Epinephrine infusion in the evaluation of unexplained cardiac arrest
... Fraction Registry (CASPER) registry have previously been reported.5 Briefly, CASPER is a national registry in 11 centers that examines phenotype-genotype correlation and assesses test performance in familial sudden death and UCA. Cardiac arrest patients were eligible for enrollment if they had exper ...
... Fraction Registry (CASPER) registry have previously been reported.5 Briefly, CASPER is a national registry in 11 centers that examines phenotype-genotype correlation and assesses test performance in familial sudden death and UCA. Cardiac arrest patients were eligible for enrollment if they had exper ...
Heart-Type Fatty Acid Binding Protein (H
... National Institute of Scientific Investigation, Korea ...
... National Institute of Scientific Investigation, Korea ...
sanger - Carolinas HealthCare System
... stent. This trial is designed to examine whether a drug-eluting stent absorbed by the body over one to two years will result in less long-term inflammatory risk than a stainless steel stent. Sanger is also involved in the NIH-sponsored EXCEL trial, looking at stenting of the left main coronary arter ...
... stent. This trial is designed to examine whether a drug-eluting stent absorbed by the body over one to two years will result in less long-term inflammatory risk than a stainless steel stent. Sanger is also involved in the NIH-sponsored EXCEL trial, looking at stenting of the left main coronary arter ...
Heart Failure Indicator Review
... • Heart Failure In‐hospital Mortality is different to a post operation complication/mortality indicator as Heart Failure is a chronic disease. Death may be due to issues other than Heart Failure e.g. pneumonia • In terms of indicator definition criteria, this indicator lacks o Responsive pote ...
... • Heart Failure In‐hospital Mortality is different to a post operation complication/mortality indicator as Heart Failure is a chronic disease. Death may be due to issues other than Heart Failure e.g. pneumonia • In terms of indicator definition criteria, this indicator lacks o Responsive pote ...
Rheumatic heart disease (RHD)
... Pathophysiology : Blood cannot flow freely from the left atrium to the left ventricle during diastole -- left atrial pressure as well as volume increases --- increase in pressure and volume occurs in the pulmonary veins and capillaries --- when the pulmonary venous pressure exceeds the plasma ...
... Pathophysiology : Blood cannot flow freely from the left atrium to the left ventricle during diastole -- left atrial pressure as well as volume increases --- increase in pressure and volume occurs in the pulmonary veins and capillaries --- when the pulmonary venous pressure exceeds the plasma ...
Right ventricular dilated cardiomyopathy - Heart
... dilatation and a low ejection fraction. In most patients the left ventricle is the more severely affected, and pathological abnormalities usually also predominate in the left heart.2 We report fourteen cases of severe right ventricular dilatation of unknown cause, in which there was preservation of ...
... dilatation and a low ejection fraction. In most patients the left ventricle is the more severely affected, and pathological abnormalities usually also predominate in the left heart.2 We report fourteen cases of severe right ventricular dilatation of unknown cause, in which there was preservation of ...
Slide ()
... Comparison of the continuous murmur and the to-fro murmur. During abnormal communication between high-pressure and low-pressure systems, a large pressure gradient exists throughout the cardiac cycle, producing a continuous murmur. A classic example is patent ductus arteriosus. At times, this type of ...
... Comparison of the continuous murmur and the to-fro murmur. During abnormal communication between high-pressure and low-pressure systems, a large pressure gradient exists throughout the cardiac cycle, producing a continuous murmur. A classic example is patent ductus arteriosus. At times, this type of ...
Cardiac arrhythmias in acute coronary syndromes
... Figure 1. Scheme of drivers for arrhythmias in acute coronary syndromes.Apre-existing substrate for ventricular arrhythmias, either secondary to an old myocardial infarction, due to a cardiomyopathy, or secondary to a genetic predisposition to ventricular arrhythmias, interacts with acute ischaemia, ...
... Figure 1. Scheme of drivers for arrhythmias in acute coronary syndromes.Apre-existing substrate for ventricular arrhythmias, either secondary to an old myocardial infarction, due to a cardiomyopathy, or secondary to a genetic predisposition to ventricular arrhythmias, interacts with acute ischaemia, ...
An early invasive strategy versus ischemia-guided
... Despite the lack of guideline support for an early invasive strategy, there is significant enthusiasm to perform early cardiac catheterization after STEMI. In fact, observational data from the United States have shown that nearly 80% of STEMI patients who were treated with fibrinolytic therapy under ...
