Barriers and opportunities for the uptake of biosimilar
... The external experts were consulted about a (preliminary) version of the scientific report. Their comments were discussed during meetings. They did not co -author author the scientific report and did d not necessarily agree with its content. Subsequently, a (final) version was submitted to the valid ...
... The external experts were consulted about a (preliminary) version of the scientific report. Their comments were discussed during meetings. They did not co -author author the scientific report and did d not necessarily agree with its content. Subsequently, a (final) version was submitted to the valid ...
Product Monograph
... Fluconazole should be administered with caution to patients with liver dysfunction. Hepatic injury: DIFLUCAN (fluconazole) has been associated with rare cases of serious hepatic toxicity, including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole- ...
... Fluconazole should be administered with caution to patients with liver dysfunction. Hepatic injury: DIFLUCAN (fluconazole) has been associated with rare cases of serious hepatic toxicity, including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole- ...
EFNS guideline on the drug treatment of migraine
... or only a little more effective than ASA. In about 60% of nonresponders to NSAID, triptans are effective [46]. Sumatriptan 6 mg subcutaneously is more effective than intravenous ASA 1000 mg s.c. but has more side effects [47]. Triptans can be effective at any time during a migraine attack. However, there ...
... or only a little more effective than ASA. In about 60% of nonresponders to NSAID, triptans are effective [46]. Sumatriptan 6 mg subcutaneously is more effective than intravenous ASA 1000 mg s.c. but has more side effects [47]. Triptans can be effective at any time during a migraine attack. However, there ...
The Role of Corticotropin-Releasing Factor in Drug Addiction
... actions of drugs of abuse has largely been driven by three main findings. First, acute administration of drugs of abuse activates the hypothalamic-pituitary-adrenocortical (HPA) stress axis (Sarnyai, 1998), historically the predominant biological marker for stress reactivity (Selye, 1976; McEwen, 19 ...
... actions of drugs of abuse has largely been driven by three main findings. First, acute administration of drugs of abuse activates the hypothalamic-pituitary-adrenocortical (HPA) stress axis (Sarnyai, 1998), historically the predominant biological marker for stress reactivity (Selye, 1976; McEwen, 19 ...
Dry Cough • Chest Congestion • Coughing Fits
... Helps loosen thick mucus Relieves dry and painful cough Relieves cough associated with a tickling in the throat Relieves barking cough worse at night Relieves cough associated with nausea Relieves wet cough during the day becoming dry at night Relieves dry cough triggered by cold air Relieves dry, c ...
... Helps loosen thick mucus Relieves dry and painful cough Relieves cough associated with a tickling in the throat Relieves barking cough worse at night Relieves cough associated with nausea Relieves wet cough during the day becoming dry at night Relieves dry cough triggered by cold air Relieves dry, c ...
PL Detail-Document
... a. Dosing interval per FDA-approved product labeling. Once or twice daily dosing is generally recommended.1,3,6,7 For psoriasis, some experts start with BID dosing, then taper as the disease responds. Once daily dosing of medium to very high potency agents helps minimize side effects.4 Even less fre ...
... a. Dosing interval per FDA-approved product labeling. Once or twice daily dosing is generally recommended.1,3,6,7 For psoriasis, some experts start with BID dosing, then taper as the disease responds. Once daily dosing of medium to very high potency agents helps minimize side effects.4 Even less fre ...
Comparison of Topical Corticosteroids
... a. Dosing interval per FDA-approved product labeling. Once or twice daily dosing is generally recommended.1,3,6,7 For psoriasis, some experts start with BID dosing, then taper as the disease responds. Once daily dosing of medium to very high potency agents helps minimize side effects.4 Even less fre ...
... a. Dosing interval per FDA-approved product labeling. Once or twice daily dosing is generally recommended.1,3,6,7 For psoriasis, some experts start with BID dosing, then taper as the disease responds. Once daily dosing of medium to very high potency agents helps minimize side effects.4 Even less fre ...
