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Nociceptive sensation. Somatic sensory analyzer
Nociceptive sensation. Somatic sensory analyzer

... Somatic sensory analyzer ...
CNS Neuroglial Cells
CNS Neuroglial Cells

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eating spaghetti!

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Slide ()
Slide ()

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Laminar and Columnar organization of the cerebral cortex
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Synapses - Franklin College

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sensory overload - Saint Michael`s College

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... Cells in the nervous system have very unique designs that allow them to carry messages to and from the brain. Using the handout provided in this activity, students will work cooperatively within their groups to understand the structure and function of a neuron. Students will individually assemble a ...
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Nervous Tissue

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Abstract View ; The Salk Inst, San Diego, CA, USA
Abstract View ; The Salk Inst, San Diego, CA, USA

... Looming is an apparent increase in the size of an approaching or receding object and can be used to assess changes in the distance between an observer and object. Intracellular recordings of identified neurons in the visual system of Manduca sexta (Sphingidae, Lepidoptera) reveal two cell classes th ...
Optogenetics Review1 - Department Of Biological Sciences
Optogenetics Review1 - Department Of Biological Sciences

... electrical field stimulation is simple, convenient and has high temporal resolution, the electrical field is generally non-uniform and many untargeted neurons are stimulated simultaneously. It is thus difficult to identify which neurons are stimulated. On the other hand, a single, identified neuron ...
Slide ()
Slide ()

... oscillation is evident in vitro in extracellular recordings from a number of cortical cells made simultaneously with an intracellular recording of a single pyramidal cell. The picture of a cortical slice shows the sites of cell recordings. (Reproduced, with permission, from Sanchez-Vives and McCormi ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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