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French Society of Cardiology guidelines for cardiac rehabilitation in
French Society of Cardiology guidelines for cardiac rehabilitation in

... intertwined mechanisms: reduction of systemic inflammation, sometimes subclinical, associated with these chronic ...
Strangulation of the heart following intrapericardial
Strangulation of the heart following intrapericardial

PDF - Nexus Academic Publishers
PDF - Nexus Academic Publishers

... progressive increase in R wave amplitude between 1–30 days after birth. Although there exist studies in the literature that have investigated the effects of computerized versus conventional electrocardiographic method (Camacho et al., 2010), different body positions (Harvey et al 2005), and standard ...
Anticoagulation Therapy for Prosthetic Valves
Anticoagulation Therapy for Prosthetic Valves

... anticoagulation therapy has been reported to be as high as 50% in different studies35,36. Anticoagulation may reduce this risk to less than 10%, although such therapy may be associated with a 14% risk of cerebral hemorrhage. Heparin is preferred in such cases which can be withdrawn if necessary. ANT ...
Left Ventricular Failure
Left Ventricular Failure

... Marvin's pulmonary capillary wedge pressure was increased because his left atrial pressure was increased. His left atrial pressure was increased secondary to decreased left ventricular stroke volume and ejection fraction. Following ejection, more blood than normal remained behind in the left ventric ...
Diastolic Heart Failure Demystified - CHEST Journal
Diastolic Heart Failure Demystified - CHEST Journal

... The mystery of diastolic heart failure (DHF), described by authorities as a “puzzle” and a “clinical paradox,” stems from the following misperception: (1) that the normal ejection fraction implies normal cardiac output (CO), (2) that therefore low CO is not operative (it is rarely mentioned in relat ...
Baroreflex modulation of ventricular rhythm in atrial fibrillation
Baroreflex modulation of ventricular rhythm in atrial fibrillation

... the stimulus intensity was 3 or 2 V, depending on the pulse width (the intensity was estimated from calibration in vitra , the in vivo voltage was imprecisely known due to the nature of the device[91). The stimulation device was activated 16 times for periods of90 s. Two min elapsed between stimulat ...
Total Anomalous Pulmonary Venous Connection in Children
Total Anomalous Pulmonary Venous Connection in Children

... malformations, clinical manifestations, and postoperative evolution. Materials and methods: Twenty-four patients with a mean age of 125 days, admitted to the Clinic of Pediatric Cardiology III between January 1, 2009 and December 31, 2015 and diagnosed with TAPVC were included in the study. The pati ...
In Mildly Symptomatic Patients, Should an Invasive Strategy with
In Mildly Symptomatic Patients, Should an Invasive Strategy with

Mechanisms for increasing stroke volume during static exercise with
Mechanisms for increasing stroke volume during static exercise with

... rapid resting HR found in most of the subjects. Individuals with dual-chamber (right atrium and right ventricle) sensing and pacing mode but normal contractile function provide a more adequate model for study of the physiology of these circulatory mechanisms because HR can be controlled and left ven ...
incidence, risk factors and outcome
incidence, risk factors and outcome

... patient age, duration of CPB and ACC, electrolyte disturbances, use of inotropes and type of surgery [2,5,13—15]. Many of the earlier studies differ in their setup and thus cannot always be compared with each other. In our study, JET patients had longer CPB time, higher body temperature at the onset ...
Cardiovascular System: The Heart B
Cardiovascular System: The Heart B

... (c) Second-degree heart block. (d) Ventricular fibrillation. These chaotic, grossly irregular ECG Some P waves are not conducted deflections are seen in acute through the AV node; hence more heart attack and electrical shock. P than QRS waves are seen. In this tracing, the ratio of P waves to QRS wa ...
Frequency of spontaneous and inducible atrioventricular nodal
Frequency of spontaneous and inducible atrioventricular nodal

... during isoproterenol infusion (Fig. 4). One may suspect that this patient had outflow tract VT due to c-AMP-mediated triggered activity that could be induced by rapid heart rhythm resulting from AVNRT in the presence of adrenergic stimulation. Kautzner et al.10 reported 3 patients with a similar mod ...
Circulation: Heart Failure Topic Review
Circulation: Heart Failure Topic Review

