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The Heart
The Heart

... Increased H+ and Ca2+ inside cell causes gap junctions to close Forces action potentials to find alternate routes (if area is large leads to heart attack) ...
Massive Submassive
Massive Submassive

... a suspected paradoxical embolus to the intestines • One patient hemodynamically stable but brain dead ...
Clinical - Bart.indd - The Minnesota Heart Failure Consortium
Clinical - Bart.indd - The Minnesota Heart Failure Consortium

... and death. There currently is no standard of care for the treatment of such patients. Practice patterns vary among regions and include diverse interventions such as withholding diuretics and replacing fluids, increasing the intensity of diuretic therapy, adding vasodilators or inotropes, and using u ...
S2213177913001182_mmc1
S2213177913001182_mmc1

... Couplets ...
Update on Percutaneous Mitral Valve Therapy
Update on Percutaneous Mitral Valve Therapy

... • 141 high risk DMR patients enrolled consecutively in US clinical trials with 1-year follow-up identified • Risk factors reviewed by 3 physicians • 2 cardiothoracic surgeons (Drs. Mack and McCarthy); • 1 cardiologist (Dr. Grayburn) ...
Basic ECG Interpretation
Basic ECG Interpretation

... Atrial – followed by P wave…. Ventricular – followed by QRS A/V – as above The type of pacemaker used and the patient’s condition may affect whether every beat is paced ...
- Korean Circulation Journal
- Korean Circulation Journal

... without neurologic sequelae. After immunosuppressive therapy, the patient was discharged. Echocardiography performed 4 months after discharge revealed normal left ventricular function without left to right shunting through the transseptal puncture site. ...
Addendum to the Guideline on antiarrhythmics on atrial fibrillation
Addendum to the Guideline on antiarrhythmics on atrial fibrillation

... more difficult to define. Suitable primary outcomes may consist of time to recurrence of AF or time in AF. In case of recurrence the number of such episodes should be taken into account as secondary endpoint. Any arrhythmia that has ECG characteristics of AF/AFL lasting longer than 30s should be rep ...
Update in the Approach to and Management of Heart Failure
Update in the Approach to and Management of Heart Failure

... HF. Aldosterone is released from the adrenal cortex in response to angiotensin II, ACTH and potassium and results in sodium and water retention as well as the loss of potassium and magnesium. Aldosterone also activates the sympathetic nervous system, inhibits the parasympathetic nervous system, caus ...
Ryan Parnham, MSN, APN, CNP
Ryan Parnham, MSN, APN, CNP

... congestive heart failure May not present clinically until 1-2 months of life Often associated with other lesions Isolated VSD’s typically have favorable surgical outcomes Many small and even mod sized VSD’s can close spontaneously for up to 4 years of age ...
Dilated Cardiomyopathy in Cats
Dilated Cardiomyopathy in Cats

... • Angiotensin-converting enzyme (ACE) inhibitors, such as enalapril, benazepril, or ramipril, may be used to improve the quality of your cat’s life and help reduce fluid retention in the body. • Pimobendan is a newer drug that acts as a vasodilator to relieve the workload of the heart and to increas ...
Cardiac Muscle Tissue
Cardiac Muscle Tissue

... cells that directly control heart rate. Although cardiac muscle cannot be consciously controlled, the pacemaker cells respond to signals from the autonomic nervous system (ANS) to speed up or slow down the heart rate. The pacemaker cells can also respond to various hormones that modulate heart rate ...
Ramesh M. Gowda, MD
Ramesh M. Gowda, MD

... • The patient was chest pain free at the end of the procedure and transferred to the CCU in stable condition. • Because of the severity of the patient’s remaining coronary disease, a heart team discussion was had and coronary artery bypass graft surgery was scheduled for the next week. • Meanwhile, ...
PhysDxStudyq
PhysDxStudyq