... Despite the lack of guideline support for an early invasive strategy, there is significant enthusiasm to perform early cardiac catheterization after STEMI. In fact, observational data from the United States have shown that nearly 80% of STEMI patients who were treated with fibrinolytic therapy under ...
Clinic
... subaortic stenosis. Essential of diagnosis: - systolic ejection murmur at upper right sternal border, - thrill in carotid arteries, - systolic clic at the apex, - dilatation of the ascending aorta on chest X-ray, left ventricular hypertrophy on ECG Clinic: Most patients may be asymptomatic until the ...
... subaortic stenosis. Essential of diagnosis: - systolic ejection murmur at upper right sternal border, - thrill in carotid arteries, - systolic clic at the apex, - dilatation of the ascending aorta on chest X-ray, left ventricular hypertrophy on ECG Clinic: Most patients may be asymptomatic until the ...
Reduced Myocardial Flow in Heart Failure Patients With Preserved
... patients with HFpEF and controls (Figure I in the Data Supplement). At the first level, subjects undergoing clinically indicated PET who had data available for quantification of MFR, with ejection fraction ≥50% and summed stress score <4 (suggestive of low likelihood of obstructive epicardial CAD)11 ...
... patients with HFpEF and controls (Figure I in the Data Supplement). At the first level, subjects undergoing clinically indicated PET who had data available for quantification of MFR, with ejection fraction ≥50% and summed stress score <4 (suggestive of low likelihood of obstructive epicardial CAD)11 ...
Journal of Molecular and Cellular Cardiology
... Among the most abundantly expressed microRNAs in the heart is miR-1. In vertebrates, members of the miR-1 (miR-1-1, miR1-2, miR206) and miR-133 (miR-133a-1, miR-133a-2, miR-133b) families are co-transcribed from the same bi-cistronic transcripts. MiR-1-1/miR133a-2 are clustered in an intergenic regi ...
... Among the most abundantly expressed microRNAs in the heart is miR-1. In vertebrates, members of the miR-1 (miR-1-1, miR1-2, miR206) and miR-133 (miR-133a-1, miR-133a-2, miR-133b) families are co-transcribed from the same bi-cistronic transcripts. MiR-1-1/miR133a-2 are clustered in an intergenic regi ...
Public Health Service DEPARTMENT OF HEALTH & HUMAN SERVICES
... and unexpected death (due to cessation of cardiac function) within a short time period, typically < to one hour." More than 90% of SCD's occur in patients with known or previously unrecognized preexisting coronary heart disease or cardiomyopathies .'9 It is often the first manifestation of coronary ...
... and unexpected death (due to cessation of cardiac function) within a short time period, typically < to one hour." More than 90% of SCD's occur in patients with known or previously unrecognized preexisting coronary heart disease or cardiomyopathies .'9 It is often the first manifestation of coronary ...
Canadian Cardiovascular Society Atrial Fibrillation Guidelines 2010
... (composite of cardiovascular death, heart failure hospitalization, stroke, systemic embolism, bleeding, and arrhythmic events) was found, and the lenient strategy rate goal was achieved in a larger proportion of patients, with lower drug doses and fewer combinations of drugs, resulting in far fewer ...
... (composite of cardiovascular death, heart failure hospitalization, stroke, systemic embolism, bleeding, and arrhythmic events) was found, and the lenient strategy rate goal was achieved in a larger proportion of patients, with lower drug doses and fewer combinations of drugs, resulting in far fewer ...
- Reviews in Clinical Medicine
... Ischemia occurs when an organ is deprived of blood flow, resulting in inadequate oxygen and nutrient supply (1). Ischemia has been implicated in the pathology of peripheral vascular insufficiency (1), angina, myocardial infarction and stroke (2). Ischemic preconditioning (with brief intermittent per ...
... Ischemia occurs when an organ is deprived of blood flow, resulting in inadequate oxygen and nutrient supply (1). Ischemia has been implicated in the pathology of peripheral vascular insufficiency (1), angina, myocardial infarction and stroke (2). Ischemic preconditioning (with brief intermittent per ...
20-1 HISTOLOGY Cardiac Muscle FIGURE 20.12 1. Comparison to
... D. Cardiac muscle cells are smaller in diameter, shorter, and branched compared to skeletal muscle. Cardiac muscle cells are also connected to each other by intercalated disks (a type of gap junction). 1) The intercalated disks have very low electrical resistance and action potentials readily pass f ...
