Ethnopharmacology Presentation (powerpoint file)
... Poor metabolizers • 2 non-functional copies of CYP2D6 gene slower than normal enzyme activity = higher level of drug in blood ...
... Poor metabolizers • 2 non-functional copies of CYP2D6 gene slower than normal enzyme activity = higher level of drug in blood ...
understanding drugs and medicinces what is the
... inactive ingredients, things that give the pill it’s shape, color, size. ...
... inactive ingredients, things that give the pill it’s shape, color, size. ...
DRUG RECEPTOR INTERACTIONS
... Receptors – are chemicals which binds to the drug to exert a pharmacologic effect. Formula: D + R = D-R ------ Drug Response Note: Binding of a drug to the receptor is usually reversible ...
... Receptors – are chemicals which binds to the drug to exert a pharmacologic effect. Formula: D + R = D-R ------ Drug Response Note: Binding of a drug to the receptor is usually reversible ...
General Issues
... – Increase the effect of neurotransmitter X (agonist) – Decrease the effect of neurotransmitter X (antagonist) Thus, in order to understand the action of a ‘drug X’, we need to understand the neurochemical system it interacts with. In other words, we need to understand how Neurotransmitter X - is pr ...
... – Increase the effect of neurotransmitter X (agonist) – Decrease the effect of neurotransmitter X (antagonist) Thus, in order to understand the action of a ‘drug X’, we need to understand the neurochemical system it interacts with. In other words, we need to understand how Neurotransmitter X - is pr ...
sample-2 - Philadelphia University Jordan
... solve familiar problems with ease and can make progress towards the solution of unfamiliar problems, and can set out reasoning and explanation in a clear and coherent manner (5 marks) Question-12: (5 marks) Omar is interested in developing new anti-lipidemic agent, he found the following 3D structur ...
... solve familiar problems with ease and can make progress towards the solution of unfamiliar problems, and can set out reasoning and explanation in a clear and coherent manner (5 marks) Question-12: (5 marks) Omar is interested in developing new anti-lipidemic agent, he found the following 3D structur ...
Receptor
... Mechanism of Drug Action Basic Concept Interaction of a drug with its target tissue involves specific binding sites ...
... Mechanism of Drug Action Basic Concept Interaction of a drug with its target tissue involves specific binding sites ...
THE INTERPLAY OF COORDINATION CHEMISTRY AND SOLVATION IN DESIGNING SELECTIVE SENSORS FOR TOXIC METALS AND OTHER IONIC TARGETS
... significant challenges. Solvent extraction from water into a less polar organic phase via the formation of complexes with distinct optical or electrochemical properties presents an opportunity for addressing selectivity issues, by combining the unique coordination properties for each species (via li ...
... significant challenges. Solvent extraction from water into a less polar organic phase via the formation of complexes with distinct optical or electrochemical properties presents an opportunity for addressing selectivity issues, by combining the unique coordination properties for each species (via li ...
Injectable formulations
... after intravenous injection, the drug is both rapidly and quantitatively released from the cyclodextrin complex upon dilution, competitive replacement, and binding of drug molecules to plasma proteins and tissue. However, since cyclodextrins are rapidly eliminated in the urine cyclodextrins can incr ...
... after intravenous injection, the drug is both rapidly and quantitatively released from the cyclodextrin complex upon dilution, competitive replacement, and binding of drug molecules to plasma proteins and tissue. However, since cyclodextrins are rapidly eliminated in the urine cyclodextrins can incr ...
Paul T. Sprieser, DC, DIBAK
... Benlysta is supposed to be a new breakthrough drug? I am using the word breakthrough very loosely. This drug is a type of monoclonal antibody that bocks the binding receptor cites on B cells lymphocytes. The article states that this drug is marginally effective and was approved by the FDA for the tr ...
... Benlysta is supposed to be a new breakthrough drug? I am using the word breakthrough very loosely. This drug is a type of monoclonal antibody that bocks the binding receptor cites on B cells lymphocytes. The article states that this drug is marginally effective and was approved by the FDA for the tr ...