... AORTIC VALVULAR SCLEROSIS OFTEN ACCOMPANIES THESE IN THE OLD NO THRILLS PULLMONIC / MITRAL AREA STILL’S MURMUR PRESENT IN 50% OF CHILDREN (GONE BY PUBERTY) PHYSIOLOGIC MURMUR TURBULENCE DUE TO TEMPORARY FLOW INCREASE RIGHT SIDED MURMUR INCREASES ON EXPIRATION LEFT SIDED MURMUR NOT EFFECTED BY RESPIR ...
Adults with Congenital Heart Disease, and the
Adults with Congenital Heart Disease, and the

... 17,088 complex. According to some experts, it would be more realistic to estimate 70% of those data, in which case the total number would be 80,822. In any case, these figures are important as burden of disease. If we consider only the presence of significant arrhythmias, one of the most important s ...
Cardiac Output
Cardiac Output

... Generally proportional to body surface area. Cardiac Index (CI): Approximately 3 liters/min/m2 of body surface area. CI varies with age, peaking at around 8 years. ...
Predictive factors of difficult implantation procedure in cardiac
Predictive factors of difficult implantation procedure in cardiac

... a second more experienced operator (5.7%). Among the remaining four patients, one patient required a surgical epicardial LV lead implantation, and the implantation was not reattempted in the other three patients. The overall success rate of CRT system implantation was 96.2% (102 of 106 patients). Pr ...
Exercise Stress Echocardiography With Tissue Doppler Imaging (TDI)
Exercise Stress Echocardiography With Tissue Doppler Imaging (TDI)

... must reverse any functional abnormalities including the object of our study. Finally, it is possible that the reduced systolic regional performance recorded with the TDI and likely to be attributed to iron damage, could be due to other factors, such as chronic anemia: infact regular transfusional sc ...
Dear Colleagues - Centre for Rare Cardiovascular Diseases
Dear Colleagues - Centre for Rare Cardiovascular Diseases

... facial muscles. The respiratory muscles may also be affected leading to respiratory failure and death [12]. In a meta‑analysis conducted by van Spaendonck‑Zwarts et al. [3], the signs of skeletal muscle disease were present in 74% of the patients with DES mutation. Distal muscle weakness was report ...
Rajiv Gandhi University of Health Sciences
Rajiv Gandhi University of Health Sciences

... also paved way for some other major dysfunctions of the respiratory and circulatory systems of the human body. Lack of lung inflation due to postoperative pain resulting in shallow and monotonous breathing pattern with the absence of periodic sighs and temporary diaphragmatic dysfunction are the som ...
Marked bradycardia in a young woman with weight loss
Marked bradycardia in a young woman with weight loss

... bowel syndrome (IBS) was admitted to the internal medicine ward with abdominal pain. During the last few weeks she had experienced a 15% weight loss due to malnourishment secondary to the abdominal complaints and light-headedness upon standing, but no syncope. Because of a regular heart rate of 35 b ...
Noninvasive Evaluation of Right Atrial Pressure
Noninvasive Evaluation of Right Atrial Pressure

... valve lesions, patients may not recognize symptoms because they may have gradually limited their daily activity levels. A detailed physical examination should be performed to diagnose and assess the severity of valve lesions based on a compilation of all findings made by inspection, palpation and au ...
Advanced Cardiac Life Support (ACLS) Review ® WWW.RN.ORG
Advanced Cardiac Life Support (ACLS) Review ® WWW.RN.ORG

... Learning Break: The LMA and the esophageal-tracheal double lumen airway are not intended for long-term use. If the victim does not need an advanced airway, but needs supplemental oxygen, a nasal cannula, Venturi mask, simple face mask, or nonrebreather mask are possibilities. The amount and precisio ...
Sudden cardiac death in apparently norma
Sudden cardiac death in apparently norma

... The diagnosis of ARVD is often difficult. Physical examination is frequently normal, but in some patients a widely split second heart sound may be heard as a result of right ventricular dysfunction. The resting electrocardiogram is abnormal in 70% of cases. T wave inversion in the chest leads is the ...
Cardiac Output and Index in Obese and Non
Cardiac Output and Index in Obese and Non

... features of obese cardiomyopathy arise in all obese patients.30,31 To date CI, despite being an important overall haemodynamic parameter, has not been systematically compared between a non-obese and obese group of patients in a clinical setting. Our findings indicated a clinically significant increa ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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