Brief Review Determinants of Left Ventricular Filling and of the
... This so-called eccentric hypertrophy also occurs in response to physical training1819 and in people with aortic or mitral insufficiency.20 The changes that accompany volume overload seem to be primarily those associated with changing size of the heart (and the related changes in equilibrium volume) ...
... This so-called eccentric hypertrophy also occurs in response to physical training1819 and in people with aortic or mitral insufficiency.20 The changes that accompany volume overload seem to be primarily those associated with changing size of the heart (and the related changes in equilibrium volume) ...
Differential expression of TNF-, IL-6, and IGF
... Although the role that these substances play is not precisely defined, it has been proposed that they may contribute to initiate and modulate critical responses within the overloaded myocardium, such as myocyte growth, apoptotic myocyte death, and reactive fibrosis, which, in turn, are the main dete ...
... Although the role that these substances play is not precisely defined, it has been proposed that they may contribute to initiate and modulate critical responses within the overloaded myocardium, such as myocyte growth, apoptotic myocyte death, and reactive fibrosis, which, in turn, are the main dete ...
Cardiac phase-dependent time normalization reduces - VU-dare
... show that isochrones and also the ESPVR are generally nonlinear and that the degree of nonlinearity depends on the contractile state. In addition, studies investigating the length-tension relationship of mammalian papillary muscle showed that the time-course of isometric and isotonic contraction var ...
... show that isochrones and also the ESPVR are generally nonlinear and that the degree of nonlinearity depends on the contractile state. In addition, studies investigating the length-tension relationship of mammalian papillary muscle showed that the time-course of isometric and isotonic contraction var ...
Regional ventricular wall thickening reflects changes in - AJP
... systolic wall thickening. However, the destructive nature of conventional histological analysis employed in such meticulous studies complicates direct evaluation of any changes in myocardial fiber and sheet structure that accompany cardiac contraction. Recently, diffusion tensor MRI (DTMRI) has been ...
... systolic wall thickening. However, the destructive nature of conventional histological analysis employed in such meticulous studies complicates direct evaluation of any changes in myocardial fiber and sheet structure that accompany cardiac contraction. Recently, diffusion tensor MRI (DTMRI) has been ...
Regional ventricular wall thickening reflects changes in cardiac fiber
... systolic wall thickening. However, the destructive nature of conventional histological analysis employed in such meticulous studies complicates direct evaluation of any changes in myocardial fiber and sheet structure that accompany cardiac contraction. Recently, diffusion tensor MRI (DTMRI) has been ...
... systolic wall thickening. However, the destructive nature of conventional histological analysis employed in such meticulous studies complicates direct evaluation of any changes in myocardial fiber and sheet structure that accompany cardiac contraction. Recently, diffusion tensor MRI (DTMRI) has been ...
Left ventricular ejection time
... Hemodynamic parameters under stimulation were analyzed as changes from baseline values. Baseline measurements were taken immediately prior to adrenergic stimulation by AMN. A dose–response curve was obtained to evaluate the effect of adrenergic stimulation on PWV. Data points of all doses for all si ...
... Hemodynamic parameters under stimulation were analyzed as changes from baseline values. Baseline measurements were taken immediately prior to adrenergic stimulation by AMN. A dose–response curve was obtained to evaluate the effect of adrenergic stimulation on PWV. Data points of all doses for all si ...
Pulmonary regurgitation in congenital heart disease
... problems relate to the state of the right ventricle late after repair, and its interaction with the pulmonary arterial tree and the left ventricle. Early mortality was very high when complete repair of tetralogy was first attempted, but with experience and introduction of the two-stage repair hospit ...
... problems relate to the state of the right ventricle late after repair, and its interaction with the pulmonary arterial tree and the left ventricle. Early mortality was very high when complete repair of tetralogy was first attempted, but with experience and introduction of the two-stage repair hospit ...
Herz Significance of Late Gadolinium Enhancement in
... Since the early use of ECG-gated spin echo imaging a number of improvements have been made. ...
... Since the early use of ECG-gated spin echo imaging a number of improvements have been made. ...
Targeting calcium transport in ischaemic heart disease
... myocardial I/R injury. These include: intracellular Ca2þ overload; the occurrence of a no reflow phenomenon due to cell swelling, impaired vascular relaxation or the formation of white cell plugs; and the formation of oxygen radicals. The oxyradical hypothesis of myocardial I/R has been reviewed in ...
