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in Congestive Heart Failure
in Congestive Heart Failure

... successfully applied in clinical congestive heart failure. The traditional approach has consisted of increasing the force and velocity of myocardial contraction with inotropic stimulating agents.' More recently afterload reducing drugs have been utilized to enhance cardiac output through lowering of ...
Advance physiology Cardiovascular system
Advance physiology Cardiovascular system

...  They are predominatly mononucleated.  The cardiac muscles, unlike skeletal ones, cannot rest, even for a moment. The density of mitochondria (the energy generators of the body) in these cells is high, which lets them produce an abundance of ATP molecules through aerobic respiration, to drive the ...
STRATEGIES TO REDUCE CARDIAC RISK IN A NON
STRATEGIES TO REDUCE CARDIAC RISK IN A NON

...  The ECG is frequently obtained as part of a preoperative evaluation in all patients over a specific age or undergoing a specific set of procedures. ...
Tetralogy of Fallot: TOF occurs in 5% to 10% of all congenital heart
Tetralogy of Fallot: TOF occurs in 5% to 10% of all congenital heart

... 8. Start beta -blockade. Beta blockade is fairly safe unless a specific contraindication like bronchial asthma or ventricular dysfunction exists. It should always be given with heart rate monitoring. Medications and dosages: 1- IV metoprolol 0.1 mg/kg, given slowly over 5 min and can repeat every 5- ...
Multi-contrast late enhancement CMR determined gray zone and
Multi-contrast late enhancement CMR determined gray zone and

... cardioverter-defibrillator (ICD) therapy. Currently, poor left ventricular ejection fraction (LVEF) is the primary index that is used to decide whether or not to implant an ICD [1-6]. However, many patients with poor LVEF may not benefit from the ICD implantation as the annual firing rates are appro ...
A1990EJ37400001
A1990EJ37400001

... It is ironic that we, having used the term obstructive cardiomyopathy (which fitted well with other concepts of obstruction in the disease at that time), should have subsequently reversed our opinion and denied the importance of obstruction! It is with some wry self-deprecation that I now regard mys ...
Sensitive cardiac troponin I predicts poor outcomes in pulmonary
Sensitive cardiac troponin I predicts poor outcomes in pulmonary

... Clinical outcomes 22 (32.4%) patients died and two (2.9%) underwent lung transplantation. Nine (53%) out of 17 patients with detectable cTnI died, compared with 13 (25%) out of 51 with undetectable cTnI (p50.041). All of the nine deaths in patients with detectable cTnI were due to RVF. Among the 13 ...
CPAP Should Be Used for Central Sleep Apnea in Congestive Heart
CPAP Should Be Used for Central Sleep Apnea in Congestive Heart

... The first moderate-sized randomized trial of the selective β1receptor blocker, metoprolol,45 for treating CHF involved 383 patients. In this trial, metoprolol increased LVEF but did not affect survival, most likely because it was underpowered to do so. Nevertheless, 6 years later, in a much larger t ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Of total 155 patients, Complete Heart Block (CHB) was found to be the commonest indication (in 94 cases, 60.6%) for permanent pacemaker implantation followed by Sick Sinus Syndrome (SSS) in 20 cases (12.9%). In the USA, sinus-node dysfunction is the primary indication for pacemaker implantation in o ...
continuing professional development Heart failure
continuing professional development Heart failure

... management of heart failure based on the most recent NICE guideline: ‘Chronic heart failure: management of chronic heart failure in adults in primary and secondary care (CG108)’, issued in August 2010, and NICE technology appraisal TA267 – ‘Ivabradine for treating chronic heart failure’, which was i ...
Vipul Brahmbhatt
Vipul Brahmbhatt

... Diagnosis <40 Year- 1/3 patient will have Symptoms Diagnosis after 40 Year unlikely to have symptoms Pt should be advised to seek attention if symptoms occur or any syncope Family H/O SCD or Prior Syncope Catheter Ablation is a choice if pt desires and in High Risk Public Job ...
Left ventricular outflow tract obstruction and Takotsubo syndrome
Left ventricular outflow tract obstruction and Takotsubo syndrome

... A 76-year-old woman with a medical history notable for factor V gene mutation (with a previous episode of deep venous thrombosis and pulmonary embolism), arthritis and hypertension, on full-dose aspirin (325 mg daily) and lisinopril and hydrochlorothiazide (unknown doses), presented in the emergency ...
Abnormal Myocardial Enhancement
Abnormal Myocardial Enhancement

