Molecular and Cellular Basis for Diastolic Dysfunction
... sarcomere length (SL) range of 1.8–2.2 μm, titin was identified as the dominant determinant of LV passive pressure, contributing approximately 80 % to LV passive stiffness, while the contribution of the ECM appeared more important at an SL higher than 2.2 μm [34]. Cardiomyocyte titin-based elasticit ...
... sarcomere length (SL) range of 1.8–2.2 μm, titin was identified as the dominant determinant of LV passive pressure, contributing approximately 80 % to LV passive stiffness, while the contribution of the ECM appeared more important at an SL higher than 2.2 μm [34]. Cardiomyocyte titin-based elasticit ...
A Randomized Comparison of Atrial and Dual
... The primary end points were changes in LA size and LV size and function during follow-up measured by M-mode echocardiography. Secondary echocardiographic end points were changes in LA volume and LV volume and left ventricular ejection fraction (LVEF) measured by twodimensional echocardiography. Seco ...
... The primary end points were changes in LA size and LV size and function during follow-up measured by M-mode echocardiography. Secondary echocardiographic end points were changes in LA volume and LV volume and left ventricular ejection fraction (LVEF) measured by twodimensional echocardiography. Seco ...
Dual atrioventricular nodal non-re
... Dual atrioventricular nodal non-re-entrant tachycardia (DAVNNT), also known as ‘double fire’, has recently received more attention since it was demonstrated to mimic more common arrhythmias such as atrial premature beats, atrial fibrillation, and ventricular tachycardia. This is important, since mis ...
... Dual atrioventricular nodal non-re-entrant tachycardia (DAVNNT), also known as ‘double fire’, has recently received more attention since it was demonstrated to mimic more common arrhythmias such as atrial premature beats, atrial fibrillation, and ventricular tachycardia. This is important, since mis ...
How to diagnose diastolic heart failure: a consensus
... failure with reduced LVEF (HFREF)] is the degree of LV ventricular dilatation and shape change or LV remodelling.36 Thus, it is postulated that there is an evolution or progression from HFNEF to HFREF with the onset of LV remodelling. LV volumes measured by three-dimensional echocardiography are ind ...
... failure with reduced LVEF (HFREF)] is the degree of LV ventricular dilatation and shape change or LV remodelling.36 Thus, it is postulated that there is an evolution or progression from HFNEF to HFREF with the onset of LV remodelling. LV volumes measured by three-dimensional echocardiography are ind ...
Prevention of atrial fibrillation following cardiac surgery: Basis for a
... latter may contribute to atrial remodelling (Korantzopoulos et al., 2003; Van Wagoner, 2003). Oxidative stress triggers proinflammatory signalling pathways that activate NF-κB and AP-1 transcription factors (Bowie & O'Neill, 2000). Marked inflammatory infiltrates, myocyte necrosis, and fibrosis have ...
... latter may contribute to atrial remodelling (Korantzopoulos et al., 2003; Van Wagoner, 2003). Oxidative stress triggers proinflammatory signalling pathways that activate NF-κB and AP-1 transcription factors (Bowie & O'Neill, 2000). Marked inflammatory infiltrates, myocyte necrosis, and fibrosis have ...
How to diagnose diastolic heart failure: a consensus statement on
... HFNEF needed to be updated. The diagnosis of HFNEF requires the following conditions to be satisfied: (i) signs or symptoms of heart failure; (ii) normal or mildly abnormal systolic LV function; (iii) evidence of diastolic LV dysfunction. Normal or mildly abnormal systolic LV function implies both an ...
... HFNEF needed to be updated. The diagnosis of HFNEF requires the following conditions to be satisfied: (i) signs or symptoms of heart failure; (ii) normal or mildly abnormal systolic LV function; (iii) evidence of diastolic LV dysfunction. Normal or mildly abnormal systolic LV function implies both an ...
1 A Stepwise Approach to the Management of Post
... ventricle. Infarct regions were sought first, and more data points (target filling threshold set to 10) were acquired in and around these areas. Refining the area under investigation relied on the usual clinical indicators, such as sinus rhythm analysis, echocardiography, and VT morphology on the 12 ...
