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2008 Slide Set - American College of Cardiology
2008 Slide Set - American College of Cardiology

... 5. Pacemaker implantation can be beneficial in ACHD patients, but access may be challenging and implantation should be performed at centers where staff is familiar with unusual anatomy of congenital heart defects. ...
ACC/AHA 2008 Guidelines for the Management of Adults With
ACC/AHA 2008 Guidelines for the Management of Adults With

... 5. Pacemaker implantation can be beneficial in ACHD patients, but access may be challenging and implantation should be performed at centers where staff is familiar with unusual anatomy of congenital heart defects. ...
Amy Jane Nayo Coarctation of the Aorta
Amy Jane Nayo Coarctation of the Aorta

... total anomalous pulmonary venous return, transposition of the great vessels, tricuspid atresia and truncus arteriosus. ● Coarctation is a secondary target, however, thus classified due to lower sensitivity. The exact sensitivity of pulse ox screenings using current criteria is not well quantified no ...
AHA Scientific Statement
AHA Scientific Statement

... Structural heart disease is the most common congenital disorder diagnosed in newborns, with birth prevalence reported to be 10 per 1000 live births,7,8 and registry studies have estimated an incidence between 3 and 20 per 1000 live births.9 The incidence of CHD based on birth prevalence may be an un ...
Pulmonary Hypertension in Mitral Regurgitation
Pulmonary Hypertension in Mitral Regurgitation

... pulmonary hypertension are distinctly different from those observed in pulmonary arterial (group 1) hypertension (PAH).19 In addition to the histological changes, significant functional abnormalities in the pulmonary vasculature result from endothelial injury in the setting of PVH. Impairment and imb ...
Posture and Gender Differentially Affect Heart Rate Variability of
Posture and Gender Differentially Affect Heart Rate Variability of

... female (higher RMSSD, nHF and lower nLF vs. male), the sympathetic outflow was higher in MVP female (lower SDNN, NN50 and higher nLF vs. normal female). While the parasympathetic activity was lower in male, sympathetic outflow was dominant in MVP male (lower nHF and higher nLF vs. normal male). Conc ...
3. Cardiac Output
3. Cardiac Output

... in muscle length beyond this limit depresses the muscle developed tension and this is not seen in the normal heart but only 4/18/12 in heart failure ...
Task Force Report Task Force on Sudden Cardiac Death of the
Task Force Report Task Force on Sudden Cardiac Death of the

... who dies from an episode of sustained ventricular tachycardia after having been admitted to the hospital in haemodynamic collapse and subsequent complications. The key concepts that are central in the definition of sudden death are the non-traumatic nature of the event and the fact that sudden death ...
Anomalous Origin of Left Main Coronary Artery from Right Sinus of
Anomalous Origin of Left Main Coronary Artery from Right Sinus of

... LMCA in relation to the aorta and pulmonary trunk en route to the LV [7-11]. 1) the septal course beneath the right ventricular infundibulum, 2) the anterior course, 3) the retro-aortic course, and 4) the interarterial course between aorta and main pulmonary artery. Among all ...
Editorial Review Abnormalities of the coronary circulation
Editorial Review Abnormalities of the coronary circulation

... associated with a sixfold increase in cardiac mortality and a threefold increase in the risk of cardiac failure [2]. The presence of repolarization changes further increases the risk of cardiac failure [4]. Hypertension, the most frequent cause of left ventricular hypertrophy, is associated with an ...
PDF - Journal of Cardiovascular Magnetic Resonance
PDF - Journal of Cardiovascular Magnetic Resonance

... trained athletes. Endurance athletes have reduced ejection fraction, circumferential and longitudinal strain of both the left and right ventricles compared to healthy controls [4–6]. The heart has a complex twisting motion where the base rotates clockwise in early systole and the apex rotates anticl ...
Normal electrocardiographic findings: recognising
Normal electrocardiographic findings: recognising

... during sport.1 2 A resting 12-lead ECG is utilised as a diagnostic tool in the evaluation of both symptomatic and asymptomatic athletes for conditions associated with sudden cardiac death (SCD). The purpose of pre-participation cardiovascular screening is to provide medical clearance for participati ...
Flecainide Therapy Reduces Exercise
Flecainide Therapy Reduces Exercise