... myocardial I/R injury. These include: intracellular Ca2þ overload; the occurrence of a no reflow phenomenon due to cell swelling, impaired vascular relaxation or the formation of white cell plugs; and the formation of oxygen radicals. The oxyradical hypothesis of myocardial I/R has been reviewed in ...
DETERMINANTS OF CARDIAC FUNCTION: SIMULATION OF A
... Three additional buttons labeled “pause,” “act tension,” and “clear graph” are also included in the lower right quadrant. They provide the following display enhancements: 1) the pause button causes the strip chart recorder to pause and inserts a new display with a sliding vertical line (blue line, F ...
... Three additional buttons labeled “pause,” “act tension,” and “clear graph” are also included in the lower right quadrant. They provide the following display enhancements: 1) the pause button causes the strip chart recorder to pause and inserts a new display with a sliding vertical line (blue line, F ...
The Heart - Pearson Higher Education
... seat of intelligence. Others thought it was the source of emotions. While these ideas have proved false, we do know that emotions affect heart rate. When your heart pounds or skips a beat, you become acutely aware of how much you depend on this dynamic organ for your very life. Despite its vital imp ...
... seat of intelligence. Others thought it was the source of emotions. While these ideas have proved false, we do know that emotions affect heart rate. When your heart pounds or skips a beat, you become acutely aware of how much you depend on this dynamic organ for your very life. Despite its vital imp ...
Caffeine and Ventricular Arrhythmias
... patients (77%), more severe in two (9%), and less severe in three (14%). In those patients with clinical ventricular arrhythmias, caffeine did not significantly alter inducibility or severity of arrhythmias, suggesting little effect on the substrate supporting ventricular arrhythmias. (JAMA. 1990;26 ...
... patients (77%), more severe in two (9%), and less severe in three (14%). In those patients with clinical ventricular arrhythmias, caffeine did not significantly alter inducibility or severity of arrhythmias, suggesting little effect on the substrate supporting ventricular arrhythmias. (JAMA. 1990;26 ...
Chapter 28: Pacemakers and Implantable
... improves septal wall motion, mitral valve function, and the dynamics of LV contraction in patients with severe HF or dilated cardiomyopathy. 7. Pacemaker therapy has been very successful in many patients with atrial ___________________ 8. Other indications for cardiac pacing include hypersensitive c ...
... improves septal wall motion, mitral valve function, and the dynamics of LV contraction in patients with severe HF or dilated cardiomyopathy. 7. Pacemaker therapy has been very successful in many patients with atrial ___________________ 8. Other indications for cardiac pacing include hypersensitive c ...
Further Insight into Mechanisms of Ventricular
... pace from the sites at which isolated diastolic potentials were recorded during VT. The demonstration of concealed entrainment at the sites at which diastolic potentials were recorded would have provided additional evidence that these sites were in a region of slow conduction which was part of the V ...
... pace from the sites at which isolated diastolic potentials were recorded during VT. The demonstration of concealed entrainment at the sites at which diastolic potentials were recorded would have provided additional evidence that these sites were in a region of slow conduction which was part of the V ...
Cardiac contractility modulation by electric currents - AJP
... might have application as a therapy for heart failure. It has recently been demonstrated (3) that extracellularly applied electric signals have a similar effect as voltage clamping in muscles isolated from normal animals and failing human hearts. In addition, when applied regionally, electrical curr ...
... might have application as a therapy for heart failure. It has recently been demonstrated (3) that extracellularly applied electric signals have a similar effect as voltage clamping in muscles isolated from normal animals and failing human hearts. In addition, when applied regionally, electrical curr ...
Ghsy4y\y45y45y5
... We use a single intervention to model the electrophysiological effect of ischemia a rise in [K+]o. Period-2 rhythms occur when [K+]o is ~13 mM (Figs. 2,7B). In the pig ventricle, alternans has been detected 39 mins post-occlusion (Downar et al., 1977), during which time the average [K+]o in the c ...
... We use a single intervention to model the electrophysiological effect of ischemia a rise in [K+]o. Period-2 rhythms occur when [K+]o is ~13 mM (Figs. 2,7B). In the pig ventricle, alternans has been detected 39 mins post-occlusion (Downar et al., 1977), during which time the average [K+]o in the c ...