... ventricle. Infarct regions were sought first, and more data points (target filling threshold set to 10) were acquired in and around these areas. Refining the area under investigation relied on the usual clinical indicators, such as sinus rhythm analysis, echocardiography, and VT morphology on the 12 ...
Simvastatin Modulates Remodeling of Kv4.3 Expression in Rat
... Furthermore, it is believed that suppression of repolarizing potassium currents leading to action potential prolongation provides an explanation for QT prolongation/dispersion, thereby accounting for a major mechanism of arrhythmogenesis [1]. Potassium channels include diverse classes of ion channel ...
... Furthermore, it is believed that suppression of repolarizing potassium currents leading to action potential prolongation provides an explanation for QT prolongation/dispersion, thereby accounting for a major mechanism of arrhythmogenesis [1]. Potassium channels include diverse classes of ion channel ...
How to diagnose diastolic heart failure: a consensus statement on
... failure with reduced LVEF (HFREF)] is the degree of LV ventricular dilatation and shape change or LV remodelling.36 Thus, it is postulated that there is an evolution or progression from HFNEF to HFREF with the onset of LV remodelling. LV volumes measured by three-dimensional echocardiography are ind ...
... failure with reduced LVEF (HFREF)] is the degree of LV ventricular dilatation and shape change or LV remodelling.36 Thus, it is postulated that there is an evolution or progression from HFNEF to HFREF with the onset of LV remodelling. LV volumes measured by three-dimensional echocardiography are ind ...
Atrial Electrophysiological Remodeling and Fibrillation in Heart Failure
... (mainly tachypacing-induced or myocardial infarction (MI)induced HF).5 In atria of dogs with short-term (three–six weeks) ventricular tachypacing-induced HF, the inducibility and duration of sustained AF 21 or atrial tachycardia (AT)22 were substantially enhanced. Focal activations were commonly see ...
... (mainly tachypacing-induced or myocardial infarction (MI)induced HF).5 In atria of dogs with short-term (three–six weeks) ventricular tachypacing-induced HF, the inducibility and duration of sustained AF 21 or atrial tachycardia (AT)22 were substantially enhanced. Focal activations were commonly see ...
as a PDF
... SPECT results interchangeably among institutes when the same workstation is used. Since QGS has the same algorithm for all workstations, we may expect similar inter-workstation stability, but it was not confirmed by this study. The limitations of this study was due to participation of many hospitals ...
... SPECT results interchangeably among institutes when the same workstation is used. Since QGS has the same algorithm for all workstations, we may expect similar inter-workstation stability, but it was not confirmed by this study. The limitations of this study was due to participation of many hospitals ...
Potentially Preventable Strokes in High
... timally anticoagulated before their stroke. Among the cohort of high-risk patients presenting with a first ischemic stroke, only 40% were taking warfarin for primary prevention before admission. Furthermore, the INR was subtherapeutic in three fourths of those who were taking warfarin. Overall, 90% ...
... timally anticoagulated before their stroke. Among the cohort of high-risk patients presenting with a first ischemic stroke, only 40% were taking warfarin for primary prevention before admission. Furthermore, the INR was subtherapeutic in three fourths of those who were taking warfarin. Overall, 90% ...
Experimental Demonstration of Concealed AV
... (Pp, i.e., atrial fusion beats), and total capture of the ventricles by some of the sinus impulses; the latter occurs exclusively and predictably whenever a sinus impulse falls, within a certain limited time, shortly after an artificial ventricular beat. The analysis of this type of complex mechanis ...
... (Pp, i.e., atrial fusion beats), and total capture of the ventricles by some of the sinus impulses; the latter occurs exclusively and predictably whenever a sinus impulse falls, within a certain limited time, shortly after an artificial ventricular beat. The analysis of this type of complex mechanis ...
