drug registration guidance document (drgd) - NPRA
... Indigenous Medicine: As defined under Regulation 2, the CDCR 1984, indigenous medicine means a system of treatment and prevention of disease established through traditional use of naturally occurring substances Licensed importer: A person to whom an import license has been issued under Regulation 12 ...
... Indigenous Medicine: As defined under Regulation 2, the CDCR 1984, indigenous medicine means a system of treatment and prevention of disease established through traditional use of naturally occurring substances Licensed importer: A person to whom an import license has been issued under Regulation 12 ...
ZOFRAN Tablets, Oral Solution and Injection PRODUCT MONOGRAPH
... (see DOSAGE AND ADMINISTRATION). ZOFRAN® is not indicated for the treatment of children 3 years of age or younger. Post-Radiotherapy Induced Nausea and Vomiting ZOFRAN® is not indicated for use in any age group of this population. Post-Operative Nausea and Vomiting ZOFRAN® is not indicated for use i ...
... (see DOSAGE AND ADMINISTRATION). ZOFRAN® is not indicated for the treatment of children 3 years of age or younger. Post-Radiotherapy Induced Nausea and Vomiting ZOFRAN® is not indicated for use in any age group of this population. Post-Operative Nausea and Vomiting ZOFRAN® is not indicated for use i ...
Presentations Indications Dosage and Administration
... Extreme caution must be taken in the following cases (see also Contraindications): Cranial lesions and high intracranial pressure. The respiratory depressant effects of methadone and its capacity to increase the cerebrospinal fluid pressure can be considerably increased in the presence of an increas ...
... Extreme caution must be taken in the following cases (see also Contraindications): Cranial lesions and high intracranial pressure. The respiratory depressant effects of methadone and its capacity to increase the cerebrospinal fluid pressure can be considerably increased in the presence of an increas ...
Study of the interaction between 3,4- methylenedioximethamphetamine and the endocannabinoid system
... Chapter 1. Neurobiology of addiction 1.2. Habitual drug use and drug dependence. After repeated administration the effects of a drug diminish, and is necessary to increase the dose to produce the same effect. This process is known as tolerance. Tolerance may develop to some of the effects of a drug ...
... Chapter 1. Neurobiology of addiction 1.2. Habitual drug use and drug dependence. After repeated administration the effects of a drug diminish, and is necessary to increase the dose to produce the same effect. This process is known as tolerance. Tolerance may develop to some of the effects of a drug ...
Evaluation of Pharmacokinetic Interaction between PA
... any acute illness within 4 weeks. Female subjects were excluded if they were pregnant (positive test for serum human chorionic gonadotropin at screening or check-in), breast feeding, or planning to conceive a child within 30 days of cessation of treatment. Male subjects were excluded if they were pl ...
... any acute illness within 4 weeks. Female subjects were excluded if they were pregnant (positive test for serum human chorionic gonadotropin at screening or check-in), breast feeding, or planning to conceive a child within 30 days of cessation of treatment. Male subjects were excluded if they were pl ...
FULL PRESCRIBING INFORMATION HIGHLIGHTS OF
... Oxcarbazepine, although there were patients who first developed a serum sodium <125 mmol/L more than one year after initiation of therapy. Most patients who developed hyponatremia were asymptomatic but patients in the clinical trials were frequently monitored and some had their Oxcarbazepine dose re ...
... Oxcarbazepine, although there were patients who first developed a serum sodium <125 mmol/L more than one year after initiation of therapy. Most patients who developed hyponatremia were asymptomatic but patients in the clinical trials were frequently monitored and some had their Oxcarbazepine dose re ...
A pharmacologic strategy for the treatment of nicotine addiction
... is modulated by gamma-aminobutyric acid (GABA). Therefore, we examined the utility of gamma vinyl-GABA (GVG, Vigabatrin) for inhibiting nicotine’s biochemical effects on NAc DA as well as its effects on behaviors associated with these biochemical changes. Given 2.5 hours prior to nicotine, GVG (75 m ...
... is modulated by gamma-aminobutyric acid (GABA). Therefore, we examined the utility of gamma vinyl-GABA (GVG, Vigabatrin) for inhibiting nicotine’s biochemical effects on NAc DA as well as its effects on behaviors associated with these biochemical changes. Given 2.5 hours prior to nicotine, GVG (75 m ...
