of suppositories: 1. The drug is made into a fine powder. 2. It is incorporated into the suppository base by kneading with it or by trituration in a mortar. 3. The kneaded mass is rolled between fingers into rod shaped ...
The safety of hydroquinone
... Interestingly, in the FDA-approved cream containing hydroquinone 4% in combination with two other active ingredients (Tri-Luma, Galderma Laboratories, L.P.), absorption was shown to be negligible. Negligible absorption was demonstrated by applying to 14 healthy volunteers 3 g of Tri-Luma cream to ea ...
... Interestingly, in the FDA-approved cream containing hydroquinone 4% in combination with two other active ingredients (Tri-Luma, Galderma Laboratories, L.P.), absorption was shown to be negligible. Negligible absorption was demonstrated by applying to 14 healthy volunteers 3 g of Tri-Luma cream to ea ...
Epidural Analgesia and Anesthesia
... a particularly effective means of providing postoperative pain control in private practice settings, where 24-hour care may not be available. Although single epidural injections are effective for intra- and postoperative analgesia, there are also cases of a more chronic nature that can benefit from ...
... a particularly effective means of providing postoperative pain control in private practice settings, where 24-hour care may not be available. Although single epidural injections are effective for intra- and postoperative analgesia, there are also cases of a more chronic nature that can benefit from ...
министерство здравоохранения республики беларусь
... e) the biotransformation of the drug in the liver. 40. Parameter that characterizes the «apparent volume of distribution». Variants of the answer: a) the rate of absorption of the drug; b) the rate of elimination of the drug; c) the decay rate of the drug; d) the efficacy of; e) the ability of the d ...
... e) the biotransformation of the drug in the liver. 40. Parameter that characterizes the «apparent volume of distribution». Variants of the answer: a) the rate of absorption of the drug; b) the rate of elimination of the drug; c) the decay rate of the drug; d) the efficacy of; e) the ability of the d ...
Word - corporate
... portfolio of product candidates in the United States, Europe and other major markets. We own two issued U.S. patents that cover the composition of matter and method of use for GBT440, which are due to expire in 2032 and 2034, respectively (absent any applicable patent term extensions), and we own or ...
... portfolio of product candidates in the United States, Europe and other major markets. We own two issued U.S. patents that cover the composition of matter and method of use for GBT440, which are due to expire in 2032 and 2034, respectively (absent any applicable patent term extensions), and we own or ...
Delirium in the Elderly
... days) and are more likely to be discharged to a nursing facility than to home (16% vs. 3%). Patients with delirium are more likely to be reintubated if they are in an ICU. Each day spent in delirium in the ICU is associated with a 20% increased risk of prolonged hospitalization and a 10% increased r ...
... days) and are more likely to be discharged to a nursing facility than to home (16% vs. 3%). Patients with delirium are more likely to be reintubated if they are in an ICU. Each day spent in delirium in the ICU is associated with a 20% increased risk of prolonged hospitalization and a 10% increased r ...
St John`s wort (Hypericum perforatum L.): a review of its
... effective as some standard antidepressants in mild-to-moderate depression. There is still a need for further trials to assess the efficacy of St John’s wort extracts, compared with that of standard antidepressants, particularly newer antidepressant agents, such as the selective serotonin reuptake in ...
... effective as some standard antidepressants in mild-to-moderate depression. There is still a need for further trials to assess the efficacy of St John’s wort extracts, compared with that of standard antidepressants, particularly newer antidepressant agents, such as the selective serotonin reuptake in ...
Bioavailability & Bioequivalence
... body into a single compartment. This model is only appropriate for drugs which rapidly and readily distribute between the plasma and other body tissues. ...
... body into a single compartment. This model is only appropriate for drugs which rapidly and readily distribute between the plasma and other body tissues. ...
About Methadone and Buprenorphine
... Methadone lasts longer. The body metabolizes methadone differently than it does heroin or morphine. When a person takes methadone regularly, it builds up and is stored in the body, so it lasts even longer when used for maintenance. Most people find that once they’re stabilized on a dose of methadone ...
... Methadone lasts longer. The body metabolizes methadone differently than it does heroin or morphine. When a person takes methadone regularly, it builds up and is stored in the body, so it lasts even longer when used for maintenance. Most people find that once they’re stabilized on a dose of methadone ...
Synthetic cannabinoids in herbal products
... status, a recent survey [8] suggest that the use of these products has dropped significantly. However, it is still increasingly popular among users who have to undergo regular urine drug screenings as current screening methods do not detect synthetic cannabinoids. This observation wa ...
... status, a recent survey [8] suggest that the use of these products has dropped significantly. However, it is still increasingly popular among users who have to undergo regular urine drug screenings as current screening methods do not detect synthetic cannabinoids. This observation wa ...
What are the perioperative risk benefits of garlic supplementation
... While previous trial focused on the effects of garlic powder, current literature suggest that aged garlic extract (AGE) is a more reliable treatment option (Reid et al., 2010). Studies suggest that AGE is safer and more tolerable than garlic powder and exerts more antihypertensive effects than other ...
