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CARDIAC DYSRHYTHMIAS Pathophysiology
CARDIAC DYSRHYTHMIAS Pathophysiology

... Knowledge of hemodynamic parameters in the heart is important to understanding disease processes, interventions, and drug treatments. Hemodynamics is the movement of the blood and the forces involved. To understand this concept, you need to know about preload, afterload, and cardiac output. These co ...
Full Text
Full Text

... Carpentier et al. (29) made the major contribution of suggesting quadrangular resection of redundant posterior leaflet segments (Fig. 1B). By undermining the remaining posterior leaflet segments, more than one-half of the posterior leaflet can be resected. This “sliding leaflet plasty” reduces the h ...
Poor R-Wave Progression
Poor R-Wave Progression

... analysis, the prevalence of coronary artery disease in an asymptomatic 46-year-old female insurance applicant with no risk factors is approximately 1%.8 Therefore, the likelihood, that such an individual’s ECG actually represents an old myocardial infarction is very low. What other possibilities cou ...
Electrocardiographic Early Repolarization A Scientific Statement
Electrocardiographic Early Repolarization A Scientific Statement

... contiguous inferior or lateral leads. The authors recognize that ERP could refer to ST-segment elevation. However, the consensus document focuses on J-point elevation without a precise definition. The authors most likely refer to the J point as the top of the QRS slurs or notches described by Haïssa ...
Electrophysiological Effects of MS
Electrophysiological Effects of MS

... model at slow and fast heart rates. Yamada et al. (1996) compared the reverse frequency-dependent prolongation of effective refractory period of sinoatrial node, papillary muscle and atrioventricular node induced by MS-551, sematilide and E-4031. There is no report on comparison of simple antiarrhyt ...
Emergencies related to implantable cardioverter
Emergencies related to implantable cardioverter

... first-shock energy based on intraoperative testing results in a very high rate of successful conversion of spontaneous arrhythmias (11). If the first shock fails, the device delivers “back-up” shocks. ICD interventions can at times induce or aggravate ventricular arrhythmias (12). In contrast to its ...
Na/K pump regulation of cardiac repolarization
Na/K pump regulation of cardiac repolarization

... and atrial tissues [9, 52, 57, 58, 59, 66]. Figures 4-6 describe some of the main results of these studies. Mathematical models of the Na/K pump have allowed dissecting multiscale mechanisms underlying smilingly counterintuitive results. Under the effects of most cardiac glycosides, Na/K current blo ...
Ventricular stroke work and efficiency both remain nearly optimal
Ventricular stroke work and efficiency both remain nearly optimal

... runs were obtained from the 10 hearts. Data sufficient to define optimal coupling for both SW and efficiency were obtained in 26 (80%) of the afterload runs. Failure in the remaining five was due to inadequate data collection at low coupling ranges (10.5) stemming from limitations in volume servo sy ...
The Anatomical Substrates of Wolff-Parkinson-White
The Anatomical Substrates of Wolff-Parkinson-White

... Patient 2. A 19-year-old man was first seen because of syncopal attacks. The site of the anticipated accessory atrioventricular connection was predicted to be left sided and posterior, close to the crux of the heart (fig. 2). The patient died suddenly at home. There were no abnormal findings during ...
pathology of inflammatory native valvular heart disease
pathology of inflammatory native valvular heart disease

... in children and adolescents and an important cause of death from cardiac disease in young people in developing countries. In India there are an estimated one million new cases of rheumatic fever each year. It has been estimated that rheumatic fever related disease is responsible for 30 to 40 % of ca ...
Patterns of muscular strain in the embryonic heart wall
Patterns of muscular strain in the embryonic heart wall

... cardiac cycle were assessed in beating hearts by 2D echocardiography as shown in Figure 6. Measures of apical wall thickness at systole and diastole demonstrated significant increases during diastole of 8 –13.9% at HH stages 20 –24. Care was taken in imaging in the mid-sagittal plane free of encroach ...
Bradycardia-dependent triggered activity: relevance
Bradycardia-dependent triggered activity: relevance

... repolarization. Cesium is known to depress normal ventricular automaticity and some experimental arrhythmias by blocking delayed outward currents and prolonging action potential duration. In 10 dogs in normal sinus rhythm, 1 to 1.5 mM/kg iv CsCl prolonged the QT (QU) interval and induced ventricular ...
15.0 Hours Cardiac Dysrhythmias and Therapeutic Modalities
15.0 Hours Cardiac Dysrhythmias and Therapeutic Modalities

