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The Muscular System
The Muscular System

... • More that 600 muscles – found under the skin. • Tendons – A tendon is a tough band of connective tissue that usually connects muscle to bone and is capable of withstanding tension. ...
Palliative Care for Advanced Heart Failure: An Overview
Palliative Care for Advanced Heart Failure: An Overview

... admissions in Hong Kong due to heart failure is both common and on the rise1, and heart failure is a final common pathway of various cardiac conditions leading to death. In fact, advanced heart failure (AHF) was described as more ‘malignant’ than cancer because of its poor one-year survival rate and ...
English
English

... 2. The AFFIRM Investigators. Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Circulation. 2004;109:1509–1513. ...
Epidemiology and management of coexisting heart failure and atrial
Epidemiology and management of coexisting heart failure and atrial

... Results   The study involved 3682 patients with HF (mean age 67.1 ±11.7 years; 58% of patients were men). AF was present in 38% of the patients. The prevalence of arrhythmia increased with the New York Heart Association class. We observed significant differences between the subgroups of patients wit ...
Chapter 12 Checkpoint Questions 2012
Chapter 12 Checkpoint Questions 2012

... 14. Why is the left ventricle more muscular than the right ventricle? ...
Anti-arrhythmic Drugs - Ipswich-Year2-Med-PBL-Gp-2
Anti-arrhythmic Drugs - Ipswich-Year2-Med-PBL-Gp-2

... sympathomimetic or membrane stabilising activity at therapeutic doses. Precautions ...
Unit One: Introduction to Physiology: The Cell and General Physiology
Unit One: Introduction to Physiology: The Cell and General Physiology

... to the waves of the EEG b. Voltage and time calibration of the EEG c. Normal voltages in P-Q or P-R interval d. Normal voltages in the Q-T interval e. Rate of Heartbeat ...
Chapter 11-day 2
Chapter 11-day 2

... • THE U.S. FOOD AND DRUG ADMINISTRATION (FDA) APPROVED USE OF THE SYNCARDIA TEMPORARY TOTAL ARTIFICIAL HEART IN 2005 • USED IN PATIENTS WITH IRREVERSIBLE FAILURE OF THE VENTRICLES • DESIGNED TO SUPPORT LIFE FUNCTIONS UNTIL A TRANSPLANT ...
Full Text:PDF - The Turkish Journal of Pediatrics
Full Text:PDF - The Turkish Journal of Pediatrics

... to the control group (p<0.001). None of the patients had a MV E/E′ ratio over 15. However, the average of this ratio was below 8 in the patients with CD (Group 1 and 2), and it was significantly different than that of the control group (p<0.001). The proportion of the peak early filling velocity (E) ...
Angiotensin-converting enzyme inhibitors: An ACE in the hole for
Angiotensin-converting enzyme inhibitors: An ACE in the hole for

... hypertension are the ALLHAT, the CAPPP trial, and the UKPDS.1-3 The ALLHAT compared lisinopril with conventional therapy (chlorthalidone or amlodipine). The CAPPP trial compared captopril with conventional therapy (beta-blocker or diuretic), while the UKPDS compared captopril with atenolol. All thre ...
Chapter 20 - Martini
Chapter 20 - Martini

... – slow potassium channels open – rapid repolarization restores resting potential ...
Clinical cardiovascular AP
Clinical cardiovascular AP

... o Heart failure develops slowly as the heart muscle gradually weakens o The "failure" refers to the heart's inability to pump enough blood. o Blood and fluid do not move efficiently through the circulatory system, and starts to "back up“ o Eventually, parts of your body (lungs, abdomen, and lower li ...
Electrocardiographs ECG
Electrocardiographs ECG

... There will be a positive end at one electrode and negative at the other. ...
The Electrical Conduction of the Heart
The Electrical Conduction of the Heart

... Slow Arrhythmias—when the heart beats too slowly it is called bradycardia (brady=slow cardia=heart). Slow arrhythmias can be a problem because they cause the oxygen and nutrient rich blood to travel more slowly to your organs. Your body may not receive enough oxygen to function properly, often makin ...
Alberta researchers get to the heart of cardiac research
Alberta researchers get to the heart of cardiac research

... (myocardial infarction), which is caused by a blocked vessel leading to loss of blood supply to a portion of the heart muscle. Instead, most sudden cardiac arrest episodes are caused by the rapid and/or chaotic activity of the heart known as ventricular tachycardia or ventricular fibrillation. These ...
Properties of cardiac muscle Properties of Cardiac Muscle
Properties of cardiac muscle Properties of Cardiac Muscle

... (c) Second-degree heart block. Some P waves are not conducted through the AV node; hence more P than QRS waves are seen. In this tracing, the ratio of P waves to QRS waves is mostly 2:1. ...
Design And Construction Of A Mock Human Circulatory System
Design And Construction Of A Mock Human Circulatory System

... Congestive heart failure (CHF) contributes to more than 300,000 deaths every year in the United States [1]. CHF is a condition that causes the heart to inadequately distribute blood to the rest of the body, resulting in heart failure, poor perfusion, and ultimately, multisystem organ failure. Approx ...
Congestive Heart Failure!! - Rowan University
Congestive Heart Failure!! - Rowan University

... determine the best course of therapy for heart failure patients. The system relates the ...
Case study 2 (continued)
Case study 2 (continued)

... Is the QRS width normal (narrow) or broad? ...
Coronary surgery - Ipswich-Year2-Med-PBL-Gp-2
Coronary surgery - Ipswich-Year2-Med-PBL-Gp-2

... • Still has reduced graft patency rates so not increased over the last several years. ...
figure 1. - (canvas.brown.edu).
figure 1. - (canvas.brown.edu).

...  Lead corrosion (with older ...
Sudden Death After Transcatheter Aortic Valve Implantation
Sudden Death After Transcatheter Aortic Valve Implantation

... of post TAVI-LBBB is not well known, and several cases of spontaneous resolution have been described.20-23 Recent reports correlate new LBBB with increased mortality24 mostly related to progression to high-degree atrioventicular conduction disorders, progression of heart failure due to left ventricu ...
Cardiac Meds - hostedvoipinfo.net
Cardiac Meds - hostedvoipinfo.net

... • Function of the volume of blood to the LV and the compliance (ability of the ventricle to stretch) of the ventricles at the end of diastole (LVEDP) • Factors affecting are: venous return, total blood volume and atrial kick • Hypovolemic patient has too little preload • Heart failure patient has to ...
What is cardiac arrest? Cardiac arrest is the abrupt loss of heart
What is cardiac arrest? Cardiac arrest is the abrupt loss of heart

... out-of-hospital cardiac arrests occur in the United States. Recently, a boy from Longview, collapsed during basketball practice. His heart stopped for five minutes. He is alive today because of the quick actions of his coach and another parent who were both trained in CPR. This boy had no prior hear ...
Heart rate
Heart rate

... Impulse conduction – step 2a ...
< 1 ... 540 541 542 543 544 545 546 547 548 ... 680 >

Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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