Non-Invasive Transcutaneous Pacing
... With the pacer on, the defibrillator marks intrinsic beats on the R-wave with a marker on the MRx and an arrow the XL+. The intrinsic beats are also marked in the print strip. When an intrinsic beat is detected, the time interval for the next pace pulse starts at the intrinsic beat. If no intrinsic ...
... With the pacer on, the defibrillator marks intrinsic beats on the R-wave with a marker on the MRx and an arrow the XL+. The intrinsic beats are also marked in the print strip. When an intrinsic beat is detected, the time interval for the next pace pulse starts at the intrinsic beat. If no intrinsic ...
Review Article Epicardial Ablation For Ventricular Tachycardia
... really high as usually happens, in normal patients, along the AV groove. How to consider a patient for an epicardial ablation Type of cardiomyopathy First published experiences about epicardial ablation [18-23] include, in small patient populations, different types of structural heart diseases. In t ...
... really high as usually happens, in normal patients, along the AV groove. How to consider a patient for an epicardial ablation Type of cardiomyopathy First published experiences about epicardial ablation [18-23] include, in small patient populations, different types of structural heart diseases. In t ...
Cardiac connexins and impulse propagation
... ECG recordings on homozygous Cx40 KO mice exhibited prolonged P-wave duration [50–52,55,57], which is compatible with the detected reduced right-atrial conduction velocity [52,55]. However, prolongation of the P-wave was not a common finding, as in other studies, a P-wave prolongation was not found [ ...
... ECG recordings on homozygous Cx40 KO mice exhibited prolonged P-wave duration [50–52,55,57], which is compatible with the detected reduced right-atrial conduction velocity [52,55]. However, prolongation of the P-wave was not a common finding, as in other studies, a P-wave prolongation was not found [ ...
Modelling and robust estimation of AV node function during AF
... the normal regular electrical impulses generated by the sinoatrial node (SA node) are compromised, bearing disorganized electrical impulses (400-700 beats/minute), and leading to irregular conduction of ventricles impulses, usually with a ventricular rate at 140-220 beats/minute. AF is often associa ...
... the normal regular electrical impulses generated by the sinoatrial node (SA node) are compromised, bearing disorganized electrical impulses (400-700 beats/minute), and leading to irregular conduction of ventricles impulses, usually with a ventricular rate at 140-220 beats/minute. AF is often associa ...
Utility of the surface electrocardiogram for confirming right
... For decades, ventricular pacing has been performed from the apex of the right ventricle (RV), because of ease of implantation and lead stability at this site. Conventional RV apical pacing, because of dyssynchronous left ventricular contraction, may have detrimental effects on cardiac structure and ...
... For decades, ventricular pacing has been performed from the apex of the right ventricle (RV), because of ease of implantation and lead stability at this site. Conventional RV apical pacing, because of dyssynchronous left ventricular contraction, may have detrimental effects on cardiac structure and ...
PDF
... with various types of devices. All patients were followed until December 2013, 1 to 109 months. VSD type treated: perimembranous (VSDpm) 93.85 % and muscular (VSDM) 6.14%. The VSD measures before the procedure by echocardiography or at cardiac cath ventriculography were 2 - 18 mm. Successful implant ...
... with various types of devices. All patients were followed until December 2013, 1 to 109 months. VSD type treated: perimembranous (VSDpm) 93.85 % and muscular (VSDM) 6.14%. The VSD measures before the procedure by echocardiography or at cardiac cath ventriculography were 2 - 18 mm. Successful implant ...
New Insights into Mechanisms of Atrial Fibrillation
... of all strokes are attributable to this disorder. AF is characterized by very rapid, chaotic electrical activity of the atria, resulting in accelerated and irregular ventricular activity, loss of atrial mechanical function and increased risk of atrial clot formation. AF can occasionally affect a str ...
... of all strokes are attributable to this disorder. AF is characterized by very rapid, chaotic electrical activity of the atria, resulting in accelerated and irregular ventricular activity, loss of atrial mechanical function and increased risk of atrial clot formation. AF can occasionally affect a str ...