... Knowledge of hemodynamic parameters in the heart is important to understanding disease processes, interventions, and drug treatments. Hemodynamics is the movement of the blood and the forces involved. To understand this concept, you need to know about preload, afterload, and cardiac output. These co ...
Tei Index - Hellenic Journal of Cardiology
Tei Index - Hellenic Journal of Cardiology

... cardiac events.50 The Tei index distinguishes patients with MI and cardiac death or heart failure from those without these adverse end-points,37 even among patients treated with angioplasty.56 The index of the RV, even independently of signs of MI, predicts future cardiac death or recurrent hospital ...
AHA Scientific Statement
AHA Scientific Statement

... the elevation of the ST segment, and concomitant electrocardiographic findings such as J-wave augmentation or short coupled premature ventricular contractions.9,10 Currently, the term ER is used to refer to nonspecific ST-segment elevation in algorithms used in commercial ECG machines.11,12 The 2009 ...
T The Basics of Neonatal EKG Interpretation C
T The Basics of Neonatal EKG Interpretation C

... slower, and more unreIiabIe than higher pacemaker sites, however.’ The depolarization of the ventricles is represented as the QRS complex on the EKG (Figure 5). The first downward deflection of the QRS complex is called the Q wave. It is produced primarily by depolarization of the ventricular septum ...
SAED Guide revised Jan 2008 - Grampians Region Health
SAED Guide revised Jan 2008 - Grampians Region Health

... The two shockable rhythms, which the AED will recognise, are VT and VF. The AED reads the ECG from the pads applied to the chest. Some AEDs have screens that show the rhythms, some do not. The AED identifies the heart rhythms. The operator does not need to be able to identify the hearts rhythm or wh ...
Cardiac Hypertrophy-Related Pathways in Obesity
Cardiac Hypertrophy-Related Pathways in Obesity

... the transition from a hypertrophic to a dilated cardiac phenotype and adverse cardiac remodeling (11). However, the roles of cardiac TNFα in obese animals and humans are still unclear. Cardiac hypertrophy, in which chamber volume enlarges without a relative increase, or even with a relative decrease ...
030814 Acute Cardiac Tamponade - Ether
030814 Acute Cardiac Tamponade - Ether

... becomes limited, ultimately equalizing mean diastolic pericardial and chamber pressures.1-3 Key elements are the rate of fluid accumulation relative to pericardial stretch and the effectiveness of compensatory mechanisms. Thus, intrapericardial hemorrhage from wounds or cardiac rupture occurs in the ...
Noninvasive reconstruction of cardiac electrical activity: update on
Noninvasive reconstruction of cardiac electrical activity: update on

... of CRT non-responders, as it has been shown that noninvasive reconstruction of local activation timing predicts clinical CRT response better than QRS duration or the presence of left bundle branch block (LBBB) [36, 37, 47, 48]. Despite the low voltage amplitudes, AF has also been characterised by no ...
Mitral Valve Surgery - HeartValveSurgery.com
Mitral Valve Surgery - HeartValveSurgery.com

... If you need to do a replacement, that’s, of course, another very interesting discussion about what type of prosthetic valve you would use. You have two main options. One’s a bioprosthetic valve and one’s a mechanical valve. I always caution patients that metal lasts forever, but mechanical valves in ...
Left Atrial Enlargement and Reduced Physical Function During Aging
Left Atrial Enlargement and Reduced Physical Function During Aging

... S. Michal Jazwinski, and David A. Welsh Diastolic dysfunction, often seen with increasing age, is associated with reduced exercise capacity and increased mortality. Mortality rates in older individuals are linked to the development of disability, which may be preceded by functional limitations. The ...
Advances in Arrhythmia and Electrophysiology
Advances in Arrhythmia and Electrophysiology

... is rarely seen and is more common with smaller animals, with baseball compared with lacrosse ball impacts, and with a higher velocity of impact (unpublished data). Impacts throughout the cardiac cycle may cause ST-segment elevation and left bundle-branch block in those impacts in which ventricular f ...
Value of Apical Circumferential Strain in the Early Post
Value of Apical Circumferential Strain in the Early Post

... morbidity and mortality. The aim of the present study was to examine whether LV deformational and torsional parameters can predict LV remodeling in patients with AMI. Methods: Forty-two patients (age 57 ± 14 years) presenting with an anterior ST-elevation AMI and treated with primary percutaneous tr ...
How to Use Imaging - Circulation: Cardiovascular Imaging
How to Use Imaging - Circulation: Cardiovascular Imaging

... Coronary CTA results in more precise imaging (Figure 2) than does MRA, but the need for ionizing radiation and intravenous contrast agents makes this technique unacceptable for primary screening, especially of children. If doubt about the presence of an important CAA should arise on clinical grounds ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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