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Levosimendan Improves Renal Outcome in Cardiac Surgery_ A
Levosimendan Improves Renal Outcome in Cardiac Surgery_ A

Best Practice - The Heart Foundation
Best Practice - The Heart Foundation

... Recommended for all patients post MI, unless contraindicated, and continued indefinitely, especially in high-risk patients. (High-risk patients are defined as those with either significant myocardial necrosis, left ventricular systolic dysfunction, persistent evidence of ischaemia or ventricular arr ...
Novel Biomarkers for Cardio-renal Syndrome
Novel Biomarkers for Cardio-renal Syndrome

... the traditional marker, serum creatinine, and therefore efforts to explore possible biomarkers for early detection of AKI are being made. Apart from predicting AKI, several biomarker studies also identified predictors for poor prognosis such as the need for renal replacement therapy (RRT) or death. ...
Ventricular Tachycardia
Ventricular Tachycardia

... Your heart rate is controlled by electrical signals transmitted across the heart muscle. When something goes wrong and signals are sent too rapidly, tachycardia can occur. Most often, ventricular tachycardia is caused by other heart problems such as coronary artery disease, high blood pressure, an e ...
Heart Failure with a Preserved Ejection Fraction
Heart Failure with a Preserved Ejection Fraction

... distinct types of structural and functional LV remodelling? LV remodelling is the product of multiple interacting and complex signalling processes. The contribution of each of these processes is linked to the patient’s biological profile and medical background. For example, some of these processes a ...
HLC1464 - Unitec Research Bank
HLC1464 - Unitec Research Bank

... Degenerative mitral regurgitation (MR) results in left ventricular (LV) volume overload and LV dysfunction that contributes to prognosis [1]. RV function is also prognostically important [2]: tricuspid annular plane systolic excursion (TAPSE), a measure of systolic annular descent, is correlated wit ...
Constrictive Pericarditis - Mike Poullis
Constrictive Pericarditis - Mike Poullis

... channel blockers should be avoided as mild sinus tachycardia is a compensatory mechanism. • The majority of patients become progressively more disabled and subsequently suffer the complications of severe cardiac cachexia. ...
Stable Ischemic Heart Disease Stable Ischemic Heart Disease
Stable Ischemic Heart Disease Stable Ischemic Heart Disease

... disease is coronary artery bypass grafting (CABG) the preferred form of revascularization? A. Most patients with left main or disease B. 3-vessel and left ventricular dysfunction C. Patients with diabetes who are being considered for revascularization, particularly in the setting of multivessel, dif ...
Biology 232
Biology 232

... voltage-gated calcium channels open – calcium ions flow in from SR and interstitial space 3) repolarization Ca channels close voltage-gated potassium channels open – potassium ions rush out and restore negative charge inside cell long refractory period – another action potential cannot occur until m ...
4 - Pass the FracP
4 - Pass the FracP

... Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, typically of a nondilated chamber, without obvious cause such as hypertension or aortic stenosis (Fig. 238-3). It is found in about 1 in 500 of the general population. Two features of HCM have attracted the greatest ...
Chapter 19 - Heart
Chapter 19 - Heart

... – Atrioventricular (AV) node is an electrical relay to the ventricles – AV bundle (bundle of His) is a pathway for signals from the AV node to muscles of ventricles. – Right and left bundle branches are divisions of the AV bundle that enter the interventricular septum and descend to the apex. – Purk ...
MK-886 and DITPA Attenuate Global Myocardial Ischemia
MK-886 and DITPA Attenuate Global Myocardial Ischemia

... Heider SH. Qassam MSc. PH. & TH. ...
What is Heart Disease? - Alvarado Veterinary Clinic
What is Heart Disease? - Alvarado Veterinary Clinic

... Heart failure is not a specific heart disease, but rather is the final common manifestation of many types of heart disease. Heart failure can manifest as inadequate blood flow to the body (low-output heart failure), accumulation of fluid behind the heart (congestive heart failure), or both. Many dif ...
A Clinical-pathological Study 2 Years Following Cardiomyoplasty
A Clinical-pathological Study 2 Years Following Cardiomyoplasty