Passive Leg Raising
... Prediction of Fluid Responsiveness by Passive Leg Raising in the Critically Ill The Issue of Predicting Fluid Responsiveness Not all patients with circulatory failure respond to fluid infusion by a significant increase in cardiac output [16]. Indeed, in about half of the critically ill patients who ...
... Prediction of Fluid Responsiveness by Passive Leg Raising in the Critically Ill The Issue of Predicting Fluid Responsiveness Not all patients with circulatory failure respond to fluid infusion by a significant increase in cardiac output [16]. Indeed, in about half of the critically ill patients who ...
Wide-QRS-Complex Tachycardia with a Negative Concordance
... bifurcation of the bundle of His). However, SVT can also manifest with a WCT. The ability to differentiate between SVT with a wide QRS complex due to aberrancy or preexcitation, and VT, often presents a diagnostic challenge. The distinction is critical because the treatment for each is different, an ...
... bifurcation of the bundle of His). However, SVT can also manifest with a WCT. The ability to differentiate between SVT with a wide QRS complex due to aberrancy or preexcitation, and VT, often presents a diagnostic challenge. The distinction is critical because the treatment for each is different, an ...
Theme: «CARDIAC INSUFFICIENCY»
... 4. ECG of a 44-year-old patient shows signs of hypertrophy of both ventricles and the right atrium. The patient was diagnosed with the tricuspid valve insufficiency. What pathogenetic variant of cardiac dysfunction is usually observed in case of such insufficiency? A Heart overload by volume ...
... 4. ECG of a 44-year-old patient shows signs of hypertrophy of both ventricles and the right atrium. The patient was diagnosed with the tricuspid valve insufficiency. What pathogenetic variant of cardiac dysfunction is usually observed in case of such insufficiency? A Heart overload by volume ...
1 Cold acclimation increases cardiac myofilament function and
... used as an estimate of the rate of cross-bridge cycling at each activation pCa (Gillis et al., 2007). ...
... used as an estimate of the rate of cross-bridge cycling at each activation pCa (Gillis et al., 2007). ...
Ventricular free wall rupture after myocardial infarction
... Only the series by Purcaro et al showed a substantially higher incidence of VFWR (53.6%) on the first day.42 Ventricular free wall rupture should be suspected when a patient recovering from acute myocardial infarction experiences chest pain and cardiovascular collapse. 79 Rupture may occur in patien ...
... Only the series by Purcaro et al showed a substantially higher incidence of VFWR (53.6%) on the first day.42 Ventricular free wall rupture should be suspected when a patient recovering from acute myocardial infarction experiences chest pain and cardiovascular collapse. 79 Rupture may occur in patien ...
Cardiac function of - Graduate School of Biomedical Sciences
... fractional shortening (28 ⫾ 2%), ejection fraction (43 ⫾ 2%), and cardiac output (6.5 ⫾ 0.4 ml/min), indicating low basal cardiac function. Histology revealed large NMR cardiomyocyte cross-sectional area (216 ⫾ 10 m2) and cardiac collagen deposition of 2.2 ⫾ 0.4%. Neither of these histomorphometric ...
... fractional shortening (28 ⫾ 2%), ejection fraction (43 ⫾ 2%), and cardiac output (6.5 ⫾ 0.4 ml/min), indicating low basal cardiac function. Histology revealed large NMR cardiomyocyte cross-sectional area (216 ⫾ 10 m2) and cardiac collagen deposition of 2.2 ⫾ 0.4%. Neither of these histomorphometric ...
- The Annals of Thoracic Surgery
... Fontan completion affects subsequent hemodynamics in patients with functional single ventricle followed for more than 3 years. Methods. Between January 1997 and December 2008, 163 patients with functional single ventricle underwent extracardiac total cavopulmonary connection (TCPC) at a single insti ...
... Fontan completion affects subsequent hemodynamics in patients with functional single ventricle followed for more than 3 years. Methods. Between January 1997 and December 2008, 163 patients with functional single ventricle underwent extracardiac total cavopulmonary connection (TCPC) at a single insti ...
Mitral Regurgitation
... DVD for corresponding video). In particular, the posteromedial papillary muscle is more susceptible to injury during infarction as its blood supply is derived almost solely from the posterior descending branch of the right coronary artery. The antero-lateral papillary muscle and those of the right v ...
... DVD for corresponding video). In particular, the posteromedial papillary muscle is more susceptible to injury during infarction as its blood supply is derived almost solely from the posterior descending branch of the right coronary artery. The antero-lateral papillary muscle and those of the right v ...
Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.