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Natural Excitation of the Heart
Natural Excitation of the Heart

Ventricular Premature Contractions and Tachycardia
Ventricular Premature Contractions and Tachycardia

... to assess the response to treatment. The duration of the therapy depends on the underlying problem. If the underlying disease process cannot be cured, the animal often remains on antiarrhythmic therapy indefinitely. Boxers, Doberman pinschers, and German shepherd dogs are usually treated for the res ...
clinical trial burden
clinical trial burden

... lead to device damage, user injury or patient injury. Use universal precautions for biohazards and sharps to avoid user injury. • Use the Steerable Guide Catheter with sterile techniques using fluoroscopy and echocardiography (e.g., transesophageal [TEE] and transthoracic [TTE]) in a facility with o ...
Reducing Heart Failure Hospital Readmissions: Are You
Reducing Heart Failure Hospital Readmissions: Are You

... End-of-life care should be considered in patients who have symptoms at rest despite repeated attempts to optimize pharmacologic, cardiac device, and other therapies, as evidenced by 1 or more of the following: ...
S SUDDEN CARDIAC DEATH
S SUDDEN CARDIAC DEATH

... the electrical activity of the heart. An echocardiogram, which is an ultrasound test to allow for direct visualization of the heart structure, will likely also be done. The specialist may also order a treadmill exercise test and a monitor to enable a longer recording of the heart rhythm. None of the ...
Sudden Cardiac Death Pamphlet Sign
Sudden Cardiac Death Pamphlet Sign

... the electrical activity of the heart. An echocardiogram, which is an ultrasound test to allow for direct visualization of the heart structure, will likely also be done. The specialist may also order a treadmill exercise test and a monitor to enable a longer recording of the heart rhythm. None of the ...
THE EFFECT OF SPIRONOLACTONE ON LEFT
THE EFFECT OF SPIRONOLACTONE ON LEFT

... Chronic blood volume overload causes development of eccentric left ventricle hypertrophy, which manifests by its dilatation without significant thickening of the walls. This occurs because the increased blood volume (increased preload) enhances pressure on left ventricle walls, which leads to the ch ...
Cardiac Catheterization
Cardiac Catheterization

... Blood supply to the heart originates at the base of the aorta with two vessels: the left main coronary artery and the right coronary artery (RCA). The left main coronary artery is relatively short; it divides into two main coronary arteries: the left anterior descending (LAD) and the left circumflex ...
Important Safety Information
Important Safety Information

... internal mammary artery (IMA) at high risk of injury, etc. n Evaluable data regarding safety or effectiveness is not available for prohibitive risk DMR patients with an LVEF < 20% or an LVESD > 60mm. MitraClip should be used only when criteria for clip suitability for DMR have been met. • The major ...
Cardiac Clearance and Sudden Cardiac Death in
Cardiac Clearance and Sudden Cardiac Death in

... occurring during the vulnerable repolarization period ( usually on the Twave and can be the QRS period also) • Some evidence support cardiac injury, but the etiology and electrophysiology have yet to be completely defined ...
Chapter 20 The Cardiovascular System
Chapter 20 The Cardiovascular System

...  CO  5 L/min (70 bts x 70 ml) ...
Obstructive Shock
Obstructive Shock

... rub and distant heart sounds may be present. Pulsus paradoxus, defined as a decline in systolic blood pressure greater than or equal to 10 mm Hg during inspiration, results from the inspiratory reduction in pleural pressure that produces a fall in left ventricular output and arterial systolic pressu ...
cardiology mcq questions
cardiology mcq questions

... Clinical predictors of SCD or ventricular arrhythmias in patients with ARVD include • The presence of the ECG abnormalities • Significant right ventricular structural disease, dilation, aneurysms, and/or fibrofatty replacement of myocardium • A family history of SCD Recommendations — The current re ...
Cardiac Physiology and Chronobiology
Cardiac Physiology and Chronobiology

... Third degree AV block, also known as complete heart block, condition when impulse generated in the sinus node does not propagate to the ventricles ...
Mikbaz I 2006
Mikbaz I 2006

... 21. Mark the correct statement regarding verapamil: a. This drug is not efficient for supra ventricular arrhythmias b. Suppresses arrhythmias without affecting the SA node depolarization rate c. Does not affect cardiac contractility d. Blocks conduction in slow fibers and blocks after-depolarization ...
Slide 1
Slide 1

... – Bradycardia: slower than normal 2. Heart Rhythm – Regular (occurs at regular intervals) – Irregular or Arrhythmia • Can range from a benign extra beat to fibrillation • “dropped beats” caused by ventricles not getting their signal to contract • Premature ventricular contractions (PVCs) –A pacemake ...
Circulatory System Teaching Syllabus
Circulatory System Teaching Syllabus

... disease is not the most important cause of valvular disease in developed countries; but valvular disease caused by rheumatic heart disease is still very common in the china and other developing countries. 2 Mitral stenosis and mitral regurgitation A. Pathophysiology: the effects of abnormal homodyna ...
A Case Report of left ventricle outflow tract (LVOT) Tumor in a 49 old
A Case Report of left ventricle outflow tract (LVOT) Tumor in a 49 old

... developed tuberous sclerosis. In 13 cases there was a spontaneous regression [12]. The other investigations have shown that rhabdomyoma regress or disappear entirely without intervention ...
S2006_74.DOC ENDOCARDIAL FIBROELASTOSIS
S2006_74.DOC ENDOCARDIAL FIBROELASTOSIS

... transposition of LCA from PA to aorta along with MV repair, her symptoms improved remarkably. Q wave and QR pattern on EKG, lead 1 also disappeared. Echo several months post surgery showed hypokinesis in left anterior descending artery distribution and persistent thickening of LV endocardium. Conclu ...
New devices in heart failure: an European Heart Rhythm
New devices in heart failure: an European Heart Rhythm

... HF extended the indications to CRT in chronic heart failure, a substantial proportion of patients remain either not eligible for CRT or simply do not respond.9,10 At a time when pharmacological therapy for HF has made only little advances, it is appropriate to explore whether new device-based therap ...
Department of Medical Nursing, Faculty of Nursing, Chiang Mai
Department of Medical Nursing, Faculty of Nursing, Chiang Mai

... Electrocardiogram (ECG) – This is a non-specific test that may be useful in diagnosing cardiac ischemia that is caused by CHF. ECG can also diagnose dysrhythmias that are caused by left ventricular hypertrophy (which often occurs in left sided failure). ...
View PDF - Sanofi
View PDF - Sanofi

... including reduced effort tolerance and symptoms that include shortness of breath and chest pain. HCM substantially increases the risk of atrial fibrillation that can lead to stroke, or malignant ventricular arrhythmias that can cause sudden cardiac death. oHCM, a subset of HCM, is a physiological co ...
Congenitally corrected transposition of the great
Congenitally corrected transposition of the great

... Congenitally corrected transposition of the great vessels (CCTGV) characterized by atrioventricular (AV) and ventriculoarterial discordance is a rare congenital anomaly which accounts for about 1% of all congenital heart disease cases (1). Only 1% of these patients are without other congenital anoma ...
Can the block help the beat? Beta blockers for ventricular fibrillation.
Can the block help the beat? Beta blockers for ventricular fibrillation.

... • Differences in baseline characteristics between survivors and non-survivors • Sample size • Treatment for patients experiencing MI was only noted for 1 patient • Landiolol was effective at inhibiting ES in the majority of patients • Non-survivors had significantly different clinical feature than s ...
6 th International Symposium on Stem Cell Therapy
6 th International Symposium on Stem Cell Therapy

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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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