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L3-IHD,angina, MI 2..
L3-IHD,angina, MI 2..

... myocardial infarction. C. Massive plaque rupture with superimposed thrombus, also triggering a fatal myocardial infarction (special stain highlighting ...
Interaction between cardiac sympathetic drive and heart rate in heart
Interaction between cardiac sympathetic drive and heart rate in heart

... deletion polymorphism according to previously published methods (11,13–15). In brief, for the determination of the ␤1-adrenoceptor genotype at position 49 a 794-bp fragment (positions 1–794) of the ␤1-adrenoceptor gene was amplified by PCR using the following primers: 5=-ATG GGC GGG GTG GTC-3= (sens ...
CorePace Module 9 - Pacemaker Troubleshooting
CorePace Module 9 - Pacemaker Troubleshooting

... Implantable Pulse Generators (IPGs) are indicated for rate adaptive pacing in patients who ay benefit from increased pacing rates concurrent with increases in activity and increases in activity and/or minute ventilation. Pacemakers are also indicated for dual chamber and atrial tracking modes in pat ...
Assessment of Early Post-Infarction Pericardial Injury by CMR
Assessment of Early Post-Infarction Pericardial Injury by CMR

... (Figs. 1 and 2). Pericardial effusion (width 8 ⫾ 3 mm; range 5 to 18 mm) was observed in 44 patients, infarct located (n ⫽ 7), at distance (n ⫽ 8), or diffuse (n ⫽ 29). Twelve patients had concomitant pericardial enhancement. Patients with pericardial injury had higher levels of cardiac biomarkers, ...
Multidimensional Rhythm Disturbances as a Precursor of Sustained
Multidimensional Rhythm Disturbances as a Precursor of Sustained

... the onset of impending VTA, and their dimensionality, defined as the number of unstable orthogonal projections, increased gradually several hours before the onset. MKLT provided greater sensitivity and specificity (70% and 93%) compared with the best traditional method (68% and 67%, respectively). W ...
BRS Physiology
BRS Physiology

... 4. The answer is B [III A]. The absent P wave indicates that the atrium is not depolarizing and, therefore, the pacemaker cannot be in the sinoatrial (SA) node. Because the QRS and T waves are normal, depolarization and repolarization of the ventricle must be proceeding in the normal sequence. This ...
Low-Dose Aspirin for Prevention of Stroke in Low
Low-Dose Aspirin for Prevention of Stroke in Low

... was blocked from previewing by the investigators and the attending physician. The dose of aspirin was selected by the attending physician and also depending on the aspirin formulation available at each hospital. Patients were instructed to take aspirin every morning after breakfast. Treatment with 3 ...
File - Sewell`s Science Site
File - Sewell`s Science Site

... QRS complex represents the depolarization of the ventricles. The repolarization of the atria is buried in the QRS complex. The width of the QRS complex often indicates the location of the originating electrical impulse. Q wave is the first negative deflection of the QRS complex. A normal Q is narrow ...
Detection of Hypokinesis by Quantitative
Detection of Hypokinesis by Quantitative

... coronary artery obstruction in the 16 patients with coronary heart disease. In the first five patients use of the quantitative method resulted in the addition of one or more hypokinetic segments on the inferior wall. In patient 6 an area on the antero-lateral wall previously thought to be hypokineti ...
Clinical Spectrum of Acute or New
Clinical Spectrum of Acute or New

... hyperthyroidism have also been found to have an increased risk of developing AF.37 In one populationbased study of 40,628 patients with clinical hyperthyroidism, 8.3 percent had atrial fibrillation or flutter. 38 Once again age was an important factor, with AF being present in 10 to 20 percent of pa ...
Serum Cortisol as a Useful Predictor of Cardiac Events in Patients
Serum Cortisol as a Useful Predictor of Cardiac Events in Patients

... to that of aldosterone (ALD), may be influenced by oxidative stress in patients with chronic heart failure. We evaluated cardiac event prediction using cortisol levels in chronic heart failure, in comparison with ALD, adrenocorticotropic hormone, and brain natriuretic peptide (BNP), and the impact o ...
PDF - Medical Journal of Australia
PDF - Medical Journal of Australia

