Receptive Fields and Binaural Interactions for Virtual
... al. 1983; see Irvine 1992 for review). However, free-field studies alone cannot determine which acoustic cues are responsible for this directional sensitivity because they do not allow independent control over each cue. Such control can be achieved in dichotic studies that deliver stimuli through cl ...
... al. 1983; see Irvine 1992 for review). However, free-field studies alone cannot determine which acoustic cues are responsible for this directional sensitivity because they do not allow independent control over each cue. Such control can be achieved in dichotic studies that deliver stimuli through cl ...
The Lactic Acid Response to Alkalosis in Panic Disorder
... patients and 17 control subjects from the two studies combined revealed a significantly greater increase in serum lactate following hyperventilation and glucose loading in the panic disorder subjects compared with the control subjects (Figure 3). When the total of 11 patients who panicked during hype ...
... patients and 17 control subjects from the two studies combined revealed a significantly greater increase in serum lactate following hyperventilation and glucose loading in the panic disorder subjects compared with the control subjects (Figure 3). When the total of 11 patients who panicked during hype ...
Disorders of mitochondrial function
... glucose enter the Krebs cycle at different sites, which are used therapeutically in some pre-Krebs cycle mitochondrial diseases [e.g. a high-fat, ketogenic diet in some cases of pyruvate dehydrogenase (PDH) deficiency]. For simplicity, amino acids are not shown; different amino acids enter the Krebs ...
... glucose enter the Krebs cycle at different sites, which are used therapeutically in some pre-Krebs cycle mitochondrial diseases [e.g. a high-fat, ketogenic diet in some cases of pyruvate dehydrogenase (PDH) deficiency]. For simplicity, amino acids are not shown; different amino acids enter the Krebs ...
Control of echolocation pulses by neurons of the nucleus ambiguus
... between the nucleus ambiguus and the parabrachial nuclei (Saper and Loewy 1980; Kalia 1981). The above mentioned periaqueductal gray is known to be part of the 'descending vocalization pathway' (Jfirgens and Pratt 1979), whereas the parabrachial nuclei and parts of the nucleus of the solitary tract ...
... between the nucleus ambiguus and the parabrachial nuclei (Saper and Loewy 1980; Kalia 1981). The above mentioned periaqueductal gray is known to be part of the 'descending vocalization pathway' (Jfirgens and Pratt 1979), whereas the parabrachial nuclei and parts of the nucleus of the solitary tract ...
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... membrane, heterozygous loss of its expression would result in decreased availability of substrates for mitochondrial metabolism, thus creating a cellular environment akin to caloric restriction and providing a molecular basis of life span extension in heterozygous mutants [10,11]. At the time when t ...
... membrane, heterozygous loss of its expression would result in decreased availability of substrates for mitochondrial metabolism, thus creating a cellular environment akin to caloric restriction and providing a molecular basis of life span extension in heterozygous mutants [10,11]. At the time when t ...
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model
... interneuronal number and reduced hypertrophy in some subregions. These results provide the first evidence for the involvement of interneurons in a mouse model of NCL. Moreover, our findings suggest that at least some populations of these neurons persist in a growth factor-responsive state. Key words ...
... interneuronal number and reduced hypertrophy in some subregions. These results provide the first evidence for the involvement of interneurons in a mouse model of NCL. Moreover, our findings suggest that at least some populations of these neurons persist in a growth factor-responsive state. Key words ...
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... Recently, interest has grown in how the habenula, a poorly understood nucleus providing descending inputs to the tegmentum and raphe, may affect these behavioral states. We have used mouse genetic models to study part of this system, the dorsal medial habenula (dMHb). Here we report that the dMHb is ...
... Recently, interest has grown in how the habenula, a poorly understood nucleus providing descending inputs to the tegmentum and raphe, may affect these behavioral states. We have used mouse genetic models to study part of this system, the dorsal medial habenula (dMHb). Here we report that the dMHb is ...
The Role of Neurotrophins in Neurotransmitter Release
... others 2001). Furthermore, BDNF can undergo both retro- and anterograde transport and signaling at the synapse in an activity-dependent manner (Kohara and others 2001). Indeed, BDNF exerts its actions on hippocampal synaptic physiology by acting pre-, post-, and perisynaptically (for review, see Poo ...
... others 2001). Furthermore, BDNF can undergo both retro- and anterograde transport and signaling at the synapse in an activity-dependent manner (Kohara and others 2001). Indeed, BDNF exerts its actions on hippocampal synaptic physiology by acting pre-, post-, and perisynaptically (for review, see Poo ...