LOSARTAN POTASSIUM AMLODIPINE CAMSYLATE
... Plasma concentrations of losartan and its active metabolite and the antihypertensive effect of losartan increase with increasing dose. Since losartan and its active metabolite are both angiotensin II receptor antagonists, they both contribute to the antihypertensive effect. In a single-dose study in ...
... Plasma concentrations of losartan and its active metabolite and the antihypertensive effect of losartan increase with increasing dose. Since losartan and its active metabolite are both angiotensin II receptor antagonists, they both contribute to the antihypertensive effect. In a single-dose study in ...
Full-Text PDF
... Abstract: Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility and cell penetration, and high instability. To overcome the ...
... Abstract: Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility and cell penetration, and high instability. To overcome the ...
AMERICAN ACADEMY OF PEDIATRICS Adolescents and Anabolic
... anabolic steroids. Athletes may need to be reminded that the health, fitness, and social benefits of sports participation can be readily met without use of performance-enhancing substances. For the athlete who is convinced that steroids are essential for success, it may be helpful to point out role ...
... anabolic steroids. Athletes may need to be reminded that the health, fitness, and social benefits of sports participation can be readily met without use of performance-enhancing substances. For the athlete who is convinced that steroids are essential for success, it may be helpful to point out role ...
Diazepam - EWU Institutional Repository
... of drugs. Diazepam and other benzodiazepines act by enhancing the effects of gamma-amino butyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits activity in the brain. Diazepam is used for the treatment of disorders ...
... of drugs. Diazepam and other benzodiazepines act by enhancing the effects of gamma-amino butyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits activity in the brain. Diazepam is used for the treatment of disorders ...
Statins - Amazon Web Services
... In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 li ...
... In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 li ...
Current Drug Therapies for Rosacea: A Chronic Vascular and
... therapy for rosacea, has been used as an off-label treatment for rosacea since the 1950s.73-75 Tetracyclines are believed to have effects on inflammation, immunomodulation, cell proliferation, and angiogenesis.76 Tetracyclines may reduce the inflammation associated with rosacea by downregulating pro ...
... therapy for rosacea, has been used as an off-label treatment for rosacea since the 1950s.73-75 Tetracyclines are believed to have effects on inflammation, immunomodulation, cell proliferation, and angiogenesis.76 Tetracyclines may reduce the inflammation associated with rosacea by downregulating pro ...
Drug Class Review HMG-CoA Reductase Inhibitors (Statins) and
... In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 li ...
... In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 li ...
Dosage Adjustment for Cytotoxics in Renal Impairment
... Astra Medical - Patients with impaired renal function have been reported to show an increase in metabolite concentration. Cyclophosphamide and its metabolites can be eliminated by haemodialysis. Availability of mesna in the urinary tract depends on renal function. Lam et al 8– If CrCl > 10 ml/min, g ...
... Astra Medical - Patients with impaired renal function have been reported to show an increase in metabolite concentration. Cyclophosphamide and its metabolites can be eliminated by haemodialysis. Availability of mesna in the urinary tract depends on renal function. Lam et al 8– If CrCl > 10 ml/min, g ...
Dosage Adjustment for Cytotoxics in Renal Impairment
... Astra Medical - Patients with impaired renal function have been reported to show an increase in metabolite concentration. Cyclophosphamide and its metabolites can be eliminated by haemodialysis. Availability of mesna in the urinary tract depends on renal function. Lam et al 8– If CrCl > 10 ml/min, g ...
... Astra Medical - Patients with impaired renal function have been reported to show an increase in metabolite concentration. Cyclophosphamide and its metabolites can be eliminated by haemodialysis. Availability of mesna in the urinary tract depends on renal function. Lam et al 8– If CrCl > 10 ml/min, g ...
Dosage Adjustment for Cytotoxics in Renal Impairment
... Astra Medical - Patients with impaired renal function have been reported to show an increase in metabolite concentration. Cyclophosphamide and its metabolites can be eliminated by haemodialysis. Availability of mesna in the urinary tract depends on renal function. Lam et al 8– If CrCl > 10 ml/min, g ...
... Astra Medical - Patients with impaired renal function have been reported to show an increase in metabolite concentration. Cyclophosphamide and its metabolites can be eliminated by haemodialysis. Availability of mesna in the urinary tract depends on renal function. Lam et al 8– If CrCl > 10 ml/min, g ...
