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(HCM), idiopathic hypertrophic
(HCM), idiopathic hypertrophic

... gradually became available. Today nobody with HCM dies in the OR. They spend time on mechanical support in the ICU instead. Over the years, as ventricular support was being developed, I worked on preventing the need for mechanical support by devising a way to protect hypertrophic hearts. Unfortunate ...
題目: Cardiorenal syndrome
題目: Cardiorenal syndrome

... improved with aggressive fluid removal even if accompanied by a rise in serum creatinine. Given the limitations imposed by impaired renal function on the ability to correct volume overload and the stron association between impaired ...
Gothe / Drinnenberg Homeopathic Clinical Pictures
Gothe / Drinnenberg Homeopathic Clinical Pictures

... patients often constitute an exception), these circulatory disturbances are accompanied by extreme pain located mostly in the left side of the thorax, shoulder and arm. The pain may, however, also radiate to other regions of the body such as the abdomen, the back or the jaw. Despite the fact that th ...
Congestive heart failure
Congestive heart failure

... It is a recombinant form of HUMAN B TYPE NATRIURETIC PEPTIDE naturally occurring hormone secreted by the ventricles Recently introduced for use in acute heart failure It ↑↑ c GMP in vascular smooth muscle & ↓↓ venous ...
chapter - Human Kinetics
chapter - Human Kinetics

... • At rest, the insides of heart muscle cells are negatively charged. • When depolarized, the insides of the cells become positively charged. • If a wave of depolarization travels toward a positive electrode on the ECG, an upward deflection occurs. ...
9. Cardio Control
9. Cardio Control

... If BP, then  freq of Action Potential firing to M.O > changes to  BP. If BP, then  freq of Action Potential firing to M.O > changes to  BP. ...
Cardiac Resynchronization Therapy (CRT)
Cardiac Resynchronization Therapy (CRT)

... other health issues. ...
Learning ECG with real-time interactive simulation
Learning ECG with real-time interactive simulation

... prototype is capable of real-time simulation of a whole heart electrophysiology on a platform independent application accessible online via the web and/or offline from disk. The spatial and temporal relationships between the heart’s function and ECG signal generation have been integrated in an elear ...
Public Summary
Public Summary

... is effective alone and in combination with other antihypertensive agents, especially thiazide-type diuretics. The blood pressure lowering effects of captopril and thiazides are approximately additive. Myocardial infarction: To improve survival following myocardial infarction in clinically stable pat ...
ANPS 020 Black 01-24
ANPS 020 Black 01-24

... Begins with initiation of action potential at SA node Produces action potentials in cardiac muscle cells (contractile cardiac cells) of Atria Both Atria begin contracting = Atrial Systole Signal is transmitted through conducting system (conducting cardiac cells of AV node, Bundle branches, Purkinje ...
Heart valve disorder
Heart valve disorder

... a. Silent ischemia: blood flow to the heart muscle is interrupted without any pain to provide warning! b. Angina pectoris: chest pain caused by inadequate O2 to the heart muscle cells. This condition may also result from stress-induced spasm of the atherosclerotic coronary arteries. c. Myocardial in ...
Normal Heart Sounds
Normal Heart Sounds

... output (anaemia, pregnancy or thyrotoxicosis), valve regurgitation or intracardiac shunt, heart block, renal failure, or excess transfused fluid or blood. Note: Important indicator of relatively advanced heart disease and almost always abnormal over the age of 40. May not appear so the absence of S3 ...
Heart failure PHL461
Heart failure PHL461

... Neck vein distension Hepatic congestion Peripheral edema Also may result in reduced forward cardiac output, but with clear lung fields ...
Implantable cardioverter defibrillator therapy for
Implantable cardioverter defibrillator therapy for

... Thus, data showing benefit from prophylactic ICD therapy in NICM seems to come mainly from meta-analyses of the above four studies. With strong influence from the NICM population from SCD-HeFT, one meta-analysis showed a statistically significant effect in favour of ICD with no statistical heterogen ...
ALLHAT
ALLHAT

... ACE inhibition in patients with history of atherosclerotic vascular disease, diabetes mellitus, or hypertension and associated risk factors ...
Ventricular repolarization - Clinical View
Ventricular repolarization - Clinical View

... heterogeneous distribution of action potential characteristics, which vary in normal hearts, and more so in abnormal hearts. Fourth, the heart is innervated in a heterogeneous manner. Hence, stimuli from different nerve fibers can regionally alter action potential duration and morphology, thus alter ...
Artificial Heart Left Ventricular Assist Devices (LVADs) : A Bridge
Artificial Heart Left Ventricular Assist Devices (LVADs) : A Bridge

... patients in the United States—tend to be older with more medical comorbidity than the bridge-to-transplant patients. Instead of the cumbersome units clinically used today (HeartMate, Novacor, and Thoratec), better LVAD designs are mandatory. The new generation of pulsatile LVADs should be smaller, s ...
PinnacleHealth CardioVascular Institute
PinnacleHealth CardioVascular Institute

Coverings, Layers & Chambers Pathway of Blood Heart Valves
Coverings, Layers & Chambers Pathway of Blood Heart Valves

... Cardiac veins return blood to this location before the blood enters the right atrium. Coronary Sinus ...
Double-blind crossover comparison of enoximone and
Double-blind crossover comparison of enoximone and

... systolic blood pressure) at maximum stress is an indication of ability to increase cardiac work12 and this was only observed during treatment with enoximone. Improvement of ejection fraction at rest has previously been shown with other orally administered positive inotropic agents13' 14 and we have ...
Cardiac Emergencies
Cardiac Emergencies

...  Ext: 2+ radial and femoral pulses ...
PVC Ablation Procedures for Ventricular Tachycardia
PVC Ablation Procedures for Ventricular Tachycardia

... I want to start by saying many patients are totally asymptomatic. So they may have frequent ventricular premature beats without being aware that they’re having them. And that’s very common. We don’t quite understand why some people are dramatically symptomatic and others having the same frequency, t ...
the heart failure symposium - Heart and Stroke Foundation of New
the heart failure symposium - Heart and Stroke Foundation of New

... The last few years have witnessed a surge in both the use of Internal Cardiac Defibrillators (ICDs) and Cardiac Resynchronization Therapies (CRT). With that we have also seen the ever evolving use of Left Ventricular Assist Devices (LVADSs). Understanding how these various device therapies come into ...
17. CV II - EKG-mechanical
17. CV II - EKG-mechanical

... QRS Wave or Complex: caused by depolarization of ventricles (atrial repolarization masked by this) T Wave: caused by repolarization of ventricles PR Interval: time elapsed between start of P wave and R wave (period of delay at AV node) (called PQ interval in text) • ECG Leads (12 combinations of ele ...
ECG Recording Basic Interpretation
ECG Recording Basic Interpretation

... bigger deflection on the ECG This is represented by the QRS complex T wave represents repolarisation – the ventricular muscle mass returning to a resting state P,Q,R & S are waves, Q,R & S make up a complex, interval between S and T is called the ST segment ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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