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PDF Article - ScienceDirect
PDF Article - ScienceDirect

... ventricularis. These include the moderator band, the muscle of Lancisi, the papillary muscle of the right ventricle and the so-called septal and parietal bands. A particularly lucid differentiation of these structures (Fig. 8) is available in Walmsley's section describing the heart in Quain's Anatom ...
Recommendations for Cardiac Chamber Quantification by
Recommendations for Cardiac Chamber Quantification by

... most echocardiographic parameters. However, this approach is fundamentally flawed. First, not all echocardiographic parameters are normally distributed (or Gaussian), even in a normal population. Second, even if a particular parameter is normally distributed in normal subjects, most echocardiographi ...
NATIONAL QUALITY FORUM
NATIONAL QUALITY FORUM

... Numerator Statement: Whether or not there is participation in at least one multi-center data collection and feedback program for pediatric and congenital heart surgery. ...
MRI Anatomy and Positioning Series
MRI Anatomy and Positioning Series

... The heart sits within a fluid-filled double-layered sac called the pericardium, which also surrounds the proximal ends of the aorta, vena cava, and pulmonary artery. Functions of the pericardium include keeping the heart contained in the chest cavity, preventing the heart from over expanding when bl ...
PDF - Circulation Research
PDF - Circulation Research

... supplemental oxygen was given or respiratory rate was changed if necessary. In addition, indomethacin (1 mg/kg i.v.) was given to the support rabbits to maintain their mean arterial pressure at more than 60 mm Hg. This dose of indomethacin was effective in improving the support rabbits' arterial pre ...
Sudden Cardiac Death in the Young
Sudden Cardiac Death in the Young

... deaths/100 000 population per year (with exclusion of infants and persons >18 years of age, <1–4 deaths/100 000 population per year). The burden of SCD in terms of lost life-years is disproportionately larger for children because of their greater life expectancy. These statistics are necessary to fo ...
ECG Analysis (Fundamentals) - American Academy of Family
ECG Analysis (Fundamentals) - American Academy of Family

... The material presented here is being made available by the American Academy of Family Physicians for educational purposes only. This material is not intended to represent the only, nor necessarily best, methods or procedures appropriate for the medical situations discussed. Rather, it is intended to ...
Recommendations for Cardiac Chamber Quantification by
Recommendations for Cardiac Chamber Quantification by

... most echocardiographic parameters. However, this approach is fundamentally flawed. First, not all echocardiographic parameters are normally distributed (or Gaussian), even in a normal population. Second, even if a particular parameter is normally distributed in normal subjects, most echocardiographi ...
Segmental Early Relaxation Phenomenon
Segmental Early Relaxation Phenomenon

... Patients: Two hundred forty-four consecutive patients referred for stress echocardiography (exercise or dobutamine) for various clinical indications. Interventions: None. Measurements and results: SERP was diagnosed as a sudden outward motion of a portion of the left ventricle during early diastole ...
Effects of myocardial ischemia on the release of cardiac troponin i in
Effects of myocardial ischemia on the release of cardiac troponin i in

... of reperfusion. Although the analogy of sequences and the preliminary study do not present a certitude, they do lead to a strong presumption that this assay is valid in rats. Cardiac troponin I release and myocardial infarction Cardiac troponin I has been shown to be a reliable marker in myocardial ...
Rapid-response extracorporeal membrane oxygenation to support
Rapid-response extracorporeal membrane oxygenation to support

... cardiac cause of cardiac arrest: myocarditis, early postcardiotomy period, and congenital heart disease, respectively. Recently, most data about E-CPR use are from children with cardiac disease, the majority of them during the early postcardiotomy period, who experienced in-hospital cardiac arrest, ...
syncope
syncope

... syncopal event accompanied by physical injury, motor vehicle accident, or in high risk setting in ...
Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction
Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

... were found to be associated with incident HF or cardiovascular death in community-dwelling older adults without known HF.84 Elevation of troponin and NT-proBNP above the age- and sex-specific 75th percentile of the population identifies a malignant subphenotype of left ventricular hypertrophy (LVH) wi ...
Anterior and posterior left ventricular sarcomere lengths behave
Anterior and posterior left ventricular sarcomere lengths behave