What factors need to be considered when prescribing for lactose
... The lactose content of oral medications is generally small in comparison to the amount of lactose in many dietary substances, particularly dairy products (2). The dose of lactose in most pharmaceuticals is usually less than 2g per day. Therefore, unless an adult has severe lactose intolerance, it is ...
... The lactose content of oral medications is generally small in comparison to the amount of lactose in many dietary substances, particularly dairy products (2). The dose of lactose in most pharmaceuticals is usually less than 2g per day. Therefore, unless an adult has severe lactose intolerance, it is ...
Artemisia annua(Sweet Annie), Other Artemisia Species, Artemisinin
... a bitter plant. Nausea cleared with termination of therapy. The total dose of artemisinin delivered on average was approximately 60 mg, far below the usual dose recommendations of purified artemisinin (500–1000 mg a day for 3–5 days). It is possible other compounds, such as the flavonoids mentioned ...
... a bitter plant. Nausea cleared with termination of therapy. The total dose of artemisinin delivered on average was approximately 60 mg, far below the usual dose recommendations of purified artemisinin (500–1000 mg a day for 3–5 days). It is possible other compounds, such as the flavonoids mentioned ...
Intranasal (IN) Medication Administration MBED Clinical Practice
... anxiolysis/mild sedation. Additionally, other medications may be administered by this route (see Dosing Guideline Chart below). Dosing is ordered in mg/kg, except for fentanyl and Precedex which is dosed in mcg/kg. The maximum volume to be delivered is 1 mL per nostril. Greater volumes are not effec ...
... anxiolysis/mild sedation. Additionally, other medications may be administered by this route (see Dosing Guideline Chart below). Dosing is ordered in mg/kg, except for fentanyl and Precedex which is dosed in mcg/kg. The maximum volume to be delivered is 1 mL per nostril. Greater volumes are not effec ...
PRODUCT MONOGRAPH CEFAZOLIN FOR INJECTION 500 mg, 1
... There are instances of patients who have had reactions to both penicillins and cephalosporins (including fatal anaphylaxis after parenteral use). Clinical and laboratory evidence of partial cross-allergenicity of the two drug classes exists. Cefazolin sodium should be administered cautiously and the ...
... There are instances of patients who have had reactions to both penicillins and cephalosporins (including fatal anaphylaxis after parenteral use). Clinical and laboratory evidence of partial cross-allergenicity of the two drug classes exists. Cefazolin sodium should be administered cautiously and the ...
PANTOPRAZOLE SODIUM DELAYED-RELEASE
... Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6 and 2C9. In in vivo drug-drug interaction studies with CYP2C19 substrates (diazepam [also a CYP3A4 substrate] and phenytoin [also a CYP3A4 inducer]), nifedipine, midazolam, and clarithromycin (CYP3A4 substrates), met ...
... Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6 and 2C9. In in vivo drug-drug interaction studies with CYP2C19 substrates (diazepam [also a CYP3A4 substrate] and phenytoin [also a CYP3A4 inducer]), nifedipine, midazolam, and clarithromycin (CYP3A4 substrates), met ...
SEROQUEL (quetiapine fumarate) TABLETS HIGHLIGHTS OF PRESCRIBING INFORMATION
... SEROQUEL is indicated as monotherapy for the acute treatment of depressive episodes associated with bipolar disorder. Efficacy was established in two 8-week monotherapy trials in adult patients with bipolar I and bipolar II disorder [see Clinical Studies (14.2)]. SEROQUEL is indicated for the mainte ...
... SEROQUEL is indicated as monotherapy for the acute treatment of depressive episodes associated with bipolar disorder. Efficacy was established in two 8-week monotherapy trials in adult patients with bipolar I and bipolar II disorder [see Clinical Studies (14.2)]. SEROQUEL is indicated for the mainte ...
Capsules
... Gelatin is a product obtained by partial hydrolysis of collagen acquired from the skin, white connective tissue, and bones of animals. Gelatin is a protein which is soluble in warm (or hot) water, but insoluble in cold water. At low temperatures, gelatin dissolved in water becomes a gel (which is in ...
... Gelatin is a product obtained by partial hydrolysis of collagen acquired from the skin, white connective tissue, and bones of animals. Gelatin is a protein which is soluble in warm (or hot) water, but insoluble in cold water. At low temperatures, gelatin dissolved in water becomes a gel (which is in ...