... D. Cardiac muscle cells are smaller in diameter, shorter, and branched compared to skeletal muscle. Cardiac muscle cells are also connected to each other by intercalated disks (a type of gap junction). 1) The intercalated disks have very low electrical resistance and action potentials readily pass f ...
unrelated patients with de novo translocation
... and Crandall5 concluded that 8q2 partial trisomy is sufficient to cause the Warkany syndrome. Rethore et al,6 Townes and White,7 Fujimoto et al,8 and Fineman et al4 were also of the opinion that trisomy 8q2 is at least partially responsible for the Warkany syndrome. The only author to disagree was S ...
... and Crandall5 concluded that 8q2 partial trisomy is sufficient to cause the Warkany syndrome. Rethore et al,6 Townes and White,7 Fujimoto et al,8 and Fineman et al4 were also of the opinion that trisomy 8q2 is at least partially responsible for the Warkany syndrome. The only author to disagree was S ...
cardiac protocol manual 04_09_04
... Krebs Henseleit bicarbonate buffer via a constant head device placed on top of the perfusion setup to allow for flow of perfusate. The constant head device consists of a 2-Liter Boston or other suitable bottle, and a two-holed rubber stopper with metal tubing. The stopper should be placed tightly in ...
... Krebs Henseleit bicarbonate buffer via a constant head device placed on top of the perfusion setup to allow for flow of perfusate. The constant head device consists of a 2-Liter Boston or other suitable bottle, and a two-holed rubber stopper with metal tubing. The stopper should be placed tightly in ...
MODULATION OF OUTPUT FROM AN ISOLATED GASTROPOD
... clearly affected by ACh between of 10~8 and 5 X 10~8 mol I"1 (Fig. 4). The effect was progressive, with increased concentrations causing an increased slowing of the prepotential and an increased prolongation of the plateau. The spike became less obvious as concentration increased and the plateau amp ...
... clearly affected by ACh between of 10~8 and 5 X 10~8 mol I"1 (Fig. 4). The effect was progressive, with increased concentrations causing an increased slowing of the prepotential and an increased prolongation of the plateau. The spike became less obvious as concentration increased and the plateau amp ...
High-pressure balloon angioplasty of coronary sinus vein
... high-pressure inflation without complication. Other authors have reported the use of cutting balloon angioplasty to facilitate the placement of coronary sinus lead.2 Interventions to the coronary sinus have been reported to improve the shortterm implant success and long-term stability of the coronary ...
... high-pressure inflation without complication. Other authors have reported the use of cutting balloon angioplasty to facilitate the placement of coronary sinus lead.2 Interventions to the coronary sinus have been reported to improve the shortterm implant success and long-term stability of the coronary ...
Position Statement - Heart and Stroke Foundation
... • Almost 80 percent of all cardiac arrests occur in homes and public places, and 35 to 55% are witnessed by a family member, co-worker or friend.5 • Unfortunately, the majority of people witnessing cardiac arrest do not perform CPR. 3,4 • Knowing how to respond to a cardiac arrest can increase th ...
... • Almost 80 percent of all cardiac arrests occur in homes and public places, and 35 to 55% are witnessed by a family member, co-worker or friend.5 • Unfortunately, the majority of people witnessing cardiac arrest do not perform CPR. 3,4 • Knowing how to respond to a cardiac arrest can increase th ...
Impact of atrial fibrillation on long-term survival after cardiac valve
... higher mortality (hazard ratio [HR] 1.02 [95% CI 1.01 to 1.04]; P=0.033) while sex, hypertension, type of valve surgery, preoperative medication use, postoperative cerebrovascular events, CABG and pulmonary vein isolation surgery were not associated with long-term mortality (Figure 3). Diabetes, chr ...
... higher mortality (hazard ratio [HR] 1.02 [95% CI 1.01 to 1.04]; P=0.033) while sex, hypertension, type of valve surgery, preoperative medication use, postoperative cerebrovascular events, CABG and pulmonary vein isolation surgery were not associated with long-term mortality (Figure 3). Diabetes, chr ...
Full Article (PDF file)
... GERD, it may present with a wide spectrum of manifestations mimicking those of cardiovascular pathology such as postprandial syncope, angina-like chest pain, recurrent dyspnea and acute heart failure due to HH induced cardiac compression [11-13]. Further, HH may simulate the appearance of an intra-a ...
... GERD, it may present with a wide spectrum of manifestations mimicking those of cardiovascular pathology such as postprandial syncope, angina-like chest pain, recurrent dyspnea and acute heart failure due to HH induced cardiac compression [11-13]. Further, HH may simulate the appearance of an intra-a ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.