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No Slide Title
No Slide Title

... “Cognitive neuroscience, by identifying the specific mechanisms responsible for behaviour, will vividly illustrate what until now could only be appreciated through esoteric theorizing: that there is something fishy about our ordinary conceptions of human action and responsibility, and that, as a res ...
Nervous System - Downey Unified School District
Nervous System - Downey Unified School District

... • THEY TRAVEL DOWN THE AXON TO THE NERVE TERMINAL • OTHER NEUROTRANSMITTERS ARE SYNTHESIZED IN THE CYTOPLASM OF THE NERVE TERMINALS AND ARE STORED IN VESICLES • WHEN AN ACTION POTENTIAL PASSES ALONG THE MEMBRANE OF A SYNAPTIC KNOB IT INCREASES PERMEABILITY ALLOWING CALCIUM IONS IN BY OPENING CHANNEL ...
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Mod 07-Lecture - Phoenix Military Academy
Mod 07-Lecture - Phoenix Military Academy

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Nervous System Part 1
Nervous System Part 1

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... organization of cells into tissues, and tissues into organs. The structure and function of organs determine their relationships within body systems of an organism. Homeostasis allows the body to perform its normal functions. ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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