... mortality or thromboembolism with rhythm control, but these studies have frequently included older people with structural heart disease, in whom the success of rhythm control has been poor.22-27 A recent meta-analysis showed no significant difference between rate and rhythm control for all-cause mor ...
The decrease of cardiac chamber volumes and output during
The decrease of cardiac chamber volumes and output during

... area ⫻ slice thickness) were automatically summed to obtain ventricular and atrial volumes, respectively. The tricuspid and mitral valve planes were defined according to methods described by Prakken et al. and others (Fig. 1) (14, 27, 31). Ejection fractions were taken as the stroke volume divided b ...
Assessment of diastolic dysfunction and heart failure with integrated
Assessment of diastolic dysfunction and heart failure with integrated

... Diastolic dysfunction and diastolic heart failure In population based studies the prevalence of heart failure is 2-3%, but in the elderly it can reach the 20%, out of whom approximately 50% have diastolic heart failure with a similar prognosis (DHF). Similar studies have shown that the prevalence of ...
Sodium Channel Mutations and Susceptibility to Heart Failure and
Sodium Channel Mutations and Susceptibility to Heart Failure and

... study provided written informed consent under protocols approved by the LDS Hospital and/or Mayo Clinic institutional review board. Medical records and electrocardiograms and echocardiography reports were reviewed. Although some testing of certain family members had been previously performed for cli ...
AV Conduction Defects/AV Blocks
AV Conduction Defects/AV Blocks

... Constant (fixed) for conducted beats May be normal or greater than 0.20 seconds. ...
in Elderly People
in Elderly People

... absolute and percentage increase in HR. This would suggest that increased vagal tone13 was an important factor in the slow heart rates in the bradyeardic subjects. It is possible that had the exercise stress been greater the bradycardic subjects would have achieved heart rates similar to the control ...
Radiofrequency ablation of premature ventricular contractions
Radiofrequency ablation of premature ventricular contractions

... discern because of their anatomic vicinity, in particular if arising from the right ventricular outflow tract, aortic sinus cusps, and aortomitral continuity (AMC).1–3 A new approach to accurately diagnose ventricular arrhythmias based on noninvasive electrocardiographic imaging was recently introduc ...
Regional differences in the Diameter of coronary Sinus among Black
Regional differences in the Diameter of coronary Sinus among Black

... Materials and Methods: Coronary sinuses of 74 cadaveric hearts from black adult Kenyans (43 males and 31 females) were examined at Department of Human Anatomy, University of Nairobi, Kenya. Samples were classified into male and female and weighed. The coronary sinus was identified and cleaned to exp ...
PDF Article
PDF Article

... BYPASS GRAFTING IN LEFT VENTRICULAR DYSFUNCTION ...
Sudden cardiac death: role of heart rate
Sudden cardiac death: role of heart rate

... variability in predicting arrhythmic deaths [9,17,19,22– 29]. Information obtained by this type of studies may have practical importance, but the study designs are also confounded by some biases, which prevent generalisation of the results. A major limitation is the problem of defining the occurrenc ...
The Nanostim™ Leadless Pacemaker
The Nanostim™ Leadless Pacemaker

... For most people, the procedure is done under local anesthetic. You will be given some medicine to calm you and numbing medicine for your upper leg. The actual procedure will take about one hour, and in some cases less time. When it is over, you will have a special closing bandage on your groin, and ...
Hemodynamic Response: Decrease in Cardiac Output vs Reduction
Hemodynamic Response: Decrease in Cardiac Output vs Reduction

... would be restoration of a normal circulatory system. In most patients with mild to moderate essential hypertension considered to need drug therapy, the cardinal hemodynamic disturbance is an increased total peripheral resistance (TPR) and a normal or reduced cardiac output (CO). During a 10- to 17ye ...
In this Issue
In this Issue

... are of low intensity (focal grade I or II/VI). Murmurs not fitting this profile are more likely to be representative of a congenital heart defect or other cardiovascular pathology. While heart murmurs fitting this profile are more likely to be representative of a functional murmur, an equivocal or m ...
Diagnosis and Management of Chronic Heart Failure in the Adult
Diagnosis and Management of Chronic Heart Failure in the Adult

... The American College of Cardiology (ACC) and the American Heart Association (AHA) first published guidelines for the evaluation and management of HF in 1995 and published revised guidelines in 2001. Since that time, a great deal of progress has been made in the development of both pharmacological a ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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