Metaxalone - McGraw-Hill
... § Metaxalone may interact with other drugs, including barbiturates (such as phenobarbital) and other central nervous system depressants. Tell all prescribers that you are taking it. § Avoid alcohol while taking this drug. STORAGE § Store drug at a controlled room temperature of 59 ° to 86 ° F. ADDIT ...
... § Metaxalone may interact with other drugs, including barbiturates (such as phenobarbital) and other central nervous system depressants. Tell all prescribers that you are taking it. § Avoid alcohol while taking this drug. STORAGE § Store drug at a controlled room temperature of 59 ° to 86 ° F. ADDIT ...
Lecture 21_Drug Design
... Therapeutic drugs for cardiovascular diseases development soared because scientists were able to investigate complex molecular interactions that occur in the onset of disease and overcome pharmacological barriers by adapting to the prodrug approach. In turn, the amalgamation of these two development ...
... Therapeutic drugs for cardiovascular diseases development soared because scientists were able to investigate complex molecular interactions that occur in the onset of disease and overcome pharmacological barriers by adapting to the prodrug approach. In turn, the amalgamation of these two development ...
Review Questions on Basic Pharmacology
... Review Questions on Basic Pharmacology. Make a list of your answers & then check them against the Answer Key 1. An antagonist is a type of drug that: A.has maximal efficacy B.has affinity for a receptor but little efficacy C.binds to a receptor and activates it D.has efficacy but low affinity E.decr ...
... Review Questions on Basic Pharmacology. Make a list of your answers & then check them against the Answer Key 1. An antagonist is a type of drug that: A.has maximal efficacy B.has affinity for a receptor but little efficacy C.binds to a receptor and activates it D.has efficacy but low affinity E.decr ...
Lecture 01 - Cal State LA
... biological targets, but also improved technology to increase pharmacophorebased projects. ...
... biological targets, but also improved technology to increase pharmacophorebased projects. ...
Lecture 12, computers CORRECTED
... If primary amino acid sequence of the receptor is known and the Xray structure of a related protein has been determined: Construct a model receptor: 1. The known structure is used as a template. The backbone of the new receptor is constructed on a computer to match that of the known protein. 2. Side ...
... If primary amino acid sequence of the receptor is known and the Xray structure of a related protein has been determined: Construct a model receptor: 1. The known structure is used as a template. The backbone of the new receptor is constructed on a computer to match that of the known protein. 2. Side ...
Medicines additional questions LT Scotland
... and noticed a fungal contaminant on an old petri dish had antibacterial activity. Since the Second World War, thousands of sulphonamide derivatives and penicillin derivatives have been made. Moreover, completely new antibacterial drugs have been discovered from a variety of ...
... and noticed a fungal contaminant on an old petri dish had antibacterial activity. Since the Second World War, thousands of sulphonamide derivatives and penicillin derivatives have been made. Moreover, completely new antibacterial drugs have been discovered from a variety of ...
Psychopharm Study Guide
... 27. The 3 major categories of adverse drug reactions are 28. The benzodiazepines (such as diazepam): 29. The benzodiazepines are MOST effective in treating: 30. The dose of a drug which will be fatal to half of the population is called: 31. The fact that caffeine cannot exert as much CNS stimulation ...
... 27. The 3 major categories of adverse drug reactions are 28. The benzodiazepines (such as diazepam): 29. The benzodiazepines are MOST effective in treating: 30. The dose of a drug which will be fatal to half of the population is called: 31. The fact that caffeine cannot exert as much CNS stimulation ...
Protein Data Bank Advisory Committee
... • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to market is huge ~$800M – drug reuse is a big business • The cost of failure is even higher e.g. Vioxx ...
... • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to market is huge ~$800M – drug reuse is a big business • The cost of failure is even higher e.g. Vioxx ...
