Simulation of signal flow in 3D reconstructions of an anatomically
... yields the number and 3D distribution of available synapses from this cell type (iii). Synapses are not placed on dendrites by geometrical proximity to axons. In turn, for each individual postsynaptic neuron, synaptic connectivity is determined as an innervation probability ((iv), see example calcul ...
... yields the number and 3D distribution of available synapses from this cell type (iii). Synapses are not placed on dendrites by geometrical proximity to axons. In turn, for each individual postsynaptic neuron, synaptic connectivity is determined as an innervation probability ((iv), see example calcul ...
Physiological Plasticity of Single Neurons in Auditory Cortex of the
... conditioning on secondary and primary (AI) auditory cortex indicates that both regions develop neuronal discharge plasticity early in the conditioning phase and that increases in background activity in primary auditory cortex are also associated with elevated levels of tonic arousal. In addition, th ...
... conditioning on secondary and primary (AI) auditory cortex indicates that both regions develop neuronal discharge plasticity early in the conditioning phase and that increases in background activity in primary auditory cortex are also associated with elevated levels of tonic arousal. In addition, th ...
NIH eRA Commons user name: AM2518 TELEPHONE NUMBER
... GOALS: The aim of this translational research project is to develop a novel treatment for patients with medicationresistant Obsessive Compulsive Disorder (OCD), informed by the neurocircuitry, neurophysiology, and neurochemistry underlying the disorder. Studies provide evidence that, in addition to ...
... GOALS: The aim of this translational research project is to develop a novel treatment for patients with medicationresistant Obsessive Compulsive Disorder (OCD), informed by the neurocircuitry, neurophysiology, and neurochemistry underlying the disorder. Studies provide evidence that, in addition to ...
the inferior colliculus of the rat: quantitative
... and Merchán, 2004). Afferent projections to the IC are both excitatory and inhibitory (Oliver, 1984a, 1987; Shneiderman and Henkel, 1987; Saint Marie et al., 1989; Saint Marie and Baker, 1990; Li and Kelly, 1992; Riquelme et al., 2001). Likewise, projections from the IC to the MGB are also excitator ...
... and Merchán, 2004). Afferent projections to the IC are both excitatory and inhibitory (Oliver, 1984a, 1987; Shneiderman and Henkel, 1987; Saint Marie et al., 1989; Saint Marie and Baker, 1990; Li and Kelly, 1992; Riquelme et al., 2001). Likewise, projections from the IC to the MGB are also excitator ...
The amygdala - University of Puget Sound
... contains a strong inhibitory network that keeps spontaneous cellular activity low and that prevents cells from firing action potentials to irrelevant stimuli. Novel stimuli elicit responses, but these rapidly habituate if the stimulus is repeated. As I shall discuss later, this inhibition can be ove ...
... contains a strong inhibitory network that keeps spontaneous cellular activity low and that prevents cells from firing action potentials to irrelevant stimuli. Novel stimuli elicit responses, but these rapidly habituate if the stimulus is repeated. As I shall discuss later, this inhibition can be ove ...
Mediation and the Brain: The Neuropsychology of
... Rationality: Serial Stage Model A social event occurs. going g on. We see and hear what is g We consciously evaluate the people and their actions. We consider an appropriate response. We respond ...
... Rationality: Serial Stage Model A social event occurs. going g on. We see and hear what is g We consciously evaluate the people and their actions. We consider an appropriate response. We respond ...
Insular cortex – review
... not only on taste of the food, but also on its texture, temperature and odor. Neurons that are involved in our perception of taste, also receive somatosensory and olfactory projections from our oral cavity, as well as the input about body’s energetic state from the periphery9. Projections from highe ...
... not only on taste of the food, but also on its texture, temperature and odor. Neurons that are involved in our perception of taste, also receive somatosensory and olfactory projections from our oral cavity, as well as the input about body’s energetic state from the periphery9. Projections from highe ...
6.12 Dorsal and Ventral Streams in the Sense of Touch
... Introduction Anatomical Localization of the Posterior Parietal Cortex Physiological Studies of Posterior Parietal Cortex Reaching as a Model System for Analyzing Sensorimotor Integration Role of Posterior Parietal Cortex in Motor Planning and the Neural Representation of ...
... Introduction Anatomical Localization of the Posterior Parietal Cortex Physiological Studies of Posterior Parietal Cortex Reaching as a Model System for Analyzing Sensorimotor Integration Role of Posterior Parietal Cortex in Motor Planning and the Neural Representation of ...