... Summary: Molecular research in heart failure points to the hypothesis that a generic cardiac genomic response is activated in the failing myocardium regardless of the original inciting cause. This cardiac genomic stress response is typified by the reexpression of fetal genes, upregulation of fibrosi ...
Swan-Ganz RN ICU
Swan-Ganz RN ICU

... 1. Preload must be Optimized PRIOR to Afterload Reduction 2. A Low Arterial Pressure may preclude SVR Manipulation 3. RV Afterload = PVR * only a massive change in PVR can induce primary heart dysfunction !! * the vast majority of RV Failure is Secondary to LVF and usually responds to measures direc ...
Dysrhythmia Recognition lecture
Dysrhythmia Recognition lecture

... P wave upright, PR interval longer than 0.20 seconds QRS usually normal Misc. data: o Most frequently associated with coronary artery disease, digitalis administration and all types of acute myocardial infarction Second Degree AV Block Mobitz Type I – Wenckebach Progressive prolongation of the PR in ...
Understanding Atrial Fibrillation/ Atrial Flutter (AF/AFL)
Understanding Atrial Fibrillation/ Atrial Flutter (AF/AFL)

... In hemodynamic studies, TIKOSYN had no effect on cardiac output, cardiac index, stroke volume index, or systemic vascular resistance in patients with ventricular tachycardia, mild to moderate congestive heart failure or angina, and either normal or low left ventricular ejection fraction. There was n ...
The Word on Heart Murmurs
The Word on Heart Murmurs

... heartbeat making a sound that goes something like lub-dub. If she hears an additional noise, such as a slight whistling or whooshing, this is a heart murmur. Innocent Murmurs Heart murmurs can stem from a number of causes. Usually, they are harmless. The technical term for a heart murmur that does n ...
Evaluation and Management of Patients with Acute Decompensated
Evaluation and Management of Patients with Acute Decompensated

... care units in the BNP aided group compared with those evaluated by standard clinical evaluation alone. The median time to discharge was 8 days in the group with BNP measured versus 11 days in the control group (P 5 .001). Although the data on outcomes from this study are not definitive and the hospi ...
an account of a seven year experience with
an account of a seven year experience with

... The results of the ARREST (Resuscitation of Refractory Sustained Ventricular Tachyarrhythmias) trial prove amiodarone to be the antiarrhythmic of choice for ventricular fibrillation /pulseless ventricular tachycardia (10). Data on amiodarone support the use of these drugs in out-of-hospital resuscit ...
11/4/16 - ERS 4 KIDS
11/4/16 - ERS 4 KIDS

... to” when his teammates roused him. No previous episodes of fainting. Mom reports that her brother (Holtz’s uncle) died of drowning when he was a teenager.  Are you concerned about Jack? Why or why not?  Yes. Red flags: Syncope with exertion, family history of possible sudden cardiac death – both c ...
Left ventricular aneurysms: early and long-term results of
Left ventricular aneurysms: early and long-term results of

... the angiographic appearance (paradoxical motion), and confirmed intraoperatively. The indication for surgery in patients with normal or moderately impaired LV function and low functional NYHA class was based on their coronary artery disease and angina class. In these cases, LV scars that clearly con ...
Management of Patients with Atrial Fibrillation: Focus on
Management of Patients with Atrial Fibrillation: Focus on

... devices functions were shown to have significant impact on the course of AF and clinical management of patients with AF. CIED play important role both in the diagnosis and treatment of atrial fibrillation. Incidence of pacemaker-detected AF may reach 50% and its burden is associated with increased s ...
Myocardial Perfusion SPECT: Current Concepts
Myocardial Perfusion SPECT: Current Concepts

... > the rate of cardiac events in persons with a pathological (high-risk) MPS increases with increasing severity of CAD; > the frequency of cardiac events in persons with a normal (low-risk) MPS is nearly always below 2% per year, regardless of the stage of CAD that is present, i.e., even in patients ...
Heart Failure Indicator Review
Heart Failure Indicator Review

... • Heart Failure In‐hospital Mortality is different to a post operation complication/mortality  indicator as Heart Failure is a chronic disease.  Death may be due to issues other than Heart  Failure e.g. pneumonia   • In terms of indicator definition criteria, this indicator lacks   o Responsive pote ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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