... the anterior and posterior sites. In our experiments, the heart was situated with its long axis approximately horizontal and oriented such that the anterior site faced upward and the posterior site was located at approximately four o’clock. If we were to rotate the left ventricle around its long axi ...
EKG2: dDiagnosis of Cardiac Rhythms
EKG2: dDiagnosis of Cardiac Rhythms

... not functioning normally! D. The axis of T-waves is in the opposite direction of the QRS complexes E. Rate = 20 – 40 bpm ...
In-Hospital Pediatric Cardiac Arrest
In-Hospital Pediatric Cardiac Arrest

... Despite evidence-based guidelines, extensive provider training, and provider credentialing in resuscitation medicine, the quality of CPR typically is poor. Slow compression rates, inadequate depth of compression, and substantial pauses are the norm [30–32]. Moreover, observed ventilation rates durin ...
PACES/HRS Expert Consensus Statement on the Management of
PACES/HRS Expert Consensus Statement on the Management of

... with an abnormal ECG pattern of ventricular preexcitation without symptoms. In response to recently published literature regarding patients with WPW, the Pediatric and Congenital Electrophysiology Society (PACES) in conjunction with the Heart Rhythm Society (HRS) created a writing committee to provi ...
Researches on the struture and function of the mammalian heart.
Researches on the struture and function of the mammalian heart.

... vessels of various sizes. The sheets or bundles composed of such networks are arranged in a complex manner both in auricle and ventricle'. Plain muscular fibres are frequently found under the endocardium and similar fibres are said to spread from the endocardium into the auriculoventricular valves. ...
Plasma Bin1 Correlates With Heart Failure And Predicts
Plasma Bin1 Correlates With Heart Failure And Predicts

... arrhythmias and right and/or left ventricular dysfunction2. Historically, it was originally believed to be the result of a developmental defect in the right ventricular myocardium and was thus originally categorized as a dysplasia3, though these views have since changed. ...
Obstructive Sleep Apnea and its Relationship to Cardiac Arrhythmias
Obstructive Sleep Apnea and its Relationship to Cardiac Arrhythmias

... airway patentcy. Arousals are triggered by the effects of hypoxemia, increased ventilatory effort, and hypercapnia, playing an important role against the consequences of extended apneas. Arousals are associated with high levels of cardiac and respiratory activity and may contribute to the developmen ...
WINFOCUS BASIC ECHO (WBE)
WINFOCUS BASIC ECHO (WBE)

... • Right  atrial  compression  should  occur  before  right  ventricular  compression  when  intrapericardial  pressure  increases,  since  right  atrial  pressure  is  lower  than  right  ventricular  pressure  during  most  of  the  cardiac  c ...
Performance Measures ACC/AHA 2016 Prevention of Sudden
Performance Measures ACC/AHA 2016 Prevention of Sudden

... Percentage of patients 18 years or older with diagnosis of heart failure and NYHA Class II or III and a quantitative left ventricular ejection fraction (LVEF) ≤ 35% on most recent measurement despite guideline directed medical therapy who received an implantable cardioverter defibrillator for preven ...
DOI: 10.1161/CIRCULATIONAHA.109.929646 published online May
DOI: 10.1161/CIRCULATIONAHA.109.929646 published online May

... Clinical Evaluation PPCM Patients in Families With DCM Patients with idiopathic DCM or other possible hereditary cardiac disorders are routinely evaluated at the cardiogenetics outpatient clinic of the University Medical Centre Groningen. Our routine procedures include recording the clinical charact ...
Sudden cardiac death: A nationwide cohort study among the young
Sudden cardiac death: A nationwide cohort study among the young

... death that suddenly and unexpectedly occurs within 1 hour of the onset of symptoms. However, other definitions, including a 24hour limit in unwitnessed cases, are also used (4). SCD has a major impact on the affected families and can also have a major economic impact on society. SCD has recently bee ...
presentation source
presentation source

... or a phenomenom: basic science. • To determine the most effective targets for therapy, either pharmaceutic or genomic. • To design artificial or tissue-engineered, biocompatible implants. Silico.6.01 ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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