... progressive pacing was used. Two months postoperatively, muscle stimulation parameters were the following. Synchronization delay: 4 ms; pulse amplitude: 5V; pulse width: 210 (js; burst rate; 30 Hz; and burst duration: 185 ms. Four months after cardiomyoplasty temporary arrest of the stimulator was f ...
Recognition And Treatment Of Fetal And Neonatal Arrhythmias
Recognition And Treatment Of Fetal And Neonatal Arrhythmias

...  Cross react with fetal conduction system  ~50% associated with complex congenital heart disease  Heterotaxy common (Polysplenia or left isomerism)  May be asymptomatic or associated with heart failure, such as hydrops  Worse outcome  Hydrops, structurally heart disease, ventricular rate less ...
fibrillation complicating acute myocardial
fibrillation complicating acute myocardial

... after diagnosis of Ml is made). Ventricutarfibrittation was defined as irregutar waves of inconsistent shaPe without distinct QRS comptexes or T-waves. Ventricutar fibritlation was ctassified as earty VF if it occurred in the first 48 h of admission, and late VF if it occurred after the first 48 h b ...
Chapter 12 * Cardiovascular System
Chapter 12 * Cardiovascular System

... RELAX and semilunar valves are closed "lub" = closing of atrioventricular valves  Then VENTRICLES CONTRACT while ATRIA RELAX and atrioventricular valves are closed. "DUPP" = closing of the semi-lunar valves ...
January - June
January - June

... majority of VATS incisions are only near one cm in length.The use of thoracoscopy eliminates the need for rib spreading. As a result, patients have much less postoperative pain and no risk of rib fractures. Pulmonary function is also much better preserved after surgery. Patients are mobilized to wal ...
SCREENING FOR AF - Atrial fibrillation information
SCREENING FOR AF - Atrial fibrillation information

...  manual pulse– rhythm, rate, volume  peripheral pulses, oedema  jugular venous pressure (JVP)  heart sounds, murmurs, gallop  systems examination  Determine clinical subtype if possible: paroxysmal, persistent, permanent ...
Prof. Raimund Erbel and Prof. Victor Aboyans discuss the 2014
Prof. Raimund Erbel and Prof. Victor Aboyans discuss the 2014

... with recent data indicating superiority. Ongoing randomized clinical trials directly compare TAVI with surgical aortic valve replacement among intermediate-risk patients, with results [expected] within the next two years. In addition, technological advances in transcatheter heart valve therapies con ...
In Patients With Chronic Atrial Fibrillation and Left Ventricular
In Patients With Chronic Atrial Fibrillation and Left Ventricular

... The main study outcome is that, despite previous good control of the ventricular rate, LVS function was greatly improved in patients with restored and sustained SR. In contrast, no changes were detected in those patients who returned to or persisted in AF during the echocardiographic follow-up. In a ...
Managing Atrial Fibrillation in Primary care
Managing Atrial Fibrillation in Primary care

... Progression of AF is thought to be driven by structural changes in the atria, including electrical, contractile changes, known as atrial remodelling1 First diagnosed episode of AF Paroxysmal (usually ≤48 hours) Persistent (>7 days or requires cardioversion) Long-standing persistent (>1 year) ...
Related Topics Pulse duration (DT), heart rate, end systolic diameter
Related Topics Pulse duration (DT), heart rate, end systolic diameter

... wall, echocardiography can help detect the presence and assess the severity of coronary artery disease, as well as help determine whether any chest pain is related to heart disease. The biggest advantage to echocardiography is that it is noninvasive (doesn't involve breaking the skin or entering bod ...
Chronic heart failure
Chronic heart failure

... this number is growing because of the ageing of nations’ populations, but also because patients are rescued from death during an acute myocardial infarction, and later develop heart failure. The prevalence of heart failure is roughly 2% of the population, and up to 10% in people aged 75 years and ol ...
Anatomy and Electrophysiology of the Heart Basic Anatomy of the
Anatomy and Electrophysiology of the Heart Basic Anatomy of the

... across cell membrane causing inside of cell to become more positive; an electrical event which is expected to result in a contraction (mechanical event • A difference between electrical charges must exist for electrical current to be generated. This electrical activity appears on an ECG as waveforms ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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