Valentin Fuster and Sidney C. Smith, Jr Joseph S. Alpert, Gabriel
... (5) All of the listed recommendations for implantation of a device presume the absence of inciting causes that may be eliminated without detriment to the patient (eg, nonessential drug therapy). (6) The committee endeavored to maintain consistency of recommendations in this and other previously publ ...
... (5) All of the listed recommendations for implantation of a device presume the absence of inciting causes that may be eliminated without detriment to the patient (eg, nonessential drug therapy). (6) The committee endeavored to maintain consistency of recommendations in this and other previously publ ...
Biochemical markers of myocardial injury
... will have increases in the absolute concentrations of CK and CK-MB. CK-BB is the predominant isoenzyme found in brain, colon, ileum, stomach and urinary bladder.89 The development of antibodies to the M-subunit of CK enabled immunoinhibition to be used as the ®rst speci®c quantitative assay for CK-M ...
... will have increases in the absolute concentrations of CK and CK-MB. CK-BB is the predominant isoenzyme found in brain, colon, ileum, stomach and urinary bladder.89 The development of antibodies to the M-subunit of CK enabled immunoinhibition to be used as the ®rst speci®c quantitative assay for CK-M ...
2011 ACCF/AHA/HRS Focused Update on the Management of Patients With... Fibrillation (Updating the 2006 Guideline): A Report of the American...
... Task Force on Practice Guidelines has created a “focused update” process to revise the existing guideline recommendations that are affected by the evolving data or opinion. Before the initiation of this focused approach, periodic updates and revisions of existing guidelines required up to 3 years to ...
... Task Force on Practice Guidelines has created a “focused update” process to revise the existing guideline recommendations that are affected by the evolving data or opinion. Before the initiation of this focused approach, periodic updates and revisions of existing guidelines required up to 3 years to ...
Right Ventricular Systolic Function
... that, in addition to the above mechanisms, left ventricular function may significantly affect right ventricular function. This so-called ventricular interdependence is defined herein as the forces that are transmitted from one ventricle to the other ventricle through the myocardium and pericardium, ...
... that, in addition to the above mechanisms, left ventricular function may significantly affect right ventricular function. This so-called ventricular interdependence is defined herein as the forces that are transmitted from one ventricle to the other ventricle through the myocardium and pericardium, ...
Mechanisms of Long-Duration Ventricular€Fibrillation in Human
... OBJECTIVES This study sought to determine the characteristics of human LDVF, particularly as it contrasts with short-duration VF (SDVF), and evaluate the role of Purkinje fibers in its maintenance. BACKGROUND The electrophysiological mechanisms of long-duration ventricular fibrillation (LDVF) have not ...
... OBJECTIVES This study sought to determine the characteristics of human LDVF, particularly as it contrasts with short-duration VF (SDVF), and evaluate the role of Purkinje fibers in its maintenance. BACKGROUND The electrophysiological mechanisms of long-duration ventricular fibrillation (LDVF) have not ...
Ventricular fibrillation
Ventricular fibrillation (V-fib or VF) is a condition in which there is uncoordinated contraction of the cardiac muscle of the ventricles in the heart, making them quiver rather than contract properly. Ventricular fibrillation is the most commonly identified arrhythmia in cardiac arrest patients. While there is some activity, the lay person is usually unable to detect it by palpating (feeling) the major pulse points of the carotid and femoral arteries. Such an arrhythmia is only confirmed by electrocardiography. Ventricular fibrillation is a medical emergency that requires prompt Advanced Life Support interventions. If this arrhythmia continues for more than a few seconds, it will likely degenerate further into asystole (""flatline""). This condition results in cardiogenic shock and cessation of effective blood circulation. As a consequence, sudden cardiac death (SCD) will result in a matter of minutes. If the patient is not revived after a sufficient period (within roughly 5 minutes at room temperature), the patient could sustain irreversible brain damage and possibly become brain-dead, due to the effects of cerebral hypoxia. On the other hand, death often occurs if sinus rhythm is not restored within 90 seconds of the onset of VF, especially if it has degenerated further into asystole.