Albuterol Protocol
... there is increased cough, wheeze or increased respiratory rate and effort at rest 2. Usually used only as needed for cats with intermittent signs of asthma (not daily signs) WHAT ARE POTENTIAL SIDE EFFECTS? 1. Musculoskeletal twitchiness 2. Excitability, insomnia, anorexia 3. THESE SIDE EFFECTS IN C ...
... there is increased cough, wheeze or increased respiratory rate and effort at rest 2. Usually used only as needed for cats with intermittent signs of asthma (not daily signs) WHAT ARE POTENTIAL SIDE EFFECTS? 1. Musculoskeletal twitchiness 2. Excitability, insomnia, anorexia 3. THESE SIDE EFFECTS IN C ...
L1: Intro to Pharm- Objectives Describe what is meant by a drug`s
... Drug size: varies from very small (Li = MW 7) to very large (eg, alteplase [t-PA] = MW 59,050). Vast majority have MW between 100 & 1,000. ...
... Drug size: varies from very small (Li = MW 7) to very large (eg, alteplase [t-PA] = MW 59,050). Vast majority have MW between 100 & 1,000. ...
Nuffield Free Standing Mathematics Activity
... …. is concerned with the rate at which an active drug is removed from your body. ...
... …. is concerned with the rate at which an active drug is removed from your body. ...
Drugs in the Body(1) ppp
... A patient is given an initial dose of 80mg of a drug. This drug is given in tablet form as 30mg tablets every hour. The drug has a decay factor of 85% ie. every 15 minutes , 85% of the drug present in the body at the start of the 15 minute interval remains in the body. Set up a recurrence relation a ...
... A patient is given an initial dose of 80mg of a drug. This drug is given in tablet form as 30mg tablets every hour. The drug has a decay factor of 85% ie. every 15 minutes , 85% of the drug present in the body at the start of the 15 minute interval remains in the body. Set up a recurrence relation a ...
Pharmacology and Older Adults
... Complete drug review with client/caregiver Instruct re: purpose, minor/major side effects Indicate when to discontinue Memory enhancement tools for compliance ...
... Complete drug review with client/caregiver Instruct re: purpose, minor/major side effects Indicate when to discontinue Memory enhancement tools for compliance ...
A Primer on Pharmacological Processes
... In a change from my traditional writing about the application of pharmacological agents to psychological disorders, I would like to discuss how psychotropic medications operate in the brain. I will focus on three important concepts: (a) Pharmacokinetics, (b) Pharmacodynamics, and (c) Pharmacometrics ...
... In a change from my traditional writing about the application of pharmacological agents to psychological disorders, I would like to discuss how psychotropic medications operate in the brain. I will focus on three important concepts: (a) Pharmacokinetics, (b) Pharmacodynamics, and (c) Pharmacometrics ...
B.P.T. [2 Prof.] Pharmacology
... Antiretro virus drugs should be given in combination. Anticholinergic drug's main side effects is dryness of mouth. Diabetic patients who are taking Insulin should avoid Alcohol drink. In variant Angina beta - blockers are avoided. On and off phenomenon occurs after chronic use of Levodopa in Parkin ...
... Antiretro virus drugs should be given in combination. Anticholinergic drug's main side effects is dryness of mouth. Diabetic patients who are taking Insulin should avoid Alcohol drink. In variant Angina beta - blockers are avoided. On and off phenomenon occurs after chronic use of Levodopa in Parkin ...
RSC PPT Template
... The increased costs in the discovery and development of new drugs, due in part to the high attrition rate of drug candidates in development, has led to a new strategy to introduce early, parallel evaluation of efficacy and biopharmaceutical properties of drug candidates. Investigation of terminated ...
... The increased costs in the discovery and development of new drugs, due in part to the high attrition rate of drug candidates in development, has led to a new strategy to introduce early, parallel evaluation of efficacy and biopharmaceutical properties of drug candidates. Investigation of terminated ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.