... While previous trial focused on the effects of garlic powder, current literature suggest that aged garlic extract (AGE) is a more reliable treatment option (Reid et al., 2010). Studies suggest that AGE is safer and more tolerable than garlic powder and exerts more antihypertensive effects than other ...
Nowhere to hide: interrogating different metabolic parameters of Plasmodium
... methods have recently been published [15–21]. Gametocytogenesis was induced by nonspecific ‘stress’ to the parasite, including a drop in haematocrit [22], the use of ‘spent’ nutrient deficient culture medium [19], lymphocytes [23], mammalian hormones [24], reticulocytes [25], some inhibitors of nucl ...
... methods have recently been published [15–21]. Gametocytogenesis was induced by nonspecific ‘stress’ to the parasite, including a drop in haematocrit [22], the use of ‘spent’ nutrient deficient culture medium [19], lymphocytes [23], mammalian hormones [24], reticulocytes [25], some inhibitors of nucl ...
Thalidomide: A Review, With a Focus on Ocular Findings and New
... large Japanese study (Arimoto, ’87). Figure 6 shows an example of the methodology in each patient with Duane syndrome comparing each with the associated limb and ear malformations. The time common to each patient was then observable to be early in the sensitive period. This same approach resulted in ...
... large Japanese study (Arimoto, ’87). Figure 6 shows an example of the methodology in each patient with Duane syndrome comparing each with the associated limb and ear malformations. The time common to each patient was then observable to be early in the sensitive period. This same approach resulted in ...
Guidelines for the Use of Antiretroviral Agents in
... existing sections. Significant updates are highlighted throughout the document. ...
... existing sections. Significant updates are highlighted throughout the document. ...
effect of cytochrome p450 2d6 and 3a enzyme inhibition on
... Oxycodone is an opioid analgesic, synthesized originally from the naturally occurring opium alkaloid thebaine. It was introduced to clinical use almost one hundred years ago. Although oxycodone is an old drug, its basic pharmacology has been poorly investigated, and the new aspects of its metabolism ...
... Oxycodone is an opioid analgesic, synthesized originally from the naturally occurring opium alkaloid thebaine. It was introduced to clinical use almost one hundred years ago. Although oxycodone is an old drug, its basic pharmacology has been poorly investigated, and the new aspects of its metabolism ...
Clinical and pharmacological evaluation of buprenorphine and
... buprenorphine and minimize opiate antagonist effects of naloxone when given sublingually. However, if the same combination was taken illicitly by a parenteral route, it would have the opposite effects, precipitating substantial opiate withdrawal. This was an unusual requirement for a new drug formul ...
... buprenorphine and minimize opiate antagonist effects of naloxone when given sublingually. However, if the same combination was taken illicitly by a parenteral route, it would have the opposite effects, precipitating substantial opiate withdrawal. This was an unusual requirement for a new drug formul ...
Gamma-butyrolactone (GBL) - World Health Organization
... to make GHB is unnecessary, however, because it is rapidly metabolized to GHB following its ingestion, and its clinical effects are identical to GHB. This makes the epidemiology of GBL's and GHB's use and abuse intrinsically (and forensically) linked. Because the onset of action of GBL is faster tha ...
... to make GHB is unnecessary, however, because it is rapidly metabolized to GHB following its ingestion, and its clinical effects are identical to GHB. This makes the epidemiology of GBL's and GHB's use and abuse intrinsically (and forensically) linked. Because the onset of action of GBL is faster tha ...
Clearing of Metabolic Waste via Enterohepatic Recirculation Table
... In fulfillment of requirements for Chemistry 399, Fall 2010 University of Wisconsin-Eau Claire, Warren Gallagher, Ph.D. Enterohepatic Recirculation Vitamin D3 undergoes an enterohepatic recirculation in both man and experimental animals. (Kumar 1990) Resveratrol, a plant phoalexin, prevents or delay ...
... In fulfillment of requirements for Chemistry 399, Fall 2010 University of Wisconsin-Eau Claire, Warren Gallagher, Ph.D. Enterohepatic Recirculation Vitamin D3 undergoes an enterohepatic recirculation in both man and experimental animals. (Kumar 1990) Resveratrol, a plant phoalexin, prevents or delay ...
Chronic tolerance to recreational MDMA
... as a general principle, those that were pharmacologically similar to MDMA would be predicted to contribute towards cross-tolerance, whereas those which were unrelated would add to the error variance. A related problem is the issue of dosage because any decrease in the strength of tablets could expla ...
... as a general principle, those that were pharmacologically similar to MDMA would be predicted to contribute towards cross-tolerance, whereas those which were unrelated would add to the error variance. A related problem is the issue of dosage because any decrease in the strength of tablets could expla ...
Levitra - GSK Source
... dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including vardenafil. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see Adverse Reactions (6.2)]. 5.6 Alpha-Blockers Caution is advis ...
... dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including vardenafil. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see Adverse Reactions (6.2)]. 5.6 Alpha-Blockers Caution is advis ...