Dendritic Morphology of Pyramidal Neurons in the
... The primate cerebral cortex is characterized by regional variation in the structure of pyramidal neurons, with more complex dendritic arbors and greater spine density observed in prefrontal compared with sensory and motor cortices. Although there are several investigations in humans and other primat ...
... The primate cerebral cortex is characterized by regional variation in the structure of pyramidal neurons, with more complex dendritic arbors and greater spine density observed in prefrontal compared with sensory and motor cortices. Although there are several investigations in humans and other primat ...
Auditory Cortical Neurons are Sensitive to Static and Continuously
... drug at regular intervals throughout the experiment. For this of either ear. When studied monaurally, spike count was paper, data were chosen from eight of these animals whose cortieither a monotonic or nonmonotonic function of stimulus cal single-cell thresholds to stimulation of each ear were with ...
... drug at regular intervals throughout the experiment. For this of either ear. When studied monaurally, spike count was paper, data were chosen from eight of these animals whose cortieither a monotonic or nonmonotonic function of stimulus cal single-cell thresholds to stimulation of each ear were with ...
The thalamus as a putative biomarker in neurodegenerative disorders
... misfolding or prions) along the same neural circuits, also resulting in topographically distinct patterns of neural loss in most age-related neurodegenerative disease (Warren et al., 2013). Indeed it is also possible that proteopathies may also contribute to trans-synaptic neurodegeneration, though ...
... misfolding or prions) along the same neural circuits, also resulting in topographically distinct patterns of neural loss in most age-related neurodegenerative disease (Warren et al., 2013). Indeed it is also possible that proteopathies may also contribute to trans-synaptic neurodegeneration, though ...
Evolution of an ancient protein function involved in
... Little is known concerning the evolution of animal spindle orientation or the GKPID-mediated complex in particular. Dlg is a member of a larger family of membrane-associated multidomain proteins, all of which contain a GKPID and form protein complexes important to cell adhesion, neural synapse organ ...
... Little is known concerning the evolution of animal spindle orientation or the GKPID-mediated complex in particular. Dlg is a member of a larger family of membrane-associated multidomain proteins, all of which contain a GKPID and form protein complexes important to cell adhesion, neural synapse organ ...
Novel Nuclear Protein Complexes of Dystrophin 71 Isoforms in
... studied in retina [13]. It has been shown that Dp71s are necessary for the stability of DAP complex in the plasma membrane of brain and retinal neurons, as well as glial cells [14, 15]. It is known that C-terminal mutations in DMD gene, that alter the expression of Dp71, are linked to a severe incid ...
... studied in retina [13]. It has been shown that Dp71s are necessary for the stability of DAP complex in the plasma membrane of brain and retinal neurons, as well as glial cells [14, 15]. It is known that C-terminal mutations in DMD gene, that alter the expression of Dp71, are linked to a severe incid ...
Reuss 9..48
... Furthermore, there is multiple evidence that amino acid transmitters are of major importance for SCN function. GABA, thought to be the principal neurotransmitter in the SCN [Moore and Speh, 1993], is found in most if not all neurons, and the mRNA for its synthesizing enzyme GAD is coexpressed with A ...
... Furthermore, there is multiple evidence that amino acid transmitters are of major importance for SCN function. GABA, thought to be the principal neurotransmitter in the SCN [Moore and Speh, 1993], is found in most if not all neurons, and the mRNA for its synthesizing enzyme GAD is coexpressed with A ...
DOES ISCHEMIA CAUSE ACUTE NEURONAL DAMAGE BY CONVERTING THE NA /K
... The gray matter of the higher brain undergoes spreading depolarization in response to ischemia, which increases metabolic demand and so promotes acute neuronal injury. The molecular mechanism linking ischemic failure of the Na+/K+ pump to the subsequent onset of a large inward current in neurons has ...
... The gray matter of the higher brain undergoes spreading depolarization in response to ischemia, which increases metabolic demand and so promotes acute neuronal injury. The molecular mechanism linking ischemic failure of the Na+/K+ pump to the subsequent onset of a large inward current in neurons has ...
Word Definition 12 Cranial Nerve innervation of
... A direction (in the horizontal plane) specified with reference to something stationary in the external environment, e.g., the earth’s magnetic field or a visually detected landmark. Cortex of the endbrain other than neocortex. A degenerative brain disease that causes gradually increasing dementia an ...
... A direction (in the horizontal plane) specified with reference to something stationary in the external environment, e.g., the earth’s magnetic field or a visually detected landmark. Cortex of the endbrain other than neocortex. A degenerative brain disease that causes gradually increasing dementia an ...
Determination of Protein Molecular Weight
... Proteins are a highly diversified class of biomolecules. Differences in their chemical properties, such as charge, functional groups, shape, size and solubility enable them to perform many biological functions. These functions include enzyme catalysis, metabolic regulation, binding and transport of ...
