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Physiology of Oculocardiac reflex
Physiology of Oculocardiac reflex

... Radial pulse was recorded. With lids closed the subject rotated, the eyeballs over the outer corner of his eyes using the index fingers, concentrating on the light between the eyebrows. The pulse was recorded again. ...
Slide 1
Slide 1

... not achieved in some studies  In CREATE-ECLA treatment arm BG actually rose, higher at 24h compared to treatment  CARDINAL study showed hyperglycemia in first 24h after AMI predicts higher mortality in non-DM ...
Introduction - Australian Doctor
Introduction - Australian Doctor

... THE prevalence of left bundle branch block (LBBB) in young healthy males has been shown to be about 0.05%. Over 90% of these have no evidence of structural heart disease on further investigation.11 No increase in mortality was observed in the subpopulation without structural heart disease. Data from ...
in Frail Elderly Detected Through a Near-Home Target
in Frail Elderly Detected Through a Near-Home Target

... doi: 10.3122/jabfm.2014.06.140045 ...
Chief complaint… “Severe chest pain for 2 hours”—first
Chief complaint… “Severe chest pain for 2 hours”—first

... overload (aortic stenosis, mitral stenosis)—stenotic valves develop slowly over time • In general, regurgitant valves lead to a state of volume overload; can develop acutely (AMI) or chronically • Stenotic valves are heart when the valve is normally OPEN—aortic valve is open during systole (ejection ...
Heart Failure - the Helderberg Cardiac Support Group
Heart Failure - the Helderberg Cardiac Support Group

... of the improved treatment of coronary heart disease (e.g. thrombolysis resulting in more people surviving a myocardial infarct but left with residual left ventricular dysfunction), and the ageing population . ...
Intermediate Cardiology
Intermediate Cardiology

... Describe the most commonly used pharmacological agents in the management of cardiac arrest for EMT-Intermediates. ...
Chapter 3 Answers (part I) - Pearson Schools and FE Colleges
Chapter 3 Answers (part I) - Pearson Schools and FE Colleges

Comparison of the Safety and Efficacy of Ivabradine and Nebivolol
Comparison of the Safety and Efficacy of Ivabradine and Nebivolol

... Each section was calculated on the basis of percentages (%). As result, an average of 0% was considered as poor, an average of 50% was considered as moderate, and an average of 100% was considered as good. The patients’ follow-ups were performed for a period of six months, with their examinations be ...
Reduction of the Risk of Recurring Heart Failure Events With
Reduction of the Risk of Recurring Heart Failure Events With

... centers in North America and Europe and randomly assigned in a 3:2 ratio to receive either CRT-D or ICD. Patients of either sex who were at least 21 years of age were enrolled in the study if they had ischemic cardiomyopathy (New York Heart Association [NYHA] functional class I or II) or nonischemic ...
Medical Policy Microvolt T
Medical Policy Microvolt T

... A 2005 review by Gehi et al. evaluated the predictive value of MTWA in determining risk stratification of ventricular tachyarrhythmic events (VTE) across a variety of subjects. The study found that the presence of significant MTWA predicted nearly a fourfold risk of VTE compared to the absence of MT ...
Biventricular Pacemakers
Biventricular Pacemakers

...  Left ventricular ejection fraction  (less than or equal to) 35%;  Sinus rhythm  Patients treated with guideline-directed medical therapy (see Policy Guidelines section)  Either left bundle branch block or QRS duration ≥150 ms* New York Heart Association class II  Left ventricular ejection fra ...
London Arrhythmia Program Academic Year in Review Sept 2014
London Arrhythmia Program Academic Year in Review Sept 2014

... Institute accounting for 2,434 visits. In addition, 1,207 patient visits were in the Outpatient Clinic at the University Hospital. The wait time for assessment is 4 -5 months. Urgent assessment requests from physicians making direct contact can be seen within one to two weeks. Total outpatient visit ...
Correlation Between Pediatric Open Heart Surgery Outcomes and
Correlation Between Pediatric Open Heart Surgery Outcomes and

... significant correlation between gender and postoperative outcome (P > 0.05).A statistically significant difference was observed between the mean ages of the complicated and the non-complicated groups (4.88 13.67 vs. 6.811 3.89 years, P < 0.05), as the complicated group was generally younger than the ...
Antifailure Therapy Including Spironolactone Improves Left
Antifailure Therapy Including Spironolactone Improves Left

... myocardial infarction on electrocardiogram (ECG), a positive stress test or angiographic coronary artery stenosis ≥50% in a major artery, severe chronic obstructive airway disease precluding adenosine use, creatinine >2.5 mg/dL, glomerular filtration rate <30 mL/min per 1.73 m2, uncontrolled atrial fi ...
Chapter_20_Heart
Chapter_20_Heart

... norepinephrine, stimulation of sympathetic nervous system) and those that decrease contractility are negative inotropic agents (e.g. inhibition of sympathetic division, acidosis and anesthetics). – Afterload: the pressure that must be overcome before a semilunar valve can open. An increase in afterl ...
Heart Rate Recovery After Exercise Is a Predictor of
Heart Rate Recovery After Exercise Is a Predictor of

Intraluminal Ascending Aorta Fibroma
Intraluminal Ascending Aorta Fibroma

... in the pediatric age group are benign; autopsy studies in children have reported incidence rates ranging from 0.027% to 0.08%.4 One echocardiography database has reported an incidence of 0.17%, which suggests that one or two new primary cardiac tumors will be detected for every 1000 firsttime pediat ...


... The heart activity includes electrical signal (electrocardiogram or ECG) and mechanical actions. The electrical system is also called the cardiac conduction system. A graphical picture of the heart electrical activity is called electrocardiogram (EKG) [1]. Events in each heartbeat are very precise a ...
cardiac cycle
cardiac cycle

... branches, Purkinje fibers, and the ventricular myocardium producing the QRS complex. • Ventricular contraction after the QRS comples and continues through the ST segment. • Repolarization of the ventricles produces the T wave. • Both atria and ventricles repolarize and the P wave ...
Point of View The Long QT Interval Syndrome
Point of View The Long QT Interval Syndrome

... To summarize, the often-quoted studies that purport to establish the foundation for the ECG characteristics of LQTS show that refractory period and T wave changes with stellate ganglion manipulation are small compared with the QT changes in patients with the LQTS. While T wave alternans and changes ...
Sudden Death In the Structurally Normal Heart
Sudden Death In the Structurally Normal Heart

... Spontaneous type 1 ECG “Asymptomatic” Negative family hx EP study (IIA indication) • Sustained VT with DES at 500 from RVA • No supraventricular arrhythmias induced • Normal AV node and His-Purkinje function ...
Reducing risk in heart disease
Reducing risk in heart disease

... ‘expert opinion’, based on independent review of the available evidence. Interpretation of this document by those without appropriate medical and/or clinical training is not recommended, other than at the request of, or in consultation with, a relevant health professional. While care has been taken ...
Organ preservation with the organ care system
Organ preservation with the organ care system

... 2002 to 2009 donor age increased significantly up to 33 years, whereas between 1992 and 2001 the corresponding value was 31 years. Additionally, donors in Europe are more than 6 years older on average compared to those in North America (1). In this context Russo et al. demonstrated that the effect o ...
outline
outline

... 2. effective refractory period, the period of time during which no propagated action potentials can be elicited regardless of stimulus strength. 3. relative refractory period (RRP) the period of time in which a response can be elicited but the stimulus required is larger than normal and the amplitud ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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