carl john wiggers - National Academy of Sciences
... research, his development of suitable equipment, and his experiments and results. Descriptions of successes are balanced by frank discussion of failures, oversights, and those second thoughts that increasing experience and new facts produced. In this brief memoir it is more appropriate to describe a ...
... research, his development of suitable equipment, and his experiments and results. Descriptions of successes are balanced by frank discussion of failures, oversights, and those second thoughts that increasing experience and new facts produced. In this brief memoir it is more appropriate to describe a ...
Effects of calcium, parathyroid hormone and
... effects on bone, kidneys and vitamin D metabolism. It reduces the urinary calcium excretion by enhancing the tubular reabsorption of calcium. Additionally, it strongly inhibits renal phosphate reabsorption and hence reduces the serum phosphate concentration. PTH also enhances the intestinal absorpti ...
... effects on bone, kidneys and vitamin D metabolism. It reduces the urinary calcium excretion by enhancing the tubular reabsorption of calcium. Additionally, it strongly inhibits renal phosphate reabsorption and hence reduces the serum phosphate concentration. PTH also enhances the intestinal absorpti ...
Central Venous Pressure: Principles, Measurement, and Interpretation
... compliance (the change in volume for a given change in pressure) shows significant individual variability in health and in disease states in people.2 Ventricular end-diastolic pressure provides an accurate reflection of end-diastolic volume only when ventricular compliance is normal. Therefore, CVP ...
... compliance (the change in volume for a given change in pressure) shows significant individual variability in health and in disease states in people.2 Ventricular end-diastolic pressure provides an accurate reflection of end-diastolic volume only when ventricular compliance is normal. Therefore, CVP ...
Chronic heart failure patients with restrictive LV filling pattern have
... T.V. Salukhe et al. / International Journal of Cardiology 100 (2005) 5–12 ...
... T.V. Salukhe et al. / International Journal of Cardiology 100 (2005) 5–12 ...
Upregulation of Heat Shock Transcription Factor 1 Plays a Critical
... wall stress. At the beginning, cardiac hypertrophy has beneficial effects to maintain cardiac output by reducing wall stress; however, long-term stresses induce systolic dysfunction, leading to heart failure.1 Clinical studies have demonstrated that cardiac hypertrophy is not only a cause of congest ...
... wall stress. At the beginning, cardiac hypertrophy has beneficial effects to maintain cardiac output by reducing wall stress; however, long-term stresses induce systolic dysfunction, leading to heart failure.1 Clinical studies have demonstrated that cardiac hypertrophy is not only a cause of congest ...
penetrating cardiac injuries. complex injuries and
... attempted the unsuccessful repair of a left ventricular stab wound. The first successful attempt is credited to Rehn (39) of Frankfurt, Germany, who also in 1896 successfully repaired a wound of the right ventricle resulting in the patient’s survival. From this moment on the era of cardiac surgery w ...
... attempted the unsuccessful repair of a left ventricular stab wound. The first successful attempt is credited to Rehn (39) of Frankfurt, Germany, who also in 1896 successfully repaired a wound of the right ventricle resulting in the patient’s survival. From this moment on the era of cardiac surgery w ...
Total Artificial Hearts And Implantable Ventricular Assist Devices
... In February 2004, the FDA approved the DeBakey VAD® Child pump under the HDE approval process. According to the FDA, this device is indicated under HDE for both home and hospital use for children who are between ages 5 and 16 years and who have end-stage ventricular failure requiring temporary mecha ...
... In February 2004, the FDA approved the DeBakey VAD® Child pump under the HDE approval process. According to the FDA, this device is indicated under HDE for both home and hospital use for children who are between ages 5 and 16 years and who have end-stage ventricular failure requiring temporary mecha ...
Sonometric Study of the Normal Tricuspid Valve Annulus in Sheep
... due to similar increases in length of the septal and free wall segments. The annulus is not in a single plane, but is saddle-shaped. The expansion and contraction of the tricuspid valve complex is stepwise, and sequential from base to apex. ...
... due to similar increases in length of the septal and free wall segments. The annulus is not in a single plane, but is saddle-shaped. The expansion and contraction of the tricuspid valve complex is stepwise, and sequential from base to apex. ...