... Proteins are a highly diversified class of biomolecules. Differences in their chemical properties, such as charge, functional groups, shape, size and solubility enable them to perform many biological functions. These functions include enzyme catalysis, metabolic regulation, binding and transport of ...
Forebrain glutamatergic neurons mediate leptin action on
... For evaluating the antidepressant-like behavioral effects of leptin (R&D Systems, Minneapolis, MN, USA) or Ro25-6981 (Sigma, St Louis, MO, USA), the drugs were dissolved in saline immediately before use and administered intraperitoneally to mice 30 min before the tail suspension test or the forced s ...
... For evaluating the antidepressant-like behavioral effects of leptin (R&D Systems, Minneapolis, MN, USA) or Ro25-6981 (Sigma, St Louis, MO, USA), the drugs were dissolved in saline immediately before use and administered intraperitoneally to mice 30 min before the tail suspension test or the forced s ...
Glycolysis Cell-Based Assay Kit
... Glycolysis is one of the major metabolic pathways in glucose metabolism. It is a process that is conserved throughout evolution and occurs in virtually all cells. Glycolysis is the primary source of ATP when oxygen is limiting, such as during intense strenuous exercise and also in erythrocytes which ...
... Glycolysis is one of the major metabolic pathways in glucose metabolism. It is a process that is conserved throughout evolution and occurs in virtually all cells. Glycolysis is the primary source of ATP when oxygen is limiting, such as during intense strenuous exercise and also in erythrocytes which ...
- D-Scholarship@Pitt
... were placed in the rostral part of the SC that represents central vision (Figure 2A), across its mediolateral extent, in order to show any topography in the projections from cortex. The DY and FR injection cores partially overlapped, allowing for uptake of either or both tracers from this zone of ov ...
... were placed in the rostral part of the SC that represents central vision (Figure 2A), across its mediolateral extent, in order to show any topography in the projections from cortex. The DY and FR injection cores partially overlapped, allowing for uptake of either or both tracers from this zone of ov ...
The basic nonuniformity of the cerebral cortex
... by more than five orders of magnitude across mammals (1) is considered a key event in mammalian brain evolution (2, 3), even though evolution is not always associated with increased brain or cortical size (4). Given that the cerebral cortex is a columnar structure (2, 5, 6), the most accepted view o ...
... by more than five orders of magnitude across mammals (1) is considered a key event in mammalian brain evolution (2, 3), even though evolution is not always associated with increased brain or cortical size (4). Given that the cerebral cortex is a columnar structure (2, 5, 6), the most accepted view o ...
Fear conditioning, synaptic plasticity and the amygdala
... kinase B (TrkB) pathway provides one example of a ligand–receptor system that underlies synaptic plasticity and has also been implicated in both PTSD in humans and in animal models of fear conditioning, extinction and ...
... kinase B (TrkB) pathway provides one example of a ligand–receptor system that underlies synaptic plasticity and has also been implicated in both PTSD in humans and in animal models of fear conditioning, extinction and ...
17. Pathways and Integrative Functions
... his illness by saying, “At the moment, I feel just fine.” Alzheimer disease is a progressive dementia that debilitates the functioning of the central nervous system (CNS) and usually affects people in their 60s or over. This neurodegenerative disease causes progressive decline in memory, judgment, a ...
... his illness by saying, “At the moment, I feel just fine.” Alzheimer disease is a progressive dementia that debilitates the functioning of the central nervous system (CNS) and usually affects people in their 60s or over. This neurodegenerative disease causes progressive decline in memory, judgment, a ...
supplemental figures
... showed marginally significant difference (P = 0.055). (c) Trend of normalized fano factor in correct trials for attention-related excited and other neurons aligned to the time from trigger. (d) Comparisons in normalized fano factor (normalized to fano factor for the total time window) in time window ...
... showed marginally significant difference (P = 0.055). (c) Trend of normalized fano factor in correct trials for attention-related excited and other neurons aligned to the time from trigger. (d) Comparisons in normalized fano factor (normalized to fano factor for the total time window) in time window ...
Clinical neurochemistry
Clinical neurochemistry is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic manifestations in humans. While neurochemistry is mostly associated with the effects of neurotransmitters and similarly-functioning chemicals on neurons themselves, clinical neurochemistry relates these phenomena to system-wide symptoms. Clinical neurochemistry is related to neurogenesis, neuromodulation, neuroplasticity, neuroendocrinology, and neuroimmunology in the context of associating neurological findings at both lower and higher level organismal functions.