Pharmaceutical Medicinal Chemistry-3
... f. Describe the structure-activity relationships (SAR) of anticancer, cardiovascular agents, diuretics, and hormones. B. Cognitive Skills a. Gain insight into the concepts of design and development of drugs and their structure-activity relationship. b. Demonstrate how structural modifications of dru ...
... f. Describe the structure-activity relationships (SAR) of anticancer, cardiovascular agents, diuretics, and hormones. B. Cognitive Skills a. Gain insight into the concepts of design and development of drugs and their structure-activity relationship. b. Demonstrate how structural modifications of dru ...
Medicinal chemistry 1 (7303301) - E-Learning/An
... Course Description: The aim of this course is to introduce the basic concepts of medicinal chemistry. Study the physicochemical properties of the drugs and study their distribution, metabolism and excretion. The course will discuss specific drug classes by covering its chemistry, some synthesis, mec ...
... Course Description: The aim of this course is to introduce the basic concepts of medicinal chemistry. Study the physicochemical properties of the drugs and study their distribution, metabolism and excretion. The course will discuss specific drug classes by covering its chemistry, some synthesis, mec ...
Drug Discovery and Development
... • Having the genetic code for the production of an enzyme or a receptor may enable us to overexpress that protein and determine its structure and biological function. If it is deemed important to the disease process, inhibitors (of enzymes), or antagonists or agonists of the receptors can be prepar ...
... • Having the genetic code for the production of an enzyme or a receptor may enable us to overexpress that protein and determine its structure and biological function. If it is deemed important to the disease process, inhibitors (of enzymes), or antagonists or agonists of the receptors can be prepar ...
Powerpoint
... • We can characterize a protein-ligand binding site from a 3D structure (primary site) and search for that site on a proteome wide scale? • We could perhaps find alternative binding sites (offtargets) for existing pharmaceuticals and NCEs? • We could use it for lead optimization and possible ADME/To ...
... • We can characterize a protein-ligand binding site from a 3D structure (primary site) and search for that site on a proteome wide scale? • We could perhaps find alternative binding sites (offtargets) for existing pharmaceuticals and NCEs? • We could use it for lead optimization and possible ADME/To ...
Adverse_Reactions_Slideshow
... Overdosage or toxicity Side effects Secondary/Indirect effects Drug interactions ...
... Overdosage or toxicity Side effects Secondary/Indirect effects Drug interactions ...
Regulatory Authority Mission
... “ … as the absence of a significant difference in the rate and extent to which the active ingredient or active moiety in the pharmaceutical equivalents or pharmaceutical alternatives becomes available at the site of drug action when administered at the same molar dose under similar conditions ...
... “ … as the absence of a significant difference in the rate and extent to which the active ingredient or active moiety in the pharmaceutical equivalents or pharmaceutical alternatives becomes available at the site of drug action when administered at the same molar dose under similar conditions ...
Overview_of_drug_development_cmh_with_animatiions
... Decision to proceed to man only after thorough characterisation of dose/concentration response relationships of candidate compound in vitro and in vivo This is the scientific basis for all rational drug development today and the essential information required before first pharmacological studies i ...
... Decision to proceed to man only after thorough characterisation of dose/concentration response relationships of candidate compound in vitro and in vivo This is the scientific basis for all rational drug development today and the essential information required before first pharmacological studies i ...
Document
... • Confirmed experimentally at 600nM: design ligands with Donepezil as a hit to improve D4 activity • Dopamine D2 receptor studied (lower prediction, not active) Wermuth, C. G. Selective optimization of side activities: the SOSA approach. Drug discovery today, 11(3-4), 2006 ...
... • Confirmed experimentally at 600nM: design ligands with Donepezil as a hit to improve D4 activity • Dopamine D2 receptor studied (lower prediction, not active) Wermuth, C. G. Selective optimization of side activities: the SOSA approach. Drug discovery today, 11(3-4), 2006 ...
2 - The 8th Mediterranean Emergency Medicine Congress
... • IF STOP THE INDUCING DRUG, MAY DEVELOP SIGNIFICANT TOXICITY OF OBJECT DRUG • BEST TO DECREASE THE DOSE OF OBJECT DRUG BEFORE STOPPING INDUCING DRUG ...
... • IF STOP THE INDUCING DRUG, MAY DEVELOP SIGNIFICANT TOXICITY OF OBJECT DRUG • BEST TO DECREASE THE DOSE OF OBJECT DRUG BEFORE STOPPING INDUCING DRUG ...
TRIAL PHASES:
... Initial safety studies on a new drug, including the first administration of the drug into humans, usually conducted in healthy volunteers. These trials may be conducted in patients when administration of the drug to healthy volunteers is not ethical. Phase I trials are designed mainly to determine t ...
... Initial safety studies on a new drug, including the first administration of the drug into humans, usually conducted in healthy volunteers. These trials may be conducted in patients when administration of the drug to healthy volunteers is not ethical. Phase I trials are designed mainly to determine t ...
CHEMICAL MESSENGERS
... (e.g. Alzheimer’s Disease is related to loss of cholinergic function in brain) 5. Endorphins - thought to modulate pain relief and to be associated with naturally occurring pleasures or “highs” 6. GABA - (gamma-aminobutyric acid) referred to as an inhibitory transmitter because when it binds to rece ...