... de Cardiologie, Hôpital Lariboisière, Assistance Publique–Hôpitaux de Paris, Université Paris Diderot, INSERM U942, Paris, France; ††Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan; ‡‡Department of Pediatr ...
Atrioventricular Nodal Function in the Immature Canine
Atrioventricular Nodal Function in the Immature Canine

... A B S T R A a . Previous studies have suggested that the atrioventricular nodal functional refractory period in the neonate is equal to or shorter than that of the ventricle, providing little or no protection to the ventricle against rapid atrial rates and allowing closely coupled atrial beats to fa ...
VEGF-C and aortic cardiomyocytes guide coronary artery stem
VEGF-C and aortic cardiomyocytes guide coronary artery stem

... they were very small (1–5 cells) and did not grow extensively in the absence of peritruncal vessels (Supplemental Figure 3B). Taken together, these observations suggest that the environment surrounding the aorta is angiogenic, while the analogous region on the pulmonary artery is not, but that ingro ...
An Improved Method for Echographic Detection of Left
An Improved Method for Echographic Detection of Left

... Ani echographic "sweep' of the left ventricular outflow tract utilizing a continuous strip) chart recorder (record not retoulched). Area A is the central region of the left ventricle (LV) and is characterized by the echoes from the interve ntricuilar septum (IVS), left ventricular posterior wall (LV ...
Frequency of Left Ventricle Diastolic Dysfunction in
Frequency of Left Ventricle Diastolic Dysfunction in

... diastolic dysfunction . Diastolic dysfunction states abnormalities in automatic function during diastole. Defects in diastolic function can be present in the absence of heart failure with or without systolic ...
Left-to-Right Shunt Lesions
Left-to-Right Shunt Lesions

... ventricular level, if large in size results in an increased right ventricular volume load in addition to the hemodynamic effects present with shunting at the great artery level. Prolonged exposure of the pulmonary vasculature to increased flow and pressure results in a fixed increase pulmonary vascu ...


... with syncope include outflow tract obstruction (hypertrophic cardiomyopathy, aortic stenosis, pulmonic stenosis, pulmonary hypertension), coronary artery anomalies, cardiomyopathies, and mitral valve prolapse. The diagnosis can often be made with a thorough history and physical examination performed ...
Aldosterone Receptor Antagonist and Heart Failure Following Acute
Aldosterone Receptor Antagonist and Heart Failure Following Acute

... post-MI animal model. 28 Given the significant role of aldosterone in post-MI pathophysiology, its blockade with agents such as spironolactone or eplerenone beyond ACE inhibition is essential for continued benefit. The endothelium plays an important role in regulating vascular tone, platelet aggrega ...
Current burden of sudden cardiac death: Multiple source
Current burden of sudden cardiac death: Multiple source

... POSTMORTEM EXAMINATION. Detailed information, including results of cardiac pathologic examination and toxicology screen, was obtained in all cases in which an autopsy was conducted. Autopsies were performed at the discretion of the medical examiner or attending physician. Patients with ⬎50% stenosis ...
ACLS-ECG-Slides - UCSF Department of Anesthesia and
ACLS-ECG-Slides - UCSF Department of Anesthesia and

... • Recognize & initiate early management of periarrest conditions that may result in cardiac arrest • Manage cardiac arrest until return of spontaneous circulation, or transfer of care • Understanding of arrhythmia interpretation ...
The second peak of the radial artery pressure wave represents
The second peak of the radial artery pressure wave represents

... and radial pressures would permit recognition of their ®rst and second systolic de¯ections, and con®rmation of the relationship between aortic pressure and the second radial wave.4 Then, it would be seen that the lowering effect of vasodilator treatment on the aortic pressure agreed with that on the ...
Doppler Tissue Imaging for the Assessment of Left Ventricular
Doppler Tissue Imaging for the Assessment of Left Ventricular

... caused in part by pulmonary congestion. If filling pressures are low, this may help explain symptoms of low cardiac output or, in an extreme case, syncope. Therefore, a noninvasive technique that could simply and reliably predict filling pressures would be invaluable not only in diagnosis, but more ...
Strain Rate Imaging in Normal and Reduced Diastolic
Strain Rate Imaging in Normal and Reduced Diastolic

... Figure 1 Motion of the heart throughout the heart cycle as shown by tissue Doppler imaging. A systolic frame from color Doppler imaging with the red color of velocities toward the probe is shown. The digital velocity values from the indicated points of the ventricle have been extracted and are displ ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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