Epigenomics Workshop - Institute for Systems Genomics
... unravel the molecular mechanism of the MMR pathway and how defects in this pathway give rise to cancer. This work involves biochemical and biophysical approaches as well as utilizing cell culture models including human embryonic stem cells. In addition to studying the MMR pathway in stem cells, his ...
... unravel the molecular mechanism of the MMR pathway and how defects in this pathway give rise to cancer. This work involves biochemical and biophysical approaches as well as utilizing cell culture models including human embryonic stem cells. In addition to studying the MMR pathway in stem cells, his ...
mirna target prediction
... (duplex stability) and 3’ complementarity (poorly understood) • High false positive rates – Some miRNAs predicted to target >25% of all human genes ...
... (duplex stability) and 3’ complementarity (poorly understood) • High false positive rates – Some miRNAs predicted to target >25% of all human genes ...
Comprehensive Analysis of Antibiotic Resistance in
... The timely and efficient determination of the antibiotic resistance genes in clinical isolates is crucial for the prevention of outbreaks and the treatment of patients. In this study, we developed pipelines to comprehensively analyze antibiotic resistance genes in carbapenemresistant Enterobacteriac ...
... The timely and efficient determination of the antibiotic resistance genes in clinical isolates is crucial for the prevention of outbreaks and the treatment of patients. In this study, we developed pipelines to comprehensively analyze antibiotic resistance genes in carbapenemresistant Enterobacteriac ...
ab initio and Evidence-Based Gene Finding
... Homology to known proteins argues against false positive Mammals have many gene families and many pseudogenes (both of these can show high similarity to your predicted gene) Consider length, percent identity when examining alignments. Human vs. chimp orthologs should differ by <1%; most paralogs or ...
... Homology to known proteins argues against false positive Mammals have many gene families and many pseudogenes (both of these can show high similarity to your predicted gene) Consider length, percent identity when examining alignments. Human vs. chimp orthologs should differ by <1%; most paralogs or ...
Phylogeny slides
... “Optimal” depends on multiple alignment scoring method No known (correct) efficient algorithms for this problem ...
... “Optimal” depends on multiple alignment scoring method No known (correct) efficient algorithms for this problem ...
Multiple Investigator Recruitments in Genomics National Human
... Multiple Investigator Recruitments in Genomics National Human Genome Research Institute (NHGRI) Intramural Research Program The NHGRI Intramural Research Program, an internationally recognized center for advancing human health through genomics research, is seeking multiple investigators to pursue in ...
... Multiple Investigator Recruitments in Genomics National Human Genome Research Institute (NHGRI) Intramural Research Program The NHGRI Intramural Research Program, an internationally recognized center for advancing human health through genomics research, is seeking multiple investigators to pursue in ...
Genomic sequence analysis of a plant
... MELD1 revealed genes involved in glycine betaine synthesis that help MELD1 to maintain osmotic balance in hyper saline environment. It was observed that MELD1 was able to grow at a salt concentration of up to 6 %. It carries an ectABC cluster responsible for synthesis and accumulation of ectoine (Ad ...
... MELD1 revealed genes involved in glycine betaine synthesis that help MELD1 to maintain osmotic balance in hyper saline environment. It was observed that MELD1 was able to grow at a salt concentration of up to 6 %. It carries an ectABC cluster responsible for synthesis and accumulation of ectoine (Ad ...
Begins of the human genome project
... began. In 1990, the Human Genome Project Began formally, the project is coordinated by the U.S. Department of Energy and the National Institutes of Health. At the time, the project was expect to last for 15 years, but with advance technology, the completion date was accelerated to 2003. ...
... began. In 1990, the Human Genome Project Began formally, the project is coordinated by the U.S. Department of Energy and the National Institutes of Health. At the time, the project was expect to last for 15 years, but with advance technology, the completion date was accelerated to 2003. ...
Genomics - WHAT IF server
... • Small distance between adjacent genes • Co-orientation (lie on the same strand) • More reliability when these features are conserved in different species Additional arguments: • Similar functional annotations of adjacent genes • Observed co-expression • Known average operon length ...
... • Small distance between adjacent genes • Co-orientation (lie on the same strand) • More reliability when these features are conserved in different species Additional arguments: • Similar functional annotations of adjacent genes • Observed co-expression • Known average operon length ...
A spruce sequence
... these plants challenging. DNA-based technology that can bypass these limitations has been particularly useful in forest trees, enabling genomic mapping, gene sequencing, genomic selection and genetic engineering. Whole-genome sequences are particularly powerful, because they provide a platform for a ...
... these plants challenging. DNA-based technology that can bypass these limitations has been particularly useful in forest trees, enabling genomic mapping, gene sequencing, genomic selection and genetic engineering. Whole-genome sequences are particularly powerful, because they provide a platform for a ...
Slide 1
... • #1: Students design and perform experiments, make observations, formulate hypothesis about identity of unknowns, and predict gene content • #2: Statistical analysis, such as bootstrapping in phylogenetic tree construction; requires quantitative reasoning • #3: Compare phylogenetic trees with those ...
... • #1: Students design and perform experiments, make observations, formulate hypothesis about identity of unknowns, and predict gene content • #2: Statistical analysis, such as bootstrapping in phylogenetic tree construction; requires quantitative reasoning • #3: Compare phylogenetic trees with those ...