Lopinavir/Ritonavir
... ritonavir contains 42.4% ethanol (v/v) and should not be coadministered with drugs capable of producing disulfiram-like reactions (e.g. disulfiram, metronidazole). Coadministration with saquinavir or indinavir requires no dosage adjustment, whereas coadministration with amprenavir, nevirapine or efa ...
... ritonavir contains 42.4% ethanol (v/v) and should not be coadministered with drugs capable of producing disulfiram-like reactions (e.g. disulfiram, metronidazole). Coadministration with saquinavir or indinavir requires no dosage adjustment, whereas coadministration with amprenavir, nevirapine or efa ...
FORM 10-K/A - corporate
... women’s health. Our marketed product and product development programs utilize our proprietary drug delivery technologies, which we believe are suited to applications in women’s health. These technologies consist of our bioadhesive delivery system (“BDS”), a polymer designed to adhere to epithelial s ...
... women’s health. Our marketed product and product development programs utilize our proprietary drug delivery technologies, which we believe are suited to applications in women’s health. These technologies consist of our bioadhesive delivery system (“BDS”), a polymer designed to adhere to epithelial s ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These - PI
... serum concentrations of methotrexate and/or its metabolite, possibly leading to toxicity. With high dose methotrexate administration, consider a temporary withdrawal of PRILOSEC (5.11, 7). ----------------------------------------- ADVERSE REACTIONS ----------------------------------------Adults: Mos ...
... serum concentrations of methotrexate and/or its metabolite, possibly leading to toxicity. With high dose methotrexate administration, consider a temporary withdrawal of PRILOSEC (5.11, 7). ----------------------------------------- ADVERSE REACTIONS ----------------------------------------Adults: Mos ...
Acute and Chronic Effects of Inhalants in Intracranial Self
... Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. Broadly defined, ...
... Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. Broadly defined, ...
PACIFIC BUSPIRONE Presentation NEW ZEALAND DATA SHEET
... statistically significantly longer half-life values than men. After a single dose of buspirone, 29 to 63% of the dose was excreted in the urine within 24 hours primarily as metabolites; faecal excretion accounted for 18 to 38% of the dose. In Renal or Hepatic Impairment Buspirone clearance is reduc ...
... statistically significantly longer half-life values than men. After a single dose of buspirone, 29 to 63% of the dose was excreted in the urine within 24 hours primarily as metabolites; faecal excretion accounted for 18 to 38% of the dose. In Renal or Hepatic Impairment Buspirone clearance is reduc ...
MDMA in humans: factors which affect the neuropsychobiological
... employ objective and subjective measures in parallel. This would address the topic of their relative sensitivity/validity as measures. For instance, do users complain of memory/cognitive problems before they become apparent on objective tasks, or can the objective tasks reveal problems before they b ...
... employ objective and subjective measures in parallel. This would address the topic of their relative sensitivity/validity as measures. For instance, do users complain of memory/cognitive problems before they become apparent on objective tasks, or can the objective tasks reveal problems before they b ...
Reviewing Clinical Trials: A Guide for the Ethics Committee
... question raised was: “Why approach The University of Hong Kong and not a leading medical institution in the US or in Europe?” The reply was: “Because of the monthly newsletter that you produce, i.e., the Clinical Trial Magnifier,” (http://www.ClinicalTrialMagnifier.com), which may be a valid reason, ...
... question raised was: “Why approach The University of Hong Kong and not a leading medical institution in the US or in Europe?” The reply was: “Because of the monthly newsletter that you produce, i.e., the Clinical Trial Magnifier,” (http://www.ClinicalTrialMagnifier.com), which may be a valid reason, ...
Teschke2009_kava
... Quantitative causality assessment was applied in the present study to five patients with suspected hepatotoxicity by the use of traditional aqueous kava extracts and kava–herbs mixtures. Their characteristics were compared with those of nine patients from Germany and Switzerland with verified kava hep ...
