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Renin-Angiotensin-Aldosterone System Activation During
Renin-Angiotensin-Aldosterone System Activation During

... excluded from the current analysis because of missing data, and there were some differences in baseline characteristics between this cohort and the study population, most notably left ventricular ejection fraction and renal function. Moreover, PRA follow-up values were missing in another 13% of pati ...
Incidence, risk factors and m profile of Surgical Site Infecti surgery
Incidence, risk factors and m profile of Surgical Site Infecti surgery

... our study also, coagulase negative staphylococcus is the prevalent microorganism, which was corroborated by other studies.11,12 In contrast to a study from Brazil, where out of the 36 patients with SSI, 14 (38.9%) patients had died, no mortality has occurred in our patients out of the infection.13 T ...
Atrial Fibrillation - Northwestern Medicine
Atrial Fibrillation - Northwestern Medicine

Role of thrombolysis in haemodynamically stable patients
Role of thrombolysis in haemodynamically stable patients

... Importantly, it is now recognised that there is another cohort of patients who, although haemodynamically stable, are nevertheless at an increased risk of death and who currently receive only standard anticoagulation regimens. To date, no consensus exists regarding the identification, appropriate ri ...
peripartum cardiomyopathy: a case report
peripartum cardiomyopathy: a case report

... DISCUSSION: The peripartum cardiomyopathy (PPCM) is classified as a specific cardiomyopathy that develops in the last period of pregnancy or in the first period Puerperium.3,4 PPCM is defined on the basis of the following criteria, adapted from Demakis et al.5,6:  Development of cardiac failure in ...
Repair of Atrial Septal Defect via Right Submammary
Repair of Atrial Septal Defect via Right Submammary

... for infants and newborns are limited. The recent reported approaches include right anterior thoracotomy, transverse submammary skin incision, and video-assisted techniques. Early clinical investigations on utilization of the abovementioned approaches in pediatric cardiac surgery showed that transatr ...
Arrhythmias - American Heart Association
Arrhythmias - American Heart Association

... This is the most common type of abnormal tachycardia in young adults. The fast heart rate — often over 150 beats a minute — starts in the heart’s upper chambers or in the upper part of the electrical conduction system. Symptoms include palpitations, chest pains, upset stomach, decreased appetite, li ...
Heart Failure With Improved Ejection Fraction: Clinical
Heart Failure With Improved Ejection Fraction: Clinical

... Background—Heart failure with recovered or improved ejection fraction (HFiEF) has been proposed as a new category of HF. Whether HFiEF is clinically distinct from HF with persistently reduced ejection fraction remains to be validated. Methods and Results—Of the 5010 subjects enrolled in the Valsarta ...
Modelling of the vital signs
Modelling of the vital signs

... This is a fatal dysrhythmia caused by the high time and location, a non-coordinated activity of a number of ectopic lesions in the wall and / or in the heart ventricular septum. The result of such electrical activity is uncoordinated contraction (Fig. 4) of individual districts ventricular muscle, o ...
Asymptomatic mitral regurgitation: does surgery save lives?
Asymptomatic mitral regurgitation: does surgery save lives?

... selected for early surgery or medical manage­ Cardiac-event-free survival 85% at 7 years 55% at 8 years 38% at 5 years ment is not clear, but it seems implicit from expected survival: 90%. expected survival: 78% the data that there was a tendency to assign patients with less complex valve patho­ log ...
future cardiac events in normally diagnosed gated myocardial
future cardiac events in normally diagnosed gated myocardial

... medicine, constituting about 40% of the total for the entire field [6]. A negative study excludes myocardial injury [7]. Many studies had tested the prognostic value of a normal myocardial perfusion scintigraphy, While in general the overwhelming majority of patients with normal MPS are low risk, it ...
To the Eisenmenger Complex Patient: How do we optimize care
To the Eisenmenger Complex Patient: How do we optimize care