... (e.g. Alzheimer’s Disease is related to loss of cholinergic function in brain) 5. Endorphins - thought to modulate pain relief and to be associated with naturally occurring pleasures or “highs” 6. GABA - (gamma-aminobutyric acid) referred to as an inhibitory transmitter because when it binds to rece ...
Tina said you all learned ALOT last week
... the enzyme CYP450 2D6, so they must metabolize drugs that require this enzyme in an alternate manner, which might not be as efficient 20% of Japanese and Chinese individuals have reduced activity in enzyme CYP450 2C19 How does this make you feel about the clinical studies that have been done with li ...
... the enzyme CYP450 2D6, so they must metabolize drugs that require this enzyme in an alternate manner, which might not be as efficient 20% of Japanese and Chinese individuals have reduced activity in enzyme CYP450 2C19 How does this make you feel about the clinical studies that have been done with li ...
lecture10-TOLERANCE
... ALTERATION Phosphorylation of R i.e. ß-adrenoceptors → ↓ activation of AC to related ionic channel [functional defect] ...
... ALTERATION Phosphorylation of R i.e. ß-adrenoceptors → ↓ activation of AC to related ionic channel [functional defect] ...
Patient Teaching-atorvastatin calcium - McGraw-Hill
... nose, infection, swelling, and allergic reactions (including rash). Notify your prescriber of serious or bothersome symptoms. INTERACTIONS § Atorvastatin calcium may interact with cyclosporine, certain other cholesterol-lowering drugs, niacin, erythromycin, some antifungal drugs, antacids, colestipo ...
... nose, infection, swelling, and allergic reactions (including rash). Notify your prescriber of serious or bothersome symptoms. INTERACTIONS § Atorvastatin calcium may interact with cyclosporine, certain other cholesterol-lowering drugs, niacin, erythromycin, some antifungal drugs, antacids, colestipo ...
02. Factors modifying drug actions
... differences in drug metabolism = propranolol, hemolytic anemia due to some oxidizing agents (primaquine, sulphonamides) ...
... differences in drug metabolism = propranolol, hemolytic anemia due to some oxidizing agents (primaquine, sulphonamides) ...
5.111 Principles of Chemical Science MIT OpenCourseWare Fall 2008 rms of Use, visit:
... In drugs containing double bonds, one geometric isomer may be significantly more potent than the other isomer, since the lack of rotation around the bond prevents rotational inter-conversion between the two forms. This means that one isomer may be able to achieve the necessary conformation to bind a ...
... In drugs containing double bonds, one geometric isomer may be significantly more potent than the other isomer, since the lack of rotation around the bond prevents rotational inter-conversion between the two forms. This means that one isomer may be able to achieve the necessary conformation to bind a ...
Medicinal Chemistry
... INTRODUCTION- Chemistry plays a very important role in our everyday lives. In particular, medicinal chemistry in its most common guise, focusing on small organic molecules, encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with c ...
... INTRODUCTION- Chemistry plays a very important role in our everyday lives. In particular, medicinal chemistry in its most common guise, focusing on small organic molecules, encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with c ...
Introduction to Pharmacology
... So researchers are frantically hunting new approaches, including taking a fresh look at some old drugs. ...
... So researchers are frantically hunting new approaches, including taking a fresh look at some old drugs. ...
Data, Data Everywhere
... Drug Administration, including a drug product marketed by any crosslicensed producers or distributors operating under the new drug application. ...
... Drug Administration, including a drug product marketed by any crosslicensed producers or distributors operating under the new drug application. ...
第一章 绪论
... of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Medicinal chemistry is a highly interdisciplinary scie ...
... of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Medicinal chemistry is a highly interdisciplinary scie ...
CHEMICAL MESSENGERS
... (e.g. Alzheimer’s Disease is related to loss of cholinergic function in brain) 5. ______________ - thought to modulate pain relief and to be associated with naturally occurring pleasures or “highs” 6. _______ - (__________-___________________ acid) referred to as an inhibitory transmitter because wh ...
... (e.g. Alzheimer’s Disease is related to loss of cholinergic function in brain) 5. ______________ - thought to modulate pain relief and to be associated with naturally occurring pleasures or “highs” 6. _______ - (__________-___________________ acid) referred to as an inhibitory transmitter because wh ...
New Hampshire EMT-Intermediate Pharmacology
... Tachyphylaxis: rapid tolerance. Typically w/ sympathetic agonists (decongestant & bronchodilation agents) ...
... Tachyphylaxis: rapid tolerance. Typically w/ sympathetic agonists (decongestant & bronchodilation agents) ...
Pharmacology 1 for pharmacy students
... purely basic sciences and clinical sciences to promote a safe and effective drug use optimizing benefits and minimizing risks. Rational drug use embraces not only rational drug prescribing by the clinical practitioner but also rational drug dispensing by the pharmacist and rational drug consumption ...
... purely basic sciences and clinical sciences to promote a safe and effective drug use optimizing benefits and minimizing risks. Rational drug use embraces not only rational drug prescribing by the clinical practitioner but also rational drug dispensing by the pharmacist and rational drug consumption ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.