... the remaining myocardium, which can regain or improve contractility when corrected (often with reperfusion procedures, such as stenting or revascularization). Transmural enhancement, on the other hand, is associated with decreased likelihood of recovery. 4 In chronic cases, transmural infarctions wi ...
Introduction to the 12
Introduction to the 12

... depolarisation and repolarisation of the atria and ventricles. Note: The ECG cannot tell us anything about the ‘mechanical activity’ (i.e. contraction and relaxation) of the myocardium. ...
Sheep Heart Dissection Lab
Sheep Heart Dissection Lab

... on the surface of the heart. Use a scalpel to remove a portion of this layer and expose the myocardium beneath. Also note the abundance of fat along the paths of various blood vessels. This adipose tissue occurs in the loose connective tissue that underlies the visceral pericardium. b. Identify the ...
c4a2539f0a5d883
c4a2539f0a5d883

... operator pushes the SHOCK button to discharge the machine. The shock can fall randomly anywhere within the cardiac cycle. The electrical shock is delivered with a peak of the R wave in the QRS Complex thus avoiding the delivery of a shock during cardiac repolarization (t-wave) ...
Decision-making and surgery results in postinfarction ventricular
Decision-making and surgery results in postinfarction ventricular

... of 30). We think it is important to perform coronary angiography before the operation in order to choose an adequate revascularisation strategy. During coronary angiography an occluded infarct-related coronary artery without collateral circulation was identified in about half of the patients. Most o ...
Value of dual-source computed tomography in evaluating left
Value of dual-source computed tomography in evaluating left

... standard for evaluation of left ventricular function (Rathi and Biederman, 2004), but tests are expensive, its spatial resolution rate is not high, and because of its lengthy duration, it is difficult for patients to tolerate. In addition, emergency patients and those with heart pacemakers or metall ...
2016_Cardiovascular_Assessment 4.0 MB
2016_Cardiovascular_Assessment 4.0 MB

... Prostaglandin may given to keep the PDA open to reduce the pressure changes The most common repair is resection of the narrowed area with re-anastomosis of the two ends Surgical complications – kidney damage due to clamping off of blood flow during surgery High blood pressure post surgery – may need ...
2012-gemc-res-vinesyoungquist
2012-gemc-res-vinesyoungquist

... Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/privacy-and-terms-use. Any medical informat ...
Pericardial diaese
Pericardial diaese

... *Corticosteroids should not be routinely used initially unless there is a rheumatologic etiology or NSAIDs and colchicine are contraindicated. ...
Sheep Heart Dissection Lab
Sheep Heart Dissection Lab

... the paths of various blood vessels. This adipose tissue occurs in the loose connective tissue that underlies the visceral pericardium. b. Identify the following: right atrium, right ventricle, left atrium, left ventricle, coronary arteries 3. Examine the dorsal surface of the heart. Locate the stump ...
Recommendation and Reasons
Recommendation and Reasons

... on all-cause age-specific mortality from Statistics Canada and CV mortality data from PARADIGM-HF. CV mortality data for years 0 to 3 were based on deaths observed in PARADIGM-HF, while a survival model was used to extrapolate values for years 3 to 20. Allcause hospitalization rates were obtained fr ...
how to distinguishing cyanotic congenital heart disease from
how to distinguishing cyanotic congenital heart disease from

... THEY MAY PLAY ACTIVELY FOR A SHORT TIME AND THEN SIT OR LIE DOWN . CHARACTERISTICALLY , CHILDREN ASSUME A SQUATTING POSITION FOR THE RELIEF OF DYSPNEA CAUSED BY PHYSICAL EFFORT ; THE CHILD IS USUALLY ABLE TO RESUME PHYSICAL ACTIVITY AFTER A FEW MINUTES OF SQUATTING . THESE FINDINGS OCCUR MOST OFTEN ...
The Heartbeat
The Heartbeat

... caused by the atrioventricular valves (bicuspid and tricuspid) closing as the ventricles contract. The “dup” is shorter and sharper. This sound is caused by the semilunar valves (pulmonary and aortic) closing after the blood is pumped out of the ventricles into either the pulmonary artery or the aor ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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