Arrhythmias in ECGs - Auckland Heart Group
... Middlemore, Auckland City and Mercy Hospitals Auckland Heart Group ...
... Middlemore, Auckland City and Mercy Hospitals Auckland Heart Group ...
Syncope in congestive heart failure
... low value if the episodes are rare. External loop monitoring is limited by the inability of many syncope patients to activate the device in a timely fashion. The diagnostic yield of external recording devices for arrhythmia detection has recently been improved by auto-triggering as well as by contin ...
... low value if the episodes are rare. External loop monitoring is limited by the inability of many syncope patients to activate the device in a timely fashion. The diagnostic yield of external recording devices for arrhythmia detection has recently been improved by auto-triggering as well as by contin ...
Impact of obstructive sleep apnoea on diastolic function
... 378 study participants with risk factors for diastolic dysfunction were prospectively included and a polygraphy was performed in all patients. Diastolic dysfunction was assessed by comprehensive echocardiography including tissue Doppler. Sleep apnoea was classified according to apnoea/ hypopnoea ind ...
... 378 study participants with risk factors for diastolic dysfunction were prospectively included and a polygraphy was performed in all patients. Diastolic dysfunction was assessed by comprehensive echocardiography including tissue Doppler. Sleep apnoea was classified according to apnoea/ hypopnoea ind ...
Left ventricular interaction with arterial load studied in isolated
... the cardiac chambers and the pulmonary vascular system parameters, interact with each other to determine the cardiac output. Piene (5) and Piene and Sund (6) recently analyzed the coupling of the right ventricle with the pulmonary arterial system. Using an iterative algorithm, they computed instanta ...
... the cardiac chambers and the pulmonary vascular system parameters, interact with each other to determine the cardiac output. Piene (5) and Piene and Sund (6) recently analyzed the coupling of the right ventricle with the pulmonary arterial system. Using an iterative algorithm, they computed instanta ...
What Do We Know About the “Malignant€Form”€of Early
... (Top panel) Examples of early repolarization (ER) with (A) rapidly ascending and (B) horizontal ST segment as presented in the landmark study by Tikkanen et al. (6). Only the horizontal form (B) was associated with increased arrhythmic mortality during long-term follow-up. (Middle panel) The 2 elect ...
... (Top panel) Examples of early repolarization (ER) with (A) rapidly ascending and (B) horizontal ST segment as presented in the landmark study by Tikkanen et al. (6). Only the horizontal form (B) was associated with increased arrhythmic mortality during long-term follow-up. (Middle panel) The 2 elect ...
pressure and volume relationships in the ventricle
... second component, which was of the same or greater size, produced by contraction of the conus itself. In the aorta this relationship was reversed with the peak pressure clearly associated with ventricular contraction and exceeding that recorded in the conus. The pressure due to conus contraction was ...
... second component, which was of the same or greater size, produced by contraction of the conus itself. In the aorta this relationship was reversed with the peak pressure clearly associated with ventricular contraction and exceeding that recorded in the conus. The pressure due to conus contraction was ...
Function and mechanics of the left ventricle: from
... In the short-axis view, radial strain and circumferential strain can be calculated. These values are not independent, one is positive (wall thickening) when the other is negative (segment shortening) in a normal heart. In the apical four-, three-, and two-chamber views, transversal strain and longit ...
... In the short-axis view, radial strain and circumferential strain can be calculated. These values are not independent, one is positive (wall thickening) when the other is negative (segment shortening) in a normal heart. In the apical four-, three-, and two-chamber views, transversal strain and longit ...
risks of exercise
... confers an 8% to 17% reduction in cardiovascular and all-cause mortality (Franklin 2007). One possible mechanism by which regular physical activity, improved aerobic fitness, or both, may provide cardioprotective benefits might be through adaptations in autonomic control, specifically reduced sympat ...
... confers an 8% to 17% reduction in cardiovascular and all-cause mortality (Franklin 2007). One possible mechanism by which regular physical activity, improved aerobic fitness, or both, may provide cardioprotective benefits might be through adaptations in autonomic control, specifically reduced sympat ...
