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The Nervous System (Chapter 7)
The Nervous System (Chapter 7)

... 20. What are the two functional properties of neurons? a. b. 21. When the plasma membrane is resting or inactive, it is said to be __________________________. a. This means what? _____________________________________________________________________________________ ___________________________________ ...
What is CDNF?
What is CDNF?

... • Rats were treated to express PD symptoms – Injected with 6-OHDA – 4 weeks later, treated with CDNF • Neuron function and viability was restored ...
Stereological estimates of neuronal loss in the primary motor cortex
Stereological estimates of neuronal loss in the primary motor cortex

... pattern of neurodegeneration contributes to the loss of motor function in pwPMS. Here, we present preliminary data on stereological estimates of neuronal cell loss in limb specific areas of the MS primary motor cortex (PMC). No limb specific neuronal cell counts had been reported to date in human br ...
Grant Mastick, Ph.D. "From brain to eye:  repulsion of neurons
Grant Mastick, Ph.D. "From brain to eye: repulsion of neurons

... ...
What is the structure of the neuron? (continued)
What is the structure of the neuron? (continued)

... than neurons. • Surround and support neurons, control the supply of nutrients to neurons, assist in the exchange of chemicals between neurons, destroy and remove damaged neurons. ...
Extracting Single-trialViews of Brain Activity
Extracting Single-trialViews of Brain Activity

... methods for studying the activity of one or perhaps a pair of neurons, we are currently unprepared to deal with the activity of the tens to hundreds of neurons that we can now monitor simultaneously. To make further scientific progress with the ever-growing volume of neural data being collected, new ...
Division of Brain Sciences Department of Medicine PhD studentship
Division of Brain Sciences Department of Medicine PhD studentship

... root causes for degeneration of this inherently vulnerable neuronal population are for the most part unknown and current therapeutic approaches fail to halt this process. Mitochondrial dysfunction, including changes in the structural integrity of mitochondria, disruption of energy metabolism and abn ...
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Modeling Synaptic Plasticity
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Katie Newhall Synchrony in stochastic pulse-coupled neuronal network models
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... Synchrony in stochastic pulse-coupled neuronal network models Many pulse-coupled dynamical systems  possess synchronous attracting states.  Even stochastically driven model networks of Integrate and Fire neurons demonstrate synchrony over a large range of parameters.  We study the interplay between ...
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Cognitive Psychology
Cognitive Psychology

... • Post-mortem lesion studies - Find someone who displays an interesting cognitive deficit. When they die, study their brain for where the damaged tissue was. (Phineas Gage, Broca’s & Wernicke’s areas) • Human-lesion studies - These days, we can take pictures of the brain while it’s still in the skul ...
Neural Ensemble www.AssignmentPoint.com A neural ensemble is
Neural Ensemble www.AssignmentPoint.com A neural ensemble is

... principle of Wikipedia operation - multiple edits by many participants. Neuroscientists have discovered that individual neurons are very noisy. For example, by examining the activity of only a single neuron in the visual cortex, it is very difficult to reconstruct the visual scene that the owner of ...
eprint_2_23793_166
eprint_2_23793_166

... peripheral sensory ganglia, such as dorsal root ganglia. c. Bipolar neurons: single axon and dendrite arise at opposite poles of the cell body. Found only in sensory neurons, such as in the retina, olfactory and auditory systems. d. Multipolar neurons: More than two dendrites just one axon ; found i ...
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Note: This hypothesis is mainly concerned with peripheral neurons
Note: This hypothesis is mainly concerned with peripheral neurons

... In vitro assays have shown that NTs enhance both axonal and dendritic growth In vivo, the situation is more difficult to study Why? In standard knockouts, it is difficult to separate the survival effects of NTs from their effects on the morphology of neurons. This problem has begun to be addressed ...
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... Elements of the nervous system • ______________ o Any organ that picks up stimulus o Ex. eye, nose, skin • Effectors o Any organ that _________________ o Ex. Muscle gland • Conductors o Transmit information about __________ between the receptor and an effector o Ex. neurons (include those in the bra ...
TOC - The Journal of Neuroscience
TOC - The Journal of Neuroscience

... Persons interested in becoming members of the Society for Neuroscience should contact the Membership Department, Society for Neuroscience, 1121 14th St., NW, Suite 1010, Washington, DC 20005, phone 202-962-4000. Instructions for Authors are available at http://www.jneurosci.org/misc/itoa.shtml. Auth ...
The Journal of Neuroscience Journal Club SYMPOSIUM
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The Nervous System
The Nervous System

... the “blood-brain barrier”. 2. Maintain the the electrochemical environment • Capture and recycle neurotransmitters • Absorb and return K+ and other ions. • Connected to one another and capable of ...
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The fertile brain - Health Research Council
The fertile brain - Health Research Council

... in transgenic mice are now able to investigate GnRH neurons in detail like never before. The introduction of various transgenic approaches by the group has put them in a world-leading position to answer the fundamental questions. “Whereas most neurons communicate with each other through chemical syn ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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