... Quantitative causality assessment was applied in the present study to five patients with suspected hepatotoxicity by the use of traditional aqueous kava extracts and kava–herbs mixtures. Their characteristics were compared with those of nine patients from Germany and Switzerland with verified kava hep ...
QUINIDINE GLUCONATE INJECTION, USP
... with corresponding increases in serum levels and half-life. Altered pharmacokinetics of other drugs: Quinidine slows the elimination of digoxin and simultaneously reduces digoxin's apparent volume of distribution. As a result, serum digoxin levels may be as much as doubled. When quinidine and digoxi ...
... with corresponding increases in serum levels and half-life. Altered pharmacokinetics of other drugs: Quinidine slows the elimination of digoxin and simultaneously reduces digoxin's apparent volume of distribution. As a result, serum digoxin levels may be as much as doubled. When quinidine and digoxi ...
Prescribing Information - PI
... serum concentrations of methotrexate and/or its metabolite, possibly leading to toxicity. With high dose methotrexate administration, consider a temporary withdrawal of PRILOSEC. (5.11, 7). ----------------------------------------- ADVERSE REACTIONS ----------------------------------------Adults: Mo ...
... serum concentrations of methotrexate and/or its metabolite, possibly leading to toxicity. With high dose methotrexate administration, consider a temporary withdrawal of PRILOSEC. (5.11, 7). ----------------------------------------- ADVERSE REACTIONS ----------------------------------------Adults: Mo ...
Naproxen Naproxen Sodium
... Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis. For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in th ...
... Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis. For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in th ...
Furosemide 10mg/ml Solution for Injection or Infusion
... reduced for at least three days, or the drug stopped, before initiating the ACE inhibitor or increasing the dose of an ACE inhibitor. The toxic effects of nephrotoxic antibiotics may be increased by concomitant administration of potent diuretics such as furosemide. Impairment of renal function may d ...
... reduced for at least three days, or the drug stopped, before initiating the ACE inhibitor or increasing the dose of an ACE inhibitor. The toxic effects of nephrotoxic antibiotics may be increased by concomitant administration of potent diuretics such as furosemide. Impairment of renal function may d ...
Consensus Guidelines for the Management of
... about 50%, and in a subset of high-risk patients, the PONV rate can be as high as 80%.9–11 Unresolved PONV may result in prolonged postanesthesia care unit (PACU) stay and unanticipated hospital admission that result in a significant increase in overall health care costs.12–14 The goal of PONV proph ...
... about 50%, and in a subset of high-risk patients, the PONV rate can be as high as 80%.9–11 Unresolved PONV may result in prolonged postanesthesia care unit (PACU) stay and unanticipated hospital admission that result in a significant increase in overall health care costs.12–14 The goal of PONV proph ...
Consensus guidelines for the management of postoperative nausea
... about 50%, and in a subset of high-risk patients, the PONV rate can be as high as 80%.9–11 Unresolved PONV may result in prolonged postanesthesia care unit (PACU) stay and unanticipated hospital admission that result in a significant increase in overall health care costs.12–14 The goal of PONV proph ...
... about 50%, and in a subset of high-risk patients, the PONV rate can be as high as 80%.9–11 Unresolved PONV may result in prolonged postanesthesia care unit (PACU) stay and unanticipated hospital admission that result in a significant increase in overall health care costs.12–14 The goal of PONV proph ...
A Review of the Use of the Number Needed to Treat to Evaluate the
... factors that may be associated with non–treatment-specific benefits in a clinical trial, such as nonspecific response, spontaneous improvements/worsening of the disease, natural history, and regression to the mean. To this end, the NNT is intending to serve as a measure of the pharmacologic benefit ...
... factors that may be associated with non–treatment-specific benefits in a clinical trial, such as nonspecific response, spontaneous improvements/worsening of the disease, natural history, and regression to the mean. To this end, the NNT is intending to serve as a measure of the pharmacologic benefit ...