... • desiccation of nasal mucosa, epistaxis, sleep disturbance • No impact of nocturnal oxygen therapy on exercise capacity, natural history and survival of the patients within a follow up period of 2 years. ...
Latissimus Dorsi Muscle Strengthening and Training before
Latissimus Dorsi Muscle Strengthening and Training before

... N.Y.H.A. functional class was not modified during and/or following the exercise training program. The long term improvement in N.Y.H.A. functional class observed in patients after cardiomyoplasty is most likely due to: first, the gradual increase in the Latissimus Dorsi muscle resistance to fatigue ...
Investigation of a novel algorithm for synchronized left
Investigation of a novel algorithm for synchronized left

... Introduction Cardiac resynchronization therapy (CRT) is an established therapy for patients with heart failure (HF) symptoms, left ventricular systolic dysfunction, and a wide QRS.1,2 However, the magnitude of clinical and hemodynamic benefit of CRT varies significantly among its recipients with no ...
Electrocardiography (ECG)
Electrocardiography (ECG)

... 3-Heart attack (Myocardial infarction) The electrocardiography assists in the diagnosis of specific cardiac abnormalities by detecting transmission of electrical impulses through the heart’s conductive tissues. This is accomplished by means of leads (or electrodes), attached to a patient’s limbs and ...
Left ventricular dysfunction
Left ventricular dysfunction

... [8] – Remes J. Validity of clinical diagnosis of heart failure in primary health care. Eur Heart J 1991. [9] – Stevenson LW. The limited reliability of physical signs for estimating hemodynamics in chronic heart failure. JAMA 1989. [10] – Nielsen OW. Retrospective analysis of the cost-effectiveness ...
Dr. Frankenstein`s Ghost Heart
Dr. Frankenstein`s Ghost Heart

... that makes them unique (decellularized them) and used their architecture to recreate a heart capable of pumping in another beings body. ...
36 - Coastal West Sussex Formulary
36 - Coastal West Sussex Formulary

... hepatic and pulmonary function. - If AF reoccurs, discontinuation of dronedarone should be considered. Treatment with dronedarone should be stopped during the course of treatment, in case the patient develops any of the conditions which would lead to a contraindication (e.g. co-administered drugs li ...
The Morphology of the Aging Heart
The Morphology of the Aging Heart

... proportions in the elderly, making it the leading cause of morbidity and mortality among this age group and a major focus of interest in geriatrics. The cardiovascular system undergoes subtle but progressive changes with age. These alterations of cardiovascular structure result in progressively alte ...
Images and Case Reports in Arrhythmia and Electrophysiology
Images and Case Reports in Arrhythmia and Electrophysiology

... fibrillation (VF), often referred to as electrical storm (ES), is a life-threatening emergency requiring immediate intervention.1 Patients presenting with ES often suffer from severe cardiomyopathy but may have structurally normal hearts with ion channelopathy. Common triggers of ES include myocardi ...
Document
Document

... Cardiovascular System Notes: Heart Disease & Disorders ...
Y-Adaptor Connection for LV Lead in Upgrading to Biventricular
Y-Adaptor Connection for LV Lead in Upgrading to Biventricular

... class, smaller heart chamber size and higher left ventricular ejection fraction, to the same extent as de novo implantation.15 In the MUSTIC (MUultisite STimulation In Cardiomyopathy) study, de novo biventricular pacing was also shown to be effective in patients with atrial fibrillation, improving 6 ...
F - Notes - Disorders of the Heart
F - Notes - Disorders of the Heart

... Cardiovascular System Notes: Heart Disease & Disorders ...
Inferior and Rt Vent MI ppt
Inferior and Rt Vent MI ppt

P R T S Q
P R T S Q

... o The period b/t the start of one heartbeat and the start of the next  Basically a single heartbeat o Importance  The fxn of the heart can be understood by a sequence of electrical and mechanical events which occur during a single cardiac cycle/heartbeat Pump Basics o 4 chambers – 2 atria, 2 ventr ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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