Glycogen storage diseases: Diagnosis, treatment and outcome
... a defect in any one of several enzymes required for either glycogen synthesis or glycogen degradation. Broadly speaking, the GSDs can be divided into those with hepatic involvement, which present as hypoglycemia, and those which are associated with neuromuscular disease and weakness (Table 1) [1]. T ...
... a defect in any one of several enzymes required for either glycogen synthesis or glycogen degradation. Broadly speaking, the GSDs can be divided into those with hepatic involvement, which present as hypoglycemia, and those which are associated with neuromuscular disease and weakness (Table 1) [1]. T ...
Can Oxytocin function as an antidepressant?
... given a CRH injection. Depressed patients have and elevated cortisol and ATCH response to the CRH injection.2 This indicates that the dexamethasone pretreatment is less capable to suppress the HPA response to the CRH injection in depressed patients and that their HPA response to stress is elevated. ...
... given a CRH injection. Depressed patients have and elevated cortisol and ATCH response to the CRH injection.2 This indicates that the dexamethasone pretreatment is less capable to suppress the HPA response to the CRH injection in depressed patients and that their HPA response to stress is elevated. ...
A transcription factor network controls cell migration
... Fig. 4. Flh acts in parallel with Tbx2b to specify parapineal fate, but does not govern migration. (A) Dorsal views of antibody labeling of parapineal neurons (krt4:eGFP+) as well as axons and dendrites (acetylated tubulin+) in the epithalamus at 5 dpf. The pineal organ regions are marked by dashed ...
... Fig. 4. Flh acts in parallel with Tbx2b to specify parapineal fate, but does not govern migration. (A) Dorsal views of antibody labeling of parapineal neurons (krt4:eGFP+) as well as axons and dendrites (acetylated tubulin+) in the epithalamus at 5 dpf. The pineal organ regions are marked by dashed ...
10-Sensation of Taste lecture
... Taste Pathway Taste information is send to the CNS by the crainial nerves # 7, 9 and 10 the taste nucleus (n. tractus solitarius) thalamus insular cortex ...
... Taste Pathway Taste information is send to the CNS by the crainial nerves # 7, 9 and 10 the taste nucleus (n. tractus solitarius) thalamus insular cortex ...
Resonance properties of different neuronal populations in the
... network activity in the hippocampus (Vanderwolf, 1988;Vinogradova, 1995;Buzsaki, 2002). In rodents, the hippocampal θ rhythm is prominent during exploration, locomotion and rapid eye movement (REM) sleep (Bland, 1986;Vanderwolf, 1988;Vinogradova, 1995;Buzsaki, 2002). θ rhythm plays an important role ...
... network activity in the hippocampus (Vanderwolf, 1988;Vinogradova, 1995;Buzsaki, 2002). In rodents, the hippocampal θ rhythm is prominent during exploration, locomotion and rapid eye movement (REM) sleep (Bland, 1986;Vanderwolf, 1988;Vinogradova, 1995;Buzsaki, 2002). θ rhythm plays an important role ...
Dynamics of sensory thalamocortical synaptic networks during
... Fig. 1. Schematic representation of major synaptic connections in the thalamocortical network. Left: Ascending projections in the thalamocortical network depicting the lemniscal fibers to VPM and POm, and the thalamocortical fibers originating in those nuclei that give rise to primary and secondary ...
... Fig. 1. Schematic representation of major synaptic connections in the thalamocortical network. Left: Ascending projections in the thalamocortical network depicting the lemniscal fibers to VPM and POm, and the thalamocortical fibers originating in those nuclei that give rise to primary and secondary ...
F-Spondin Is Required for Accurate Pathfinding of Commissural
... can act either as short-range cues in the form of membrane-attached and extracellular matrix-bound proteins or as long-range cues in the form of diffusible molecules. It is the relative balance between attractive and repulsive forces that regulates the directionality of axonal outgrowth during devel ...
... can act either as short-range cues in the form of membrane-attached and extracellular matrix-bound proteins or as long-range cues in the form of diffusible molecules. It is the relative balance between attractive and repulsive forces that regulates the directionality of axonal outgrowth during devel ...
On-line Optical Operant Conditioning of Cortical Activity
... Figure 1.2 Organization of motor cortex and related areas ............................................ 17 Figure 1.3 Operant conditioning with Skinner box ............................................................. 19 Figure ...
... Figure 1.2 Organization of motor cortex and related areas ............................................ 17 Figure 1.3 Operant conditioning with Skinner box ............................................................. 19 Figure ...
The Locus Ceruleus Responds to Signaling Molecules Obtained
... treated with 1 mg/ml trypsin for 3 min and then incubated with the primary antibody (1:100) in 0.1% Triton X-100 overnight; the sections were incubated with biotinylated goat-anti-rabbit secondary antibody (1:500) followed by streptavidin Alexa Fluor 488 conjugate (1:100). Sections were imaged on a ...