Targeting the Noncoding Genome with CRISPR
... transcription and vemurafenib resistance. “Compared to the sequences of protein-coding genes, we don’t know much about noncoding regulatory elements,” said study coauthor Neville Sanjana, of the New York Genome Center and New York University who was a postdoc in Zhang’s lab. “Our study and other gen ...
... transcription and vemurafenib resistance. “Compared to the sequences of protein-coding genes, we don’t know much about noncoding regulatory elements,” said study coauthor Neville Sanjana, of the New York Genome Center and New York University who was a postdoc in Zhang’s lab. “Our study and other gen ...
DNA and the Genome - Speyside High School
... Multi-cellular organisms are comprised of a large number of cells. These are specialised to carry out specific roles in the body. Differentiation is the process by which unspecialised cells become altered and adapted to form a special function in the body. CFE Higher Biology ...
... Multi-cellular organisms are comprised of a large number of cells. These are specialised to carry out specific roles in the body. Differentiation is the process by which unspecialised cells become altered and adapted to form a special function in the body. CFE Higher Biology ...
The human genome: a prospect for paediatrics
... In the human species, information is limited labelled with a radioisotope, and this 'hybrito that arising from random mating through a dises' to fragments bearing the complementary limited number of generations. This is a severe sequence of bases. It is the extraordinary specirestraint, but more imp ...
... In the human species, information is limited labelled with a radioisotope, and this 'hybrito that arising from random mating through a dises' to fragments bearing the complementary limited number of generations. This is a severe sequence of bases. It is the extraordinary specirestraint, but more imp ...
High-throughput genotyping
... • May cause or predispose to inheritable diseases • Determines e.g. individual drug response • Used as markers to identify disease genes Finnish Genome Center ...
... • May cause or predispose to inheritable diseases • Determines e.g. individual drug response • Used as markers to identify disease genes Finnish Genome Center ...
Impact of New Diagnostic Technologies in the Clinical Microbiology
... – most “unknown” organisms (88.5% concordance with reference method) ...
... – most “unknown” organisms (88.5% concordance with reference method) ...
Aalborg Universitet Using metagenomics and metatranscriptomics to study specific bacterial species
... Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. ? Users may download a ...
... Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. ? Users may download a ...
Organization of the eukaryotic genomes
... The DNA of eukaryotic cell is tightly bound to small basic proteins (histones) that package the DNA in an orderly way in the cell nucleus. ...
... The DNA of eukaryotic cell is tightly bound to small basic proteins (histones) that package the DNA in an orderly way in the cell nucleus. ...
Slide 1
... a) Evolution of both coding and non-coding sequences is important for adaptation b) The target for strong positive selection is narrow at each moment c) Tightly related genes can perform rather different functions 3. Origin of novelties a) New non-coding regulatory sites, but not new genes, often ap ...
... a) Evolution of both coding and non-coding sequences is important for adaptation b) The target for strong positive selection is narrow at each moment c) Tightly related genes can perform rather different functions 3. Origin of novelties a) New non-coding regulatory sites, but not new genes, often ap ...
mnw2yr_lec17_2004
... An allele/trait/SNP A and a are on the same position in genome (locus), thus on a single chromosome an individual can have either of them – but not both – fA - frequency of occurrences of trait A in population ...
... An allele/trait/SNP A and a are on the same position in genome (locus), thus on a single chromosome an individual can have either of them – but not both – fA - frequency of occurrences of trait A in population ...
Mouse Repeats
... up to 5 nucleotides) the mouse genome contains two to three times more of these sequences. Of the longer variety (over 20 nucleotides) the difference between mouse and human is even greater. This suggests that the reason for more SSRs in mouse is due to both initiation and extension (Waterston, Lind ...
... up to 5 nucleotides) the mouse genome contains two to three times more of these sequences. Of the longer variety (over 20 nucleotides) the difference between mouse and human is even greater. This suggests that the reason for more SSRs in mouse is due to both initiation and extension (Waterston, Lind ...
Genome browsers and other resources
... Interpret the results for me. Which hit is the ‘best’ hit? If there is no ‘best’ hit, how do you interpret these results? ...
... Interpret the results for me. Which hit is the ‘best’ hit? If there is no ‘best’ hit, how do you interpret these results? ...
Document
... • 1975 George Kohler and Cesar Milstein show that fusing cells can generate monoclonal antibodies. • • 1982 First genetically engineered product - human insulin produced by Eli Lilly and Company using E. coli bacteria - is approved for use by diabetics. ...
... • 1975 George Kohler and Cesar Milstein show that fusing cells can generate monoclonal antibodies. • • 1982 First genetically engineered product - human insulin produced by Eli Lilly and Company using E. coli bacteria - is approved for use by diabetics. ...
Human Genome Project
The Human Genome Project (HGP) is an international scientific research project with the goal of determining the sequence of chemical base pairs which make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and functional standpoint. It remains the world's largest collaborative biological project. The project was proposed and funded by the US government; planning started in 1984, got underway in 1990, and was declared complete in 2003. A parallel project was conducted outside of government by the Celera Corporation, or Celera Genomics, which was formally launched in 1998. Most of the government-sponsored sequencing was performed in twenty universities and research centers in the United States, the United Kingdom, Japan, France, Germany, and China.The Human Genome Project originally aimed to map the nucleotides contained in a human haploid reference genome (more than three billion). The ""genome"" of any given individual is unique; mapping ""the human genome"" involves sequencing multiple variations of each gene.