Original Contributions Left Ventricular Insulin-like
... Increasing interest has been directed toward the possible role of trophically acting molecules as modulators or initiators, or both, of myocardial hypertrophy. The aim of the present study was to investigate the possible role of one such molecule, namely, insulin-like growth factor I, in myocardial ...
... Increasing interest has been directed toward the possible role of trophically acting molecules as modulators or initiators, or both, of myocardial hypertrophy. The aim of the present study was to investigate the possible role of one such molecule, namely, insulin-like growth factor I, in myocardial ...
Effect of Parameter Variations on the Hemodynamic
... example, Arndt et al. (17) have reported a dependency of the pulsatility index (PI) on heart contractility, afterload, and preload. Therefore, the aim of the present article is to study the effect of alterations in the model parameter values, that is, cardiac contractility, systemic vascular resista ...
... example, Arndt et al. (17) have reported a dependency of the pulsatility index (PI) on heart contractility, afterload, and preload. Therefore, the aim of the present article is to study the effect of alterations in the model parameter values, that is, cardiac contractility, systemic vascular resista ...
Timely Pulmonary Valve Replacement May Allow Preservation of
... We did not show any impairment in circumferential strain in our TOF patients compared to controls and no change after PVR. Furthermore, our study confirms the reproducibility of tissue tracking for LV strain analysis. However, the LV in TOF has been shown to suffer together with the RV in the long t ...
... We did not show any impairment in circumferential strain in our TOF patients compared to controls and no change after PVR. Furthermore, our study confirms the reproducibility of tissue tracking for LV strain analysis. However, the LV in TOF has been shown to suffer together with the RV in the long t ...
Impact of ejection on magnitude and time course of ventricular
... (Heart Circ. Physiol. 34): H899-H909, 1993.-This study focuseson elucidating how ventricular afterloading conditions affect the time course of change of left ventricular pressure (LVP) throughout the cardiac cycle, with particular emphasis on revealing specific limitations in the time-varying elasta ...
... (Heart Circ. Physiol. 34): H899-H909, 1993.-This study focuseson elucidating how ventricular afterloading conditions affect the time course of change of left ventricular pressure (LVP) throughout the cardiac cycle, with particular emphasis on revealing specific limitations in the time-varying elasta ...
The Cardiac Conduction System
... is slower in structures further along the activation pathway. For example, the atrioventricular (AV) nodal rate is slower than the SA nodal rate. This prevents the AV node from generating a spontaneous rhythm under normal conditions because it remains refractory at rates above 55 beats/ min. If the ...
... is slower in structures further along the activation pathway. For example, the atrioventricular (AV) nodal rate is slower than the SA nodal rate. This prevents the AV node from generating a spontaneous rhythm under normal conditions because it remains refractory at rates above 55 beats/ min. If the ...
CARDIAC MEMORY T WAVE FREQUENCY AS AN ELECTROCARDIOGRAPHIC SURROGATE FOR
... heart disease and therefore, these T wave changes are also not primary. Therefore, these are another example of “pseudoprimary” T wave changes and Denes et al became the first authors to refer to the concept that the heart muscle can “remember” periods of abnormal ventricular activation, causing abn ...
... heart disease and therefore, these T wave changes are also not primary. Therefore, these are another example of “pseudoprimary” T wave changes and Denes et al became the first authors to refer to the concept that the heart muscle can “remember” periods of abnormal ventricular activation, causing abn ...
Management of Intra-Aortic Balloon Pumps
... In the United States, it is estimated that IABP augmentation is used in approximately 30% of complex cardiovascular procedures.38 However, there is much debate over the evidence behind many of the clinical settings and indications for which IABP augmentation is used. The Benchmark Registry demonstra ...
... In the United States, it is estimated that IABP augmentation is used in approximately 30% of complex cardiovascular procedures.38 However, there is much debate over the evidence behind many of the clinical settings and indications for which IABP augmentation is used. The Benchmark Registry demonstra ...
Name of presentation
... -size varies with respiratory cycle -only severe enlargement is reliably detected ...
... -size varies with respiratory cycle -only severe enlargement is reliably detected ...
Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.