... treated with 1 mg/ml trypsin for 3 min and then incubated with the primary antibody (1:100) in 0.1% Triton X-100 overnight; the sections were incubated with biotinylated goat-anti-rabbit secondary antibody (1:500) followed by streptavidin Alexa Fluor 488 conjugate (1:100). Sections were imaged on a ...
Mammalian CSAD and GADL1 have distinct biochemical properties
... selectivity for either CSAD or GADL1. Lithium had minimal effect on their enzyme activities. In conclusion, taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (CSAD and GADL1) that have partially overlapping catalytic properties but different tissue di ...
... selectivity for either CSAD or GADL1. Lithium had minimal effect on their enzyme activities. In conclusion, taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (CSAD and GADL1) that have partially overlapping catalytic properties but different tissue di ...
Introduction to Carbohydrates
... biosynthetic, and regulatory mechanisms has evolved. • The liver plays a central role in the regulation of the body's cholesterol homeostasis. ...
... biosynthetic, and regulatory mechanisms has evolved. • The liver plays a central role in the regulation of the body's cholesterol homeostasis. ...
Single-Amino Acid Substitutions Alter the Specificity and Affinity of
... nNOS (Figure 1C, R70A). However, R70A failed to bind Kv1.4. Thus, a single-amino acid substitution (Arg to Ala) confers nNOS binding on PDZ1 of PSD-95, but disrupts C-terminal peptide binding. These results suggest that an Arg or Lys residue in the carboxylate-binding loop of PDZ domains is required ...
... nNOS (Figure 1C, R70A). However, R70A failed to bind Kv1.4. Thus, a single-amino acid substitution (Arg to Ala) confers nNOS binding on PDZ1 of PSD-95, but disrupts C-terminal peptide binding. These results suggest that an Arg or Lys residue in the carboxylate-binding loop of PDZ domains is required ...
Homologous Neurons and their Locomotor Functions in Nudibranch
... during the course of evolution than the periphery (Bramble and Wake, 1985; Wainwright and Lauder, 1986; Lauder and Shaffer, 1988; Sanderson, 1988; Goslow et al., 1989; Wainwright, 1989; Wainwright et al., 1989; Kavanau, 1990; Arbas et al., 1991; Edwards and Palka, 1991; Paul, 1991; Katz and Tazaki, ...
... during the course of evolution than the periphery (Bramble and Wake, 1985; Wainwright and Lauder, 1986; Lauder and Shaffer, 1988; Sanderson, 1988; Goslow et al., 1989; Wainwright, 1989; Wainwright et al., 1989; Kavanau, 1990; Arbas et al., 1991; Edwards and Palka, 1991; Paul, 1991; Katz and Tazaki, ...
Here follows a list of recently published papers
... T. Rolland et al., “A proteome-scale map of the human interactome network,” Cell, 159:1212-26, 2014. A massive screen yields the most comprehensive map of binary human protein interactions to date. Illuminating the Interactome A massive screen yields the most comprehensive map of binary human protei ...
... T. Rolland et al., “A proteome-scale map of the human interactome network,” Cell, 159:1212-26, 2014. A massive screen yields the most comprehensive map of binary human protein interactions to date. Illuminating the Interactome A massive screen yields the most comprehensive map of binary human protei ...
Early Functional Impairment of Sensory-Motor Connectivity in a Mouse Model of Spinal Muscular Atrophy
... models, the primary targets and the precise sequence of functional and cellular changes that initiate the disease process remain unclear. ...
... models, the primary targets and the precise sequence of functional and cellular changes that initiate the disease process remain unclear. ...
The Formation of Terminal Fields in the Absence of Competitive
... junctions almost exclusively on appropriate muscle fibers, rather than by overproduction and selective elimination of inappropriate branches. Retraction of the few branches that are inappropriately placed, though correlated in time with the ingrowth of branches from appropriate motoneurons, occurs i ...
... junctions almost exclusively on appropriate muscle fibers, rather than by overproduction and selective elimination of inappropriate branches. Retraction of the few branches that are inappropriately placed, though correlated in time with the ingrowth of branches from appropriate motoneurons, occurs i ...
Clinical neurochemistry
Clinical neurochemistry is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic manifestations in humans. While neurochemistry is mostly associated with the effects of neurotransmitters and similarly-functioning chemicals on neurons themselves, clinical neurochemistry relates these phenomena to system-wide symptoms. Clinical neurochemistry is related to neurogenesis, neuromodulation, neuroplasticity, neuroendocrinology, and neuroimmunology in the context of associating neurological findings at both lower and higher level organismal functions.